LOCUS       NM_001166396            1228 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus selenoprotein V (Selenov), transcript variant 1,
            mRNA.
ACCESSION   NM_001166396 XR_009209
VERSION     NM_001166396.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1228)
  AUTHORS   Liu,A., Li,F., Xu,P., Chen,Y., Liang,X., Zheng,S., Meng,H., Zhu,Y.,
            Mo,J., Gong,C. and Zhou,J.C.
  TITLE     Gpx4, Selenov, and Txnrd3 Are Three Most Testis-Abundant
            Selenogenes Resistant to Dietary Selenium Concentrations and
            Actively Expressed During Reproductive Ages in Rats
  JOURNAL   Biol Trace Elem Res 201 (1), 250-259 (2023)
   PUBMED   35076866
  REMARK    GeneRIF: Gpx4, Selenov, and Txnrd3 Are Three Most Testis-Abundant
            Selenogenes Resistant to Dietary Selenium Concentrations and
            Actively Expressed During Reproductive Ages in Rats.
            Erratum:[Biol Trace Elem Res. 2022 Mar 1;:. PMID: 35233715]
REFERENCE   2  (bases 1 to 1228)
  AUTHORS   Gladyshev,V.N., Arner,E.S., Berry,M.J., Brigelius-Flohe,R.,
            Bruford,E.A., Burk,R.F., Carlson,B.A., Castellano,S., Chavatte,L.,
            Conrad,M., Copeland,P.R., Diamond,A.M., Driscoll,D.M., Ferreiro,A.,
            Flohe,L., Green,F.R., Guigo,R., Handy,D.E., Hatfield,D.L.,
            Hesketh,J., Hoffmann,P.R., Holmgren,A., Hondal,R.J., Howard,M.T.,
            Huang,K., Kim,H.Y., Kim,I.Y., Kohrle,J., Krol,A., Kryukov,G.V.,
            Lee,B.J., Lee,B.C., Lei,X.G., Liu,Q., Lescure,A., Lobanov,A.V.,
            Loscalzo,J., Maiorino,M., Mariotti,M., Sandeep Prabhu,K.,
            Rayman,M.P., Rozovsky,S., Salinas,G., Schmidt,E.E., Schomburg,L.,
            Schweizer,U., Simonovic,M., Sunde,R.A., Tsuji,P.A., Tweedie,S.,
            Ursini,F., Whanger,P.D. and Zhang,Y.
  TITLE     Selenoprotein Gene Nomenclature
  JOURNAL   J Biol Chem 291 (46), 24036-24040 (2016)
   PUBMED   27645994
REFERENCE   3  (bases 1 to 1228)
  AUTHORS   Varlamova,E.G. and Novoselov,V.I.
  TITLE     [The search of partners of a new mammalian selenium-containing
            protein V (SelV) and expression it's mRNA during ontogenesis and
            spermatogenesis]
  JOURNAL   Mol Biol (Mosk) 46 (2), 276-284 (2012)
   PUBMED   22670524
  REMARK    GeneRIF: expression of SelV mRNA in the later stages
            spermatogenesis, as well as in puberty and reproductive periods of
            rats is shown.
REFERENCE   4  (bases 1 to 1228)
  AUTHORS   Mariotti,M., Ridge,P.G., Zhang,Y., Lobanov,A.V., Pringle,T.H.,
            Guigo,R., Hatfield,D.L. and Gladyshev,V.N.
  TITLE     Composition and evolution of the vertebrate and mammalian
            selenoproteomes
  JOURNAL   PLoS One 7 (3), e33066 (2012)
   PUBMED   22479358
REFERENCE   5  (bases 1 to 1228)
  AUTHORS   Kryukov,G.V., Castellano,S., Novoselov,S.V., Lobanov,A.V.,
            Zehtab,O., Guigo,R. and Gladyshev,V.N.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000001.1 and
            BC158767.1.
            
            On Oct 23, 2009 this sequence version replaced XR_009209.1.
            
            Summary: This gene encodes a selenoprotein containing a
            selenocysteine (Sec) residue, which is encoded by the UGA codon
            that normally signals translation termination. The 3' UTRs of
            selenoprotein mRNAs contain a conserved stem-loop structure, the
            Sec insertion sequence (SECIS) element, which is necessary for the
            recognition of UGA as a Sec codon rather than as a stop signal.
            This protein is specifically expressed in the testis. It belongs to
            the SelWTH family, which possesses a thioredoxin-like fold and a
            conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox
            function for this gene. Alternatively spliced transcript variants
            have been found for this gene. [provided by RefSeq, Apr 2017].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes a selenoprotein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript and
            the encoded protein are supported by orthologous mouse data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.2198.1,
                                           SRR26360181.833023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate                   :: translation inferred from
                                               conservation
            protein contains selenocysteine :: inferred from conservation
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-801               JAXUCZ010000001.1  92685520-92686320   c
            802-1228            BC158767.1         654-1080
FEATURES             Location/Qualifiers
     source          1..1228
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1228
                     /gene="Selenov"
                     /gene_synonym="RGD1562943; Selv"
                     /note="selenoprotein V"
                     /db_xref="GeneID:499113"
                     /db_xref="RGD:1562943"
     exon            1..801
                     /gene="Selenov"
                     /gene_synonym="RGD1562943; Selv"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1033
                     /gene="Selenov"
                     /gene_synonym="RGD1562943; Selv"
                     /note="UGA stop codon recoded as selenocysteine"
                     /codon_start=1
                     /transl_except=(pos:809..811,aa:Sec)
                     /product="selenoprotein V"
                     /protein_id="NP_001159868.1"
                     /db_xref="GeneID:499113"
                     /db_xref="RGD:1562943"
                     /translation="MNNKARNPAPSSVRANTPSRTPTPVRTATPVRASTPAHNRSPVR
                     TSIRVRTPANPVPIRFPTPAPAPAPTPTPAPTPAPVPAAAPVRTPAPVRASIQGRSFP
                     TISPVRFLRNLALPAAQPLSSGGAGSLSKDLTLAQKQKPSIHSLAEAIQGPFPVLTPS
                     ASSETHGSIPDPAPPTDSLASTAMASSTLDPIPGPKPTLEFLASPLKETPDLGKLSTI
                     SPAQNFVSTKEVPSTSEDVPTANRILIRVMYCGLUSYGLRYILLKKTLEHQFPNLLEF
                     EEERATQVTGEFEVFVDGKLIHSKKKGDGFVDETSLKKLVGAIDEEIKKR"
     exon            802..826
                     /gene="Selenov"
                     /gene_synonym="RGD1562943; Selv"
                     /inference="alignment:Splign:2.1.0"
     exon            827..880
                     /gene="Selenov"
                     /gene_synonym="RGD1562943; Selv"
                     /inference="alignment:Splign:2.1.0"
     exon            881..955
                     /gene="Selenov"
                     /gene_synonym="RGD1562943; Selv"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1093
                     /gene="Selenov"
                     /gene_synonym="RGD1562943; Selv"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1204
                     /gene="Selenov"
                     /gene_synonym="RGD1562943; Selv"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1094..1166
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Selenov"
                     /gene_synonym="RGD1562943; Selv"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
ORIGIN      
        1 cagggcgaag cgggagggtc agcctggggt acgcgggtct cacctggtcc ccatgaataa
       61 caaggcgcgg aaccccgctc cctcttcagt ccgggcaaac accccgtccc ggacacccac
      121 tcccgtccga accgcgaccc cagtcagggc ctcgaccccg gcgcacaacc ggtctccggt
      181 ccgaacatcc atccgggtcc ggactcctgc taaccctgtt ccaattcggt tccctactcc
      241 agccccagcc cctgccccaa ctccaacccc agccccaact ccagccccag tcccggccgc
      301 agcaccggtg cggactccag caccagtccg ggcctccatt caaggtcgga gctttcccac
      361 gatctctcca gtgagattct tacggaactt ggccttgccc gcggcacagc ccctttcttc
      421 cgggggtgct ggctctctct caaaggatct cacgctcgct caaaagcaga agccctcgat
      481 ccacagccta gcggaggcca tccaggggcc ctttccagtg ctcactccct cggcctcctc
      541 ggagacccac ggctccatac cggaccccgc ccctcccact gactccttgg cttccactgc
      601 catggcctcc agtaccttgg accccattcc gggccccaaa cctacactag agttcttggc
      661 ctccccgctg aaggaaaccc ctgatttggg taagctctcc acaatttccc cagcacagaa
      721 cttcgtttcc actaaggagg tcccctccac cagcgaggac gtcccaacgg ccaacagaat
      781 cttgatccgt gtgatgtact gtggcctctg aagctatggc cttcggtaca ttctactgaa
      841 aaagaccctg gagcatcaat ttccaaacct tctggagttt gaggaggaaa gagctaccca
      901 ggttacaggg gagtttgaag tgtttgtgga tgggaaattg atccattcca agaagaaagg
      961 cgatggcttt gtggatgaga ctagtctgaa gaaacttgtg ggtgctattg atgaagagat
     1021 caagaaaagg tagcagcaat agtggagctg gacatgagtg aggtgcaatg gagggtcatg
     1081 aggaagcgtg caagaacctc agcgggatga tgagaagggc tgaaatgctg ccaaaccagg
     1141 tccttttctg atggtggctg gggcttggtt agggcttggg agagtaaaga aaaatataat
     1201 ctgcaaaaaa aaaaaaaaaa aaaaaaaa
//
