LOCUS       NM_177933               6382 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus SEL1L adaptor subunit of SYVN1 ubiquitin ligase
            (Sel1l), mRNA.
ACCESSION   NM_177933
VERSION     NM_177933.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6382)
  AUTHORS   Hosokawa,N. and Wada,I.
  TITLE     Association of the SEL1L protein transmembrane domain with HRD1
            ubiquitin ligase regulates ERAD-L
  JOURNAL   FEBS J 283 (1), 157-172 (2016)
   PUBMED   26471130
REFERENCE   2  (bases 1 to 6382)
  AUTHORS   Zhong,Y., Shen,H., Wang,Y., Yang,Y., Yang,P. and Fang,S.
  TITLE     Identification of ERAD components essential for dislocation of the
            null Hong Kong variant of alpha-1-antitrypsin (NHK)
  JOURNAL   Biochem Biophys Res Commun 458 (2), 424-428 (2015)
   PUBMED   25660456
REFERENCE   3  (bases 1 to 6382)
  AUTHORS   Sha,H., Sun,S., Francisco,A.B., Ehrhardt,N., Xue,Z., Liu,L.,
            Lawrence,P., Mattijssen,F., Guber,R.D., Panhwar,M.S., Brenna,J.T.,
            Shi,H., Xue,B., Kersten,S., Bensadoun,A., Peterfy,M., Long,Q. and
            Qi,L.
  TITLE     The ER-associated degradation adaptor protein Sel1L regulates LPL
            secretion and lipid metabolism
  JOURNAL   Cell Metab 20 (3), 458-470 (2014)
   PUBMED   25066055
REFERENCE   4  (bases 1 to 6382)
  AUTHORS   Iida,Y., Fujimori,T., Okawa,K., Nagata,K., Wada,I. and Hosokawa,N.
  TITLE     SEL1L protein critically determines the stability of the HRD1-SEL1L
            endoplasmic reticulum-associated degradation (ERAD) complex to
            optimize the degradation kinetics of ERAD substrates
  JOURNAL   J Biol Chem 286 (19), 16929-16939 (2011)
   PUBMED   21454652
REFERENCE   5  (bases 1 to 6382)
  AUTHORS   Francisco,A.B., Singh,R., Li,S., Vani,A.K., Yang,L., Munroe,R.J.,
            Diaferia,G., Cardano,M., Biunno,I., Qi,L., Schimenti,J.C. and
            Long,Q.
  TITLE     Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice
            leads to systemic endoplasmic reticulum stress and embryonic
            lethality
  JOURNAL   J Biol Chem 285 (18), 13694-13703 (2010)
   PUBMED   20197277
REFERENCE   6  (bases 1 to 6382)
  AUTHORS   Cattaneo,M., Orlandini,S., Beghelli,S., Moore,P.S., Sorio,C.,
            Bonora,A., Bassi,C., Talamini,G., Zamboni,G., Orlandi,R.,
            Menard,S., Bernardi,L.R., Biunno,I. and Scarpa,A.
  TITLE     SEL1L expression in pancreatic adenocarcinoma parallels SMAD4
            expression and delays tumor growth in vitro and in vivo
  JOURNAL   Oncogene 22 (41), 6359-6368 (2003)
   PUBMED   14508516
REFERENCE   7  (bases 1 to 6382)
  AUTHORS   Furue,M., Zhang,Y., Okamoto,T., Hata,R.I. and Asashima,M.
  TITLE     Activin A induces expression of rat Sel-1l mRNA, a negative
            regulator of notch signaling, in rat salivary gland-derived
            epithelial cells
  JOURNAL   Biochem Biophys Res Commun 282 (3), 745-749 (2001)
   PUBMED   11401526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000166.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_177933.5.
            
            On Feb 10, 2021 this sequence version replaced NM_177933.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF304853.2, SRR8487227.270368.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               JACYVU010000166.1  10778952-10779113   c
            163-200             JACYVU010000166.1  10772787-10772824   c
            201-429             JACYVU010000166.1  10771484-10771712   c
            430-597             JACYVU010000166.1  10762128-10762295   c
            598-703             JACYVU010000166.1  10760580-10760685   c
            704-866             JACYVU010000166.1  10759685-10759847   c
            867-920             JACYVU010000166.1  10755806-10755859   c
            921-980             JACYVU010000166.1  10755660-10755719   c
            981-1062            JACYVU010000166.1  10754518-10754599   c
            1063-1217           JACYVU010000166.1  10753753-10753907   c
            1218-1274           JACYVU010000166.1  10752386-10752442   c
            1275-1343           JACYVU010000166.1  10748856-10748924   c
            1344-1421           JACYVU010000166.1  10747057-10747134   c
            1422-1484           JACYVU010000166.1  10746114-10746176   c
            1485-1572           JACYVU010000166.1  10745165-10745252   c
            1573-1721           JACYVU010000166.1  10744714-10744862   c
            1722-1887           JACYVU010000166.1  10743736-10743901   c
            1888-1962           JACYVU010000166.1  10743375-10743449   c
            1963-2135           JACYVU010000166.1  10742602-10742774   c
            2136-2264           JACYVU010000166.1  10740793-10740921   c
            2265-6382           JACYVU010000166.1  10734915-10739032   c
FEATURES             Location/Qualifiers
     source          1..6382
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..6382
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /note="SEL1L adaptor subunit of SYVN1 ubiquitin ligase"
                     /db_xref="GeneID:314352"
                     /db_xref="RGD:620147"
     exon            1..162
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2474
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /note="protein sel-1 homolog 1; sel-1L; suppressor of
                     lin-12-like protein 1; Sel1 (suppressor of lin-12) 1
                     homolog; SEL1L adaptor subunit of ERAD E3 ubiquitin
                     ligase; sel-1 suppressor of lin-12-like; SEL1L ERAD E3
                     ligase adaptor subunit"
                     /codon_start=1
                     /product="protein sel-1 homolog 1 precursor"
                     /protein_id="NP_808794.2"
                     /db_xref="GeneID:314352"
                     /db_xref="RGD:620147"
                     /translation="MQVRVRLLLLLCAVLLGSAAASSDEETNQDESLDSKGALPTDGS
                     VKDHTTGKVVAGQRFVDSEDSEVESLLQDEEESSKSQEEVSVTEDISFLDSPNPSSKT
                     YEELKRVRKPVLTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKT
                     DEKWGFCETEEDAAKRRQMQEAEAIYQSGMKILNGSTRKNQKREAYRYLQKAAGMNHT
                     KALERVSYALLFGDYLTQNIQAAKEMFEKLTEEGSPKGQTGLGFLYASGLGVNSSQAK
                     ALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGS
                     VVQRIRLPDEVENPGMNSGMLEEDLIQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQN
                     HQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQS
                     GLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKY
                     FNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKNVCERGRWSERLMTAYNSYK
                     DDDYNAAVVQYLLLAEQGYEVAQSNAAFILDQREATIVGENETYPRALLHWNRAASQG
                     YTVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQD
                     IHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQYIREANIRDLFTQLDMDQLLGP
                     EWDLYLMTIIALLLGTVIAYRQRQHQDIPVPRPPGPRPAPPQQEGPPEQQPPQ"
     exon            163..200
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            201..429
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            430..597
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            598..703
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            704..866
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            867..920
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            921..980
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1062
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1217
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1274
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1343
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1421
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1484
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1572
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1721
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1887
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..1962
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2135
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2264
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..6382
                     /gene="Sel1l"
                     /gene_synonym="Sel1h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagagcgg ctgcgaggcg gcggcgcaga ggcagcggct gagttggtcg cggcgacggc
       61 gacagcgagg gctctcgacc ttcgagagca ggatgcaggt ccgcgtcaga ctgttgttgc
      121 tgctctgcgc ggtgctcctg ggctcggccg ccgcgtcctc agatgaggaa actaaccagg
      181 atgaatcctt agattccaag ggtgctttac ccacagatgg gtcggtgaag gaccacacca
      241 ctggcaaagt agttgctggc cagagatttg ttgattctga ggactcagag gtggaatccc
      301 ttcttcagga cgaggaagag agctccaaga gccaggagga agtcagtgtc acggaagaca
      361 tcagcttttt agactctcca aatccaagca gcaagaccta cgaagaacta aagagagtgc
      421 ggaagccagt tttgactgcc attgaaggta cggcgcacgg ggagccctgc cacttccctt
      481 tccttttcct ggataaggaa tatgatgagt gcacatcaga cgggagggaa gatggcagac
      541 tgtggtgtgc cacaacctat gactacaaga cagatgagaa gtggggcttc tgcgaaaccg
      601 aagaagatgc tgccaaaagg cgacagatgc aggaagcaga agccatctat cagagcggga
      661 tgaagatcct gaacggcagc accaggaaga accaaaagag agaagcatat cggtaccttc
      721 agaaggcagc aggcatgaat cacaccaaag ccctggagag agtgtcctat gctctcttgt
      781 ttggtgatta cctcacacag aatatccagg cagctaaaga gatgtttgag aaactgactg
      841 aggaagggtc tcccaaagga caaactggtc ttggctttct ctacgcttct ggacttggtg
      901 ttaattcaag tcaggcgaag gctcttgtgt attacacttt tggagctctt ggaggcaacc
      961 tgatagcgca tatggttttg ggttaccgct actgggctgg catcggagtc ctccagagtt
     1021 gcgagtcggc actgacccat tatcgtcttg ttgccaatca tgtcgctagt gatatctccc
     1081 taactggagg ctctgtagtc cagagaatac ggctgcctga tgaagtggaa aacccaggga
     1141 tgaacagtgg gatgctggaa gaagatctga ttcagtatta ccagttccta gctgagaagg
     1201 gtgatgtcca agcacaggtt ggtctgggac agctgcatct gcatggaggg cgtggagtag
     1261 aacagaatca ccagagagcg tttgactact tcaacttagc agcaaatgct ggcaattcac
     1321 atgctatggc cttcctggga aagatgtatt ctgagggaag tgacatcgtg cctcagagta
     1381 acgagacggc acttcactac ttcaagaaag ctgctgacat gggcaacccg gtgggacaga
     1441 gcggacttgg aatggcctac ctctatggaa gaggagttca agttaattat gacctggcac
     1501 tcaagtattt ccagaaagct gctgagcaag gctgggtgga cgggcagctg cagcttggct
     1561 ctatgtacta caatggcatt ggagtcaaga gagattataa acaggccttg aagtatttta
     1621 atttagcttc tcagggaggc catatcttgg ctttctataa cctagcacag atgcacgcca
     1681 gcggcacagg ggtgatgaga tcctgccaca ctgcagtgga gttgtttaag aacgtgtgtg
     1741 agcgtggtcg ctggtcagag aggctgatga ccgcctacaa cagctataaa gacgacgact
     1801 acaacgccgc tgtggtccag tacctcctgc tggcggagca gggctacgag gtggcgcaga
     1861 gcaacgcagc cttcatcctc gaccagagag aagcaaccat tgtaggtgag aatgaaactt
     1921 accccagagc tttgctgcat tggaataggg ccgcctccca aggttatact gtggctagaa
     1981 ttaaacttgg agactaccat ttctatggat ttggcactga tgtggattac gagactgcgt
     2041 ttattcatta ccgcctggcc tcagagcaac agcacagtgc ccaagctatg tttaacctgg
     2101 ggtacatgca tgagaagggc ctaggcatta aacaggatat ccacctggca aaacgctttt
     2161 atgacatggc agccgaagcc agcccagatg cacaagtacc tgtattcctc gcactctgca
     2221 aattaggtgt cgtctatttc ttacagtaca tacgggaagc aaacattcga gatctattca
     2281 cacaactgga tatggaccag ctcttgggac ctgagtggga tctttacctc atgaccatca
     2341 ttgcactgct gttgggtaca gtcatagcct acaggcagcg acagcaccag gacataccag
     2401 ttcccaggcc cccagggcca cggccagctc ctccccagca ggaaggaccc ccagagcagc
     2461 agccaccaca gtagcagcca ccctcgcctg ggtccgtgac cactaaggag ctgctcactg
     2521 agaacactcg catttgatgt agggctctgg atggtggcca ccacctggaa gaggcgtgag
     2581 gaagtgttga atcccagaag ctgcttagaa cctgctgcct tccttttcag ggacgagtag
     2641 ctctcaccag agctacagtg aatgtttgtt tcagtgccat atggaatgac atctctcagt
     2701 ggctttcctt tttccttctt tttctctctt cgttctgcaa acatacacaa gacactcaag
     2761 tcatgtctac tgtacccact gtctttcctg agagaccttt tgtcatcctg ttgatgtgca
     2821 taacttctta catccatgtc ttttaaggtc ctgagcattg acaacctggg aaaacccagt
     2881 tagttgcaag tttaacccta aaaacatgct taagtctgag aatagaactt gcctttaagt
     2941 caaaagcaaa acaagccaag caggatgtct tcagggtgtt tgggaaatcc taccagtcta
     3001 catgcgcgtt cctatatttg gcactcttgt tttaaaagga attattgatt cctgcactgt
     3061 ggctgtgaca ggtcatggca gacttctctt cctcgaagac tgaaaggctt tactaaagaa
     3121 gtctttgtgg ccgtcacttc cttgcagtgg aacagaagta aaactcaatg aactgactcc
     3181 ttactcttac gttggacttt accccaagta ctcgtgtgat ttgcttgttg gtttgagtgt
     3241 acagagccct agtccagaca ccagaggatg gactaactgg agaaatcaga aaacagcctt
     3301 aaccgacttg aggtgggatc tgagacacgc cctccctcgg gttgattcga tgcttcccag
     3361 gtttcgttgt actttgcatt tcttatggca caggaacaga cagccctccg aaatcttcaa
     3421 atacgaaatt ctgttgtcaa gatatggcag gtggtgactt cctttgtaat tctaaaactc
     3481 agatgattga ggatgggtta gacccagtgc atggcaaaaa caaaggcctg ggtgtaccgt
     3541 ggtgtgtgct gtggtagctt ttcgtttctg acgtttcctg tggctgtaga acgtcagcca
     3601 ctgctcagcg gccatgctgc cacccttctg ttgtaaacgc taggaaactg aagttgttac
     3661 agtgagcgag cagcaaacat tgagagcttc acacactcac ccgtgtgaaa ggactgaagc
     3721 ccaagcccag caccccacgg ggctcaggct ggcctgctca ctgtcacctt gaccttgttt
     3781 tctgtaatcc ctgtctgcaa cgcaactgga gtttatcact tgtggacttt ggaaagcttt
     3841 gagtttgaat gttggggttg taatcagaat tcaatttagt tcctctataa cgaacatgaa
     3901 ggctttaaat gtgaagttgt gtacatttgt gtatgctcac agtattatgg gaaacccagt
     3961 aagcaaattt tcctcgaaga tatttgcctc caaatttgaa gacatggcca cagaagggcc
     4021 atgtacacaa aagcagatct ttgagaggca gccaccattt ctctctttga gcagcactgg
     4081 taaatagtga ggcttgtttg gtgtcctgtg cttggagatt agattgtgag tggtacagta
     4141 agcagggtcc tttactgctg cctcctctcc cagccccacc ctcagcccag cgagtgaatt
     4201 ccatggtccc agcgctgttt agaaggcagg tcttacatta ttacaggaac tgggcgcagt
     4261 ggtctgtccc tgtagtcccc tgtcactggg ggactgaggg acgaagagca cattaggctg
     4321 ggagttcaag accaacttag gcaacacaac aagacccagt ctctaaaaat aaactctaag
     4381 atgccagtgg cttctatggt tttcccgtgc cattccacct caagcctcct tggacagcag
     4441 catttttgcg tccgtcttta cttcgcacag agagtacttg gagagaacat ttcttaaaat
     4501 agcatacact acctacggct gcacacagtc taggtttgct cttcgtgtag cagacttgcc
     4561 ccttgctatc ctctttactg tcactactgc agacgccctt ccctcggctt attaccctgt
     4621 ctccagcctg ggctgtctgc taccggaagt ctgaatggcg ggtttaaaat aattcagtcc
     4681 ttaccacttc tttcacacat ggtctcaagc tgctttgctc ctgttctctt aacagttcac
     4741 gggaaatggt accttagcaa ataggattgg gttcggtgtt tctcttaaaa ctaatgcaca
     4801 gtacttacta atggcatcca tttgaataaa gtggcaataa agctagttaa tgtcagtgac
     4861 attaagccaa ctccaggatt cgggagttct agcgttaggg tttagattta ccagatagag
     4921 cgtgacttcc ttcctccctg tagcccatcc ctgctgctgc ctttcgtggt ctgtcttgca
     4981 gcctacgaag gctctgtcca gcctctgttc tcctgtgcac ctgccccacc gggccaccaa
     5041 ctgtttcaga gtctagagac cacaagtttt acttctgtgg tgttgtacaa aggtggagtt
     5101 tttgttcttg aattttttgt ttctgatttc cgggttttct tagttactag ccaataatac
     5161 agaaaaaggt tggacagggg ctttttcccc cccgaaattc attaatacct aaactagatt
     5221 aatgtaaaaa tgcaagtcct aaatcttgat attcctgaag gtttgtaatt ctactgaaaa
     5281 tatatataga ttaatttctg aacattttta ttaccatctc taccatggag aagcattaaa
     5341 aactaccagg gatctggtaa ggagccggtg gctgggtgtt ctatacacaa aatttggttt
     5401 tgtttggctg cttggttggg ttttctctct ctcttccctg ctcctcatgc ttgtcctcta
     5461 gtgcttggag caggcctgta ggcctccaaa tgcagacctc aactccttgt gtgtgtgtgt
     5521 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtggcatttg caccagtgtc
     5581 taattacatc tgcgaaattt tcctctccag gggtttggac taacacctca catgtatatt
     5641 tcaaaacaag atgcttctag tgatccccct ccctgccaag aagagcaggc ttatatttac
     5701 ttcaggaaca gctggtattt gaagtgattc taaagtatgg tatacaatat tacggccctg
     5761 agagatccaa gaaataacca gagcaaaaaa aaaaaaaaaa caattttatg caaaaaaaaa
     5821 atttgctcag atacgagaga aactatttct ggatgctata ttgtcaggtt tttaaatgag
     5881 tagtgttctt tgaaaaagga cctaagtgtc ttcacccact aggggtttca agaaaatacc
     5941 cctagtgaaa tagccccata taccaatgat ctgtatctta aagagactgt ttacacatta
     6001 aaagccggtt ttgtatgcag atgaagggcc cctttggtta tgttcaagga ggcattcaga
     6061 tgttcttcct ttactattta ttggtgaacg atctgacact atttctcttt tatttaaaaa
     6121 caatgttgat atgatcaaaa tatgaccact ataaacgctg agggacatat ttaaagaaca
     6181 taagctgaca ttgtgaagga acaccatact agactttttg taaatttatt ttatatttaa
     6241 tggaatgcag tataacggct ggtgaagtgt attataattg tgtaaacaaa tcctgttaat
     6301 agagagatgt acagactcat tttgtactgt atcttgaaac ttgtgaaata aagatcccat
     6361 ctctggctac ctgtttgtgg ta
//
