LOCUS       NM_033021               4423 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus SEC31 homolog A, COPII coat complex component
            (Sec31a), mRNA.
ACCESSION   NM_033021
VERSION     NM_033021.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4423)
  AUTHORS   Elo,P., Tadayon,S., Liljenback,H., Teuho,J., Kakela,M.,
            Koskensalo,K., Saunavaara,V., Virta,J., Veres,T.Z., Kiviniemi,A.,
            Saraste,A., Marjamaki,P., Airas,L., Jalkanen,S. and Roivainen,A.
  TITLE     Vascular adhesion protein-1 is actively involved in the development
            of inflammatory lesions in rat models of multiple sclerosis
  JOURNAL   J Neuroinflammation 15 (1), 128 (2018)
   PUBMED   29716612
  REMARK    GeneRIF: VAP-1 is expressed in the vasculature within induced focal
            experimental autoimmune encephalomyelitis during the acute phase of
            inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4423)
  AUTHORS   Zhang,Y., Yi,W., Yao,J., Yu,X., Qian,C. and Hu,Z.
  TITLE     Hypoxia serves a key function in the upregulated expression of
            vascular adhesion protein-1 in vitro and in a rat model of
            hemorrhagic shock
  JOURNAL   Mol Med Rep 16 (2), 1189-1199 (2017)
   PUBMED   28627649
  REMARK    GeneRIF: the present study provided evidence that VAP-1 expression
            is upregulated by hypoxia during acute hemorrhagic shock, and that
            inhibition of VAP-1 may be beneficial in the setting of hemorrhagic
            shock.
REFERENCE   3  (bases 1 to 4423)
  AUTHORS   Maeda,M., Katada,T. and Saito,K.
  TITLE     TANGO1 recruits Sec16 to coordinately organize ER exit sites for
            efficient secretion
  JOURNAL   J Cell Biol 216 (6), 1731-1743 (2017)
   PUBMED   28442536
REFERENCE   4  (bases 1 to 4423)
  AUTHORS   McGourty,C.A., Akopian,D., Walsh,C., Gorur,A., Werner,A.,
            Schekman,R., Bautista,D. and Rape,M.
  TITLE     Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent
            Co-adaptor
  JOURNAL   Cell 167 (2), 525-538 (2016)
   PUBMED   27716508
REFERENCE   5  (bases 1 to 4423)
  AUTHORS   Cho,H.J., Yu,J., Xie,C., Rudrabhatla,P., Chen,X., Wu,J.,
            Parisiadou,L., Liu,G., Sun,L., Ma,B., Ding,J., Liu,Z. and Cai,H.
  TITLE     Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to
            allow ER-Golgi export
  JOURNAL   EMBO J 33 (20), 2314-2331 (2014)
   PUBMED   25201882
REFERENCE   6  (bases 1 to 4423)
  AUTHORS   Mancias,J.D. and Goldberg,J.
  TITLE     Structural basis of cargo membrane protein discrimination by the
            human COPII coat machinery
  JOURNAL   EMBO J 27 (21), 2918-2928 (2008)
   PUBMED   18843296
REFERENCE   7  (bases 1 to 4423)
  AUTHORS   Mancias,J.D. and Goldberg,J.
  TITLE     The transport signal on Sec22 for packaging into COPII-coated
            vesicles is a conformational epitope
  JOURNAL   Mol Cell 26 (3), 403-414 (2007)
   PUBMED   17499046
REFERENCE   8  (bases 1 to 4423)
  AUTHORS   Shibata,H., Suzuki,H., Yoshida,H. and Maki,M.
  TITLE     ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum
            exit sites in a Ca2+-dependent manner
  JOURNAL   Biochem Biophys Res Commun 353 (3), 756-763 (2007)
   PUBMED   17196169
REFERENCE   9  (bases 1 to 4423)
  AUTHORS   Yamasaki,A., Tani,K., Yamamoto,A., Kitamura,N. and Komada,M.
  TITLE     The Ca2+-binding protein ALG-2 is recruited to endoplasmic
            reticulum exit sites by Sec31A and stabilizes the localization of
            Sec31A
  JOURNAL   Mol Biol Cell 17 (11), 4876-4887 (2006)
   PUBMED   16957052
REFERENCE   10 (bases 1 to 4423)
  AUTHORS   Matovcik,L.M., Karapetian,O., Czernik,A.J., Marino,C.R.,
            Kinder,B.K. and Gorelick,F.S.
  TITLE     Antibodies to an epitope on synapsin I detect a protein associated
            with the endocytic compartment in non-neuronal cells
  JOURNAL   Eur J Cell Biol 65 (2), 327-340 (1994)
   PUBMED   7536673
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 26, 2020 this sequence version replaced NM_033021.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF034582.1, SRR26643287.29936.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               JAXUCZ010000014.1  9518737-9518996
            261-340             JAXUCZ010000014.1  9528457-9528536
            341-464             JAXUCZ010000014.1  9529212-9529335
            465-663             JAXUCZ010000014.1  9530801-9530999
            664-759             JAXUCZ010000014.1  9532198-9532293
            760-900             JAXUCZ010000014.1  9533900-9534040
            901-1043            JAXUCZ010000014.1  9534995-9535137
            1044-1143           JAXUCZ010000014.1  9538589-9538688
            1144-1305           JAXUCZ010000014.1  9541146-9541307
            1306-1458           JAXUCZ010000014.1  9541500-9541652
            1459-1692           JAXUCZ010000014.1  9541904-9542137
            1693-1767           JAXUCZ010000014.1  9543802-9543876
            1768-1806           JAXUCZ010000014.1  9545561-9545599
            1807-1884           JAXUCZ010000014.1  9546043-9546120
            1885-1963           JAXUCZ010000014.1  9548509-9548587
            1964-2142           JAXUCZ010000014.1  9549012-9549190
            2143-2269           JAXUCZ010000014.1  9550852-9550978
            2270-2415           JAXUCZ010000014.1  9551835-9551980
            2416-2589           JAXUCZ010000014.1  9553384-9553557
            2590-2763           JAXUCZ010000014.1  9555526-9555699
            2764-2856           JAXUCZ010000014.1  9558316-9558408
            2857-2980           JAXUCZ010000014.1  9558997-9559120
            2981-3316           JAXUCZ010000014.1  9560879-9561214
            3317-3375           JAXUCZ010000014.1  9566038-9566096
            3376-3639           JAXUCZ010000014.1  9568300-9568563
            3640-3759           JAXUCZ010000014.1  9570769-9570888
            3760-3831           JAXUCZ010000014.1  9571236-9571307
            3832-4423           JAXUCZ010000014.1  9572987-9573578
FEATURES             Location/Qualifiers
     source          1..4423
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..4423
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /note="SEC31 homolog A, COPII coat complex component"
                     /db_xref="GeneID:93646"
                     /db_xref="RGD:620233"
     exon            1..260
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            261..340
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..4011
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /note="SEC31-related protein A; vesicle-associated protein
                     1; SEC31-like protein 1; SEC31-like 1; vesicle associated
                     protein; SEC31 homolog A, COPII coating complex component"
                     /codon_start=1
                     /product="protein transport protein Sec31A"
                     /protein_id="NP_148981.2"
                     /db_xref="GeneID:93646"
                     /db_xref="RGD:620233"
                     /translation="MKLKEIDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLE
                     IFELDLSDPSLDMKSCATFSSSHRYHKLIWGPHKMDSKGDVSGVLIAGGENGNIILYD
                     PSKIIAGDKEVVIAQKDKHTGPVRALDVNIFQTNLVASGANESEIYIWDLNNFATPMT
                     PGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNRMHCSG
                     LAWHPDVATQMVLASEDDRLPVVQMWDLRFASSPLRVLENHARGILAIAWSMADPELL
                     LSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRIRVYSIM
                     GGSIDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQTSQHSIVLPLKKPPKWIRR
                     PVGASFSFGGKLVTFENVTGQPQQGAEQPRRQPVFISQVVTEKDFLSRSEQLQHVVQS
                     QGFISYCQKKIDASQTDFEKNVWSFLKVNFEEDSRGKYLELLGYRREDLGEKIALALN
                     RVDGSDVALKDSDRVAQSDGEESPAEEGQLLGERIKEEKQECDFLPSAGGGTFNISVS
                     GDIDGLITRALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSK
                     ITRLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGARLESEGDS
                     LLRTQACLCYICAGNVERLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQALDTN
                     TVGALLAEKMSQYANLLAAQGSIAAALAFLPDNTNQPDIVQLRDRLCRAQGRSVPGQE
                     SSRSSYEGQPLPKGGPGPLAGHPQVSRVQSQQYYPQVRIAPTVTTWSDRTPTALPSHP
                     PAACPSDTQGGNPPPPGFIMHGNVVPNSPAPLPTSPGHMHSQPPPYPQPQPYQPAQQY
                     SFGTGGSAVYRPQQPVAPPASNAYPNAPYVSPVASYSGQPQMYTAQPASSPTSSSAPL
                     PPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTPPAASELPASQRTGPQNGWNDPPAL
                     NRVPKKKKLPENFMPPVPITSPIMNPGGDPQPQGLQQQPSASGPRSSHASFPQPHLAG
                     GQPFHGIQQPLAQTGMPPSFSKPNTEGAPGAPIGNTIQHVQALPTEKITKKPIPDEHL
                     ILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLECLYDKLRDQTLSPTIISGLHSIAR
                     SIETRNYSEGLTVHTHIVSTSNFSETSAFMPVLKVVLSQASKLGV"
     exon            341..464
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..663
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            664..759
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..900
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1043
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1143
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1305
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1458
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1692
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1767
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1806
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1884
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1963
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2142
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2269
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2415
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2589
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2763
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2856
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2980
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3316
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3375
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3639
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3640..3759
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3760..3831
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3832..4423
                     /gene="Sec31a"
                     /gene_synonym="Sec31l1; VAP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatcctggga gagtccgacg ttcgccggct aacgcaggac aggtcactga ggtccgccag
       61 gtgtgtccgc cgtttgtttc ctgcccctcg ccaggttcgg tgtccgctgc cgaggcccga
      121 ggcccttctt ccgctgtcgg cgcgcccccc tgtctcgttt cggccccgcc gggacaacgc
      181 ctggagtcgc agcagccggg tgatcgcgcc cgtcatcctc taccaacgtt tccaggctgc
      241 cctgctcggg agtgagtgag aatgaagcta aaggagatag accgcacggc gatgcaggcg
      301 tggagccctg cccagaacca ccccatttac ctggccacag ggacatctgc tcagcagttg
      361 gacgcgacat tcagtaccaa cgcttccctt gagatattcg agctcgacct ttccgacccg
      421 tccttggata tgaagtcctg tgctactttc tcctcgtctc acaggtacca caagctgatc
      481 tggggacctc ataaaatgga ttccaaagga gatgtttctg gagttttgat tgcaggtgga
      541 gaaaatggaa acattattct ctacgatcct tctaaaatta tagctggaga caaggaagtt
      601 gtgattgccc aaaaggacaa gcatactggg ccagtgagag ccttggatgt aaacatcttc
      661 cagaccaatt tggtggcctc tggtgctaat gaatctgaaa tctacatttg ggatctaaac
      721 aattttgcaa ctccaatgac gccaggagct aaaacacagc caccagaaga tatcagctgc
      781 atagcctgga acagacaggt ccagcatatc ttagcatcag ccagtcccag tggccgggca
      841 acggtctggg atctcaggaa aaacgagcct attatcaaag tcagcgacca cagtaacagg
      901 atgcactgct ctgggctggc atggcaccct gatgtcgcta ctcagatggt ccttgcttct
      961 gaggatgatc gattaccagt ggtccagatg tgggatcttc gatttgcttc ctctcccctc
     1021 cgggttctgg aaaatcatgc cagggggatt ttggcaattg cttggagcat ggcagatcct
     1081 gaattgttgt taagctgtgg aaaagatgct aagattctct gctctaaccc taacacggga
     1141 gaggtattat atgaacttcc caccaacaca cagtggtgct ttgatatcca gtggtgtcct
     1201 cggaatcctg ccgtcctgtc tgccgcttcc ttcgatggtc gcatccgtgt ctactccatc
     1261 atgggaggga gcatagacgg cttaaggcag aaacaagttg acaagctttc gtcgtctttt
     1321 gggaatcttg atccgtttgg cacaggacag ccgctccctc cattacaaat cccacagcag
     1381 acttcacagc acagcatcgt gctgcccctg aagaagccac ccaagtggat ccggagacct
     1441 gtgggcgcct ccttctcatt cggagggaag ttggtgactt tcgagaacgt tacagggcag
     1501 cctcagcagg gagctgagca gccacggcgg cagcccgtgt tcatcagtca ggtggtgaca
     1561 gaaaaggact tcctcagccg ctcagagcag ctacagcacg tcgtgcagtc tcagggcttt
     1621 atcagttact gccagaaaaa gatcgatgcg tcccagactg acttcgagaa gaatgtgtgg
     1681 tccttcttga aggtaaactt tgaggaggat tctcgtggga aataccttga gcttcttgga
     1741 tatagaagag aagatctggg agagaagatt gctttggcct tgaacagagt ggacggatcc
     1801 gatgtggctc ttaaggactc tgaccgagta gcgcagagtg atggggagga gagccctgcc
     1861 gaggaagggc agctcctggg agagcgcatt aaagaggaaa aacaggagtg tgactttctg
     1921 ccctcggctg gcggtgggac ctttaacatc tccgtcagtg gggatattga tggtttaatt
     1981 acccgggctt tgctgaccgg caattttgag agcgcagttg acctttgttt acacgataac
     2041 cgaatggctg atgccatcat attagccatc gcaggtgggc aggagctctt ggctcaaacg
     2101 cagaagaaat actttgcaaa atcccaaagc aagattacca ggcttatcac tgcggtggtg
     2161 atgaagaact ggaaggagat tgttgaatcc tgtgatctta aaaattggag agaggcttta
     2221 gctgcggtcc tcacttatgc taagccagat gagttctccg ccctgtgtga tctcttggga
     2281 gccaggcttg aaagtgaagg agacagcctc ctgcggactc aggcctgcct ctgctatatc
     2341 tgtgccggga atgtagagag attagttgct tgttggacca aagctcaaga tggtagcaac
     2401 cccttgtctc tccaggatct gattgagaaa gttgtcatcc tccgaaaagc tgtacagctc
     2461 acgcaagccc tggacacgaa cactgtcggg gctcttctgg ccgagaagat gagtcagtat
     2521 gccaacttgt tggcagccca gggcagtatt gccgcggcct tggcgtttct gcctgacaac
     2581 accaaccagc cagatatcgt gcagctgcgt gacagactct gcagagctca aggcaggtct
     2641 gtgccggggc aggagtcctc taggagctcc tacgaggggc agccgctgcc caagggcggg
     2701 cccgggccgc ttgctggcca cccgcaggtg tccagagttc aaagtcagca atattatccc
     2761 caggttagaa ttgcccctac tgtcactacc tggagtgaca gaactcccac tgccctcccc
     2821 agccatccac ctgcagcctg tccctctgac acacagggag ggaatcctcc acctccaggt
     2881 ttcataatgc atggcaacgt tgttccaaat agccctgccc cactgccgac gtctccaggc
     2941 cacatgcaca gccagccacc accttatccg cagccgcagc cttaccagcc agcccagcag
     3001 tattccttcg gaacaggggg gtcagcagtt tatcgacctc aacagcctgt tgctcctcct
     3061 gcttctaacg cttaccctaa cgccccatac gtatctcctg tcgcttccta ctccgggcag
     3121 cctcagatgt acacagcaca gccagcctcc tcccctacct ccagctctgc tcctcttccc
     3181 cctccccctt cctctggagc gtccttccag catggcggac caggagctcc accgtcatct
     3241 tcagcttatg cactgcctcc tggaacaaca ggtacaccgc ctgctgccag tgagctgcct
     3301 gcgtcccaga gaacaggtcc tcagaatggt tggaatgatc ctcccgcttt gaacagagta
     3361 ccgaagaaga agaagctgcc tgagaacttc atgcctcctg tccccattac gtcaccaatc
     3421 atgaaccccg ggggagatcc ccagccacag gggctgcagc aacagccttc agcttcaggg
     3481 ccacggtcaa gccacgcctc cttcccgcag ccgcacctag ccggcggcca gcccttccac
     3541 gggatccagc agcctcttgc tcaaacaggc atgccaccgt ctttctcgaa gcccaacact
     3601 gaaggggccc ccggcgctcc cattgggaac accatccagc atgtgcaggc tctgccaaca
     3661 gaaaaaatta ccaagaagcc tattccagac gagcacctca ttctaaagac tacgtttgag
     3721 gaccttatcc agcgctgcct ctcctcagct acagaccccc aaaccaagag gaagctggac
     3781 gacgccagca aacgcctgga gtgtctgtac gacaaactta gggaccagac actttctcca
     3841 acaatcatca gcggtctcca cagcattgcg aggagcattg agacgaggaa ctactctgaa
     3901 gggttgaccg tccacactca catcgtcagc accagcaact tcagtgagac ctcagccttc
     3961 atgccagtcc tcaaggttgt gctcagccag gccagtaagc tgggcgtctg agacagctgc
     4021 catgacctcc gactccgcca cttctccaaa gaaagccatg ctaagactgg gaccagcccc
     4081 tcattagcat gtttccatgg ccacccgcca cccaggagct ttgacatttc tgcaggcaaa
     4141 ctcccctaga actgcttgaa ccccccctcc caccccgccc gtgctttcct ttgttttaat
     4201 cccctcgccc attatgattt tcccattctg caaatagtgt ctttcctgga ttacacatag
     4261 tgtggtttcc tgagggattc tgacaaaatg tggtttttaa aactttggtg tactttttag
     4321 gaaaattgca tctggctgtg tataaaacag acctaaaata gatttcttta atgtcttccc
     4381 taccttcttc acgttgatca gattaaagtt gtaatcccat ctt
//
