LOCUS       NM_001105732            2510 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus Sec23 homolog A, COPII coat complex component
            (Sec23a), mRNA.
ACCESSION   NM_001105732 XM_001076053 XM_347236
VERSION     NM_001105732.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2510)
  AUTHORS   Tomoishi,S., Fukushima,S., Shinohara,K., Katada,T. and Saito,K.
  TITLE     CREB3L2-mediated expression of Sec23A/Sec24D is involved in hepatic
            stellate cell activation through ER-Golgi transport
  JOURNAL   Sci Rep 7 (1), 7992 (2017)
   PUBMED   28801610
  REMARK    GeneRIF: Sec23A expression is upregulated via CREB3L2 during
            hepatic stellate cells activation.  Sec23A knockdown abrogated the
            activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2510)
  AUTHORS   Maeda,M., Katada,T. and Saito,K.
  TITLE     TANGO1 recruits Sec16 to coordinately organize ER exit sites for
            efficient secretion
  JOURNAL   J Cell Biol 216 (6), 1731-1743 (2017)
   PUBMED   28442536
REFERENCE   3  (bases 1 to 2510)
  AUTHORS   Bruno,J., Brumfield,A., Chaudhary,N., Iaea,D. and McGraw,T.E.
  TITLE     SEC16A is a RAB10 effector required for insulin-stimulated GLUT4
            trafficking in adipocytes
  JOURNAL   J Cell Biol 214 (1), 61-76 (2016)
   PUBMED   27354378
REFERENCE   4  (bases 1 to 2510)
  AUTHORS   Valkova,C., Albrizio,M., Roder,I.V., Schwake,M., Betto,R.,
            Rudolf,R. and Kaether,C.
  TITLE     Sorting receptor Rer1 controls surface expression of muscle
            acetylcholine receptors by ER retention of unassembled
            alpha-subunits
  JOURNAL   Proc Natl Acad Sci U S A 108 (2), 621-625 (2011)
   PUBMED   21187406
REFERENCE   5  (bases 1 to 2510)
  AUTHORS   Mancias,J.D. and Goldberg,J.
  TITLE     Structural basis of cargo membrane protein discrimination by the
            human COPII coat machinery
  JOURNAL   EMBO J 27 (21), 2918-2928 (2008)
   PUBMED   18843296
REFERENCE   6  (bases 1 to 2510)
  AUTHORS   Mancias,J.D. and Goldberg,J.
  TITLE     The transport signal on Sec22 for packaging into COPII-coated
            vesicles is a conformational epitope
  JOURNAL   Mol Cell 26 (3), 403-414 (2007)
   PUBMED   17499046
REFERENCE   7  (bases 1 to 2510)
  AUTHORS   Zhang,J., Wang,Y., Zhou,Y., Cao,Z., Huang,P. and Lu,B.
  TITLE     Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are
            potential interaction partners of testicular germ cell-specific
            protein GGN1
  JOURNAL   FEBS Lett 579 (2), 559-566 (2005)
   PUBMED   15642376
REFERENCE   8  (bases 1 to 2510)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
REFERENCE   9  (bases 1 to 2510)
  AUTHORS   Paccaud,J.P., Reith,W., Carpentier,J.L., Ravazzola,M., Amherdt,M.,
            Schekman,R. and Orci,L.
  TITLE     Cloning and functional characterization of mammalian homologues of
            the COPII component Sec23
  JOURNAL   Mol Biol Cell 7 (10), 1535-1546 (1996)
   PUBMED   8898360
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC169006.1.
            
            [WARNING] On Oct 22, 2024 this sequence was replaced by
            NM_001105732.3.
            
            On Sep 4, 2008 this sequence version replaced NM_001105732.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169006.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2510
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     gene            1..2510
                     /gene="Sec23a"
                     /note="Sec23 homolog A, COPII coat complex component"
                     /db_xref="GeneID:58817"
                     /db_xref="RGD:1309103"
     exon            1..74
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            75..316
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..2393
                     /gene="Sec23a"
                     /note="Sec23 homolog A, coat complex II component"
                     /codon_start=1
                     /product="protein transport protein Sec23A"
                     /protein_id="NP_001099202.1"
                     /db_xref="GeneID:58817"
                     /db_xref="RGD:1309103"
                     /translation="MTTYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPVAALFTP
                     LKERPDLPPIQYEPVLCSRTTCRAVLNPLCQVDYRAKLWACNFCYQRNQFPPTYAGIS
                     ELNQPAELLPQFSSIEYVVLRGPQMPLIFLYVVDTCIEDEDLQALKESMQMSLSLLPP
                     TALVGLITFGRMVQVHELGCEGISKSYVFRGTKDLSAKQLQEMLGLSKVPVTQATRGP
                     QVQQPPPSNRFLQPVQKIDMNLTDLLGELQRDPWPVPQGKRPLRSSGVALSIAVGLLE
                     CTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSWHDIEKDNAKYVKKGTKHFEAL
                     ANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGGYMVMGDSFNTSLFKQTFQRVFTK
                     DIHGQFKMGFGGTLEIKTSREIKISGAIGPCVSLNSKGPCVSENEIGTGGTCQWKICG
                     LSPTTTLAIYFEVVNQHNAPIPQGGRGAVQFVTQYQHSSGQRRIRVTTIARNWADAQT
                     QIQNIAASFDQEAAAILMARLAIYRAETEEGPDVLRWLDRQLIRLCQKFGEYHKDDPN
                     SFRFSETFSLYPQFMFHLRRSPFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILY
                     AYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFR
                     HLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQESGA
                     PILTDDVSLQVFMDHLKKLAVSSAA"
     exon            317..374
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            375..461
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            462..698
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            699..778
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            779..923
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1082
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1198
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1322
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1403
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1493
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1600
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1754
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1832
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1994
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2081
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2237
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2303
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2488
                     /gene="Sec23a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagggctgct ccagggcttt ggagcggact gactgcaagg cggaggctgt ggccgtcacg
       61 gagctcctag gaagaaataa gaatcaagtg ctacaatgac aacctatttg gaatttatcc
      121 aacaaaatga agaacgagac ggggtcaggt tcagttggaa tgtttggcca tctagtcgtc
      181 tggaagctac aagaatggtt gttccagtgg cagccctgtt tacacctttg aaggagagac
      241 ctgacttacc acccattcag tacgagcctg tcctgtgcag taggacgact tgccgtgcag
      301 ttttgaatcc tttatgtcaa gttgattatc gagcaaaact ctgggcttgc aacttttgtt
      361 accaaaggaa tcagtttcca cctacatatg ctgggatatc tgaattgaac cagcctgccg
      421 agcttttacc ccagttttca agcattgaat atgtagttct gcgtggtccc cagatgcctt
      481 tgatatttct ctatgtggtt gatacttgca tagaggatga agatttacag gctctgaagg
      541 aatccatgca gatgtcgttg agccttttgc cacctacagc tttggttggc cttattactt
      601 ttgggagaat ggtgcaggtt catgagcttg gatgtgaagg catttcaaaa agctatgtct
      661 tcagaggaac aaaggatctg tctgccaaac aactgcagga aatgctgggg ctctctaaag
      721 tacctgttac tcaggccacc cgtggtcctc aggtacagca accacctcct tccaatagat
      781 tcttacagcc agtacagaaa atagacatga atctcacaga tcttctgggg gaacttcagc
      841 gagacccttg gcctgtacca caaggaaaga gacctttgcg ttcctcagga gtggcgcttt
      901 ctatagctgt aggactgctt gagtgtacgt tcccaaacac tggcgcgcgg atcatgatgt
      961 tcattggtgg ccctgctacc caggggcctg ggatggtggt tggagatgag ctaaagacac
     1021 ctataagatc ctggcacgac attgaaaagg acaatgccaa atatgttaaa aagggaacca
     1081 agcattttga agcactggct aatcgagctg ctacgacagg gcatgtcatt gatatctacg
     1141 cctgtgcact agatcagaca ggtctcttgg agatgaagtg ctgccctaac cttactggag
     1201 gatacatggt aatgggtgac tctttcaata cctccttatt caagcaaact tttcaaagag
     1261 tcttcaccaa agatatacat ggccagttta aaatgggctt tggtggcaca ttagagataa
     1321 agacctcaag ggaaataaag atttcaggag ctatcggtcc ctgtgtgtct cttaattcta
     1381 aaggaccttg cgtgtctgaa aatgagattg gaacaggtgg cacttgtcag tggaagatat
     1441 gtggacttag tcccactaca accttagcca tatattttga agttgttaat cagcataatg
     1501 ctccaattcc ccaaggaggg cgaggtgcag tccagttcgt gacccagtat cagcactcaa
     1561 gtgggcagag acgcatccga gtgaccacga ttgctaggaa ctgggcagat gctcaaactc
     1621 agatccagaa cattgctgca tcttttgacc aggaagcagc tgccattctc atggctaggt
     1681 tggcaatata cagagcggag acagaggaag ggccagacgt gcttaggtgg ttggatagac
     1741 agctcattcg actgtgtcag aaatttggag agtatcacaa agatgatcca aattccttcc
     1801 ggttttcaga aacattttcc ctttatccac agtttatgtt tcatttaaga agatctccct
     1861 tcttgcaagt ttttaacaac agtcctgatg agagttcata ctatcgccac catttcatgc
     1921 gccaggatct gacacagtct ctaatcatga tccagcccat tctgtatgcc tattccttca
     1981 gtggcccacc agagccggtg cttctcgata gcagcagcat tctcgcagat cgaattctcc
     2041 tcatggacac gtttttccag atcctgattt atcacggtga gactatagca cagtggcgga
     2101 agtctggata ccaggacatg ccagaatatg aaaatttccg acacctcctg caagccccag
     2161 tagatgacgc acaagagatt cttcactcca gattccccat gccgagatac attgacaccg
     2221 agcatggtgg cagccaggca cgtttccttc tttcaaaagt caacccttca cagactcata
     2281 ataacatgta tgcctggggg caggagtccg gagcaccaat cctcacagat gatgttagct
     2341 tacaagtgtt catggatcat ttgaagaaac ttgctgtgtc aagtgctgct tgatatgcca
     2401 gatgtgtcag acactcaaga attactactt cagtttcttt tgcttttttc atttatctgt
     2461 ggaaacaaca gagctctctc tctctaaaaa aaaaaaaaaa aaaaaaaaaa
//
