LOCUS       NM_001395153            2124 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus selectin P ligand (Selplg), mRNA.
ACCESSION   NM_001395153 XM_039089641
VERSION     NM_001395153.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2124)
  AUTHORS   Xu,T., Liu,W., Yang,C., Ba,X., Wang,X., Jiang,Y. and Zeng,X.
  TITLE     Lipid raft-associated beta-adducin is required for PSGL-1-mediated
            neutrophil rolling on P-selectin
  JOURNAL   J Leukoc Biol 97 (2), 297-306 (2015)
   PUBMED   25425738
REFERENCE   2  (bases 1 to 2124)
  AUTHORS   Zivkovic,M., Kolakovic,A., Radak,D., Dincic,D., Radak,S., Djuric,T.
            and Stankovic,A.
  TITLE     The sex-specific association of Met62Ile gene polymorphism in
            P-selectin glycoprotein ligand (PSGL-1) with carotid plaque
            presence: preliminary study
  JOURNAL   Mol Biol Rep 39 (6), 6479-6485 (2012)
   PUBMED   22307784
REFERENCE   3  (bases 1 to 2124)
  AUTHORS   Brown,J.B., Cheresh,P., Zhang,Z., Ryu,H., Managlia,E. and
            Barrett,T.A.
  TITLE     P-selectin glycoprotein ligand-1 is needed for sequential
            recruitment of T-helper 1 (Th1) and local generation of Th17 T
            cells in dextran sodium sulfate (DSS) colitis
  JOURNAL   Inflamm Bowel Dis 18 (2), 323-332 (2012)
   PUBMED   22009715
REFERENCE   4  (bases 1 to 2124)
  AUTHORS   Affentranger,S., Martinelli,S., Hahn,J., Rossy,J. and Niggli,V.
  TITLE     Dynamic reorganization of flotillins in chemokine-stimulated human
            T-lymphocytes
  JOURNAL   BMC Cell Biol 12, 28 (2011)
   PUBMED   21696602
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2124)
  AUTHORS   Wyllie,S., Barshes,N.R., Gao,F.Q., Karpen,S.J. and Goss,J.A.
  TITLE     Failure of P-selectin blockade alone to protect the liver from
            ischemia-reperfusion injury in the isolated blood-perfused rat
            liver
  JOURNAL   World J Gastroenterol 14 (44), 6808-6816 (2008)
   PUBMED   19058306
  REMARK    GeneRIF: Blockade of P-selectin alone failed to reduced
            polymorphonuclear leukocyte accumulation in the liver and protect
            hepatocytes from ischemia-reperfusion injury in the isolated
            blood-perfused cold-ex vivo rat liver model.
REFERENCE   6  (bases 1 to 2124)
  AUTHORS   Baisse,B., Galisson,F., Giraud,S., Schapira,M. and Spertini,O.
  TITLE     Evolutionary conservation of P-selectin glycoprotein ligand-1
            primary structure and function
  JOURNAL   BMC Evol Biol 7, 166 (2007)
   PUBMED   17868453
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2124)
  AUTHORS   Wang,H.B., Wang,J.T., Zhang,L., Geng,Z.H., Xu,W.L., Xu,T., Huo,Y.,
            Zhu,X., Plow,E.F., Chen,M. and Geng,J.G.
  TITLE     P-selectin primes leukocyte integrin activation during inflammation
  JOURNAL   Nat Immunol 8 (8), 882-892 (2007)
   PUBMED   17632516
  REMARK    Erratum:[Nat Immunol. 2014 Mar;15(3):305]
REFERENCE   8  (bases 1 to 2124)
  AUTHORS   Tsuchihashi,S., Fondevila,C., Shaw,G.D., Lorenz,M., Marquette,K.,
            Benard,S., Shen,X.D., Ke,B., Busuttil,R.W. and
            Kupiec-Weglinski,J.W.
  TITLE     Molecular characterization of rat leukocyte P-selectin glycoprotein
            ligand-1 and effect of its blockade: protection from
            ischemia-reperfusion injury in liver transplantation
  JOURNAL   J Immunol 176 (1), 616-624 (2006)
   PUBMED   16365457
REFERENCE   9  (bases 1 to 2124)
  AUTHORS   Dole,V.S., Bergmeier,W., Mitchell,H.A., Eichenberger,S.C. and
            Wagner,D.D.
  TITLE     Activated platelets induce Weibel-Palade-body secretion and
            leukocyte rolling in vivo: role of P-selectin
  JOURNAL   Blood 106 (7), 2334-2339 (2005)
   PUBMED   15956287
REFERENCE   10 (bases 1 to 2124)
  AUTHORS   Peterson,R.S., Lim,L., Ye,H., Zhou,H., Overdier,D.G. and Costa,R.H.
  TITLE     The winged helix transcriptional activator HFH-8 is expressed in
            the mesoderm of the primitive streak stage of mouse embryos and its
            cellular derivatives
  JOURNAL   Mech Dev 69 (1-2), 53-69 (1997)
   PUBMED   9486531
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Jun 4, 2021 this sequence version replaced XM_039089641.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.194599.1, FQ205951.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000012.1  48458637-48458724
            89-2124             JAXUCZ010000012.1  48468409-48470444
FEATURES             Location/Qualifiers
     source          1..2124
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2124
                     /gene="Selplg"
                     /gene_synonym="Psgl1; Selpl"
                     /note="selectin P ligand"
                     /db_xref="GeneID:363930"
                     /db_xref="RGD:1307971"
     exon            1..88
                     /gene="Selplg"
                     /gene_synonym="Psgl1; Selpl"
                     /inference="alignment:Splign:2.1.0"
     exon            89..2124
                     /gene="Selplg"
                     /gene_synonym="Psgl1; Selpl"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1386
                     /gene="Selplg"
                     /gene_synonym="Psgl1; Selpl"
                     /note="leukocyte cell surface adhesion molecule;
                     P-selectin glycoprotein ligand 1 propeptide; selectin,
                     platelet (p-selectin) ligand"
                     /codon_start=1
                     /product="P-selectin glycoprotein ligand 1 precursor"
                     /protein_id="NP_001382082.1"
                     /db_xref="GeneID:363930"
                     /db_xref="RGD:1307971"
                     /translation="MFPHFLLLLTVLGPGNSLHLQEPWGHETMEGLGPVHLRERRQVV
                     GDDDFEYPDYSVYGTDPPETLISVPNMVAAHLELRTMVAVLEQRVSAGAGTSETVTAQ
                     VATTGPADPDTERPAVGMLSTESVTQRRLSPVEMTTRLAPTEAETSQPAPREAETSQP
                     APIKAETSQPAPIKAETSQPAPREAETSQPAPTEAETSQPAPTKAETSQPAPTEAETS
                     QPAPTEVETSQPAPTEAETSQPAPTEAETSQPASTETETTQLPRSQVVESLFTTSAVT
                     EAPSTEPTAMETLSTEANESAIFLGPSIGHLPDTGLKKGLIVTPGSSLAPTPPGTSDL
                     IPVKQCLLAILILASLATIFLVCTVVLAVRLSRKTHMYPVRNYSPTEMICISSLLPEG
                     GDGAPVTANGGLPKVQDQKTERSGDPDGDDLTLHSFLP"
ORIGIN      
        1 agcatctggc agtgtggacg gggccttgtc acggaggcag agtcacttct gggccccgag
       61 gcagctgccc catgctctgc tgggcacggt accatgttcc cacacttcct tctgctgctg
      121 accgtcttgg gccctggcaa cagccttcat ctgcaggagc cgtgggggca tgaaaccatg
      181 gaaggcctgg gccctgtgca tctccgggaa cggagacagg tggttgggga tgatgatttt
      241 gaataccccg actacagcgt gtatggcaca gatcccccag aaacgttgat aagtgtcccc
      301 aacatggtgg cggctcacct tgagcttcgg acaatggtgg ccgtgttaga gcagagagtt
      361 tccgcggggg ctggaacttc tgagactgtc actgcgcagg ttgccaccac tggccctgct
      421 gacccggata cagaaaggcc agcagttggg atgctgagca ctgaatctgt cacacagcgg
      481 agactaagcc cagtggagat gactacccgg ctagcaccca cggaggcaga gacctcacag
      541 ccagcaccca gggaggcaga gacctcacag ccagcaccca taaaggcaga gacctcacag
      601 ccagcaccca taaaggcaga gacctcacag ccagcaccca gggaggcaga gacctcacag
      661 ccagcaccca cggaggcaga gacctcacag ccagcaccca caaaggcaga gacctcacag
      721 ccagcaccca cagaggcaga gacctcacag ccagcaccca cggaggtaga gacctcacag
      781 ccagcaccca cagaggcaga gacctcacag ccagcaccca cggaggcaga gacctcacag
      841 ccagcgtcca cagagacaga gaccacccag cttcccagga gtcaggttgt agaaagtcta
      901 tttacaacat ctgcggtcac agaagcccct tctacggaac ccaccgccat ggagaccctg
      961 tccacagagg ctaatgagtc tgccatcttc cttgggcctt ccattggcca cttacctgac
     1021 accgggctga agaaagggct gattgtcacc cctgggagtt ctctggcccc aaccccgcca
     1081 gggacctcgg acctcatccc ggtgaagcaa tgtttgctgg ccattctcat cttagcctcc
     1141 ctggccacca tcttccttgt gtgcacggtg gtgctggccg tccgcctctc ccgtaagacg
     1201 cacatgtacc cagtgcggaa ctactccccc acagagatga tctgcatctc atccttgctt
     1261 cccgaggggg gtgacggggc ccctgtcaca gccaacgggg gcctgcccaa ggtccaggac
     1321 cagaagacag aacgcagtgg ggacccggat ggggatgacc tcaccctgca cagcttcctc
     1381 ccttagccca cctgagcaag acccttgctg gttccatgat taccccatca gtcatgaagg
     1441 ccatagattt gggcctcctg ggtgaagtgt atacacagga ctctttaggg aagggacctt
     1501 acgccactcc aatcagggtc cagagccccc aaggtcctga gcttcctgct ttgttcctgg
     1561 agcctggtgg cctccaggac aaggtctaca gtaacattaa cattctccac ctcttttctg
     1621 ttttgtctga tatccccgtc cccattgccc tcccactgct gtgtgtcccc cgcaggtcac
     1681 tggattcctg tccttccatt aagaaggact cagctccctt cccccactcc caaagccatt
     1741 ctctctctct ctctctctct ctctctctct ctctctctct ctctctcttt ttttttccgg
     1801 agctggggac cgaacccagg gctttgctag ggtcttgatc ttgctaggca agcgctctac
     1861 cactgagcta aatccccaac cccccaaagc cattctcttg gttgccatgg ttgcctgata
     1921 agaatgaagc attatgggag gccaccatgt ctgttcctct gtcccctgtg aggggcatct
     1981 tggctttccc aggcccctgg cttggaagga tggtccttcc tttgggtctg tgtgaaccaa
     2041 tgagtttcca tccagcgaca gtgacatcac actgctgcct ggcccagcac aggtgttcaa
     2101 taaaattatg ataacaaatg gcaa
//
