LOCUS       NM_013114               3187 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus selectin P (Selp), mRNA.
ACCESSION   NM_013114
VERSION     NM_013114.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3187)
  AUTHORS   Horioka,K., Tanaka,H., Isozaki,S., Okuda,K., Asari,M., Shiono,H.,
            Ogawa,K. and Shimizu,K.
  TITLE     Hypothermia-induced activation of the splenic platelet pool as a
            risk factor for thrombotic disease in a mouse model
  JOURNAL   J Thromb Haemost 17 (10), 1762-1771 (2019)
   PUBMED   31237986
REFERENCE   2  (bases 1 to 3187)
  AUTHORS   Jing,Y., Hu,Y., Li,H., Wang,J., Si,X., Zheng,H., Liu,J., Liao,W.,
            Liao,Y. and Bin,J.
  TITLE     Assessment of Thrombotic Risk in Atrial Fibrillation with
            Ultrasound Molecular Imaging of P-Selectin
  JOURNAL   Thromb Haemost 118 (2), 388-400 (2018)
   PUBMED   29378361
  REMARK    GeneRIF: P-selectin may indicate thrombotic risk assessment in
            atrial fibrillation
REFERENCE   3  (bases 1 to 3187)
  AUTHORS   Mehta-D'souza,P., Klopocki,A.G., Oganesyan,V., Terzyan,S.,
            Mather,T., Li,Z., Panicker,S.R., Zhu,C. and McEver,R.P.
  TITLE     Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to
            Stabilize the High Affinity State under Force
  JOURNAL   J Biol Chem 292 (6), 2510-2518 (2017)
   PUBMED   28011641
REFERENCE   4  (bases 1 to 3187)
  AUTHORS   Vogel,K.U., Edelmann,S.L., Jeltsch,K.M., Bertossi,A., Heger,K.,
            Heinz,G.A., Zoller,J., Warth,S.C., Hoefig,K.P., Lohs,C., Neff,F.,
            Kremmer,E., Schick,J., Repsilber,D., Geerlof,A., Blum,H., Wurst,W.,
            Heikenwalder,M., Schmidt-Supprian,M. and Heissmeyer,V.
  TITLE     Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40
            costimulator mRNAs and control follicular helper T cell
            differentiation
  JOURNAL   Immunity 38 (4), 655-668 (2013)
   PUBMED   23583643
REFERENCE   5  (bases 1 to 3187)
  AUTHORS   Ehlers,P.I., Kivimaki,A.S., Siltari,A., Turpeinen,A.M., Korpela,R.
            and Vapaatalo,H.
  TITLE     Plant sterols and casein-derived tripeptides attenuate blood
            pressure increase in spontaneously hypertensive rats
  JOURNAL   Nutr Res 32 (4), 292-300 (2012)
   PUBMED   22575043
  REMARK    GeneRIF: Aortic cyclooxygenase-2 and P-selectin were significantly
            down-regulated in plant sterols and plant sterols + tripeptides
            groups.
REFERENCE   6  (bases 1 to 3187)
  AUTHORS   Ruppert,M., Aigner,S., Hubbe,M., Yagita,H. and Altevogt,P.
  TITLE     The L1 adhesion molecule is a cellular ligand for VLA-5
  JOURNAL   J Cell Biol 131 (6 Pt 2), 1881-1891 (1995)
   PUBMED   8557754
REFERENCE   7  (bases 1 to 3187)
  AUTHORS   Auchampach,J.A., Oliver,M.G., Anderson,D.C. and Manning,A.M.
  TITLE     Cloning, sequence comparison and in vivo expression of the gene
            encoding rat P-selectin
  JOURNAL   Gene 145 (2), 251-255 (1994)
   PUBMED   7520013
REFERENCE   8  (bases 1 to 3187)
  AUTHORS   Sammar,M., Aigner,S., Hubbe,M., Schirrmacher,V., Schachner,M.,
            Vestweber,D. and Altevogt,P.
  TITLE     Heat-stable antigen (CD24) as ligand for mouse P-selectin
  JOURNAL   Int Immunol 6 (7), 1027-1036 (1994)
   PUBMED   7524641
REFERENCE   9  (bases 1 to 3187)
  AUTHORS   Mayadas,T.N., Johnson,R.C., Rayburn,H., Hynes,R.O. and Wagner,D.D.
  TITLE     Leukocyte rolling and extravasation are severely compromised in P
            selectin-deficient mice
  JOURNAL   Cell 74 (3), 541-554 (1993)
   PUBMED   7688665
REFERENCE   10 (bases 1 to 3187)
  AUTHORS   Nelson,R.M., Dolich,S., Aruffo,A., Cecconi,O. and Bevilacqua,M.P.
  TITLE     Higher-affinity oligosaccharide ligands for E-selectin
  JOURNAL   J Clin Invest 91 (3), 1157-1166 (1993)
   PUBMED   7680663
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013114.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L23088.1, SRR26643297.41795.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                JAXUCZ010000013.1  79009511-79009530
            21-111              JAXUCZ010000013.1  79018990-79019080
            112-498             JAXUCZ010000013.1  79021440-79021826
            499-606             JAXUCZ010000013.1  79023010-79023117
            607-792             JAXUCZ010000013.1  79023793-79023978
            793-978             JAXUCZ010000013.1  79025556-79025741
            979-1164            JAXUCZ010000013.1  79027669-79027854
            1165-1350           JAXUCZ010000013.1  79030252-79030437
            1351-1536           JAXUCZ010000013.1  79033430-79033615
            1537-1722           JAXUCZ010000013.1  79036616-79036801
            1723-1932           JAXUCZ010000013.1  79037893-79038102
            1933-2118           JAXUCZ010000013.1  79039116-79039301
            2119-2238           JAXUCZ010000013.1  79040098-79040217
            2239-2269           JAXUCZ010000013.1  79042272-79042302
            2270-2325           JAXUCZ010000013.1  79043466-79043521
            2326-3187           JAXUCZ010000013.1  79044132-79044993
FEATURES             Location/Qualifiers
     source          1..3187
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q23"
     gene            1..3187
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /note="selectin P"
                     /db_xref="GeneID:25651"
                     /db_xref="RGD:3656"
     exon            1..20
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..2324
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /note="P-selectin; LECAM3; PADGEM; GMP-140; granule
                     membrane protein 140; CD62 antigen-like family member P;
                     leukocyte-endothelial cell adhesion molecule 3; platelet
                     activation dependent granule-external membrane protein;
                     selectin, platelet"
                     /codon_start=1
                     /product="P-selectin precursor"
                     /protein_id="NP_037246.2"
                     /db_xref="GeneID:25651"
                     /db_xref="RGD:3656"
                     /translation="MAGCPKGSWKPRLRSVVLGAAQLVWLSALISELVNQKEVAAWTY
                     NYSTKAYSWNNSRAFCKRHFTDLVAIQNKNEIAHLNDVIPYVNSYYWIGIRKINNKWT
                     WVGTNKTLTAEAENWADNEPNNKRNNQDCVEIYIKSNSAPGKWNDEPCFKRKRALCYT
                     ASCQDMSCNSQGECIETIGSYTCSCYPGFYGPECEYVQECGKFDIPQHVLMNCSHPLG
                     DFSFSSQCTFSCPEGYDLNGPSEMQCLASGIWTNNPPQCKAVQCQSLEAPLHGTMDCT
                     HPLAAFAYDSSCKFECQPGYRMRGSDILHCTDSGQWSEPLPTCEAIACEPLESPLHGS
                     MDCFPSTGAFGYNSSCTFRCTEGFVLMGNDAIHCADLGQWTAPAPVCEALQCQEFPVP
                     SKAQVSCSDPFGTLKYQSACSFSCDEGSLLVGASVIRCLATGHWSEAPPECQAVSCTP
                     LLSPENGTMTCIQPLGHSNYKSTCQFMCDEGFYLSGPERLDCSPSGHWTGSPPMCEAI
                     KCPEIFAPEQGSLDCSHVHGEFSVGSTCHFSCNEEFELLGSRNVECTVSGRWSAPPPT
                     CKGVTSLPVPSVRCPALTTPGQGTMSCRHHLESFGPNTTCYFGCKTGFTLRGANSLRC
                     GASGQWTAVTPVCRAVKCSELHMDTAVAMNCSNPWGNFSYGSTCAFHCPEGQSLNGSA
                     RTTCREDGHWSDAMPTCQAGTLTIQEALTYLGGALASTTGLAVGGTLLALLRKRLRKK
                     DDGKCPLNPHSHLGTYGVFTNAAYDPTP"
     exon            21..111
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /inference="alignment:Splign:2.1.0"
     exon            112..498
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /inference="alignment:Splign:2.1.0"
     exon            499..606
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /inference="alignment:Splign:2.1.0"
     exon            607..792
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /inference="alignment:Splign:2.1.0"
     exon            793..978
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1164
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1350
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1536
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1722
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1932
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2118
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2238
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2269
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2325
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..3187
                     /gene="Selp"
                     /gene_synonym="PSELECT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgggtcgg agaggacatg gccggctgcc caaaaggttc ttggaagcca agactccgga
       61 gtgtggtcct gggagccgct cagcttgtct ggctcagtgc tttgatctct gagcttgtaa
      121 atcagaagga agtggccgcg tggacctata actacagcac gaaagcatac tcatggaata
      181 actcacgggc attctgcaag aggcacttca cagacttagt ggccatccag aacaagaatg
      241 aaatcgctca cctcaatgac gtcatcccat acgtcaactc ttactactgg attggtatcc
      301 gaaagatcaa caataagtgg acctgggtgg gaaccaataa gactctcacg gcggaggctg
      361 agaactgggc agacaacgag cccaacaaca agaggaacaa ccaggactgt gtggagatct
      421 acatcaagag taattcggcc cctggcaagt ggaatgatga gccctgcttt aaacgaaagc
      481 gggccctgtg ctacacagcc tcctgccagg acatgtcttg caacagccaa ggggagtgca
      541 tcgagaccat tgggagctac acctgctcct gctacccggg cttctatggg ccagagtgtg
      601 aatacgtcca agagtgtgga aaattcgaca tcccgcaaca cgttctcatg aactgcagcc
      661 accctctggg ggacttctcc ttcagctcac agtgcacctt cagctgtcct gagggctatg
      721 acctgaacgg acccagtgag atgcaatgtt tggcctctgg aatctggaca aataatcccc
      781 cgcagtgtaa agctgtgcag tgccagagcc tggaagcccc tctccatgga accatggact
      841 gtacacaccc attggctgcc tttgcctatg actccagctg taaatttgag tgccagcctg
      901 gatatcggat gaggggctct gacatactcc actgcactga ctctggtcag tggagtgaac
      961 cattgccaac ctgtgaagcc attgcatgcg aaccgctgga gagccccctc catgggagca
     1021 tggactgctt cccatccaca ggagcattcg ggtacaacag cagctgcact tttcgctgca
     1081 cagagggatt cgtgctgatg ggaaatgatg ccattcattg tgctgacttg gggcagtgga
     1141 cagccccagc cccagtctgt gaagcgttgc aatgtcagga gtttccggtc ccaagtaaag
     1201 cccaggtgag ctgctcggac cccttcggga ccttgaagta ccagtcagcc tgcagctttt
     1261 cctgtgatga aggctcactc ttggtgggag caagtgtgat aagatgcttg gctactggac
     1321 actggagtga ggcccctcct gaatgtcaag ctgtctcctg cacccctttg ctcagccctg
     1381 agaatggaac catgacgtgt atccagcctc ttgggcattc caactacaaa tccacatgcc
     1441 agttcatgtg tgacgaagga ttttatctat ctggaccaga aagattggac tgttctccat
     1501 ctggacactg gacaggcagc cctccaatgt gtgaagccat caagtgccca gaaatctttg
     1561 ccccagaaca aggcagcttg gactgctctc atgttcatgg agaattcagt gtcggctcca
     1621 cctgtcactt ctcctgcaac gaggagtttg agctcctggg atctcgaaat gtggagtgca
     1681 cagtgtctgg aagatggtca gcgcctccac caacctgcaa aggtgtaaca tcacttcctg
     1741 tcccatcggt tcgatgcccc gccctcacta ctcctggaca gggcacaatg tcctgtcgac
     1801 accacctgga aagctttggt ccgaacacca cttgttactt tgggtgcaaa actggattta
     1861 cactcagagg agccaactct ctccgctgcg gggcttcagg acaatggaca gcagtgacgc
     1921 ccgtgtgcag agccgtcaaa tgctcagaat tgcacatgga cacagcagtc gcgatgaact
     1981 gttccaaccc ctggggaaac tttagctacg gatcaacctg tgccttccac tgtccagagg
     2041 ggcagtcact gaatggctct gccaggacaa cctgccgaga ggacggtcac tggtcagatg
     2101 ccatgccaac ctgccaagca gggacgctga cgatccagga agctctgact tacttgggtg
     2161 gcgccttggc ttctacaaca ggcctggcag tgggcgggac gctactggct ctgctaagaa
     2221 agcgtctcag aaagaaagat gatggaaaat gccccctgaa ccctcacagc cacctaggaa
     2281 catatggagt cttcacgaac gctgcatatg acccaacccc ttaagaggcc tggcctcccg
     2341 atgtcaattg gatctctcag gattccgcat gcagataaca agtttcctgg tcgacttgac
     2401 tgtcactccc cagcatttgc tgcggttctt tgtggtaaat aattggacag gaaccaaacg
     2461 aaaggacgat gtgctccgcc caccccttcc tgctccgccc ctcaccttcc tcgggctcag
     2521 ccacagaaac aggagcaaat gtttctgctg tggtctgtgg cttgatgtta ctttgctgtt
     2581 actgaaaacc cgagttagtc caaggcactg gagcatctgc ctcaccaggt gaccaggctg
     2641 tggaaaaccg gaagtctgtc tgctttctct tgggattgaa gaatggcgat gttggtgggc
     2701 aggcagacct ctcgtttaag ggaacgcctg ctttaagatc tcctgggtct tccgtgtttc
     2761 ttatctctga ggttgtttac acctctgctg ctgagacttt cagatggtac taggggacac
     2821 agaagatcgg gaacagagca tggacaccac atctgactgc agactttccg tccaccaaag
     2881 cacccaaagg ccattgtttg actgtagagt tcaactcccc cagctatcaa gctcttcacg
     2941 ttttgttcag tgaggtctgt gtatctcact ttgtctacca ccaatgtggt cacagttaca
     3001 ctcctccaaa tgacagctgg accctccagt gagcccacaa atatatgttg tatgtcgcct
     3061 gtccacagag agaaaaatca gaggagcagg aaaggtcctc ttttcgttat tttgttctgc
     3121 aggaaagaac agttatgttt tatacgtaac ttaattcaca tatttaataa ataagtcact
     3181 gaaaatt
//
