LOCUS       NM_001114939             735 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus selenoprotein H (Selenoh), transcript variant 1,
            mRNA.
ACCESSION   NM_001114939 XR_008616
VERSION     NM_001114939.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 735)
  AUTHORS   Hughes DJ, Kunicka T, Schomburg L, Liska V, Swan N and Soucek P.
  TITLE     Expression of Selenoprotein Genes and Association with Selenium
            Status in Colorectal Adenoma and Colorectal Cancer
  JOURNAL   Nutrients 10 (11), 1812 (2018)
   PUBMED   30469315
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 735)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 735)
  AUTHORS   Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigo
            R and Gladyshev VN.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from FQ144408.1 and BQ781777.1.
            
            On Mar 18, 2016 this sequence version replaced NM_001114939.1.
            
            Summary: This gene encodes a nucleolar protein, which belongs to
            the SelWTH family. It functions as an oxidoreductase, and has been
            shown to protect neurons against UVB-induced damage by inhibiting
            apoptotic cell death pathways, promote mitochondrial biogenesis and
            mitochondrial function, and suppress cellular senescence through
            genome maintenance and redox regulation. This protein is a
            selenoprotein, containing the rare amino acid selenocysteine (Sec)
            at its active site. Sec is encoded by the UGA codon, which normally
            signals translation termination. The 3' UTRs of selenoprotein mRNAs
            contain a conserved stem-loop structure, designated the Sec
            insertion sequence (SECIS) element, that is necessary for the
            recognition of UGA as a Sec codon, rather than as a stop signal.
            Alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, May 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ144408.1, BI285703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN12840109
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            protein contains selenocysteine :: inferred from conservation
            RefSeq Select criteria          :: based on conservation,
                                               expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-674               FQ144408.1         1-674
            675-735             BQ781777.1         1-61                c
FEATURES             Location/Qualifiers
     source          1..735
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..735
                     /gene="Selenoh"
                     /gene_synonym="RGD1563348; Selh"
                     /note="selenoprotein H"
                     /db_xref="GeneID:502642"
                     /db_xref="RGD:1563348"
     exon            1..221
                     /gene="Selenoh"
                     /gene_synonym="RGD1563348; Selh"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..468
                     /gene="Selenoh"
                     /gene_synonym="RGD1563348; Selh"
                     /note="UGA stop codon recoded as selenocysteine"
                     /codon_start=1
                     /transl_except=(pos:229..231,aa:Sec)
                     /product="selenoprotein H"
                     /protein_id="NP_001108411.1"
                     /db_xref="GeneID:502642"
                     /db_xref="RGD:1563348"
                     /translation="MAPLGRKRKAGAAPIESADKREKLAEGAAVVIEHCTSURVYGRH
                     AAALSQALQLEAPEISVQVNRSKPRRGSFEVTLLRPDNSRVELWTGIKKGPPRKLKFP
                     EPQEMVEELKKYLS"
     exon            222..367
                     /gene="Selenoh"
                     /gene_synonym="RGD1563348; Selh"
                     /inference="alignment:Splign:2.1.0"
     exon            368..496
                     /gene="Selenoh"
                     /gene_synonym="RGD1563348; Selh"
                     /inference="alignment:Splign:2.1.0"
     exon            497..719
                     /gene="Selenoh"
                     /gene_synonym="RGD1563348; Selh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      506..579
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Selenoh"
                     /gene_synonym="RGD1563348; Selh"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      651..656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Selenoh"
                     /gene_synonym="RGD1563348; Selh"
     polyA_site      677
                     /gene="Selenoh"
                     /gene_synonym="RGD1563348; Selh"
     polyA_site      719
                     /gene="Selenoh"
                     /gene_synonym="RGD1563348; Selh"
ORIGIN      
        1 acttcccgtt tgctgcgaga tttgaacttt gcaactgtga ttccgggcag ctgctttctc
       61 cctctcgggt tgcgtcgcca ctttattcct ccaacgctcc attcggagat ccgagccatg
      121 gcccctctcg gaagaaagcg taaggccggg gccgcgccta tcgagtcggc ggacaagcgc
      181 gagaaactgg cggagggcgc ggccgtggtc attgagcatt gtacgagctg acgtgtctac
      241 ggccgccatg ctgctgccct gagccaggct ctgcaactgg aggccccaga gatatctgtg
      301 caagtgaacc ggtccaagcc gcggaggggc agcttcgaag tgacgctgct gcgcccggac
      361 aacagtcgtg ttgaactctg gactggtatt aagaagggcc ctccacgaaa gctcaaattt
      421 cctgagcctc aagagatggt tgaagaattg aagaagtacc tttcataaga ggttgggaaa
      481 gagtcctctt gttgagcttt cagtccctgg agatgttgaa gcatttatga tggtgcatgg
      541 ccaaacttaa gctatgtacc tgaagccata gtttcttcct caccagaagt gatggttcag
      601 ttctgaggca gatctccagc aaggcactgt aaaagtgtgt tgatttgttt aataaaagtt
      661 caagtatttg caaataagga tcaagtttaa attttgtctt aaagaatgga tacaaccaaa
      721 aaaaaaaaaa aaaaa
//
