LOCUS       NM_138879               3351 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus selectin E (Sele), mRNA.
ACCESSION   NM_138879
VERSION     NM_138879.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3351)
  AUTHORS   Smadja,D.M., Guerin,C.L., Chocron,R., Yatim,N., Boussier,J.,
            Gendron,N., Khider,L., Hadjadj,J., Goudot,G., Debuc,B., Juvin,P.,
            Hauw-Berlemont,C., Augy,J.L., Peron,N., Messas,E., Planquette,B.,
            Sanchez,O., Charbit,B., Gaussem,P., Duffy,D., Terrier,B.,
            Mirault,T. and Diehl,J.L.
  TITLE     Angiopoietin-2 as a marker of endothelial activation is a good
            predictor factor for intensive care unit admission of COVID-19
            patients
  JOURNAL   Angiogenesis 23 (4), 611-620 (2020)
   PUBMED   32458111
REFERENCE   2  (bases 1 to 3351)
  AUTHORS   Mehta-D'souza,P., Klopocki,A.G., Oganesyan,V., Terzyan,S.,
            Mather,T., Li,Z., Panicker,S.R., Zhu,C. and McEver,R.P.
  TITLE     Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to
            Stabilize the High Affinity State under Force
  JOURNAL   J Biol Chem 292 (6), 2510-2518 (2017)
   PUBMED   28011641
REFERENCE   3  (bases 1 to 3351)
  AUTHORS   Song,S., Yi,Z., Zhang,M., Mao,M., Fu,L., Zhao,X., Liu,Z., Gao,J.,
            Cao,W., Liu,Y., Shi,H. and Zhu,D.
  TITLE     Hypoxia inhibits pulmonary artery endothelial cell apoptosis via
            the e-selectin/biliverdin reductase pathway
  JOURNAL   Microvasc Res 106, 44-56 (2016)
   PUBMED   27033411
  REMARK    GeneRIF: The e-selectin/biliverdin reductase pathway participates
            in the inhibitory process of hypoxia in pulmonary artery
            endothelial cell apoptosis which is mediated by the
            mitochondrial-dependent apoptosis pathway.
REFERENCE   4  (bases 1 to 3351)
  AUTHORS   Mokhtar,H.M., Giribabu,N., Muniandy,S. and Salleh,N.
  TITLE     Testosterone decreases the expression of endometrial pinopode and
            L-selectin ligand (MECA-79) in adult female rats during uterine
            receptivity period
  JOURNAL   Int J Clin Exp Pathol 7 (5), 1967-1976 (2014)
   PUBMED   24966906
  REMARK    GeneRIF: Decrease in uterine pinopodes and L-selectin ligand
            MECA-79 expression during uterine receptivity period by
            testosterone may cause failure of blastocyst implantation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3351)
  AUTHORS   Anuncibay-Soto,B., Perez-Rodriguez,D., Llorente,I.L.,
            Regueiro-Purrinos,M., Gonzalo-Orden,J.M. and Fernandez-Lopez,A.
  TITLE     Age-dependent modifications in vascular adhesion molecules and
            apoptosis after 48-h reperfusion in a rat global cerebral ischemia
            model
  JOURNAL   Age (Dordr) 36 (5), 9703 (2014)
   PUBMED   25182537
  REMARK    GeneRIF: Expression of E-selectin and CAMs was also modified in an
            age- and ischemia/reperfusion-dependent manner.
REFERENCE   6  (bases 1 to 3351)
  AUTHORS   Yoshida,M., Westlin,W.F., Wang,N., Ingber,D.E., Rosenzweig,A.,
            Resnick,N. and Gimbrone,M.A. Jr.
  TITLE     Leukocyte adhesion to vascular endothelium induces E-selectin
            linkage to the actin cytoskeleton
  JOURNAL   J Cell Biol 133 (2), 445-455 (1996)
   PUBMED   8609175
REFERENCE   7  (bases 1 to 3351)
  AUTHORS   Wang,X., Yue,T.L., Barone,F.C. and Feuerstein,G.Z.
  TITLE     Demonstration of increased endothelial-leukocyte adhesion
            molecule-1 mRNA expression in rat ischemic cortex
  JOURNAL   Stroke 26 (9), 1665-8 (1995)
   PUBMED   7544926
REFERENCE   8  (bases 1 to 3351)
  AUTHORS   Ulich,T.R., Howard,S.C., Remick,D.G., Yi,E.S., Collins,T., Guo,K.,
            Yin,S., Keene,J.L., Schmuke,J.J., Steininger,C.N. et al.
  TITLE     Intratracheal administration of endotoxin and cytokines: VIII. LPS
            induces E-selectin expression; anti-E-selectin and soluble
            E-selectin inhibit acute inflammation
  JOURNAL   Inflammation 18 (4), 389-398 (1994)
   PUBMED   7527013
REFERENCE   9  (bases 1 to 3351)
  AUTHORS   Fries,J.W., Williams,A.J., Atkins,R.C., Newman,W., Lipscomb,M.F.
            and Collins,T.
  TITLE     Expression of VCAM-1 and E-selectin in an in vivo model of
            endothelial activation
  JOURNAL   Am J Pathol 143 (3), 725-737 (1993)
   PUBMED   7689792
REFERENCE   10 (bases 1 to 3351)
  AUTHORS   Nelson,R.M., Dolich,S., Aruffo,A., Cecconi,O. and Bevilacqua,M.P.
  TITLE     Higher-affinity oligosaccharide ligands for E-selectin
  JOURNAL   J Clin Invest 91 (3), 1157-1166 (1993)
   PUBMED   7680663
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L25527.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L25527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345329
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3351
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q23"
     gene            1..3351
                     /gene="Sele"
                     /note="selectin E"
                     /db_xref="GeneID:25544"
                     /db_xref="RGD:3654"
     CDS             1..1650
                     /gene="Sele"
                     /note="selectin, endothelial cell; E-selectin; ELAM-1;
                     LECAM2; CD62 antigen-like family member E; endothelial
                     leukocyte adhesion molecule 1; leukocyte-endothelial cell
                     adhesion molecule 2"
                     /codon_start=1
                     /product="E-selectin precursor"
                     /protein_id="NP_620234.1"
                     /db_xref="GeneID:25544"
                     /db_xref="RGD:3654"
                     /translation="MNASCFLSALTFVLLIGKSIAWYYNASSELMTYDEASAYCQRDY
                     THLVAIQNKEEINYLNSTLRYSPSYYWIGIRKVNNVWIWVGTQKPLTEEAKNWAPGEP
                     NNKQRNEDCVEIYIQRPKDSGMWNDERCDKKKLALCYTASCTNTSCSGHGECVETINS
                     YTCKCHPGFLGPKCDQVVTCQEQEYPDHGSLNCTHPFGLFSYNSSCSFSCERGYVPSS
                     METTVRCTSSGEWSAPAPACHVVECKALTQPAHGVRKCSSNPGSYPWNTTCTFDCEEG
                     YRRVGAQNLQCTSSGVWDNEKPSCKAVTCDAIPRPQNGSVSCSNSTAGALAFKSSCNF
                     TCEHSFTLQGPAQVECSAQGQWTPQIPVCKASQCEALSAPQRGHMKCLPSASAPFQSG
                     SSCKFSCDEGFELKGSRRLQCGPRGEWDSEKPTCAGVQCSSLDLPGKMNMSCSGPAVF
                     GTVCEFTCPEGWTLNGSSILTCGATGRWSAMLPTCEAPANPPRPLVVALSVAATSLLT
                     LSSLIYVLKRFFWKKAKKFVPASSCQSLQSFENYQGPSYII"
     exon            1..37
                     /gene="Sele"
                     /inference="alignment:Splign:2.1.0"
     exon            38..421
                     /gene="Sele"
                     /inference="alignment:Splign:2.1.0"
     exon            422..529
                     /gene="Sele"
                     /inference="alignment:Splign:2.1.0"
     exon            530..718
                     /gene="Sele"
                     /inference="alignment:Splign:2.1.0"
     exon            719..904
                     /gene="Sele"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1093
                     /gene="Sele"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1282
                     /gene="Sele"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1459
                     /gene="Sele"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1570
                     /gene="Sele"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1592
                     /gene="Sele"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1665
                     /gene="Sele"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..3351
                     /gene="Sele"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaatgcct cgtgctttct ctctgctctc acctttgttc tcctcattgg aaagagcata
       61 gcttggtact acaatgcctc cagtgagctc atgacatatg atgaagcaag tgcgtattgt
      121 caacgggact acacacatct ggtggcgatt cagaacaagg aagagatcaa ttacctaaac
      181 tccactctga ggtattcacc aagttattac tggattggaa tcagaaaagt caataatgta
      241 tggatctggg tggggaccca gaagcctctg acggaggaag ctaagaactg ggcgccaggt
      301 gaaccaaaca acaaacaaag aaacgaggac tgtgtagaga tctacatcca aagacccaaa
      361 gactccggca tgtggaatga cgagagatgt gacaaaaaga aactggctct gtgttacaca
      421 gcttcctgta ccaacacatc ctgcagtggt cacggtgaat gcgttgagac catcaatagt
      481 tatacctgca aatgtcaccc cggcttcctg ggacccaagt gtgaccaagt tgtgacctgc
      541 caagaacagg aataccctga ccatggaagc ctgaactgca cccacccatt cggcctcttc
      601 agctataatt catcctgctc cttcagctgt gaaaggggct atgtgcccag cagcatggag
      661 accacagtgc ggtgtacgtc ctctggagag tggagtgcac ctgctcctgc ctgccatgtg
      721 gttgaatgta aagctttgac ccaacctgcc cacggagtca ggaaatgttc ctcaaatcct
      781 gggagctacc catggaatac aacgtgcacg tttgattgtg aggaagggta caggagagtt
      841 ggagctcaga atctacagtg tacctcatcc ggtgtctggg acaacgagaa gccatcgtgc
      901 aaagctgtga cctgtgatgc catccctcgg cctcagaatg gctctgtgag ctgcagcaac
      961 tcaacggctg gagcgcttgc ctttaagtct tcctgtaatt ttacctgtga gcacagtttc
     1021 acattgcagg gcccagccca ggttgaatgc agtgcacaag ggcagtggac accacaaatc
     1081 ccagtgtgca aagcttccca gtgtgaagcc ttatctgcac cacagcgagg ccacatgaaa
     1141 tgtcttccca gtgcctctgc acccttccaa agtgggtcca gttgtaagtt ctcctgtgac
     1201 gaaggatttg aattgaaggg atcaagaagg cttcagtgtg gtccaagagg ggagtgggac
     1261 agcgaaaagc ccacatgtgc aggggtacag tgttcaagcc ttgaccttcc aggaaagatg
     1321 aacatgagtt gcagtgggcc agcagttttt ggcacggtat gtgaatttac atgtcctgag
     1381 ggttggacac tcaacggatc ttcaatcctg acatgtggtg ccacaggacg ctggtctgcg
     1441 atgctgccta cttgtgaagc cccagccaac cctccccgtc ccttggtagt ggcactctct
     1501 gtggcagcaa cctcacttct gacattgtcc tcattgatct acgtgttgaa gagattcttt
     1561 tggaagaaag caaagaaatt cgttcctgct agtagctgcc aaagtcttca atcgtttgaa
     1621 aactatcaag ggccttctta catcatctaa gatgcgagca atcaggaaca caaatgcatc
     1681 atgggaaata gaacgatata ctgaagacag caggaaatga actgtctgca gaatcctggt
     1741 ctctcttgcc tgcttaaaaa ctgggatcct gactccatgg atcgaagctg agcgacaagg
     1801 ccagccctct accagaatga ctacgtttgc tccttcctag ttagtggcaa tatccaccat
     1861 gtgctgctac aggaggtgga ggctctctct tcaaaagaga gtgaatagac caggggcctg
     1921 ggacagcaga attcctcctg actcttcgtc actctggaat ttgggacaga aacagcattt
     1981 ggttgcattg ttcttctctc attccccaca cagtgtgtca agagctagtt ccagtattgt
     2041 tgtcacaggg ataaataata tttatcagca gtttttgaac agacaaattt ctatttctat
     2101 cttggaaaaa aaaaggcaaa tttgccacat tctcaggtta tggctagggg tgtcattatg
     2161 gttcaaatcc tgctgagtat tacatggtaa gccttactgg ctttatccct gtggatttgg
     2221 tggcctctga agtattcttg aacattgtgt tctgtgtcct ggcattgagt ccagcataat
     2281 gtccgttatt cttagttcag tgcaaaaaga cttaaaaagt cagaatcctg tggcccatca
     2341 caaggcaaag gttatcctaa atctcttttt gattagaaaa tcccaggatt atatctgcaa
     2401 taaacctatt ttcaagatga gacattaata atcagtgtga aattctgagt atttaatggt
     2461 agctggtttt cagacatggt actatcaaaa ggatagaaag taaagagagt gtatatctgg
     2521 ggttcccagc ccacccccag tgtttttttt ctggaagaaa aaacatcctt gaagccaaat
     2581 gttctgattt aataaaagca taagtcataa aagtacatct taaagtattt ttaagagcct
     2641 gtcaaagcgt gaatgtgctt tgattcctaa aagagtggtt cttatacatg gcaaatatat
     2701 tcttgtatat tgtattcgat tctaaatccg tggtgagtat tcaccctcta atagatggac
     2761 aaaagcagtg gacttttaaa gaccaaaggt gtctacgagt tattctgttc tggttcacaa
     2821 gttctagaga aggggaaagc ttgtgtgcac aatgattatg cagagattaa aattcctaaa
     2881 caatttcacc tgtagctggc agtgacaaac gcttggtcaa taagtgccag aactgttcct
     2941 gcacaaagtg tcccaacttc tgaattaact cgttaaagaa atttcttgaa aggtccttgc
     3001 tgattggggt tggtgggaaa agccaacagt gaacaggaag tgataagcat tagaatgaaa
     3061 ggggagagag gaataagtga cagcaagaga gagagagaga gagagagaga gagagagaga
     3121 gggagagaga gagattgaga ctgtgaggaa ccacacaatg taaatggttg tatattttgt
     3181 attagaaatt actgtgtgaa atatatatgt agtctgtatc tgagttctaa tagaatattt
     3241 taaattatga tttaaaatat tttatggtgt aagagtatgt atttatttaa atatattaaa
     3301 cttattgtat tcacatgtta gtatgttttg gcaataaatg tgtttctact t
//
