LOCUS       NM_024002               3240 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SECIS binding protein 2 (Secisbp2), mRNA.
ACCESSION   NM_024002
VERSION     NM_024002.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3240)
  AUTHORS   Seeher,S., Atassi,T., Mahdi,Y., Carlson,B.A., Braun,D., Wirth,E.K.,
            Klein,M.O., Reix,N., Miniard,A.C., Schomburg,L., Hatfield,D.L.,
            Driscoll,D.M. and Schweizer,U.
  TITLE     Secisbp2 is essential for embryonic development and enhances
            selenoprotein expression
  JOURNAL   Antioxid Redox Signal 21 (6), 835-849 (2014)
   PUBMED   24274065
REFERENCE   2  (bases 1 to 3240)
  AUTHORS   Seeher,S., Carlson,B.A., Miniard,A.C., Wirth,E.K., Mahdi,Y.,
            Hatfield,D.L., Driscoll,D.M. and Schweizer,U.
  TITLE     Impaired selenoprotein expression in brain triggers striatal
            neuronal loss leading to co-ordination defects in mice
  JOURNAL   Biochem J 462 (1), 67-75 (2014)
   PUBMED   24844465
REFERENCE   3  (bases 1 to 3240)
  AUTHORS   Bubenik,J.L., Miniard,A.C. and Driscoll,D.M.
  TITLE     Characterization of the UGA-recoding and SECIS-binding activities
            of SECIS-binding protein 2
  JOURNAL   RNA Biol 11 (11), 1402-1413 (2014)
   PUBMED   25692238
  REMARK    GeneRIF: Data show that a purified recombinant protein encompassing
            amino acids 517-777 of SECIS-binding protein 2 (SBP2) binds to
            SECIS elements with high affinity and selectivity.
REFERENCE   4  (bases 1 to 3240)
  AUTHORS   Bifano,A.L., Atassi,T., Ferrara,T. and Driscoll,D.M.
  TITLE     Identification of nucleotides and amino acids that mediate the
            interaction between ribosomal protein L30 and the SECIS element
  JOURNAL   BMC Mol Biol 14, 12 (2013)
   PUBMED   23777426
  REMARK    GeneRIF: L30 and SBP2 bind to overlapping but non-identical sites
            on the SECIS.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3240)
  AUTHORS   Gonzalez-Flores,J.N., Gupta,N., DeMong,L.W. and Copeland,P.R.
  TITLE     The selenocysteine-specific elongation factor contains a novel and
            multi-functional domain
  JOURNAL   J Biol Chem 287 (46), 38936-38945 (2012)
   PUBMED   22992746
  REMARK    GeneRIF: SBP2/SECIS complex activates eEFSec by directing
            functional interactions between Domain IV and the ribosome to
            promote Sec-tRNA(Sec) binding and accommodation into the ribosomal
            A-site
REFERENCE   6  (bases 1 to 3240)
  AUTHORS   Lu,C., Qiu,F., Zhou,H., Peng,Y., Hao,W., Xu,J., Yuan,J., Wang,S.,
            Qiang,B., Xu,C. and Peng,X.
  TITLE     Identification and characterization of selenoprotein K: an
            antioxidant in cardiomyocytes
  JOURNAL   FEBS Lett 580 (22), 5189-5197 (2006)
   PUBMED   16962588
REFERENCE   7  (bases 1 to 3240)
  AUTHORS   Chavatte,L., Brown,B.A. and Driscoll,D.M.
  TITLE     Ribosomal protein L30 is a component of the UGA-selenocysteine
            recoding machinery in eukaryotes
  JOURNAL   Nat Struct Mol Biol 12 (5), 408-416 (2005)
   PUBMED   15821744
REFERENCE   8  (bases 1 to 3240)
  AUTHORS   Copeland,P.R., Stepanik,V.A. and Driscoll,D.M.
  TITLE     Insight into mammalian selenocysteine insertion: domain structure
            and ribosome binding properties of Sec insertion sequence binding
            protein 2
  JOURNAL   Mol Cell Biol 21 (5), 1491-1498 (2001)
   PUBMED   11238886
REFERENCE   9  (bases 1 to 3240)
  AUTHORS   Copeland,P.R., Fletcher,J.E., Carlson,B.A., Hatfield,D.L. and
            Driscoll,D.M.
  TITLE     A novel RNA binding protein, SBP2, is required for the translation
            of mammalian selenoprotein mRNAs
  JOURNAL   EMBO J 19 (2), 306-314 (2000)
   PUBMED   10637234
REFERENCE   10 (bases 1 to 3240)
  AUTHORS   Copeland,P.R. and Driscoll,D.M.
  TITLE     Purification, redox sensitivity, and RNA binding properties of
            SECIS-binding protein 2, a protein involved in selenoprotein
            biosynthesis
  JOURNAL   J Biol Chem 274 (36), 25447-25454 (1999)
   PUBMED   10464275
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ251245.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ251245.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3240
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..3240
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /note="SECIS binding protein 2"
                     /db_xref="GeneID:79049"
                     /db_xref="RGD:620991"
     exon            1..79
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..2584
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /function="essential for selenocysteine incorporation"
                     /codon_start=1
                     /product="selenocysteine insertion sequence-binding
                     protein 2"
                     /protein_id="NP_076492.1"
                     /db_xref="GeneID:79049"
                     /db_xref="RGD:620991"
                     /translation="MASERPREPEGEDSIKLSADVKPFVPKFAGLNVAWSESSEACVF
                     PGCAATYYPFVQESPAAEQKMYPEDMAFGAPAFPAQYVSSEIALHPFAYPTYALESTQ
                     SVCSVPTLQYDYSQAQCHPGFRPAKPRNEHACPPQEAKCVFKKKSSDERRAWEEQKSS
                     NRRADGAVPCEARPARGSCHLKSDGYHKRPDRKSRILTKSASTSKPEFEFSRLDFPEL
                     QSPKNSNLPETQKQPRWGPLGPAASNMSLLGEAGKPVADMVEGKMVKTDHTDGAVTNN
                     AATSSPSCTRELSWTPMGYIVRQTVSSDSAAATETVNSIINLKKTTSSADAKNVSVTS
                     EALSSDPSFSREKRVHPGPKAKASQGSELEQNESSKKNKKKKEKSKSSYEVLPVQEPP
                     RIEDAEEFPNLSVASERRHRGESPKLQSKQQAQNDFKTGGKKSQVPVQLDLGGMLAAL
                     EKQQHAPHAKPSSRPVVFSVGAVPVLSKDASSGERGRRSSQVKTPHNPLDSSAPLMKK
                     GKQREIPKAKKPTSLKKIILKERQERMQQRLQESAVSPTVASDDSQDVESGVTNQIPS
                     PDNPTGPEKTEEPMSSTPVVEGESEEPAGTEFQRDPEACQPAPDSATFPKIHSRRFRD
                     YCSQMLSKEVDACVTGLLKELVRFQDRMYQKDPVKAKTKRRLVLGLREVLKHLKLRKL
                     KCIIISPNCEKTQSKGGLDDTLHTIIDCACEQNIPFVFALNRKALGRSLNKAVPVSIV
                     GIFSYDGAQDQFHKMVELTMAARQAYKTMLETMRQEQAGEPGPQTPPSPPMQDPIQST
                     DEGTLASTGEEPHYIEIWRKHLEAYSQHALELEDSLEASTSQMMNLNL"
     exon            80..228
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            229..475
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            476..593
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            594..823
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            824..902
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1105
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1228
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1318
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1451
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1618
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1757
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1914
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2135
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2290
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2480
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..3240
                     /gene="Secisbp2"
                     /gene_synonym="Sbp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcgccgc aggttttacg gcgcgggctc ttccgtggcc gccatggcgt cggagcggcc
       61 gcgggagccc gaaggcgagg atagcatcaa gttgtcagct gatgtcaaac catttgtccc
      121 taagtttgct gggctcaatg tggcgtggtc agagtcctca gaagcttgtg tcttcccagg
      181 ctgtgcagcc acttactatc cattcgtaca ggagtcacca gcggctgaac aaaaaatgta
      241 tcctgaagac atggcttttg gagcccctgc ctttccagca cagtacgtgt cttctgagat
      301 agcactgcat ccttttgcct atcccactta cgccctcgag tccacacaga gtgtttgctc
      361 agtgccaacc ctgcagtacg attacagcca agcacagtgt cacccaggct ttcggccagc
      421 aaagccccga aatgagcacg catgccctcc tcaggaagca aagtgtgtat ttaagaaaaa
      481 atcctctgat gagagaagag catgggaaga gcaaaagtca agcaacagaa gggctgatgg
      541 tgcagtgccc tgtgaggcga gaccagccag agggtcatgc cacctgaaat ctgatggtta
      601 tcacaagcgg cctgatcgga agtccaggat ccttacaaaa agtgcatcta cctctaaacc
      661 cgaatttgaa tttagcaggt tggactttcc tgaactgcag agtccaaaga acagtaatct
      721 gccagagaca cagaagcagc ccaggtgggg gcctcttggc cctgctgcca gtaacatgtc
      781 tctcctggga gaagcgggca agccagttgc agatatggta gagggtaaaa tggtgaagac
      841 ggatcacact gatggagctg tgactaacaa tgccgctacc agttccccct cgtgtacacg
      901 agagttgtct tggacaccaa tgggttatat tgttcggcag acagtgtctt cagactcagc
      961 agcagcgact gaaactgtta attccatcat aaacctaaag aagactacgt catcagctga
     1021 tgctaaaaac gttagcgtga catctgaggc gttatcttca gatccttcct tcagcaggga
     1081 aaagcgtgtt catcctggtc caaaggccaa agcatcacaa ggaagtgaac ttgaacaaaa
     1141 cgaaagctcc aaaaagaata agaaaaagaa agaaaagtct aaatcaagtt atgaagtcct
     1201 gccggttcag gagccaccga ggattgaaga tgctgaggaa ttccccaacc tgtcagttgc
     1261 atctgaaaga agacacagag gggaatcacc aaaacttcag agtaaacagc aggcgcagaa
     1321 tgactttaaa acgggtggaa agaagagcca ggttccggtg cagctggacc tggggggcat
     1381 gttggcagca ctggagaagc agcagcacgc cccgcacgcc aagccatcct ccagacccgt
     1441 cgtgttctca gttggagcag tgccagtcct ttccaaggat gcctcctcag gtgagagggg
     1501 tcgccgctct agtcaggtga agaccccaca caaccccctg gactccagtg cccccctaat
     1561 gaagaagggg aagcagaggg agatacctaa ggccaagaag cccacctcac tgaagaagat
     1621 aattttgaaa gaacggcaag agagaatgca gcagcgactc caagaaagtg ctgtgagccc
     1681 gactgtggcc agtgatgact cacaggatgt ggagagtggt gttactaacc aaatccccag
     1741 cccggacaac cccacaggtc cagagaagac agaagaaccc atgtcttcta cacctgtggt
     1801 tgagggtgag tcagaagagc cagctggcac agagttccag agggacccag aggcttgcca
     1861 gcctgcccct gacagtgcca ccttccccaa gatccacagc cggaggttcc gggactactg
     1921 cagccagatg cttagtaaag aagtcgatgc ttgtgtcacg ggtctcctca aggaactggt
     1981 gcgcttccaa gaccggatgt accagaagga tcctgtcaag gccaagacaa aacgccggct
     2041 tgtgctgggg ctgagggagg tcctgaaaca cctgaagctc aggaagctga agtgtatcat
     2101 catctctccc aactgtgaga agacacagtc taaaggtgga ctggacgaca cactgcacac
     2161 catcatcgat tgcgcctgtg agcagaacat cccctttgtg tttgcactca accgcaaggc
     2221 actggggcgg agtctgaata aagcagttcc tgtcagcatt gtagggatct tcagttacga
     2281 tggggcccag gaccagttcc acaagatggt tgagctgacc atggcagccc gtcaggcata
     2341 caagaccatg ttggagacga tgcggcagga gcaggcagga gaacctgggc ctcagacccc
     2401 tcccagccca cccatgcagg accccatcca gtccaccgac gaaggcaccc tagcttccac
     2461 tggagaagag ccacactata ttgagatttg gagaaagcat ctggaagcgt acagtcagca
     2521 tgccctggag ctggaagact cactggaggc atcaacctct cagatgatga acttgaattt
     2581 ataagaagag ttcttgcctg tgtgtctgtg ttttgggtaa ggatggggag gtaggaaaaa
     2641 gacttccttc tcagttctgt actgacctgg tgtatttatg tgactgttga gttggaaatg
     2701 cactggccta cgggcaaagg aagcaccagg tgtggcaccg ttcatcatcc gtcagatgga
     2761 cagacaccca gacactcccg tgggcaccct tcccaagagc ctggtgattc agctttggtt
     2821 ctctctgcac tggatctgga aaatgctaga gaatgtggtc ctgggtactg tggctgccta
     2881 ggaaccacta tccacagcgc cactggggat ggtggaacag gagctgtgct ccagggacgg
     2941 tagagggccc tccttaggga tggagccctg ccactttgtg ctgccaagga tttgctaaga
     3001 tgagcctcag aaaaaaatta gtttctaaca tgactttttg acataaatta atgcttttag
     3061 tttttatttt ccaaagaagc agtatatatc aaatttgtag ttttcagttt ggtatctaca
     3121 aatcttttta ctgaacagag gataaatgtg gtttctgtct tggaggacag agcttacttg
     3181 cgtgtttccc tgcaagcaag agggcttatt tgttagaata aagagtgatt atttaatttc
//
