LOCUS       NM_001134754            2636 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus selenoprotein I (Selenoi), mRNA.
ACCESSION   NM_001134754 XM_001069697 XM_343031
VERSION     NM_001134754.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2636)
  AUTHORS   Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang
            C, Heman-Ackah SM, Hessa T, Guha R, Martin SE and Youle RJ.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   2  (bases 1 to 2636)
  AUTHORS   Horibata Y and Hirabayashi Y.
  TITLE     Identification and characterization of human
            ethanolaminephosphotransferase1
  JOURNAL   J Lipid Res 48 (3), 503-508 (2007)
   PUBMED   17132865
REFERENCE   3  (bases 1 to 2636)
  AUTHORS   Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigo
            R and Gladyshev VN.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC168235.1.
            
            On or before Sep 5, 2008 this sequence version replaced
            XM_343031.3, XM_001069697.1.
            
            Summary: The multi-pass transmembrane protein encoded by this gene
            belongs to the CDP-alcohol phosphatidyltransferase class-I family.
            It catalyzes the transfer of phosphoethanolamine from
            CDP-ethanolamine to diacylglycerol to produce
            phosphatidylethanolamine, which is involved in the formation and
            maintenance of vesicular membranes, regulation of lipid metabolism,
            and protein folding. This protein is a selenoprotein, containing
            the rare selenocysteine (Sec) amino acid at its active site. Sec is
            encoded by the UGA codon, which normally signals translation
            termination. The 3' UTRs of selenoprotein mRNAs contain a conserved
            stem-loop structure, designated the Sec insertion sequence (SECIS)
            element, that is necessary for the recognition of UGA as a Sec
            codon rather than as a stop signal. [provided by RefSeq, Jul 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            protein contains selenocysteine :: inferred from conservation
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2636
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..2636
                     /gene="Selenoi"
                     /gene_synonym="Ept1; RGD1560938; Seli"
                     /note="selenoprotein I"
                     /db_xref="GeneID:362713"
                     /db_xref="RGD:1560938"
     exon            1..154
                     /gene="Selenoi"
                     /gene_synonym="Ept1; RGD1560938; Seli"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1294
                     /gene="Selenoi"
                     /gene_synonym="Ept1; RGD1560938; Seli"
                     /EC_number="2.7.8.1"
                     /note="UGA stop codon recoded as selenocysteine;
                     ethanolaminephosphotransferase 1
                     (CDP-ethanolamine-specific)"
                     /codon_start=1
                     /transl_except=(pos:1259..1261,aa:Sec)
                     /product="ethanolaminephosphotransferase 1"
                     /protein_id="NP_001128226.2"
                     /db_xref="GeneID:362713"
                     /db_xref="RGD:1560938"
                     /translation="MAGYEYVSPEQLAGFDKYKYSALDTNPLSLYVMHPFWNTIVKVF
                     PTWLAPNLITFSGFMLLVFNFLLLTYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYT
                     LDGVDGKQARRTNSSTPLGELFDHGLDSWACVYFVVTVYSIFGRGPTGVSVFVLYLLL
                     WVVLFSFILSHWEKYNTGVLFLPWGYDISQVTISFVYIVTAVVGVEAWYEPFLFNFLY
                     RDLFTAMIIGCALCVTLPMSLLNFYRSYKSNSLKHNSIYEAMVPFFSPCLLFTLSTVW
                     ILRSPSDILEMHPRIFYFMVGTAFANITCQLIVCQMSSTRCPTLNWLLLPLFLVVATV
                     IVGTTTSRLESVLLYTLTAAFTLAHIHYGVQVVKQLSRHFQIYPFSLRKPNSDULGLE
                     EKSIGP"
     exon            155..223
                     /gene="Selenoi"
                     /gene_synonym="Ept1; RGD1560938; Seli"
                     /inference="alignment:Splign:2.1.0"
     exon            224..332
                     /gene="Selenoi"
                     /gene_synonym="Ept1; RGD1560938; Seli"
                     /inference="alignment:Splign:2.1.0"
     exon            333..407
                     /gene="Selenoi"
                     /gene_synonym="Ept1; RGD1560938; Seli"
                     /inference="alignment:Splign:2.1.0"
     exon            408..670
                     /gene="Selenoi"
                     /gene_synonym="Ept1; RGD1560938; Seli"
                     /inference="alignment:Splign:2.1.0"
     exon            671..779
                     /gene="Selenoi"
                     /gene_synonym="Ept1; RGD1560938; Seli"
                     /inference="alignment:Splign:2.1.0"
     exon            780..828
                     /gene="Selenoi"
                     /gene_synonym="Ept1; RGD1560938; Seli"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1009
                     /gene="Selenoi"
                     /gene_synonym="Ept1; RGD1560938; Seli"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1195
                     /gene="Selenoi"
                     /gene_synonym="Ept1; RGD1560938; Seli"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..2612
                     /gene="Selenoi"
                     /gene_synonym="Ept1; RGD1560938; Seli"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2498..2575
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Selenoi"
                     /gene_synonym="Ept1; RGD1560938; Seli"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      2590..2595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Selenoi"
                     /gene_synonym="Ept1; RGD1560938; Seli"
     polyA_site      2612
                     /gene="Selenoi"
                     /gene_synonym="Ept1; RGD1560938; Seli"
ORIGIN      
        1 cctaaccctg cacatcgccg tgcgctgctc ctgtttcctt accctgtcga gcagtgtcgc
       61 tgccgctgcg gagtgggcgt tcagttttcg ggtcatcatg gctggctacg aatacgtgag
      121 cccagagcag ctggcgggct ttgacaagta taagtacagc gctttggata ccaacccact
      181 ctctctgtat gtcatgcacc cattttggaa cactatagtg aaggtatttc ccacttggct
      241 ggctcccaat cttataacct tttctggctt tatgctgctt gtgttcaatt tcctactcct
      301 gacatacttc gaccctgact tctatgcttc agcgccaggt cataagcatg tacctgattg
      361 ggtctggatc gttgtgggca tcctcaactt cgttgcctac actctagatg gagtagatgg
      421 aaaacaagct cgtagaacta attccagcac cccattaggg gagctgtttg accacggcct
      481 ggacagttgg gcatgcgttt atttcgttgt gactgtgtac tctatctttg gacgaggacc
      541 gactggcgtc agtgtttttg ttctttacct cctgctgtgg gtggttttgt tttcttttat
      601 cctgtctcac tgggagaaat ataacacagg cgttcttttc ctgccatggg gatatgacat
      661 tagccaagtg actatttctt ttgtctacat agtgactgcg gttgtgggag ttgaggcctg
      721 gtatgaacct ttcctgttta atttcttata tagagaccta ttcactgcaa tgattattgg
      781 atgtgcattg tgtgtgactc ttccaatgag tttattaaac ttttatagaa gctataaaag
      841 caactctctg aagcacaatt ccatctatga agccatggtc cccttcttct ctccatgcct
      901 gctcttcact ctgtcgacag tgtggatcct ccggtcacct tcagatattt tagaaatgca
      961 ccctagaata ttctacttca tggtcggaac agcttttgcc aatatcacat gtcagctaat
     1021 cgtttgccaa atgagcagca cacggtgccc aactttgaac tggttgctgc ttcctctctt
     1081 cttggtcgtg gcaactgtga tcgtaggcac aacaacctcc cgccttgaga gtgttctcct
     1141 ttacacactc actgctgcct tcactctggc tcacatccat tatggagtac aagtggtaaa
     1201 gcagctgagc cgacattttc agatttatcc tttttcattg aggaaaccaa actcagattg
     1261 actaggactg gaagagaaga gtatcggtcc gtaatcttga ggaagtactg taaatagatg
     1321 cgtgtaaata cttcatccat caccattgac ctaaacggat ctgcttgaca gacatgggat
     1381 ctcagtgtgc gctatgtgga cggaagaaca aagcatggtc tgagcttgtg gaatttcaga
     1441 ctttctaact cccagcttat tttattttat ttttttacag aaccacgaga catttggtta
     1501 agcacagtgt acattaaacc agctaaatgt tcctagattc atgagtccat acattttgac
     1561 tcctacagag ttgaagatga tttactttta tgtttaaagt ccccagatga ttcaggaaca
     1621 ctaataacat tcagatagcc acagcctttc ttagcatctg ataatttatg gcaggtctat
     1681 agctgtggga atgatagccc aaatttaatg tagaaatcgt caaaaaagtc tcttcagcca
     1741 gagatgccag ggactccaga acagtgtaca gttgccaaac cctggttgtt ctccagtgac
     1801 tcgccttccc ctgccgtggc gatcgtcgag tattcctgcc tcttgctgta gctgaatcct
     1861 gacaagtgat taatcttctt ctagagtgaa atgctctgct gttgcttagc agagagcggg
     1921 ttgtaaccac agctggccaa tgtggcatat ttcattgtct cactggggca ggttctctgt
     1981 cagcagtgca ttgctgggat tgggtgccta tgagctgtga tttctaagaa tacatacgac
     2041 agtcccaatc ttgcacactc acttgtgagg atatagataa agtaccttgt gagaggaaat
     2101 ttaagctgga gttaggagtc tcagaactcc cacagttagt atcctaaccc tgtctgccca
     2161 gtcttttctt actttcattc tctcctgggg gtgaggtgct gtggttttta ttcttacaca
     2221 gaataaaaca gagagatagt ctatttctcc taactaccca cctccctatt tgaagaaaac
     2281 ttttgatata tatgccttac tgagtattta ctcccttaat atgactcaaa ataacttttg
     2341 aggtttactg acaacataaa aaaatccctt ccgctgtatt gtggttattt ataaatcaca
     2401 cctttttatg aatgtggata tttccttcct ttggactttg tctttattta gtttggtggt
     2461 ggtgaaattt acttgctgat tttattttcc actgaatgaa gtttgtgctt aaatgaagag
     2521 tgtgtcttaa accctttttt ttggacaggt tgcacttgga taacataggc accgctgtgt
     2581 tgatatgtaa ttaaattcgt aactcttatt taaaaaaaaa aaaaaaaaaa aaaaaa
//
