LOCUS       NM_001393776            2942 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SEC62 homolog, preprotein translocation factor
            (Sec62), mRNA.
ACCESSION   NM_001393776 XM_006232224
VERSION     NM_001393776.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2942)
  AUTHORS   Hassdenteufel,S., Johnson,N., Paton,A.W., Paton,J.C., High,S. and
            Zimmermann,R.
  TITLE     Chaperone-Mediated Sec61 Channel Gating during ER Import of Small
            Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy
            Barrier
  JOURNAL   Cell Rep 23 (5), 1373-1386 (2018)
   PUBMED   29719251
REFERENCE   2  (bases 1 to 2942)
  AUTHORS   Lang,S., Benedix,J., Fedeles,S.V., Schorr,S., Schirra,C.,
            Schauble,N., Jalal,C., Greiner,M., Hassdenteufel,S., Tatzelt,J.,
            Kreutzer,B., Edelmann,L., Krause,E., Rettig,J., Somlo,S.,
            Zimmermann,R. and Dudek,J.
  TITLE     Different effects of Sec61alpha, Sec62 and Sec63 depletion on
            transport of polypeptides into the endoplasmic reticulum of
            mammalian cells
  JOURNAL   J Cell Sci 125 (Pt 8), 1958-1969 (2012)
   PUBMED   22375059
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 10, 2021 this sequence version replaced XM_006232224.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2478292.1,
                                           SRR22582416.937296.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-655               JAXUCZ010000002.1  114526051-114526705 c
            656-764             JAXUCZ010000002.1  114519647-114519755 c
            765-870             JAXUCZ010000002.1  114518505-114518610 c
            871-1075            JAXUCZ010000002.1  114510347-114510551 c
            1076-1168           JAXUCZ010000002.1  114509788-114509880 c
            1169-1229           JAXUCZ010000002.1  114507917-114507977 c
            1230-1349           JAXUCZ010000002.1  114505814-114505933 c
            1350-2942           JAXUCZ010000002.1  114499317-114500909 c
FEATURES             Location/Qualifiers
     source          1..2942
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..2942
                     /gene="Sec62"
                     /gene_synonym="Ab2-292; Tloc1"
                     /note="SEC62 homolog, preprotein translocation factor"
                     /db_xref="GeneID:294912"
                     /db_xref="RGD:1308862"
     exon            1..655
                     /gene="Sec62"
                     /gene_synonym="Ab2-292; Tloc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             620..1816
                     /gene="Sec62"
                     /gene_synonym="Ab2-292; Tloc1"
                     /note="translocation protein 1"
                     /codon_start=1
                     /product="translocation protein SEC62"
                     /protein_id="NP_001380705.1"
                     /db_xref="GeneID:294912"
                     /db_xref="RGD:1308862"
                     /translation="MAERRRHKKRIQEVGEPSKEEKAVAKYLRFNCPTKSTNMMGHRV
                     DYFIASKAVECLLDSKWAKAKKGEEALFTTRESVVDYCNRLLKKQFFHRALKVMKMKY
                     DKDIKKEKEKGKSESGKEDDKKSKKESIKEEKTKKEKEKKKDGEKEDSKKEETPGTPK
                     KKETKKKFKLEPHDDQVFLDGNEVFVWIYDPVHIKTFVMGLILVIAVIAATLFPLWPA
                     EMRVGVYYLSVGAGCFVASILLLAIARCILFLIIWLITGGRHHFWFLPNLTADVGFID
                     SFRPLYTHEYKGPKADLKKDEKSEAKKQHKSDSEEKSDSEKKEDEEGKGAPGDHGPEG
                     SGGERHSDTDSDRREDDRSQHSSGNGNDFEMITKEELEQQTDGDCDEEDDDKDGEMPK
                     SAQEKS"
     exon            656..764
                     /gene="Sec62"
                     /gene_synonym="Ab2-292; Tloc1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..870
                     /gene="Sec62"
                     /gene_synonym="Ab2-292; Tloc1"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1075
                     /gene="Sec62"
                     /gene_synonym="Ab2-292; Tloc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1168
                     /gene="Sec62"
                     /gene_synonym="Ab2-292; Tloc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1229
                     /gene="Sec62"
                     /gene_synonym="Ab2-292; Tloc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1349
                     /gene="Sec62"
                     /gene_synonym="Ab2-292; Tloc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..2942
                     /gene="Sec62"
                     /gene_synonym="Ab2-292; Tloc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcccaactag tcttgctcct ttccatctta ctaacttccc ggggctcttc tcgacttctg
       61 aattctaagg atgggttatg aagagtcacg tgatgagtgg gcattccaag cctttgggaa
      121 caagctgtgt aactccctat gctccttaaa ggagtcgctt tccatctttt aaagggaact
      181 tcatgggact gaagtggggt gccacggagc ttgttggggc aggaagcggc ataggtgacg
      241 ctttgggtcc cggtggtcca ggtcctttcc tcagcaaagg cctcaccggc gtcggtgact
      301 ccgaggggtg gggcccgggg atctgtattt acacgccagc caggtgactc cgacgttcag
      361 tcaggcttga gagccgaagc ctcttgccgg cctccagcgc tctgactcac ttcgcgccga
      421 cctcccgggc ccagcctcca ccgcccgcca ccccagggac aggaacgaag accacagagc
      481 ccggccctcg gctgccccca gcccacagcc cgcggcgggt tacataacgg gccgcgagcc
      541 gccgcactct cgcgagactt ccaccgcccc ccctcccctg ctcgctccac gtcagaagga
      601 accgggcgga gcggccaaca tggcggaacg caggcgacac aagaagcgga tccaggaagt
      661 tggtgaacca tctaaagaag agaaggctgt agccaagtat cttcgattca actgtccaac
      721 aaaatccacc aacatgatgg gtcatcgggt tgattatttt attgcttcaa aagcagtgga
      781 gtgcctcttg gattctaaat gggcaaaggc caagaaagga gaggaagctt tatttacaac
      841 cagggagtct gtggttgact actgcaacag gcttttaaag aaacagtttt ttcatcgggc
      901 cctaaaagta atgaaaatga aatatgacaa agacataaaa aaagaaaaag aaaaaggaaa
      961 atctgaaagt gggaaagaag atgataaaaa gagcaagaaa gaaagtatta aagaagaaaa
     1021 aacaaaaaag gaaaaagaaa aaaagaaaga tggtgaaaag gaagattcca aaaaggaaga
     1081 aactccagga actccaaaaa agaaggaaac taagaagaaa ttcaaacttg agccacatga
     1141 tgaccaagtc tttctggatg gaaatgaggt ttttgtgtgg atctatgacc cagttcacat
     1201 taaaacattt gtcatgggat taattcttgt gattgcagta atagctgcca ccctcttccc
     1261 tctctggcca gcagaaatga gagtaggtgt gtattacctc agtgtgggcg caggctgttt
     1321 tgtagccagc attctcctcc ttgctattgc tcgctgcatc ctgttcctca tcatctggct
     1381 gataactgga ggaaggcacc acttttggtt cctgccaaac ctgactgctg acgtgggctt
     1441 cattgactcc ttcaggcctc tgtacacaca tgagtacaaa ggaccaaaag cagacttaaa
     1501 gaaggatgag aaatctgaag ccaaaaagca gcacaagtcc gacagtgagg aaaagtcaga
     1561 cagtgagaaa aaggaggatg aagaagggaa aggagctcca ggagaccacg gaccagaagg
     1621 ctcgggcgga gagcgccact cagacacaga cagtgacagg cgggaagatg accgctccca
     1681 acacagtagt gggaacggga atgattttga aatgatcacg aaagaggaac tggaacagca
     1741 gacagatggg gattgtgatg aggaagatga cgacaaagat ggagaaatgc ctaaatctgc
     1801 acaagaaaaa tcataatctg actagttggg gactgaatac aacaggttgg gttctctgtg
     1861 ttggccgatc atcatgatgt acagatggca tttgtagcat tctttaaatc catcttctga
     1921 actgtatttg acattcagtt atagtcagcc ttttgttttg tagagcattg gtactactat
     1981 tggtacagtc taaagccatt aataagtttt atccacctga taattttaca gtgagtaggc
     2041 ctcattttga tagtcatcag aggtaccttg tccacaatga catttagatt aagggcattt
     2101 ttgatagttg tatggctttt tactgttaga ctaatggaaa tcactaaaga aactgcagca
     2161 tttcagatta tgcggaaata tatagccatt tcgcagtttc tttagaaaaa tgcttcaact
     2221 cgttgttctt gctagttaca ctcttttcat tttggttttt tggggttttt tttgtttttt
     2281 gttttctttc tttttttttt tggtcataaa attacaccag aaaattcctt ttttaaagtt
     2341 tttgagttag cagggatcaa cagcattttg tggaaacaga ccagctagta acagtgcagc
     2401 aaccctttta attcagctac agattctcct tttccagctt aggaaatccc aactgacttg
     2461 tatgttcaat ccagagaaag gtcatctcca gcagaagtga ggggcactga gtggacgacg
     2521 aggctcttcc ttcctcccca gctccttgtc ataacataaa aatgtattct gtacataatt
     2581 tacaaataaa acattttatt ttaattgtta cttattattt agacatttct caacacttag
     2641 atttgtaaag cggaaaccat gtaaggtgtg ttcttagcga gcttcagtaa cccacagaac
     2701 atctgatctt tctacagcag ctgcagttgt gtgccaacat tccatgtgtt ttaatatgag
     2761 taaaaattat cctgattaag aacagctgtg tgtacgcctt aatgttcatt ttgatttatt
     2821 ttaaatcttt acatttagaa atggggactg tgttatcaga tgaggaggca ctgctgtgaa
     2881 agacaatttg ctgtcctaaa ataccaatta aaaataaagg atataaaaga aaacatagaa
     2941 aa
//
