LOCUS       NM_001014253            3157 bp    mRNA    linear   ROD 27-MAY-2024
DEFINITION  Rattus norvegicus selenoprotein T (Selenot), mRNA.
ACCESSION   NM_001014253 XM_345215
VERSION     NM_001014253.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3157)
  AUTHORS   De Bartolo,A., Pasqua,T., Romeo,N., Rago,V., Perrotta,I.,
            Giordano,F., Granieri,M.C., Marrone,A., Mazza,R., Cerra,M.C.,
            Lefranc,B., Leprince,J., Anouar,Y., Angelone,T. and Rocca,C.
  TITLE     The redox-active defensive Selenoprotein T as a novel stress sensor
            protein playing a key role in the pathophysiology of heart failure
  JOURNAL   J Transl Med 22 (1), 375 (2024)
   PUBMED   38643121
  REMARK    GeneRIF: The redox-active defensive Selenoprotein T as a novel
            stress sensor protein playing a key role in the pathophysiology of
            heart failure.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3157)
  AUTHORS   Huang,J., Bao,D., Lei,C.T., Tang,H., Zhang,C.Y., Su,H. and Zhang,C.
  TITLE     Selenoprotein T protects against cisplatin-induced acute kidney
            injury through suppression of oxidative stress and apoptosis
  JOURNAL   FASEB J 34 (9), 11983-11996 (2020)
   PUBMED   32686857
  REMARK    GeneRIF: Selenoprotein T protects against cisplatin-induced acute
            kidney injury through suppression of oxidative stress and
            apoptosis.
REFERENCE   3  (bases 1 to 3157)
  AUTHORS   Abid,H., Cartier,D., Hamieh,A., Francois-Bellan,A.M., Bucharles,C.,
            Pothion,H., Manecka,D.L., Leprince,J., Adriouch,S., Boyer,O.,
            Anouar,Y. and Lihrmann,I.
  TITLE     AMPK Activation of PGC-1alpha/NRF-1-Dependent SELENOT Gene
            Transcription Promotes PACAP-Induced Neuroendocrine Cell
            Differentiation Through Tolerance to Oxidative Stress
  JOURNAL   Mol Neurobiol 56 (6), 4086-4101 (2019)
   PUBMED   30267375
  REMARK    GeneRIF: PACAP and cAMP-activated AMPK-PGC-1alpha/NRF-1 cascade is
            critical for the coupling of oxidative stress tolerance, via
            SELENOT gene expression, and mitochondrial biogenesis in order to
            achieve PC12 cell differentiation.
REFERENCE   4  (bases 1 to 3157)
  AUTHORS   Gladyshev,V.N., Arner,E.S., Berry,M.J., Brigelius-Flohe,R.,
            Bruford,E.A., Burk,R.F., Carlson,B.A., Castellano,S., Chavatte,L.,
            Conrad,M., Copeland,P.R., Diamond,A.M., Driscoll,D.M., Ferreiro,A.,
            Flohe,L., Green,F.R., Guigo,R., Handy,D.E., Hatfield,D.L.,
            Hesketh,J., Hoffmann,P.R., Holmgren,A., Hondal,R.J., Howard,M.T.,
            Huang,K., Kim,H.Y., Kim,I.Y., Kohrle,J., Krol,A., Kryukov,G.V.,
            Lee,B.J., Lee,B.C., Lei,X.G., Liu,Q., Lescure,A., Lobanov,A.V.,
            Loscalzo,J., Maiorino,M., Mariotti,M., Sandeep Prabhu,K.,
            Rayman,M.P., Rozovsky,S., Salinas,G., Schmidt,E.E., Schomburg,L.,
            Schweizer,U., Simonovic,M., Sunde,R.A., Tsuji,P.A., Tweedie,S.,
            Ursini,F., Whanger,P.D. and Zhang,Y.
  TITLE     Selenoprotein Gene Nomenclature
  JOURNAL   J Biol Chem 291 (46), 24036-24040 (2016)
   PUBMED   27645994
REFERENCE   5  (bases 1 to 3157)
  AUTHORS   Li,J.P., Zhou,J.X., Wang,Q., Gu,G.Q., Yang,S.J., Li,C.Y., Qiu,C.W.,
            Deng,G.Z. and Guo,M.Y.
  TITLE     Se Enhances MLCK Activation by Regulating Selenoprotein T (SelT) in
            the Gastric Smooth Muscle of Rats
  JOURNAL   Biol Trace Elem Res 173 (1), 116-125 (2016)
   PUBMED   26779623
  REMARK    GeneRIF: Se plays a major role in regulating the contraction
            processes of gastric smooth muscle with the SelT.
REFERENCE   6  (bases 1 to 3157)
  AUTHORS   Boukhzar,L., Hamieh,A., Cartier,D., Tanguy,Y., Alsharif,I.,
            Castex,M., Arabo,A., El Hajji,S., Bonnet,J.J., Errami,M.,
            Falluel-Morel,A., Chagraoui,A., Lihrmann,I. and Anouar,Y.
  TITLE     Selenoprotein T Exerts an Essential Oxidoreductase Activity That
            Protects Dopaminergic Neurons in Mouse Models of Parkinson's
            Disease
  JOURNAL   Antioxid Redox Signal 24 (11), 557-574 (2016)
   PUBMED   26866473
REFERENCE   7  (bases 1 to 3157)
  AUTHORS   Guo,M., Gao,X., Zhang,N., Qiu,C., Li,C. and Deng,G.
  TITLE     Effects of Se on the Diversity of SelT Synthesis and Distribution
            in Different Smooth Muscle Tissues in Rats
  JOURNAL   Biol Trace Elem Res 170 (2), 340-347 (2016)
   PUBMED   26280902
  REMARK    GeneRIF: SelT may play a major role in the mechanisms underlying
            the biological activity of Se in smooth muscle tissues.
REFERENCE   8  (bases 1 to 3157)
  AUTHORS   Prevost,G., Arabo,A., Jian,L., Quelennec,E., Cartier,D., Hassan,S.,
            Falluel-Morel,A., Tanguy,Y., Gargani,S., Lihrmann,I.,
            Kerr-Conte,J., Lefebvre,H., Pattou,F. and Anouar,Y.
  TITLE     The PACAP-regulated gene selenoprotein T is abundantly expressed in
            mouse and human beta-cells and its targeted inactivation impairs
            glucose tolerance
  JOURNAL   Endocrinology 154 (10), 3796-3806 (2013)
   PUBMED   23913443
REFERENCE   9  (bases 1 to 3157)
  AUTHORS   Tanguy,Y., Falluel-Morel,A., Arthaud,S., Boukhzar,L., Manecka,D.L.,
            Chagraoui,A., Prevost,G., Elias,S., Dorval-Coiffec,I., Lesage,J.,
            Vieau,D., Lihrmann,I., Jegou,B. and Anouar,Y.
  TITLE     The PACAP-regulated gene selenoprotein T is highly induced in
            nervous, endocrine, and metabolic tissues during ontogenetic and
            regenerative processes
  JOURNAL   Endocrinology 152 (11), 4322-4335 (2011)
   PUBMED   21896670
  REMARK    GeneRIF: SelT induction is associated with ontogenesis, tissue
            maturation, and regenerative mechanisms, indicating that this
            PACAP-regulated selenoprotein may play a crucial role in cell
            growth and activity in nervous, endocrine, and metabolic tissues.
REFERENCE   10 (bases 1 to 3157)
  AUTHORS   Grumolato,L., Ghzili,H., Montero-Hadjadje,M., Gasman,S., Lesage,J.,
            Tanguy,Y., Galas,L., Ait-Ali,D., Leprince,J., Guerineau,N.C.,
            Elkahloun,A.G., Fournier,A., Vieau,D., Vaudry,H. and Anouar,Y.
  TITLE     Selenoprotein T is a PACAP-regulated gene involved in intracellular
            Ca2+ mobilization and neuroendocrine secretion
  JOURNAL   FASEB J 22 (6), 1756-1768 (2008)
   PUBMED   18198219
  REMARK    GeneRIF: role in the regulation of Ca(2+) homeostasis and
            neuroendocrine secretion in response to a cAMP-stimulating trophic
            factor.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000002.1, FM042340.1
            and FM061880.1.
            
            On Apr 19, 2017 this sequence version replaced NM_001014253.2.
            
            Summary: This gene encodes a selenoprotein, containing a
            selenocysteine (Sec) residue at the active site. Sec is encoded by
            the UGA codon that normally signals translation termination. The 3'
            UTRs of selenoprotein mRNAs contain a conserved stem-loop
            structure, the Sec insertion sequence (SECIS) element, that is
            necessary for the recognition of UGA as a Sec codon rather than as
            a stop signal. This protein is localized in the endoplasmic
            reticulum. It belongs to the SelWTH family that possesses a
            thioredoxin-like fold and a conserved CxxU (C is cysteine, U is
            Sec) motif found in several redox active proteins. Studies in rat
            indicate a role for this gene in the regulation of calcium
            homeostasis and smooth muscle contraction. High induction of this
            gene is also associated with ontogenetic and regenerative processes
            in nervous, endocrine, and metabolic tissues. A pseudogene of this
            locus has been identified on chromosome 4. [provided by RefSeq, Aug
            2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211813.1, SRR26643293.12308.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            protein contains selenocysteine :: inferred from conservation
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                JAXUCZ010000002.1  144954324-144954335
            13-376              FM042340.1         1-364
            377-849             FM061880.1         154-626
            850-3157            JAXUCZ010000002.1  144969068-144971375
FEATURES             Location/Qualifiers
     source          1..3157
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..3157
                     /gene="Selenot"
                     /note="selenoprotein T"
                     /db_xref="GeneID:365802"
                     /db_xref="RGD:1359128"
     exon            1..204
                     /gene="Selenot"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..655
                     /gene="Selenot"
                     /EC_number="1.8.1.9"
                     /note="UGA stop codon recoded as selenocysteine;
                     thioredoxin reductase-like enzyme; thioredoxin
                     reductase-like selenoprotein T"
                     /codon_start=1
                     /transl_except=(pos:212..214,aa:Sec)
                     /product="thioredoxin reductase-like selenoprotein T
                     precursor"
                     /protein_id="NP_001014275.2"
                     /db_xref="GeneID:365802"
                     /db_xref="RGD:1359128"
                     /translation="MRLLLLLLVAASAVVRSEASANLGGVPSKRLKMQYATGPLLKFQ
                     ICVSUGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYRHIASFLSVFKLVLIGLIIV
                     GKDPFAFFGMQAPSIWQWGQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWS
                     KLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS"
     exon            205..315
                     /gene="Selenot"
                     /inference="alignment:Splign:2.1.0"
     exon            316..442
                     /gene="Selenot"
                     /inference="alignment:Splign:2.1.0"
     exon            443..530
                     /gene="Selenot"
                     /inference="alignment:Splign:2.1.0"
     exon            531..684
                     /gene="Selenot"
                     /inference="alignment:Splign:2.1.0"
     exon            685..3157
                     /gene="Selenot"
                     /inference="alignment:Splign:2.1.0"
     regulatory      711..784
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Selenot"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
ORIGIN      
        1 agttcgtggc taggttttgg gctgcagtct cggtctgaag gcggccggag cggctgtctc
       61 aattaagatg aggctcttgc tgcttctgct ggtggcggcg tcggcggtgg tccgcagcga
      121 ggcctctgcc aacctgggcg gcgtgcccag caagagatta aagatgcagt acgccacggg
      181 gccgctgctc aagtttcaga tttgtgtatc ctgagggtac aggcgggtgt ttgaggagta
      241 catgcgggtt attagccagc ggtatccaga catccgcatt gagggggaga attatctccc
      301 tcaaccaatt tatagacaca tagcatcttt cctgtcagtc ttcaaactag tattaatagg
      361 cttaataatt gttggcaaag atccttttgc ttttttcggc atgcaagctc ctagcatctg
      421 gcagtggggc caagaaaata aggtttatgc atgtatgatg gtcttcttct tgagcaacat
      481 gattgagaac cagtgtatgt caacaggtgc atttgagata actttaaatg atgtaccggt
      541 atggtctaag ctggaatctg gacatcttcc atccatgcaa caacttgttc aaattcttga
      601 caatgaaatg aaactcaatg tgcatatgga ttcaatccca catcatcgat catagcccta
      661 cctatcagca ctgaaaactc ttttacacta agggattttg caagagcagc gtgactgaca
      721 ttatgaaggc ctgtactgaa gacagcaagc tgttagtaca gaccagatgt ttcttggcag
      781 gctcgttgta cctcttggaa aacctcagtg caagacagtt ttccatgctg gcacgtgctg
      841 aactctgcac acacatgcag tgcagtgata ctgtgtagct tccccgagcc cactgttaat
      901 agtttcttct tgacatggca ttactacttg taattctttt cttggtcatg tttaagaaag
      961 tacagaattg agttgcaact tgagtttttt tcaacatgtg tgttaagtcg gttgtgtttt
     1021 tatatgaatt ttcatttttt ttaatagtta agcatcagct ttcatggggc aacacctgaa
     1081 gttcccaaat aatttttaag agtttctcag atagctctaa ttggccatgt ttaatacata
     1141 gttttaaaaa cactgcagat tgtgaacagt aaaaattata caggattatg ggagaaaatc
     1201 caatgtccaa aatactctac caagttgtgt gtgtgttgcc tagtaagtgt gatatatatg
     1261 tatgtgtgag tgagtgtgtg tgtgtgtgtg tgtgtgtgta tgtgtgtgtg tgtgtgtgtg
     1321 agagagagag gggtggggga gagagagaga ttatcaagaa cagcaaaacc aactgcttta
     1381 aaaatcctat tgttcaaatt gtcttgacca atctaataaa ttaattaacg ggccctttat
     1441 actaaactaa ttttagaaaa actgaggaga tgttaaatga aaaagtttat tgttcagtgt
     1501 atctgttagc attattttta ataaccatct gcctaatttt tttgtttttg acttacagat
     1561 aatctcataa aggacatact ttagattcac acataagtaa tgagctaatt tactgttttt
     1621 agaacagttg aaactcacct cactaaagaa caattcagtg aaacctcttt acaaagtatg
     1681 tattatgtaa acggagatca tttgtctagt aattgaatta tcttaacatc atatatcaga
     1741 attttattgt atttgaaaga caaaattaaa aatattttta atgttttcat attgttccag
     1801 agttctaaaa agaaacttag ggttgataaa gacagtaaga atgattttgc agaaatagag
     1861 aataattttg aatagcagtt acatagcagc tgtggcaaca gaaagacgtt aggtggaaga
     1921 accaaacata gcctggacct gtgagtggga gttaggagcc cacgggaagg agatgcaggg
     1981 ggtgatggtg ttgatgccac ctgactctta gatgttgaga acagcttgac tcctggacgt
     2041 acactgagtg cactcaggca atgcctctta cagcctaaag tggaatctac tgtggtcctc
     2101 ggatagcagg aagttagtcc agtgattaac agaagaaaac agatggaata ttaccctttt
     2161 ggtcaggatt atagcactgc tagcctaggt tcttttggtg atagacattg taatttaacc
     2221 gaagttccat atatatgtat atattgacta agtcttaaaa ccttgctaat atggttgcct
     2281 accacttcag actccacacc ttgcagagtt taacatcaga ggggcctttc ttcaagtaat
     2341 ggacattcca tgtgtgatgc agttagcttt atggcacata gacattcata atttgagcca
     2401 tggatgttca tgtgtacttg acaggtcaaa ctatgaagaa cccaatgtca aatccaactt
     2461 tgtccatgtt tgccttaggg ttgagtttgt ctctaagtta atagctttta ctggcttaga
     2521 cattcacact catctctttt attttatgct tagtcatatt taaatccaga atgtaatagt
     2581 ctactagaca gataaatgag atgcatgaat ataaaaatat ataaggaaaa ggagaaggta
     2641 aactatttat aactattata ttactaacat ttcaaaatgt attaattgct tataaactgt
     2701 ataattacaa catgtctatg ctctattaac cagaaggccg aggacgtatc aacaggctgg
     2761 ctactgtact ggagtgttca gcacagttgc cattgtggaa ggtttttgca cagttaaaac
     2821 attggtaaaa catggcttta accctcagcg tgtcagatat gagtgacttt ggctgtagac
     2881 tagcattagt gatggttgct cagcctgaag agctgtgaaa tggggtgaga tcagtcatgg
     2941 ttcattctta cttcaaaggt ttaatagttt ggaattttga ttgacttggc acgttctatc
     3001 attgtcataa cttaaataat tcagttaaaa attttttaaa catgatttga tattctaggg
     3061 cttttctttt ttaaaaaatg agaagcaggt aaagaattgt aaagatttgg gacttctctg
     3121 tggcattgtg aaaataaata agccaatgtg aaaggaa
//
