LOCUS       NM_001025686            1465 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus SEC22 homolog B, vesicle trafficking protein
            (Sec22b), mRNA.
ACCESSION   NM_001025686 XM_227499
VERSION     NM_001025686.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1465)
  AUTHORS   Li,D., Zhang,Y., Lu,L., Zhang,L., Ma,J., Ji,J., Li,H. and Chen,G.
  TITLE     Upregulation of Sec22b plays a neuroprotective role in a rat model
            of traumatic brain injury via inducing protective autophagy
  JOURNAL   Brain Res Bull 166, 29-36 (2021)
   PUBMED   33186631
  REMARK    GeneRIF: Upregulation of Sec22b plays a neuroprotective role in a
            rat model of traumatic brain injury via inducing protective
            autophagy.
REFERENCE   2  (bases 1 to 1465)
  AUTHORS   Renna,M., Schaffner,C., Winslow,A.R., Menzies,F.M., Peden,A.A.,
            Floto,R.A. and Rubinsztein,D.C.
  TITLE     Autophagic substrate clearance requires activity of the syntaxin-5
            SNARE complex
  JOURNAL   J Cell Sci 124 (Pt 3), 469-482 (2011)
   PUBMED   21242315
REFERENCE   3  (bases 1 to 1465)
  AUTHORS   Verrier,S.E., Willmann,M., Wenzel,D., Winter,U., von Mollard,G.F.
            and Soling,H.D.
  TITLE     Members of a mammalian SNARE complex interact in the endoplasmic
            reticulum in vivo and are found in COPI vesicles
  JOURNAL   Eur J Cell Biol 87 (11), 863-878 (2008)
   PUBMED   18834646
REFERENCE   4  (bases 1 to 1465)
  AUTHORS   Cao,Z., Li,C., Higginbotham,J.N., Franklin,J.L., Tabb,D.L.,
            Graves-Deal,R., Hill,S., Cheek,K., Jerome,W.G., Lapierre,L.A.,
            Goldenring,J.R., Ham,A.J. and Coffey,R.J.
  TITLE     Use of fluorescence-activated vesicle sorting for isolation of
            Naked2-associated, basolaterally targeted exocytic vesicles for
            proteomics analysis
  JOURNAL   Mol Cell Proteomics 7 (9), 1651-1667 (2008)
   PUBMED   18504258
REFERENCE   5  (bases 1 to 1465)
  AUTHORS   Mancias,J.D. and Goldberg,J.
  TITLE     The transport signal on Sec22 for packaging into COPII-coated
            vesicles is a conformational epitope
  JOURNAL   Mol Cell 26 (3), 403-414 (2007)
   PUBMED   17499046
REFERENCE   6  (bases 1 to 1465)
  AUTHORS   Volchuk,A., Ravazzola,M., Perrelet,A., Eng,W.S., Di Liberto,M.,
            Varlamov,O., Fukasawa,M., Engel,T., Sollner,T.H., Rothman,J.E. and
            Orci,L.
  TITLE     Countercurrent distribution of two distinct SNARE complexes
            mediating transport within the Golgi stack
  JOURNAL   Mol Biol Cell 15 (4), 1506-1518 (2004)
   PUBMED   14742712
REFERENCE   7  (bases 1 to 1465)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
REFERENCE   8  (bases 1 to 1465)
  AUTHORS   Xu,D., Joglekar,A.P., Williams,A.L. and Hay,J.C.
  TITLE     Subunit structure of a mammalian ER/Golgi SNARE complex
  JOURNAL   J Biol Chem 275 (50), 39631-39639 (2000)
   PUBMED   11035026
REFERENCE   9  (bases 1 to 1465)
  AUTHORS   Steegmaier,M., Oorschot,V., Klumperman,J. and Scheller,R.H.
  TITLE     Syntaxin 17 is abundant in steroidogenic cells and implicated in
            smooth endoplasmic reticulum membrane dynamics
  JOURNAL   Mol Biol Cell 11 (8), 2719-2731 (2000)
   PUBMED   10930465
REFERENCE   10 (bases 1 to 1465)
  AUTHORS   Hay,J.C., Chao,D.S., Kuo,C.S. and Scheller,R.H.
  TITLE     Protein interactions regulating vesicle transport between the
            endoplasmic reticulum and Golgi apparatus in mammalian cells
  JOURNAL   Cell 89 (1), 149-158 (1997)
   PUBMED   9094723
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098725.1.
            
            On Jul 22, 2005 this sequence version replaced XM_227499.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098725.1, FQ211503.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1465
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1465
                     /gene="Sec22b"
                     /gene_synonym="Sec22l1"
                     /note="SEC22 homolog B, vesicle trafficking protein"
                     /db_xref="GeneID:310710"
                     /db_xref="RGD:1309988"
     exon            1..181
                     /gene="Sec22b"
                     /gene_synonym="Sec22l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..754
                     /gene="Sec22b"
                     /gene_synonym="Sec22l1"
                     /note="ERS24; ERS-24; SEC22 vesicle-trafficking
                     protein-like 1; ER-Golgi SNARE of 24 kDa; SEC22 vesicle
                     trafficking protein homolog B"
                     /codon_start=1
                     /product="vesicle-trafficking protein SEC22b"
                     /protein_id="NP_001020857.1"
                     /db_xref="GeneID:310710"
                     /db_xref="RGD:1309988"
                     /translation="MVLLTMIARVADGLPLAASMQEDEQSGRDLQQYQSQAKQLFRKL
                     NEQSPTRCTLEAGAMTFHYIIEQGVCYLVLCEAAFPKKLAFAYLEDLHSEFDEQHGKK
                     VPTVSRPYSFIEFDTFIQKTKKLYIDSRARRNLGSINTELQDVQRIMVANIEEVLQRG
                     EALSALDSKANNLSSLSKKYRQDAKYLNMRSTYAKLAAVAVFFIMLIVYVRFWWL"
     exon            182..291
                     /gene="Sec22b"
                     /gene_synonym="Sec22l1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..452
                     /gene="Sec22b"
                     /gene_synonym="Sec22l1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..599
                     /gene="Sec22b"
                     /gene_synonym="Sec22l1"
                     /inference="alignment:Splign:2.1.0"
     exon            600..1411
                     /gene="Sec22b"
                     /gene_synonym="Sec22l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccagca gctagttgtt ggagacctca gctggaggtg taactggcca ccgcgggaga
       61 agaaggggca gtgactgagg cggccgggtc tccgtagcca gggaagatgg tgctgctgac
      121 gatgatcgcc cgcgtagcgg acgggcttcc tctggccgcc tcgatgcagg aggacgagca
      181 gtcaggccgg gaccttcagc agtatcagag tcaggctaag caactctttc gaaagttgaa
      241 tgaacagtcc cctaccagat gtaccttgga agcaggagcc atgacttttc actacattat
      301 tgagcagggg gtgtgttact tggttttgtg tgaagctgcc ttccctaaga agttggcctt
      361 tgcctaccta gaagacttgc actcggaatt tgacgagcag catgggaaga aggtgcccac
      421 tgtgtctagg ccctattcct tcatcgagtt tgacaccttc attcagaaga ccaagaaact
      481 ctacattgat agccgtgctc ggagaaatct cggctccatc aacaccgaat tgcaagatgt
      541 gcagaggatc atggtggcga atattgaaga agtcctacag cggggagaag cactctcagc
      601 attggattcg aaggctaaca atttgtccag tctatctaag aaataccgcc aggatgcgaa
      661 gtacctgaac atgcgttcca cctacgccaa gcttgcagca gtagccgtgt tcttcatcat
      721 gctgatagtg tatgtgcggt tttggtggct gtgagatagt gaagcctcgt cactagtaag
      781 ggagaaccta gaacccagca ggtgtatgtt ttcaggaaac tgagctcaca gggctgtgtg
      841 ttagaaccca agtggaactt ctgcctctaa agaccttgca agaaaagacc tgtcctgaaa
      901 tgaaagatgg cgcctcgttt aaggaagctt gacccatgtg gatgtctccg gggcagagac
      961 cttctctggg tgctaagcca tatgtattag ggaacagtag gttgtctgtt ttgtttcttc
     1021 cctccccagt acatttgtga gacagcagag atggggcggt ctctctgatg gagccatcag
     1081 tgagatttaa ggtagccaac ccattctagc agcatcctga aattctgtca gagtttccct
     1141 ttggggagtc ctaaccttaa tcgacattcc tttgttggtt acatgtgtga ttaactttca
     1201 agtaagactc aaagtatgtg aaggttaatt gcttcggtgc acaggtcctg tgtgttggcc
     1261 gctgtaggaa gttaactttt gttttttgtt tttttttctt ttatattttg cttattgcac
     1321 agttgctttg gaattaaatc aattatatta atatgccttg aaattatata gtattgcttg
     1381 actaaaagga tgaatttttt tctgtcattt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaaaaaa aaaaaaaaaa aaaaa
//
