LOCUS       NM_053571               4356 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus SEC16 homolog B, endoplasmic reticulum export
            factor (Sec16b), mRNA.
ACCESSION   NM_053571 XM_001073324
VERSION     NM_053571.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4356)
  AUTHORS   Yamaguchi,M., Ghanem,N.Z., Hashimoto,K., Ramos,J.W. and Murata,T.
  TITLE     The overexpressed transcription factor RGPR-p117 suppresses the
            proliferation of normal rat kidney proximal tubular epithelial
            NRK-52E cells: Involvement of diverse signaling pathways
  JOURNAL   Life Sci 306, 120795 (2022)
   PUBMED   35835253
  REMARK    GeneRIF: The overexpressed transcription factor RGPR-p117
            suppresses the proliferation of normal rat kidney proximal tubular
            epithelial NRK-52E cells: Involvement of diverse signaling
            pathways.
REFERENCE   2  (bases 1 to 4356)
  AUTHORS   Yonekawa,S., Furuno,A., Baba,T., Fujiki,Y., Ogasawara,Y.,
            Yamamoto,A., Tagaya,M. and Tani,K.
  TITLE     Sec16B is involved in the endoplasmic reticulum export of the
            peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in
            mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 108 (31), 12746-12751 (2011)
   PUBMED   21768384
REFERENCE   3  (bases 1 to 4356)
  AUTHORS   Witte,K., Schuh,A.L., Hegermann,J., Sarkeshik,A., Mayers,J.R.,
            Schwarze,K., Yates,J.R. 3rd, Eimer,S. and Audhya,A.
  TITLE     TFG-1 function in protein secretion and oncogenesis
  JOURNAL   Nat Cell Biol 13 (5), 550-558 (2011)
   PUBMED   21478858
REFERENCE   4  (bases 1 to 4356)
  AUTHORS   Budnik,A., Heesom,K.J. and Stephens,D.J.
  TITLE     Characterization of human Sec16B: indications of specialized,
            non-redundant functions
  JOURNAL   Sci Rep 1, 77 (2011)
   PUBMED   22355596
REFERENCE   5  (bases 1 to 4356)
  AUTHORS   Yamaguchi,M., Tomono,S. and Nakagawa,T.
  TITLE     Overexpression of RGPR-p117 suppresses apoptotic cell death and its
            related gene expression in cloned normal rat kidney proximal
            tubular epithelial NRK52E cells
  JOURNAL   Int J Mol Med 20 (4), 565-571 (2007)
   PUBMED   17786289
  REMARK    GeneRIF: This study demonstrates that overexpression of RGPR-p117
            has a suppressive effect on cell death and apoptosis.
REFERENCE   6  (bases 1 to 4356)
  AUTHORS   Sawada,N. and Yamaguchi,M.
  TITLE     Overexpression of RGPR-p117 enhances regucalcin gene promoter
            activity in cloned normal rat kidney proximal tubular epithelial
            cells: involvement of TTGGC motif
  JOURNAL   J Cell Biochem 99 (2), 589-597 (2006)
   PUBMED   16676356
  REMARK    GeneRIF: RGPR-p117 can enhance the regucalcin promoter activity
            which is related to the NF-1 consensus sequences including TTGGC
            motif, and its enhancing effect is partly mediated through
            phosphorylation and dephosphorylation
REFERENCE   7  (bases 1 to 4356)
  AUTHORS   Sawada,N. and Yamaguchi,M.
  TITLE     Overexpression of RGPR-p117 enhances regucalcin gene expression in
            cloned normal rat kidney proximal tubular epithelial cells
  JOURNAL   Int J Mol Med 16 (6), 1049-1055 (2005)
   PUBMED   16273285
  REMARK    GeneRIF: This study demonstrates that overexpression of RGPR-p117
            enhances the expression of regucalcin mRNA and its protein level in
            NRK52E cells. RGPR-p117 may play a role as a transcriptional
            factor.
REFERENCE   8  (bases 1 to 4356)
  AUTHORS   Sawada,N., Nakagawa,T., Murata,T. and Yamaguchi,M.
  TITLE     Nuclear localization of a novel protein, RGPR-p117, in cloned
            normal rat kidney proximal tubular epithelial cells
  JOURNAL   Int J Mol Med 16 (5), 809-814 (2005)
   PUBMED   16211248
  REMARK    GeneRIF: RGPR-p117 is localized in the nucleus of kidney cells, and
            may be involved in gene expression.
REFERENCE   9  (bases 1 to 4356)
  AUTHORS   Yamaguchi,M., Misawa,H. and Ma,Z.J.
  TITLE     Novel protein RGPR-p117: the gene expression in physiologic state
            and the binding activity to regucalcin gene promoter region in rat
            liver
  JOURNAL   J Cell Biochem 88 (6), 1092-1100 (2003)
   PUBMED   12647292
  REMARK    GeneRIF: determined expression of mRNA in liver with change in sex,
            age and fasting; did not directly bind to the regucalcin TTGGC
            motif
REFERENCE   10 (bases 1 to 4356)
  AUTHORS   Misawa,H. and Yamaguchi,M.
  TITLE     Molecular cloning and sequencing of the cDNA coding for a novel
            regucalcin gene promoter region-related protein in rat, mouse and
            human liver
  JOURNAL   Int J Mol Med 8 (5), 513-520 (2001)
   PUBMED   11605020
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053571.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB060653.1, SRR26643287.29094.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                JAXUCZ010000013.1  72217833-72217896
            65-407              JAXUCZ010000013.1  72220962-72221304
            408-520             JAXUCZ010000013.1  72223867-72223979
            521-641             JAXUCZ010000013.1  72224649-72224769
            642-741             JAXUCZ010000013.1  72225604-72225703
            742-886             JAXUCZ010000013.1  72226808-72226952
            887-1038            JAXUCZ010000013.1  72227556-72227707
            1039-1100           JAXUCZ010000013.1  72228062-72228123
            1101-1236           JAXUCZ010000013.1  72230012-72230147
            1237-1467           JAXUCZ010000013.1  72230605-72230835
            1468-1565           JAXUCZ010000013.1  72235566-72235663
            1566-1647           JAXUCZ010000013.1  72238339-72238420
            1648-1765           JAXUCZ010000013.1  72242971-72243088
            1766-1877           JAXUCZ010000013.1  72244643-72244754
            1878-1983           JAXUCZ010000013.1  72246431-72246536
            1984-2124           JAXUCZ010000013.1  72248381-72248521
            2125-2238           JAXUCZ010000013.1  72249685-72249798
            2239-2311           JAXUCZ010000013.1  72250991-72251063
            2312-2623           JAXUCZ010000013.1  72252216-72252527
            2624-2691           JAXUCZ010000013.1  72253009-72253076
            2692-2841           JAXUCZ010000013.1  72255694-72255843
            2842-2940           JAXUCZ010000013.1  72256009-72256107
            2941-3049           JAXUCZ010000013.1  72257485-72257593
            3050-3129           JAXUCZ010000013.1  72257715-72257794
            3130-3228           JAXUCZ010000013.1  72258734-72258832
            3229-4356           JAXUCZ010000013.1  72259606-72260733
FEATURES             Location/Qualifiers
     source          1..4356
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..4356
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /note="SEC16 homolog B, endoplasmic reticulum export
                     factor"
                     /db_xref="GeneID:89868"
                     /db_xref="RGD:621658"
     exon            1..64
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            65..407
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..3300
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /note="protein SEC16 homolog B; regucalcin gene promoter
                     region related protein; regucalcin gene promoter
                     region-related protein p117; regucalcin gene promotor
                     region related protein; leucine zipper transcription
                     regulator 2; RGPR-p117"
                     /codon_start=1
                     /product="protein transport protein Sec16B"
                     /protein_id="NP_446023.2"
                     /db_xref="GeneID:89868"
                     /db_xref="RGD:621658"
                     /translation="MELWVPQTQGRTTGPSRDANRRLQSGHYRPRPHPQYSGDNYHQW
                     QDTHKNSKPQQDPRDDHQQPHYVPRSGEWSQPVSGADYLKGSYPSHPYSRSGYEDPYQ
                     SYHTPTPRDEYAYGNYYYHGHPQLPQGERVARQGSPYIWHEDHRDQRHFSEHHWEKHN
                     STFEANSDTQFQFTSKNPYNDNPASAFGLEQPGEFFPESGAQKQKPSLTSKSNLLQQH
                     ESGLSSSSYELSQYMTEAPEQYEPMVSATWRPIQADDTSATVPKAPMRFYVPHVSVSF
                     GPGGQLICVSPNSPADGQTALVEVHSMEVILNDFEDQEEMRAFPGPLIREDIHKVDIM
                     TFCQKKAAQCLKSETPGSRDSALLWQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKYK
                     RQPPVANLINLTDEDWPVLSSGTRNLLTGEIPLNVDTPAQIVEKFTNLLYYGRKKEAL
                     EWAMKNHLWGHALFLASKMDPRTYNWVMSGFTTTLALNDPLQTLFQLMSGRIPQAATC
                     CGDKQWGDWRPHLAVILSNQAGDAELYQRAIVSMGDTLAGKGLVEASHFCYLMAHVPF
                     GHYTVKTDHLALVGSNHSQEFLKFATIEAIQRTEIFEYCQMLGRPKSFIPSFQVYKLL
                     YASRLADYGLASQALHYCEAIGAAVLSEGGSSHPVLLAELIKLAEKLKLSDPLVLESR
                     RGDRVLEPDWLVQLRRKHKELEQTRTGDLRDPDLTPSDIYGARGTTDTPYRDLYGQQN
                     YSEDSEYSSALWPTSEQTSLTNPTPQQPFPLQRDTYSERDGPVHMGTPVPLYSVPATH
                     LTVISGSSSGSGVAVTGAPGGRVGEEMLQKHPALGENTVPQEAVQDPDGLAVISSPQT
                     PLAPRDRSFSEDSAISAKEDEEGTSDGADKPPHPDASQKEKLRDGKNTKSSGFGWFSW
                     FRSKPASSVSTSGDEDSVDSSDSEESPRASPPHHASLGLSPTPPLSSPSLPGASTFPR
                     GTGGNSLQGSSNSSGMAEGVGIGGFSGPQGVSSEFYSQPGALPPPPTLQGAVPLYNPS
                     QVPQLPTASSLNRPNRLAQRRYPSQPC"
     exon            408..520
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            521..641
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            642..741
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            742..886
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1038
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1100
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1236
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1467
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1565
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1647
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1765
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1877
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..1983
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2124
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2238
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2311
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2623
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2691
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2841
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..2940
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3049
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3129
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3228
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            3229..4356
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaagcagt cctcagcagg tccctagagc aacgctgaag gaaggtggag agtcagcaaa
       61 gcaggaaatt aaataattac ataacaacct caagacccaa agggggaaaa aatcaaaggg
      121 tcagagatgg aactttgggt tcctcagaca caaggaagga ccacgggacc atcaagggat
      181 gcaaatagaa gacttcagag tggacattat agaccccgtc ctcaccctca gtacagcgga
      241 gataactacc accaatggca ggatacccac aagaactcaa agccacagca ggaccccagg
      301 gatgaccacc aacagccaca ctatgtaccc aggagtgggg agtggtccca gcctgtgtct
      361 ggagctgact acttgaaagg atcttatccc agtcacccat actcaaggtc aggctacgag
      421 gacccctatc agagctacca cactccgaca ccgagggatg agtacgctta tggaaattac
      481 tactaccacg ggcatccaca gctgccgcaa ggagaaagag tggcaaggca agggagtcct
      541 tatatctggc atgaagatca cagagaccaa aggcacttca gtgagcatca ttgggaaaag
      601 cacaacagta catttgaagc aaacagtgac acccaattcc aatttaccag taagaatcca
      661 tacaatgaca accctgcttc cgcgtttgga ctggagcagc ctggggagtt ctttccagag
      721 agtggagccc agaaacaaaa gccatcgttg accagcaaat ccaaccttct ccaacagcac
      781 gagtctgggc tcagctctag tagctatgag ctcagtcagt acatgaccga ggcccctgag
      841 cagtatgaac ctatggtgtc agcaacttgg aggcctattc aagctgatga cacctcagcg
      901 accgttccca aggcacccat gaggttctac gttccccacg tgtctgtgag ctttgggcca
      961 ggaggccagc tgatatgtgt gtcccccaac tctcctgctg atggacaaac ggcccttgtt
     1021 gaagtgcaca gcatggaggt tatacttaat gattttgagg atcaagagga gatgagagct
     1081 ttcccagggc ccctcatcag ggaggacata cacaaggtgg atatcatgac attttgtcag
     1141 aagaaagcag ctcagtgtct caaatctgag acgccaggga gcagggactc agctctgctt
     1201 tggcaactgc tggttctcct ttgtcgacag aatgggtcca tggtggggtc tgacattgcc
     1261 gagctgctga tgcaagactg caagaagctg gagaagtaca agaggcagcc ccctgtagcc
     1321 aacctcatca acctgactga cgaggactgg ccggtgctga gttctgggac tcgcaacctg
     1381 ctcactgggg agattcccct caacgtggat acgcctgcgc agatcgtgga gaaattcacc
     1441 aatctgctct actatggaag gaagaaggag gccttggaat gggctatgaa gaaccacttg
     1501 tggggccatg ccttgttcct agccagtaag atggatccaa ggacctacaa ctgggtcatg
     1561 agtggcttca ccactacgct ggcgctcaat gaccctctgc agaccctctt ccagctcatg
     1621 tcaggaagga ttccacaagc agccacgtgt tgtggagaca aacagtgggg agactggcgg
     1681 ccccatttgg ctgtgatcct gtcaaatcag gccggagacg cagagttgta ccagcgagcg
     1741 attgtcagca tgggggacac cctggctgga aaagggcttg tggaggcatc tcacttctgc
     1801 tacctcatgg ctcacgtgcc cttcggccac tatacggtga agacagacca tctggccttg
     1861 gtgggcagta accacagtca agagtttttg aaatttgcaa caattgaggc tatccagcgg
     1921 acggaaatct tcgagtactg ccagatgctg ggccgcccca aatccttcat cccgtccttc
     1981 caggtgtata agctccttta tgcttcccgt ctggcagatt acggcctggc atcccaagcc
     2041 ttgcattact gtgaagccat tggtgcagct gtcctgagcg agggagggag cagtcacccc
     2101 gtgctattag cggagctcat caagcttgca gagaaactga agctgtcgga tcctctggtt
     2161 ttagaaagcc gccgtgggga cagggtcctg gaaccggatt ggcttgtgca actgcggagg
     2221 aagcacaagg aactggagca aactagaact ggagacctca gagatcctga tctgactcct
     2281 tcagatattt atggagccag aggaacaaca gacactccct accgcgatct ttatggccag
     2341 caaaactact cagaagactc tgagtacagc tcagccttgt ggccaacatc tgagcagaca
     2401 agcctgacca atcccacccc acagcagcct ttccccctgc agcgagatac ctactcagag
     2461 agagatggcc cagtacacat ggggacccca gtgcctcttt actcagttcc tgcaacccac
     2521 ctgacagtga ttagtggctc cagtagtggc agcggtgtgg cagtgacagg ggctcctgga
     2581 ggaagggttg gagaggagat gctgcagaaa catcctgccc ttggagagaa cacagtgcct
     2641 caagaagccg tgcaggatcc tgatggtcta gcagtcattt ccagtcctca gacaccactg
     2701 gctcccaggg atcgaagttt ttctgaggat tctgccattt cagccaagga ggatgaggag
     2761 ggcacttctg atggagcaga caaaccacct caccctgacg cttcacagaa agaaaagctg
     2821 agagatggga agaatacaaa gagctctgga ttcggctggt tcagctggtt tcgatcaaag
     2881 cctgccagca gtgtgtccac ctctggagat gaagactctg tggacagttc tgactcagag
     2941 gagtctccca gagcatcacc tcctcaccat gccagcctgg gcctctcacc aacacctcct
     3001 ctctcatccc catctctgcc aggtgccagc accttcccga gaggcacagg tgggaatagt
     3061 ctccagggat cctcaaacag cagtggaatg gctgaaggcg tggggattgg agggttctcg
     3121 gggccacagg gcgtttcttc tgagttctac tcccagcctg gtgccctgcc tcctccacct
     3181 accttgcaag gtgctgttcc tctctacaat ccatctcagg tccctcagct tcccactgct
     3241 agtagcctga accggccaaa ccgcctagcc cagcgccgct acccaagcca accatgctga
     3301 gagcgaccgt ctgtcccagg gccatgagga tgaccaccta cccatcctgg gctcctcttc
     3361 tggagcacag ctttcctgtt gctttctact tctcagtgtc acctcacctc gtcacgctca
     3421 ggcccgtgtc gtgagcctgc tgcacgggca tacctggagt ttgaggacag gatatcctag
     3481 acaacaactt ggtccagtct tcagcttagt ttgagagtga tggaaattgt ctcattagac
     3541 ggaggaacgg gggccaatgt ctatggtaga gtgtcatggc agcagacttg aggtagaagc
     3601 ttgagcacct cgggaaagcg agggccccga gaatcccggg tgaaaaccgg agatgacact
     3661 acccggctgt acagtaggag ctcagagcaa tgtcccagaa taactcagac tccctccata
     3721 gatccgctta aagaccagtt tatggctctt gttagtgaag tttttacatt gaatttgatt
     3781 atcgctgccc ttcagtgatt cccttttcaa tgacatttca gcaattttcc tcctggtcct
     3841 agttttgcgc acattttctg tgtggttcag actaattata tttctctcac tttcttagcc
     3901 ggtcctattt tttttcacat tctgacatct ggctatcaag ttagattgct gtaggcattg
     3961 tattgtcatg gtaactactg aacctaatga tgcagatgga ggaacatcag tataataaat
     4021 agtggaaaac gtttcctaag acgtcatcct ttccataaga ggggagggat gggcgcttca
     4081 tattgctaat acctgccttc ctacctcagg cctttgcaaa tcgatgttct gtgagggtca
     4141 ccggggcccc atggaggaga aagctgtctt ggaaatttcc attttttcct ttcaaacctc
     4201 aaatagaaat gcttcttgct gtttgtcaga tttgcttaaa attgctcgtc acaaagaaca
     4261 ttttttgtat gtgtaattgt acataaaagt tttgtacttt aatgtactat ggttctgatg
     4321 ttgatagcga ttaaatccag ataattttat agcaaa
//
