LOCUS       NM_199256               3061 bp    mRNA    linear   ROD 02-FEB-2024
DEFINITION  Rattus norvegicus SEC61 translocon subunit alpha 1 (Sec61a1), mRNA.
ACCESSION   NM_199256 XM_342720
VERSION     NM_199256.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3061)
  AUTHORS   Hassdenteufel,S., Johnson,N., Paton,A.W., Paton,J.C., High,S. and
            Zimmermann,R.
  TITLE     Chaperone-Mediated Sec61 Channel Gating during ER Import of Small
            Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy
            Barrier
  JOURNAL   Cell Rep 23 (5), 1373-1386 (2018)
   PUBMED   29719251
REFERENCE   2  (bases 1 to 3061)
  AUTHORS   Schubert,D., Klein,M.C., Hassdenteufel,S., Caballero-Oteyza,A.,
            Yang,L., Proietti,M., Bulashevska,A., Kemming,J., Kuhn,J.,
            Winzer,S., Rusch,S., Fliegauf,M., Schaffer,A.A., Pfeffer,S.,
            Geiger,R., Cavalie,A., Cao,H., Yang,F., Li,Y., Rizzi,M., Eibel,H.,
            Kobbe,R., Marks,A.L., Peppers,B.P., Hostoffer,R.W., Puck,J.M.,
            Zimmermann,R. and Grimbacher,B.
  TITLE     Plasma cell deficiency in human subjects with heterozygous
            mutations in Sec61 translocon alpha 1 subunit (SEC61A1)
  JOURNAL   J Allergy Clin Immunol 141 (4), 1427-1438 (2018)
   PUBMED   28782633
REFERENCE   3  (bases 1 to 3061)
  AUTHORS   Bolar,N.A., Golzio,C., Zivna,M., Hayot,G., Van Hemelrijk,C.,
            Schepers,D., Vandeweyer,G., Hoischen,A., Huyghe,J.R., Raes,A.,
            Matthys,E., Sys,E., Azou,M., Gubler,M.C., Praet,M., Van Camp,G.,
            McFadden,K., Pediaditakis,I., Pristoupilova,A., Hodanova,K.,
            Vyletal,P., Hartmannova,H., Stranecky,V., Hulkova,H., Baresova,V.,
            Jedlickova,I., Sovova,J., Hnizda,A., Kidd,K., Bleyer,A.J.,
            Spong,R.S., Vande Walle,J., Mortier,G., Brunner,H., Van Laer,L.,
            Kmoch,S., Katsanis,N. and Loeys,B.L.
  TITLE     Heterozygous Loss-of-Function SEC61A1 Mutations Cause
            Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney
            Disease with Anemia
  JOURNAL   Am J Hum Genet 99 (1), 174-187 (2016)
   PUBMED   27392076
REFERENCE   4  (bases 1 to 3061)
  AUTHORS   Lang,S., Benedix,J., Fedeles,S.V., Schorr,S., Schirra,C.,
            Schauble,N., Jalal,C., Greiner,M., Hassdenteufel,S., Tatzelt,J.,
            Kreutzer,B., Edelmann,L., Krause,E., Rettig,J., Somlo,S.,
            Zimmermann,R. and Dudek,J.
  TITLE     Different effects of Sec61alpha, Sec62 and Sec63 depletion on
            transport of polypeptides into the endoplasmic reticulum of
            mammalian cells
  JOURNAL   J Cell Sci 125 (Pt 8), 1958-1969 (2012)
   PUBMED   22375059
REFERENCE   5  (bases 1 to 3061)
  AUTHORS   Daniel,C.J., Conti,B., Johnson,A.E. and Skach,W.R.
  TITLE     Control of translocation through the Sec61 translocon by nascent
            polypeptide structure within the ribosome
  JOURNAL   J Biol Chem 283 (30), 20864-20873 (2008)
   PUBMED   18480044
REFERENCE   6  (bases 1 to 3061)
  AUTHORS   Pirot,P., Eizirik,D.L. and Cardozo,A.K.
  TITLE     Interferon-gamma potentiates endoplasmic reticulum stress-induced
            death by reducing pancreatic beta cell defence mechanisms
  JOURNAL   Diabetologia 49 (6), 1229-1236 (2006)
   PUBMED   16604358
REFERENCE   7  (bases 1 to 3061)
  AUTHORS   Stockton,J.D., Merkert,M.C. and Kellaris,K.V.
  TITLE     A complex of chaperones and disulfide isomerases occludes the
            cytosolic face of the translocation protein Sec61p and affects
            translocation of the prion protein
  JOURNAL   Biochemistry 42 (44), 12821-12834 (2003)
   PUBMED   14596596
REFERENCE   8  (bases 1 to 3061)
  AUTHORS   Houde,M., Bertholet,S., Gagnon,E., Brunet,S., Goyette,G.,
            Laplante,A., Princiotta,M.F., Thibault,P., Sacks,D. and
            Desjardins,M.
  TITLE     Phagosomes are competent organelles for antigen cross-presentation
  JOURNAL   Nature 425 (6956), 402-406 (2003)
   PUBMED   14508490
REFERENCE   9  (bases 1 to 3061)
  AUTHORS   Guermonprez,P., Saveanu,L., Kleijmeer,M., Davoust,J., Van Endert,P.
            and Amigorena,S.
  TITLE     ER-phagosome fusion defines an MHC class I cross-presentation
            compartment in dendritic cells
  JOURNAL   Nature 425 (6956), 397-402 (2003)
   PUBMED   14508489
REFERENCE   10 (bases 1 to 3061)
  AUTHORS   Gorlich,D., Prehn,S., Hartmann,E., Kalies,K.U. and Rapoport,T.A.
  TITLE     A mammalian homolog of SEC61p and SECYp is associated with
            ribosomes and nascent polypeptides during translocation
  JOURNAL   Cell 71 (3), 489-503 (1992)
   PUBMED   1423609
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC094530.1.
            
            [WARNING] On Apr 9, 2024 this sequence was replaced by NM_199256.3.
            
            On May 15, 2005 this sequence version replaced NM_199256.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094530.1, SRR8487231.156652.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3061
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..3061
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /note="SEC61 translocon subunit alpha 1"
                     /db_xref="GeneID:80843"
                     /db_xref="RGD:68321"
     exon            1..114
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1538
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /note="Sec61 alpha subunit homolog; protein transport
                     protein Sec61 subunit alpha; sec61 alpha-1; SEC61, alpha
                     subunit; Sec61 alpha 1 subunit; Sec61 translocon alpha 1
                     subunit"
                     /codon_start=1
                     /product="protein transport protein Sec61 subunit alpha
                     isoform 1"
                     /protein_id="NP_954865.1"
                     /db_xref="GeneID:80843"
                     /db_xref="RGD:68321"
                     /translation="MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLV
                     CCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEV
                     GDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGL
                     IVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFH
                     LLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQY
                     NTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPAR
                     AYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAK
                     QLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLA
                     VTIIYQYFEIFVKEQSEVGSMGALLF"
     exon            115..182
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            183..248
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            249..327
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            328..459
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            460..569
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            570..723
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            724..884
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1082
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1274
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1351
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..3036
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgtgtctc tcggctgagg aagcgcgctc cagatctagc agcaccgtcg cctcactcga
       61 agtggagcgc agtcgaggca gggagtgtag tcggaccagc caccgccatg gcgatcaaat
      121 ttctggaagt catcaagcca ttctgtgtca tcttgccgga aattcagaag ccagagagaa
      181 agattcagtt taaggagaag gtgttgtgga cggccatcac cctcttcatc ttcttagtat
      241 gctgccagat tcccctgttt ggcatcatgt cttcagactc agctgacccc ttctactgga
      301 tgcgagtgat tctggcctct aacagaggta ccttgatgga gctgggtatc tctcctattg
      361 tcacgtccgg ccttatcatg cagctcttag ctggtgccaa gataattgaa gttggggaca
      421 ccccgaaaga ccgagctctc ttcaatggag cccaaaagtt gtttggaatg atcatcacta
      481 tcggtcagtc cattgtgtac gtgatgacgg gcatgtacgg ggacccttca gagatgggtg
      541 ctggaatctg cctgctgatc accattcagc tctttgttgc tggcttaatt gtcctacttt
      601 tggatgaact cctgcagaaa ggatatggct tgggctctgg catctctctc ttcattgcga
      661 ctaatatctg tgagaccatt gtatggaagg cattcagccc caccactgtc aacactggcc
      721 gagggatgga atttgaaggc gccatcattg cgctgttcca cctgctggcc acccgcacag
      781 acaaggtccg agcccttcga gaggcattct accgccagaa cctccctaac ctcatgaacc
      841 tgattgccac catcttcgtc tttgctgttg tcatctattt ccagggcttc cgagtggacc
      901 ttccaatcaa gtcggcgcgt taccgaggcc agtacaatac ctaccccatc aagctcttct
      961 acacctccaa cattcccatc atcttgcagt ctgctctggt gtccaacctg tatgtcatct
     1021 cccagatgct gtcagcacgt ttcagtggca acctgctggt tagcctgctg ggcacctggt
     1081 cggatacgtc atctgggggc ccagcccgtg cttacccagt tggtggcctg tgttactacc
     1141 tgtctcctcc ggaatcattc ggctcagtgc tggaggaccc tgtccatgcg gtcgtgtaca
     1201 ttgtattcat gctgggttcc tgtgcattct tttccaaaac atggatcgaa gtttcgggtt
     1261 cttctgccaa agatgttgcc aagcagctga aggagcagca gatggtgatg agaggccaca
     1321 gggagacctc catggtgcat gagctcaacc ggtacatccc cacagctgca gccttcggtg
     1381 ggctgtgcat tggggccctc tctgtcctgg ctgatttcct gggtgctatc gggtctggca
     1441 ccgggatcct gctggcggtc accatcatct accagtactt tgagatcttc gtcaaagagc
     1501 agagcgaggt gggcagcatg ggagcccttc tcttctgagc ctcgtgtgcc tgtggaccag
     1561 ggtgagggca caggctccag aactgccccg gaagggtgct cttactgctg gagcatgcta
     1621 ctgtggcata gggactttaa tttttttttt tttaatttca tatcttttca ttccactgtg
     1681 taaagtgcta ggaaatttcc aatttgaagt tttgcttttt ctgacattgg caagagactg
     1741 atagaagtga attgttagct gatgtctggg gtgtgataac aaattgtccc caagtttcca
     1801 atgtaacttt tatttaaacc cttgcacttc tcagtgcctg gcagctgcaa gggtcccaac
     1861 tgccccgagg cagtctgtgg ccctggttga aggaagcaca aactacaaga tgtctgcatc
     1921 tcctctgggc atgcagacgg gtgaggatca gcatccgcgt gtctgctgtt gccagcaggg
     1981 aggggattac tggctttacc ttgagcctgg cctcactagg tagctaggca catgtaaagg
     2041 gtccttgtgc tcttttccag gtcccactag aaagggaggt cctgtggtgg ccacctctgt
     2101 cttcctaccg agaacttcct gttccaggtt ttagagtttt cttgttgtta ggaccaaatg
     2161 tagactggct gaggacctat aggaaaatca aactgggttc agagatctct taaggaagtt
     2221 gctcaaaatc ctttttatag ttaaggtgtc tggggtagca gataacatgg gtctgagggt
     2281 tagaagcctc aggtctatag gaaaggcccc ttcttaagat agaaactgtc taacagcaag
     2341 ggtacaaagg ctacagtttg aggtcagagc aatcagagct tgtcagctta ccttaagaca
     2401 caggagggtc cagttgttca cacaaggggg caggagctct ggtgggtgtg cagccatgtg
     2461 gtcacagcct gccagcagca agacacgtgg gtccgccaca cctcagtgga agtagcaaat
     2521 gcctccctga cccagggctt ctagggactc ttgctgctat gcttgccagc aaatggcaat
     2581 caagggacaa ttagccactt gccccgacac aggtcagcat cagggccctt gcacatagcc
     2641 caggactcac accatatcac acgtggcctt gtctagaccc agtcctgagc agaggagcct
     2701 ggtgccctcc cagtccacag ggtcttccca ctgcccctcc tctgccactg ccacagagca
     2761 gcagggcttc ccacctaccg tagggactcc acagcttctg gcaagcgggt gcagagtccc
     2821 cagctctggg ctgtgctgag gagcatcagg cctagaggag tccacagtct cacttgctgc
     2881 tgtagctgtc agccgggcct ggtggcttgt ggttgatggt cactgttagt gggtgagtag
     2941 ggatgacctg gcttccaaga ggactgtcac tgtggacacc aaaatggctt aactgagata
     3001 cagtgaaaac atgacaaata aaccaacttt ttacaaaaaa aaaaaaaaaa aaaaaaaaag
     3061 g
//
