LOCUS       NM_001106474            5001 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus SEC24 homolog B, COPII coat complex component
            (Sec24b), mRNA.
ACCESSION   NM_001106474 XM_001075268 XM_215706
VERSION     NM_001106474.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5001)
  AUTHORS   Chen XW, Wang H, Bajaj K, Zhang P, Meng ZX, Ma D, Bai Y, Liu HH,
            Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Lin J, Young SG,
            Schekman R and Ginsburg D.
  TITLE     SEC24A deficiency lowers plasma cholesterol through reduced PCSK9
            secretion
  JOURNAL   Elife 2, e00444 (2013)
   PUBMED   23580231
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5001)
  AUTHORS   Bonnon C, Wendeler MW, Paccaud JP and Hauri HP.
  TITLE     Selective export of human GPI-anchored proteins from the
            endoplasmic reticulum
  JOURNAL   J Cell Sci 123 (Pt 10), 1705-1715 (2010)
   PUBMED   20427317
REFERENCE   3  (bases 1 to 5001)
  AUTHORS   Wansleeben C, Feitsma H, Montcouquiol M, Kroon C, Cuppen E and
            Meijlink F.
  TITLE     Planar cell polarity defects and defective Vangl2 trafficking in
            mutants for the COPII gene Sec24b
  JOURNAL   Development 137 (7), 1067-1073 (2010)
   PUBMED   20215345
REFERENCE   4  (bases 1 to 5001)
  AUTHORS   Merte J, Jensen D, Wright K, Sarsfield S, Wang Y, Schekman R and
            Ginty DD.
  TITLE     Sec24b selectively sorts Vangl2 to regulate planar cell polarity
            during neural tube closure
  JOURNAL   Nat Cell Biol 12 (1), 41-6 (2010)
   PUBMED   19966784
REFERENCE   5  (bases 1 to 5001)
  AUTHORS   Mancias JD and Goldberg J.
  TITLE     Structural basis of cargo membrane protein discrimination by the
            human COPII coat machinery
  JOURNAL   EMBO J 27 (21), 2918-2928 (2008)
   PUBMED   18843296
REFERENCE   6  (bases 1 to 5001)
  AUTHORS   Mancias JD and Goldberg J.
  TITLE     The transport signal on Sec22 for packaging into COPII-coated
            vesicles is a conformational epitope
  JOURNAL   Mol Cell 26 (3), 403-414 (2007)
   PUBMED   17499046
REFERENCE   7  (bases 1 to 5001)
  AUTHORS   Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L
            and Paccaud JP.
  TITLE     Sec24 proteins and sorting at the endoplasmic reticulum
  JOURNAL   J Biol Chem 274 (12), 7833-7840 (1999)
   PUBMED   10075675
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473952.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001075268.1, XM_215706.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..5001
                     /gene="Sec24b"
                     /note="SEC24 homolog B, COPII coat complex component"
                     /db_xref="GeneID:295461"
                     /db_xref="RGD:1309358"
     exon            1..255
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..3884
                     /gene="Sec24b"
                     /note="SEC24 related gene family, member B; SEC24 family,
                     member B"
                     /codon_start=1
                     /product="protein transport protein Sec24B"
                     /protein_id="NP_001099944.1"
                     /db_xref="GeneID:295461"
                     /db_xref="RGD:1309358"
                     /translation="MSAPAGSPHPAAGARMPPKLGGAVSGLAPPQQNGPAQSQMQVPS
                     GYGLPHQNYMAPSGHYSQGPGKMTSLPLDNQCENYYSRPYTAPTQNVGTPSSANQPGA
                     QLMYGRGPSAPHMGASMPGPFQGAPASASHSYPSASQPYSSLGNRYSSPATYSATASV
                     ASQGYPSTCSHYPISTVSNVVYPNVSYPSLPASEPYGQMFTSQSAPPPARPLKESYSG
                     PSTAVAYPSRPPPPPSQHQQQQQQQQQQQQQSHSGYSSLPWSGPGLPPAQDSLIRNQM
                     GSLAIPNSHPAINENVQPPKPSSVVATVLPGPSSTRMPPAPSHPVGPVPSAPPPPEQM
                     QTKGMQYGDYVNNQASSTPTPLSSASDDEEEEDEDEEAGVDSSSTTSSASPLPNSYDA
                     LEGGSYPDMHSSSASSPVPDRAPEPNSTLVPTPTAAQPAKVAKPFGYGYPTLQPAYQN
                     AAAPPTTAHPSGPAYSGYPQQYPGVHQLSSGLGGLSLQSSPQPESLRPVNLTQEKNIL
                     PATPIWAPVPNLSAELSKLNCSPDSFRCTLTSIPQTQALLNKAKLPLGLLLHPFRDLT
                     QLPVITSNTIVRCRSCRTYINPFVSFIDQRRWKCNLCYRVNDVPEEFLYNPLTRSYGE
                     PHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTVLCQSLLENLD
                     KLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPTPDSLLVNLYESK
                     ELIKDLLNALPNMFINTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQ
                     SREDPNQRSSTKVVHHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSK
                     YSAGCIFYYPSFHSTHNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGN
                     FFVRSTDLLSLANINPDAGFAVQLSIEESLADTSLVCFQTALLYTSSKGERRIRVHTL
                     CLPVVSSLADVYAGVDVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDPLSAYSSA
                     VSSVPRSTLTAPSSLKLLPLYVLALLKQKAFRTGTSTRLDDRVYAMCQMKSQPLVHLM
                     KMIHPNLYRIDRLTDEGAIHVNDRVVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWIG
                     KGCDSNFIENVLGYPDFGSIPQKMTHLPELDTLPSERTRSFVTWLRDSRPLSPVLHVV
                     KDESPARTDFFQHLVEDRTEAALSYYEFLIHVQQQVCK"
     exon            256..1023
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1167
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1272
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1353
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1565
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1750
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1853
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1980
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2090
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2203
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2322
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2378
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2585
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2709
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2868
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..3042
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3153
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            3154..3329
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..3467
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            3468..3572
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            3573..3665
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            3666..3769
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
     exon            3770..5001
                     /gene="Sec24b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgtgggtg cccgggccgc ggtccttagt gagagtgact cggcctgtga cgcgggcgcg
       61 ttccttcctc ttcctcttcc tccgcggccc cgccttcctt ccctccgccc atctcccgcc
      121 gcggaggagc cgccgccgcc gacagccgcg ccgtcatgtc ggcccccgcc gggtcccctc
      181 acccggccgc cggcgcccgg atgccgccca agctcggcgg agcagtctct ggcctggcgc
      241 cgccgcagca gaatggtcca gcacagagtc aaatgcaagt tccatctggg tatgggctgc
      301 ctcatcaaaa ctatatggcc ccctcaggac actactctca aggacctggg aaaatgacct
      361 ccttgccgtt ggataaccag tgtgagaatt actactctcg tccatataca gcaccaacac
      421 agaatgtggg gactcccagc tcagcaaacc aaccaggagc acagctcatg tatggcagag
      481 gtccttctgc ccctcacatg ggggcatcca tgccaggacc tttccaagga gctccagcat
      541 cggcgtccca ttcgtacccg agtgcctccc agccctattc ctctcttggg aaccgctaca
      601 gtagtcctgc cacatactcc gccaccgctt ctgttgcttc tcagggatac ccctccactt
      661 gtagtcatta tcccatctcc actgtgtcta atgtcgtgta tcctaacgtt tcatacccct
      721 cgctgcctgc cagtgagccg tatgggcaga tgtttacctc acagagtgct cctccgcctg
      781 ccaggccact taaagagtca tactctggcc caagcacagc tgttgcctac ccatcgagac
      841 ctccgcctcc accttcccag caccagcagc agcagcagca gcagcagcag cagcagcagc
      901 agagtcattc aggatacagt tctctaccat ggtcaggtcc aggccttcca ccagcccaag
      961 acagtctcat ccgaaaccaa atgggatcct tggctatacc gaacagccac ccagcaatta
     1021 acgaaaatgt ccaaccacct aagcccagct ccgtagtagc cacagttttg ccaggaccct
     1081 catcaacaag aatgccacct gccccaagtc acccagttgg gcctgtgccg tctgctccac
     1141 cccccccaga gcagatgcag acaaaaggca tgcagtatgg tgactatgtt aataatcaag
     1201 ctagctccac accaactccc ttgtcatcag cttccgatga tgaggaagag gaggatgagg
     1261 atgaggaagc aggtgttgac agctcttcta ccacaagcag cgcttcgccc ttgcccaaca
     1321 gttatgatgc cttggaagga ggaagctacc cagatatgca ttcttcttca gcaagcagcc
     1381 ccgttcctga tcgtgccccg gaacctaact ccaccctcgt ccccactccc actgctgctc
     1441 agccagccaa ggtagcaaag ccttttggct atggctaccc aacgctgcag cctgcttatc
     1501 agaatgcagc agcaccaccc accacagccc accccagcgg gccagcgtat tctggatatc
     1561 ctcagcagta tccaggtgtg caccaactgt cctcaggtct gggagggcta agcctgcaga
     1621 gctctccaca gccagaaagc ctacggcctg tgaacctcac ccaggagaag aacatcttac
     1681 ctgcaactcc catttgggca cctgtaccta acctgagtgc agagctcagc aagttaaact
     1741 gtagcccaga ctcgtttcga tgtaccttga ccagtatccc acagacacag gctttactga
     1801 ataaagctaa gcttcccttg ggactgctgc tgcacccctt cagagacctg acgcaattgc
     1861 cagtgataac ctccaacacc attgtgaggt gccggtcctg tcggacgtac atcaaccctt
     1921 ttgtgtcctt catcgatcag cgcaggtgga aatgcaacct gtgctacaga gtgaatgatg
     1981 ttccagaaga gtttttgtac aaccccctga ctcggtctta cggagagcct cataaacggc
     2041 cggaagttca gaattcaact gtggagttca tcgcttcctc agactacatg ctccggcctc
     2101 ctcagcctgc agtctacttg tttgttttag atgtgtctca taacgcagtg gaagctgggt
     2161 acttgacagt tctatgccag tccttattag aaaacttaga caagcttcct ggagactcac
     2221 gaacaagaat aggattcatg actttcgaca gcactattca tttctacaat ttacaagaag
     2281 gattatccca gcctcagatg ttgattgtat ctgatataga cgatgttttc ttgcccacac
     2341 cggatagtct gcttgtgaat ctgtatgaaa gtaaagagct tataaaagac ttactgaacg
     2401 cattaccaaa tatgttcatc aataccagag aaacgcacag tgctcttgga cctgcacttc
     2461 aggctgcctt caaactaatg tctcccacgg gcggacgagt gtctgtgttt cagacacagt
     2521 taccttcctt gggggcagga cttctgcagt ccagagaaga tccgaatcag aggtcgagca
     2581 ccaaggtggt gcaccatctc ggccctgcca ccgactttta taagaaactt gctttagatt
     2641 gctcaggaca gcagaccgca gtggatttgt tcctgctaag ttcacagtat tctgacctcg
     2701 cttctctggc ctgcatgtcc aagtactccg cagggtgcat attctactac ccatcgttcc
     2761 actccaccca caacccttcg caagcagaga agttacagaa agacctaaaa cggtacctca
     2821 ccaggaagat cggatttgaa gctgttatga ggataagatg taccaaagga ctttcgatgc
     2881 acactttcca cgggaacttc tttgtccggt ccactgactt gctgtctctt gccaacatca
     2941 atcctgatgc tgggtttgca gtgcagttgt caattgagga aagcctggcg gacacttccc
     3001 tggtgtgctt ccagactgcc ctgctgtaca catcaagcaa aggtgagcgg agaattcgag
     3061 ttcacacact gtgcttgcca gtggtgagtt cactggctga tgtttatgca ggagtggatg
     3121 tgcaagctgc catctgcctt ctggccaaca tggctgtgga ccgctcagtg tcatccagcc
     3181 tgtcggatgc cagggacgcc ctggtgaatg ccgtggtgga tcccctgtct gcctacagct
     3241 ctgcagtgtc gagtgtgccc cgctccaccc tgacagcacc gagctcactg aagctgctcc
     3301 ctctctatgt tctggcactt ctcaaacaga aagcatttag aacaggtaca agcacgcgcc
     3361 tggacgaccg tgtgtacgcc atgtgccaga tgaagtcgca gccacttgtg catctaatga
     3421 aaatgattca tcccaacttg tacaggatag accggctgac ggatgagggt gccatacatg
     3481 tcaacgacag ggtagtaccc cagccacctc ttcaaaaact gtctgcagag aaactgacca
     3541 gagaaggtgc tttcctcatg gactgtggct cagttttcta catttggatt ggcaaaggct
     3601 gtgacagtaa tttcatagag aatgtgcttg ggtatcctga ttttggatca ataccacaga
     3661 aaatgacaca tcttccagag ctagacacac ttccgtcaga gagaactaga tcctttgtaa
     3721 cttggctcag agacagccga ccattaagcc ctgtccttca cgtggtaaaa gatgagagtc
     3781 ctgccagaac agactttttc cagcatttgg tggaagaccg caccgaagcc gcactctcct
     3841 actatgagtt tctgattcac gttcagcagc aggtttgtaa gtgaggtgaa cagagcccgt
     3901 cagatgagcg ctccacagcc tggaggagct agtccatcgg agaagcacat ggggacttga
     3961 cactgagaag acacgatgca caccactctg tctgaggctt aggccagaga tacggaaaga
     4021 cagcaagaca gagcagagct gaccagggag ccgacgcagc cgccagtgga tgcggatgga
     4081 gtcggtttct gcgaacttcc gggagagcag cagtgcagtg ctcttctgcc cgcccaggcc
     4141 tgaggaccat ggaatgacat gtcacaatct aaagccagat aaagccatcg cacagttaac
     4201 atttcccagc tggaactctg acaagagatg ccaaggggca ccgagcggta ccacagtact
     4261 cgtctgtatg atttacttaa atacggatga ctcatgtcca ttaaatgaat tcagcatttt
     4321 ccctgtaaag accatagagt ttcagtacat gaaccataga catatatata tatgtacata
     4381 cgtgttacat ttgtaaagaa atgtaaaatg tacctgagac tgaattgctg acgtgtgctg
     4441 catcgtcaga cggcagctct ggcagagagg gacgaggtga ctaatgcata ttatgagttg
     4501 agtccacaaa agaaacatga aactttgtaa ttctgttgaa tcttttatgt ggatttattt
     4561 atgatcagcc tactaattaa aaatattttg cttgacagtt ggtttggtgg ttcgtttgtt
     4621 tgtagaagtt tttggtttgg gtggtattgg tgataaacag tgggagtctt aaatttgcag
     4681 cttggaggaa atgcaatacc aagttccatt catcagtgaa tgaatatttt gtcatgggtt
     4741 tgtggtacta ccaagaaatt actgtttgta ttctaaaacc atgttatttt cagaatacat
     4801 ttaatgacta agcataatct tatctcattt aaattaagga tttttttcct acctatttgt
     4861 aatgagagtt ttttaagaat atgtgacttt cctttctaat tgacttgacg attatcatat
     4921 tgaactctga gaaagttttg ttctgatcaa gaattctgtc attcacagca ggttatttgc
     4981 tataaaaact gatgctgatc c
//
