LOCUS       NM_019192               2043 bp    mRNA    linear   ROD 06-OCT-2023
DEFINITION  Rattus norvegicus selenoprotein P (Selenop), transcript variant 1,
            mRNA.
ACCESSION   NM_019192 XM_579424
VERSION     NM_019192.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2043)
  AUTHORS   Sun Q, Hackler J, Hilger J, Gluschke H, Muric A, Simmons S,
            Schomburg L and Siegert E.
  TITLE     Selenium and Copper as Biomarkers for Pulmonary Arterial
            Hypertension in Systemic Sclerosis
  JOURNAL   Nutrients 12 (6), 1894 (2020)
   PUBMED   32630589
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2043)
  AUTHORS   Hughes DJ, Kunicka T, Schomburg L, Liska V, Swan N and Soucek P.
  TITLE     Expression of Selenoprotein Genes and Association with Selenium
            Status in Colorectal Adenoma and Colorectal Cancer
  JOURNAL   Nutrients 10 (11), 1812 (2018)
   PUBMED   30469315
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2043)
  AUTHORS   Kikuchi N, Satoh K, Kurosawa R, Yaoita N, Elias-Al-Mamun M,
            Siddique MAH, Omura J, Satoh T, Nogi M, Sunamura S, Miyata S, Saito
            Y, Hoshikawa Y, Okada Y and Shimokawa H.
  TITLE     Selenoprotein P Promotes the Development of Pulmonary Arterial
            Hypertension: Possible Novel Therapeutic Target
  JOURNAL   Circulation 138 (6), 600-623 (2018)
   PUBMED   29636330
  REMARK    GeneRIF: Selenoprotein P promotes the development of pulmonary
            hypertension by stimulating excessive proliferation and apoptosis
            resistance of pulmonary artery smooth muscle cells.
REFERENCE   4  (bases 1 to 2043)
  AUTHORS   Tajima-Shirasaki N, Ishii KA, Takayama H, Shirasaki T, Iwama H,
            Chikamoto K, Saito Y, Iwasaki Y, Teraguchi A, Lan F, Kikuchi A,
            Takeshita Y, Murao K, Matsugo S, Kaneko S, Misu H and Takamura T.
  TITLE     Eicosapentaenoic acid down-regulates expression of the
            selenoprotein P gene by inhibiting SREBP-1c protein independently
            of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes
  JOURNAL   J Biol Chem 292 (26), 10791-10800 (2017)
   PUBMED   28465347
  REMARK    GeneRIF: A chromatin immunoprecipitation (ChIP) assay revealed that
            EPA decreases binding of SREBP-1c to the SELENOP promoter.
            Knockdown of Srebf1 resulted in a significant down-regulation of
            Selenop expression.
REFERENCE   5  (bases 1 to 2043)
  AUTHORS   Gladyshev VN, Arner ES, Berry MJ, Brigelius-Flohe R, Bruford EA,
            Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland
            PR, Diamond AM, Driscoll DM, Ferreiro A, Flohe L, Green FR, Guigo
            R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A,
            Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, Kohrle J, Krol A,
            Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV,
            Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP,
            Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U,
            Simonovic M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD
            and Zhang Y.
  TITLE     Selenoprotein Gene Nomenclature
  JOURNAL   J Biol Chem 291 (46), 24036-24040 (2016)
   PUBMED   27645994
REFERENCE   6  (bases 1 to 2043)
  AUTHORS   Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigo
            R and Gladyshev VN.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
REFERENCE   7  (bases 1 to 2043)
  AUTHORS   Hill KE, Zhou J, McMahan WJ, Motley AK, Atkins JF, Gesteland RF and
            Burk RF.
  TITLE     Deletion of selenoprotein P alters distribution of selenium in the
            mouse
  JOURNAL   J Biol Chem 278 (16), 13640-13646 (2003)
   PUBMED   12574155
REFERENCE   8  (bases 1 to 2043)
  AUTHORS   Ma S, Hill KE, Caprioli RM and Burk RF.
  TITLE     Mass spectrometric characterization of full-length rat
            selenoprotein P and three isoforms shortened at the C terminus.
            Evidence that three UGA codons in the mRNA open reading frame have
            alternative functions of specifying selenocysteine insertion or
            translation termination
  JOURNAL   J Biol Chem 277 (15), 12749-12754 (2002)
   PUBMED   11821412
  REMARK    GeneRIF: mass spectrometric characterization of full-length protein
            and three isoforms shortened at the C terminus
REFERENCE   9  (bases 1 to 2043)
  AUTHORS   Burk RF and Hill KE.
  TITLE     Selenoprotein P. A selenium-rich extracellular glycoprotein
  JOURNAL   J Nutr 124 (10), 1891-1897 (1994)
   PUBMED   7931697
  REMARK    Review article
REFERENCE   10 (bases 1 to 2043)
  AUTHORS   Hill KE, Lloyd RS, Yang JG, Read R and Burk RF.
  TITLE     The cDNA for rat selenoprotein P contains 10 TGA codons in the open
            reading frame
  JOURNAL   J Biol Chem 266 (16), 10050-10053 (1991)
   PUBMED   2037562
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN933732.1, BC072539.1 and
            BF389559.1.
            
            On Apr 11, 2007 this sequence version replaced NM_019192.1.
            
            Summary: This gene encodes a selenoprotein that is predominantly
            expressed in the liver and secreted into the plasma. This
            selenoprotein is unique in that it contains multiple selenocysteine
            (Sec) residues per polypeptide (10 in rat), and accounts for most
            of the selenium in plasma. It has been implicated as an
            extracellular antioxidant, and in the transport of selenium to
            extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2).
            Mice lacking this gene exhibit neurological dysfunction, suggesting
            its importance in normal brain function. Sec is encoded by the UGA
            codon, which normally signals translation termination. The 3' UTRs
            of selenoprotein mRNAs contain a conserved stem-loop structure,
            designated the Sec insertion sequence (SECIS) element, that is
            necessary for the recognition of UGA as a Sec codon, rather than as
            a stop signal. The mRNA for this selenoprotein contains two SECIS
            elements. Alternatively spliced transcript variants have been found
            for this gene. [provided by RefSeq, Feb 2017].
            
            Transcript Variant: This variant (1, also known as Sepp1a)
            represents the predominant transcript. Variants 1 and 2 encode the
            same protein containing 10 selenocysteine residues.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ110608.1, BC072539.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            protein contains selenocysteine :: PMID: 2037562
            RefSeq Select criteria          :: based on conservation,
                                               expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DN933732.1         322-353
            33-2024             BC072539.1         22-2013
            2025-2043           BF389559.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2043
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..2043
                     /gene="Selenop"
                     /gene_synonym="Sepp1"
                     /note="selenoprotein P"
                     /db_xref="GeneID:29360"
                     /db_xref="RGD:3660"
     exon            1..61
                     /gene="Selenop"
                     /gene_synonym="Sepp1"
                     /inference="alignment:Splign:2.1.0"
     exon            62..277
                     /gene="Selenop"
                     /gene_synonym="Sepp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1232
                     /gene="Selenop"
                     /gene_synonym="Sepp1"
                     /note="UGA stop codons recoded as selenocysteine; seP;
                     selenoprotein P, plasma, 1"
                     /codon_start=1
                     /transl_except=(pos:249..251,aa:Sec)
                     /transl_except=(pos:864..866,aa:Sec)
                     /transl_except=(pos:918..920,aa:Sec)
                     /transl_except=(pos:1041..1043,aa:Sec)
                     /transl_except=(pos:1077..1079,aa:Sec)
                     /transl_except=(pos:1143..1145,aa:Sec)
                     /transl_except=(pos:1185..1187,aa:Sec)
                     /transl_except=(pos:1191..1193,aa:Sec)
                     /transl_except=(pos:1212..1214,aa:Sec)
                     /transl_except=(pos:1218..1220,aa:Sec)
                     /product="selenoprotein P precursor"
                     /protein_id="NP_062065.2"
                     /db_xref="GeneID:29360"
                     /db_xref="RGD:3660"
                     /translation="MWRSLGLALALCLLPYGGAESQGQSPACKQAPPWNIGDQNPMLN
                     SEGTVTVVALLQASUYLCLLQASRLEDLRIKLENQGYFNISYIVVNHQGSPSQLKHAH
                     LKKQVSDHIAVYRQDEHQTDVWTLLNGNKDDFLIYDRCGRLVYHLGLPYSFLTFPYVE
                     EAIKIAYCEKRCGNCSFTSLEDEAFCKNVSSATASKTTEPSEEHNHHKHHDKHGHEHL
                     GSSKPSENQQPGALDVETSLPPSGLHHHHHHHKHKGQHRQGHLESUDMGASEGLQLSL
                     AQRKLURRGCINQLLCKLSEESGAATSSCCCHCRHLIFEKSGSAITUQCAENLPSLCS
                     UQGLFAEEKVIESCQCRSPPAAUHSQHVSPTEASPNUSUNNKTKKUKUNLN"
     exon            278..490
                     /gene="Selenop"
                     /gene_synonym="Sepp1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..608
                     /gene="Selenop"
                     /gene_synonym="Sepp1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..2029
                     /gene="Selenop"
                     /gene_synonym="Sepp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1241..1246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Selenop"
                     /gene_synonym="Sepp1"
     polyA_site      1266
                     /gene="Selenop"
                     /gene_synonym="Sepp1"
     regulatory      1501..1572
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Selenop"
                     /gene_synonym="Sepp1"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      1880..1945
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Selenop"
                     /gene_synonym="Sepp1"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      2003..2008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Selenop"
                     /gene_synonym="Sepp1"
     polyA_site      2029
                     /gene="Selenop"
                     /gene_synonym="Sepp1"
ORIGIN      
        1 gtggatctgc cctaactaga gcaaagagag gggaagacgc aagctagtct gaaggggttg
       61 cgaaaacccc agcaatgtgg agaagcctag ggcttgccct ggctctctgt ctcctcccct
      121 atggaggagc agagagccaa ggccaaagcc ctgcttgtaa gcaagctcca ccctggaaca
      181 taggagatca aaatccaatg ctaaactccg agggcacagt gacagtggtt gctcttcttc
      241 aagccagctg atacctgtgc cttctgcagg catccagatt ggaagacctg cgaataaaac
      301 tagagaacca aggatatttt aacatctcct atattgttgt taatcatcaa ggatctcctt
      361 cccaattaaa acatgcacat cttaaaaagc aggtgtcaga tcacattgct gtttacagac
      421 aagatgaaca tcaaacagat gtctggacac tcttaaatgg aaacaaagat gacttcctca
      481 tatatgacag atgtggccgt cttgtgtatc accttggttt gccctactcc ttcctcactt
      541 tcccgtatgt tgaagaagcc atcaagatcg cttactgtga gaagaggtgt ggaaactgct
      601 ctttcacgag tcttgaagat gaagccttct gtaaaaacgt gtcctcggct actgcaagta
      661 aaaccacaga gccctcagag gagcataacc accacaagca ccatgacaaa catgggcatg
      721 agcatcttgg gagcagtaag ccttcagaga atcagcaacc aggggcatta gatgttgaga
      781 caagtcttcc tccttcaggc ttgcaccacc accaccacca ccataagcac aagggccagc
      841 acaggcaggg tcacttagag agctgagaca tgggggcaag tgaaggcttg caactttcac
      901 ttgcccagag gaagctctga cgaaggggat gcataaacca gctcctgtgt aagttatctg
      961 aggagtctgg ggcagctacc agtagctgct gctgccactg ccgacacctc atatttgaga
     1021 agtcaggatc tgcaatcact tgacagtgtg ccgaaaacct cccatccttg tgtagctgac
     1081 aggggctttt cgcggaggag aaagtcattg aatcctgtca atgtagatca cctccagctg
     1141 cctgacacag tcagcatgta agccccacag aagccagccc caactgaagc tgaaataata
     1201 agaccaagaa gtgaaaatga aatttgaact aaatatttaa aataaagcgt actctcccca
     1261 actccatcta aagacacaat ttcatttcta gaatgtttcc aatccattta attaattagt
     1321 gaagtaaaag tagttgaaat tggatttgtg caaacatgga gaaatctacc acattggctt
     1381 ctaaaattta aaatttttat gccacaaacc atttcatcca aatcagattt gtaccgtggg
     1441 gcaactgaaa agtgattgcg gccattggtt aatatgtctt cctttttctt tctccagtgt
     1501 tctagttaca ttgatgagaa cagaaacata aactatgacc taggggtttc tgttggatag
     1561 ctcgtaatta agaacggaga aagaacaaca aagacatatt ttccagtttt ttttctttac
     1621 ttaaaacttt caaaacaata gaaactttgt ctttctaatc ttatacttta aaccgattaa
     1681 atctttaaca gactacattt taaatatcta cttatctttt ttatctctaa gactcctagt
     1741 ttgagtttca ctacatatat ctgtgaatct tgtttttttc atctaatgct gtatcagtct
     1801 tctgagttgt gagtgactgt cttgaaagat gtaatggaag aaaagtatgg tgttaatctg
     1861 catagtgctt aagacagtat ttccataatc aatgacggtt taatagagaa actgagtcct
     1921 atgaacctga actcctttat ggctaataca attaagcaag aatggagaat agaattgatt
     1981 ggctacagta cagattatca aaaataaatg caacttaaaa agctggaaaa aaaaaaaaaa
     2041 aaa
//
