LOCUS       NM_001106654             562 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SEC61 translocon subunit beta (Sec61b), mRNA.
ACCESSION   NM_001106654 XM_001056613 XM_216400
VERSION     NM_001106654.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 562)
  AUTHORS   Dickson,E.J., Jensen,J.B., Vivas,O., Kruse,M., Traynor-Kaplan,A.E.
            and Hille,B.
  TITLE     Dynamic formation of ER-PM junctions presents a lipid phosphatase
            to regulate phosphoinositides
  JOURNAL   J Cell Biol 213 (1), 33-48 (2016)
   PUBMED   27044890
REFERENCE   2  (bases 1 to 562)
  AUTHORS   Yi,K., Rubinstein,B., Unruh,J.R., Guo,F., Slaughter,B.D. and Li,R.
  TITLE     Sequential actin-based pushing forces drive meiosis I chromosome
            migration and symmetry breaking in oocytes
  JOURNAL   J Cell Biol 200 (5), 567-576 (2013)
   PUBMED   23439682
REFERENCE   3  (bases 1 to 562)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 562)
  AUTHORS   Lang,S., Benedix,J., Fedeles,S.V., Schorr,S., Schirra,C.,
            Schauble,N., Jalal,C., Greiner,M., Hassdenteufel,S., Tatzelt,J.,
            Kreutzer,B., Edelmann,L., Krause,E., Rettig,J., Somlo,S.,
            Zimmermann,R. and Dudek,J.
  TITLE     Different effects of Sec61alpha, Sec62 and Sec63 depletion on
            transport of polypeptides into the endoplasmic reticulum of
            mammalian cells
  JOURNAL   J Cell Sci 125 (Pt 8), 1958-1969 (2012)
   PUBMED   22375059
REFERENCE   5  (bases 1 to 562)
  AUTHORS   Kuang,E., Okumura,C.Y., Sheffy-Levin,S., Varsano,T., Shu,V.C.,
            Qi,J., Niesman,I.R., Yang,H.J., Lopez-Otin,C., Yang,W.Y.,
            Reed,J.C., Broday,L., Nizet,V. and Ronai,Z.A.
  TITLE     Regulation of ATG4B stability by RNF5 limits basal levels of
            autophagy and influences susceptibility to bacterial infection
  JOURNAL   PLoS Genet 8 (10), e1003007 (2012)
   PUBMED   23093945
  REMARK    Erratum:[PLoS Genet. 2020 May 11;16(5):e1008795. PMID: 32392217]
REFERENCE   6  (bases 1 to 562)
  AUTHORS   Liao,H.J. and Carpenter,G.
  TITLE     Role of the Sec61 translocon in EGF receptor trafficking to the
            nucleus and gene expression
  JOURNAL   Mol Biol Cell 18 (3), 1064-1072 (2007)
   PUBMED   17215517
REFERENCE   7  (bases 1 to 562)
  AUTHORS   Hori,O., Miyazaki,M., Tamatani,T., Ozawa,K., Takano,K., Okabe,M.,
            Ikawa,M., Hartmann,E., Mai,P., Stern,D.M., Kitao,Y. and Ogawa,S.
  TITLE     Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum
            (ER) translocation sites, leads to ER stress
  JOURNAL   Mol Cell Biol 26 (11), 4257-4267 (2006)
   PUBMED   16705175
REFERENCE   8  (bases 1 to 562)
  AUTHORS   Kamhi-Nesher,S., Shenkman,M., Tolchinsky,S., Fromm,S.V., Ehrlich,R.
            and Lederkremer,G.Z.
  TITLE     A novel quality control compartment derived from the endoplasmic
            reticulum
  JOURNAL   Mol Biol Cell 12 (6), 1711-1723 (2001)
   PUBMED   11408579
REFERENCE   9  (bases 1 to 562)
  AUTHORS   Greenfield,J.J. and High,S.
  TITLE     The Sec61 complex is located in both the ER and the ER-Golgi
            intermediate compartment
  JOURNAL   J Cell Sci 112 (Pt 10), 1477-1486 (1999)
   PUBMED   10212142
REFERENCE   10 (bases 1 to 562)
  AUTHORS   Wiertz,E.J., Tortorella,D., Bogyo,M., Yu,J., Mothes,W., Jones,T.R.,
            Rapoport,T.A. and Ploegh,H.L.
  TITLE     Sec61-mediated transfer of a membrane protein from the endoplasmic
            reticulum to the proteasome for destruction
  JOURNAL   Nature 384 (6608), 432-438 (1996)
   PUBMED   8945469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2010 this sequence version replaced NM_001106654.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167110.1, FQ217838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               JAXUCZ010000005.1  66569184-66569288
            106-203             JAXUCZ010000005.1  66569422-66569519
            204-305             JAXUCZ010000005.1  66574208-66574309
            306-562             JAXUCZ010000005.1  66577138-66577394
FEATURES             Location/Qualifiers
     source          1..562
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..562
                     /gene="Sec61b"
                     /note="SEC61 translocon subunit beta"
                     /db_xref="GeneID:298068"
                     /db_xref="RGD:1304997"
     exon            1..105
                     /gene="Sec61b"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..393
                     /gene="Sec61b"
                     /note="Sec61 beta subunit; Sec61 translocon beta subunit"
                     /codon_start=1
                     /product="protein transport protein Sec61 subunit beta"
                     /protein_id="NP_001100124.1"
                     /db_xref="GeneID:298068"
                     /db_xref="RGD:1304997"
                     /translation="MPGPTPSATNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSA
                     GRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS"
     exon            106..203
                     /gene="Sec61b"
                     /inference="alignment:Splign:2.1.0"
     exon            204..305
                     /gene="Sec61b"
                     /inference="alignment:Splign:2.1.0"
     exon            306..562
                     /gene="Sec61b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggcggtg ccagagcctg tccctaggag tcttctgagt gctccgcaac ttcccgacta
       61 ccatcttcat atctcttgtg cctactgttc ttagacatca gcatgccggg tccaacgcct
      121 agtgccacca acgtgggctc ctctgggcgt tctcctagca aagcagtggc cgcacgggcg
      181 gcgggatcca ctgtccggca gagaaaaaat gccagctgcg gaacccggag tgcaggccgc
      241 accacctctg cagggactgg ggggatgtgg cgattctaca cagaagattc cccagggctc
      301 aaagttggcc ctgtcccagt actggtgatg agtcttctgt tcatcgcttc tgtgtttatg
      361 ctgcacattt ggggcaagta cacgcgttca tagattttgg ctgcatctat ccatcatctg
      421 aagaagaagg aaaaacccaa catatcttgg accaaaagta tagtgatttc tgttcatgtg
      481 tattatttta cagagaataa gaattgactt tgagaaatca gttttttcta tggcaataaa
      541 ctttggaatt gctttatatg ga
//
