LOCUS       NM_001085485            2481 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus selenoprotein O (Selenoo), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001085485 XM_001053546 XM_235559
VERSION     NM_001085485.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2481)
  AUTHORS   Sreelatha,A., Yee,S.S., Lopez,V.A., Park,B.C., Kinch,L.N.,
            Pilch,S., Servage,K.A., Zhang,J., Jiou,J., Karasiewicz-Urbanska,M.,
            Lobocka,M., Grishin,N.V., Orth,K., Kucharczyk,R., Pawlowski,K.,
            Tomchick,D.R. and Tagliabracci,V.S.
  TITLE     Protein AMPylation by an Evolutionarily Conserved Pseudokinase
  JOURNAL   Cell 175 (3), 809-821 (2018)
   PUBMED   30270044
REFERENCE   2  (bases 1 to 2481)
  AUTHORS   Gladyshev,V.N., Arner,E.S., Berry,M.J., Brigelius-Flohe,R.,
            Bruford,E.A., Burk,R.F., Carlson,B.A., Castellano,S., Chavatte,L.,
            Conrad,M., Copeland,P.R., Diamond,A.M., Driscoll,D.M., Ferreiro,A.,
            Flohe,L., Green,F.R., Guigo,R., Handy,D.E., Hatfield,D.L.,
            Hesketh,J., Hoffmann,P.R., Holmgren,A., Hondal,R.J., Howard,M.T.,
            Huang,K., Kim,H.Y., Kim,I.Y., Kohrle,J., Krol,A., Kryukov,G.V.,
            Lee,B.J., Lee,B.C., Lei,X.G., Liu,Q., Lescure,A., Lobanov,A.V.,
            Loscalzo,J., Maiorino,M., Mariotti,M., Sandeep Prabhu,K.,
            Rayman,M.P., Rozovsky,S., Salinas,G., Schmidt,E.E., Schomburg,L.,
            Schweizer,U., Simonovic,M., Sunde,R.A., Tsuji,P.A., Tweedie,S.,
            Ursini,F., Whanger,P.D. and Zhang,Y.
  TITLE     Selenoprotein Gene Nomenclature
  JOURNAL   J Biol Chem 291 (46), 24036-24040 (2016)
   PUBMED   27645994
REFERENCE   3  (bases 1 to 2481)
  AUTHORS   Han,S.J., Lee,B.C., Yim,S.H., Gladyshev,V.N. and Lee,S.R.
  TITLE     Characterization of mammalian selenoprotein o: a redox-active
            mitochondrial protein
  JOURNAL   PLoS One 9 (4), e95518 (2014)
   PUBMED   24751718
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2481)
  AUTHORS   Kryukov,G.V., Castellano,S., Novoselov,S.V., Lobanov,A.V.,
            Zehtab,O., Guigo,R. and Gladyshev,V.N.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000007.1, CK479732.1,
            DV727162.1, DV724467.1 and BQ200446.1.
            
            On or before May 25, 2007 this sequence version replaced
            XM_235559.4, XM_001053546.1.
            
            Summary: This gene encodes a selenoprotein that is localized to the
            mitochondria. It is the largest mammalian selenoprotein, containing
            the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA
            codon, which normally signals translation termination. The 3' UTRs
            of selenoprotein mRNAs contain a conserved stem-loop structure,
            designated the Sec insertion sequence (SECIS) element, that is
            necessary for the recognition of UGA as a Sec codon, rather than as
            a stop signal. The exact function of this selenoprotein is not
            known, but it is thought to have redox activity. [provided by
            RefSeq, Jan 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166588.1, SRR22582416.1200107.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            protein contains selenocysteine    :: inferred from conservation
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-665               JAXUCZ010000007.1  122047555-122048219
            666-671             JAXUCZ010000007.1  122051285-122051290
            672-1329            CK479732.1         1-658
            1330-1465           DV727162.1         267-402
            1466-1948           DV724467.1         272-754
            1949-2481           BQ200446.1         1-533               c
FEATURES             Location/Qualifiers
     source          1..2481
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2481
                     /gene="Selenoo"
                     /gene_synonym="RGD1311907; Selo"
                     /note="selenoprotein O"
                     /db_xref="GeneID:315216"
                     /db_xref="RGD:1311907"
     exon            1..665
                     /gene="Selenoo"
                     /gene_synonym="RGD1311907; Selo"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2109
                     /gene="Selenoo"
                     /gene_synonym="RGD1311907; Selo"
                     /EC_number="2.7.7.108"
                     /note="UGA stop codon recoded as selenocysteine"
                     /codon_start=1
                     /transl_except=(pos:2098..2100,aa:Sec)
                     /product="protein adenylyltransferase SelO, mitochondrial"
                     /protein_id="NP_001078954.1"
                     /db_xref="GeneID:315216"
                     /db_xref="RGD:1311907"
                     /translation="MASFRAAFGASLAVARTRPQCVGLELQSSAPWSAWAAAMEPTPR
                     WLARLRFDNRALRALPVETPPPGPEDSLSTPRPVPGACFSRARPAPLRQPRLVALSEP
                     ALALLGLEVSEEAEVEAEAALFFSGNALLPGTEPAAHCYCGHQFGQFAGQLGDGAAMY
                     LGEVCTAAGERWELQLKGAGPTAFSRQADGRKVLRSSIREFLCSEAMFHLGIPTTRAG
                     ACVTSESTVMRDVFYDGNPKYEKCTVVLRIAPTFIRFGSFEIFKPPDELTGRAGPSVG
                     RNDIRVQMLDYVISSFYPEIQAAHTCDTDNIQRNAAFFREVTRRTARMVAEWQCVGFC
                     HGVLNTDNMSIVGLTIDYGPFGFLDRYDPDHVCNASDNAGRYTYSKQPQVCRWNLQKL
                     AEALEPELPLVLAEAILKEEFDTEFQRHYLQKMRKKLGLVRVEKEDETLVAKLLETMH
                     QTGADFTNTFCVLSSFPAEPSDTAEFLTQLTSQCASLEELKLAFRPQMDPRQLSMMLM
                     LAQSNPQLFALIGTQANVTKELERVEHQSRLEQLSPSELQSKNRDHWETWLQEYRERL
                     DKEKEGVGDIAAWQAERVRIMHANNPKYVLRNYIAQKAIEAAENGDFSEVRRVLKLLE
                     SPYHSEEEATGPEAVARTTDEQSSYSSRPPLWAAELCVTUSS"
     exon            666..869
                     /gene="Selenoo"
                     /gene_synonym="RGD1311907; Selo"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1056
                     /gene="Selenoo"
                     /gene_synonym="RGD1311907; Selo"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1187
                     /gene="Selenoo"
                     /gene_synonym="RGD1311907; Selo"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1465
                     /gene="Selenoo"
                     /gene_synonym="RGD1311907; Selo"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1610
                     /gene="Selenoo"
                     /gene_synonym="RGD1311907; Selo"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1796
                     /gene="Selenoo"
                     /gene_synonym="RGD1311907; Selo"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1953
                     /gene="Selenoo"
                     /gene_synonym="RGD1311907; Selo"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2464
                     /gene="Selenoo"
                     /gene_synonym="RGD1311907; Selo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2194..2274
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Selenoo"
                     /gene_synonym="RGD1311907; Selo"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
ORIGIN      
        1 gagaggcaac caatcagaac caagcttctg ggcatgcctc ccaccaaccc ataattgggc
       61 ggaggtaaac ttccggtcgg ggtgagcggg cttccggcga cgcggcgaat ggcctctttc
      121 agggccgcgt tcggggcctc gctcgcggtt gcccgaaccc ggccacagtg tgtcggcctc
      181 gagcttcagt cgtccgcgcc ctggtccgcc tgggctgctg ccatggagcc cacgccgcgt
      241 tggctggcga ggctgcgctt cgacaaccgt gccctgcgtg cgctgccggt agagacgcca
      301 ccgcccgggc cggaggactc cttgtccacc ccgcgtccgg tgccgggagc ctgcttcagc
      361 cgtgcacggc cggccccgct gcggcagcca cgtctagtgg cgctgtcaga gcccgcactg
      421 gcgctgctgg ggctcgaggt cagcgaggag gcggaggtcg aggccgaagc tgcgctcttc
      481 ttcagcggca atgcgctgct gccgggcacc gagcccgccg cgcactgcta ctgtggacac
      541 cagttcggtc agttcgctgg gcagttgggc gacggtgccg ccatgtacct gggcgaggtg
      601 tgcacagcgg ccggcgagcg ctgggagctg cagctcaaag gcgccggccc cacggccttc
      661 tccagacaag ctgatggtcg caaagtcctg cggtcaagca tccgtgagtt cctgtgcagc
      721 gaagccatgt ttcacctggg gatccccacc acgagggccg gggcctgcgt tacgtctgag
      781 tctacagtga tgcgagacgt gttctatgat ggtaatccaa aatatgaaaa gtgcacggtt
      841 gtgttgcgta tagctcccac tttcataaga ttcggctcct ttgaaatttt taagcctcct
      901 gatgagctca cagggcgtgc aggccctagt gtaggacgaa atgatatccg agtgcagatg
      961 cttgactatg tcatcagctc tttctaccct gaaatccagg ctgcccacac ctgcgacaca
     1021 gacaacatac agaggaacgc tgcctttttc agagaggtga caaggcgaac agcacggatg
     1081 gtggctgaat ggcagtgtgt cggcttttgc catggagtgc tcaacactga caacatgagc
     1141 atcgtgggcc tcacgatcga ctatggaccc tttggcttcc tggataggta tgaccctgac
     1201 catgtgtgta acgcctctga caatgctggg cgctacacat acagtaagca gccacaggtg
     1261 tgcaggtgga acctgcagaa actagctgaa gccctggagc ctgagctgcc gcttgtgcta
     1321 gctgaggcca ttctcaaaga ggagtttgac acagagttcc aaaggcacta tctacagaag
     1381 atgcgtaaga agctgggcct tgttcgcgtg gagaaggaag atgagacact tgtggccaaa
     1441 cttctagaga ctatgcatca gactggcgct gacttcacta acaccttctg tgttctgagc
     1501 tccttcccgg ctgaaccgtc agacacagca gagttcctga cccagctgac ctcccagtgt
     1561 gcctctctgg aagagctaaa gcttgccttc agaccccaga tggatccccg gcagctctct
     1621 atgatgctga tgctggcaca gtcgaaccca cagctctttg cactcattgg cactcaagca
     1681 aatgtcacaa aggagctgga acgtgtggag catcagtcac ggctggaaca gctgagcccc
     1741 tctgaactgc agagcaagaa cagagaccac tgggaaacct ggctacagga atacagagag
     1801 cgtctggaca aggagaagga gggtgtcgga gacattgctg cctggcaggc agaacgtgta
     1861 cgcatcatgc atgccaacaa ccccaagtac gtcctaagga actatattgc acagaaagcc
     1921 attgaagctg cagaaaatgg agacttttca gaggtgcgac gtgtcctgaa gctgctagag
     1981 tctccttacc acagtgaaga ggaggccaca ggccctgagg cagtggcgag gaccactgac
     2041 gagcagtctt cctacagtag caggcctcca ctctgggcag cagaactctg cgtaacatga
     2101 tcctcataaa ggcctcggtg gctccacatg tctggagtct cccgaggcct ccccagtgct
     2161 gctgagctgc tgagaccact gggatgcctg tcctcacggt ctctccatga cggcagaggt
     2221 ctccagtcaa aacctgaccc atctctgtct gatactacct tagcagtact gccctggtct
     2281 agcattcaag atgcccccag cacacagtgc ttcatgctag gatatcagtc ccatgtttaa
     2341 gtaatgcaaa caggcctaag taagccttgt gacctgcttg tgcatcttgc ccaaagggca
     2401 ggggctgggc ctcacacctg ttgaatctcc cagggctcta aataaagcag cttcctcagg
     2461 tctaaaaaaa aaaaaaaaaa a
//
