LOCUS       NM_001276417            8889 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus SEC16 homolog A, endoplasmic reticulum export
            factor (Sec16a), mRNA.
ACCESSION   NM_001276417 XM_002729146 XM_003753686
VERSION     NM_001276417.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8889)
  AUTHORS   Wu,Y., Guo,X.P., Kanemoto,S., Maeoka,Y., Saito,A., Asada,R.,
            Matsuhisa,K., Ohtake,Y., Imaizumi,K. and Kaneko,M.
  TITLE     Sec16A, a key protein in COPII vesicle formation, regulates the
            stability and localization of the novel ubiquitin ligase RNF183
  JOURNAL   PLoS One 13 (1), e0190407 (2018)
   PUBMED   29300766
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8889)
  AUTHORS   Maeda,M., Katada,T. and Saito,K.
  TITLE     TANGO1 recruits Sec16 to coordinately organize ER exit sites for
            efficient secretion
  JOURNAL   J Cell Biol 216 (6), 1731-1743 (2017)
   PUBMED   28442536
REFERENCE   3  (bases 1 to 8889)
  AUTHORS   Piao,H., Kim,J., Noh,S.H., Kweon,H.S., Kim,J.Y. and Lee,M.G.
  TITLE     Sec16A is critical for both conventional and unconventional
            secretion of CFTR
  JOURNAL   Sci Rep 7, 39887 (2017)
   PUBMED   28067262
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8889)
  AUTHORS   Bruno,J., Brumfield,A., Chaudhary,N., Iaea,D. and McGraw,T.E.
  TITLE     SEC16A is a RAB10 effector required for insulin-stimulated GLUT4
            trafficking in adipocytes
  JOURNAL   J Cell Biol 214 (1), 61-76 (2016)
   PUBMED   27354378
REFERENCE   5  (bases 1 to 8889)
  AUTHORS   Cho,H.J., Yu,J., Xie,C., Rudrabhatla,P., Chen,X., Wu,J.,
            Parisiadou,L., Liu,G., Sun,L., Ma,B., Ding,J., Liu,Z. and Cai,H.
  TITLE     Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to
            allow ER-Golgi export
  JOURNAL   EMBO J 33 (20), 2314-2331 (2014)
   PUBMED   25201882
REFERENCE   6  (bases 1 to 8889)
  AUTHORS   Yonekawa,S., Furuno,A., Baba,T., Fujiki,Y., Ogasawara,Y.,
            Yamamoto,A., Tagaya,M. and Tani,K.
  TITLE     Sec16B is involved in the endoplasmic reticulum export of the
            peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in
            mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 108 (31), 12746-12751 (2011)
   PUBMED   21768384
REFERENCE   7  (bases 1 to 8889)
  AUTHORS   Budnik,A., Heesom,K.J. and Stephens,D.J.
  TITLE     Characterization of human Sec16B: indications of specialized,
            non-redundant functions
  JOURNAL   Sci Rep 1, 77 (2011)
   PUBMED   22355596
REFERENCE   8  (bases 1 to 8889)
  AUTHORS   Hughes,H., Budnik,A., Schmidt,K., Palmer,K.J., Mantell,J.,
            Noakes,C., Johnson,A., Carter,D.A., Verkade,P., Watson,P. and
            Stephens,D.J.
  TITLE     Organisation of human ER-exit sites: requirements for the
            localisation of Sec16 to transitional ER
  JOURNAL   J Cell Sci 122 (Pt 16), 2924-2934 (2009)
   PUBMED   19638414
REFERENCE   9  (bases 1 to 8889)
  AUTHORS   Iinuma,T., Shiga,A., Nakamoto,K., O'Brien,M.B., Aridor,M.,
            Arimitsu,N., Tagaya,M. and Tani,K.
  TITLE     Mammalian Sec16/p250 plays a role in membrane traffic from the
            endoplasmic reticulum
  JOURNAL   J Biol Chem 282 (24), 17632-17639 (2007)
   PUBMED   17428803
REFERENCE   10 (bases 1 to 8889)
  AUTHORS   Cros,N., Tkatchenko,A.V., Pisani,D.F., Leclerc,L., Leger,J.J.,
            Marini,J.F. and Dechesne,C.A.
  TITLE     Analysis of altered gene expression in rat soleus muscle atrophied
            by disuse
  JOURNAL   J Cell Biochem 83 (3), 508-519 (2001)
   PUBMED   11596118
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Feb 10, 2013 this sequence version replaced
            XM_002729146.2, XM_003753686.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.11972.1,
                                           SRR26643292.11644.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               JAXUCZ010000003.1  29661997-29662319   c
            324-3970            JAXUCZ010000003.1  29655264-29658910   c
            3971-4107           JAXUCZ010000003.1  29652930-29653066   c
            4108-4205           JAXUCZ010000003.1  29650428-29650525   c
            4206-4329           JAXUCZ010000003.1  29649033-29649156   c
            4330-4528           JAXUCZ010000003.1  29648307-29648505   c
            4529-4703           JAXUCZ010000003.1  29647992-29648166   c
            4704-4846           JAXUCZ010000003.1  29647286-29647428   c
            4847-4908           JAXUCZ010000003.1  29646976-29647037   c
            4909-5047           JAXUCZ010000003.1  29646730-29646868   c
            5048-5293           JAXUCZ010000003.1  29646025-29646270   c
            5294-5391           JAXUCZ010000003.1  29644693-29644790   c
            5392-5473           JAXUCZ010000003.1  29644339-29644420   c
            5474-5591           JAXUCZ010000003.1  29644040-29644157   c
            5592-5703           JAXUCZ010000003.1  29643751-29643862   c
            5704-5809           JAXUCZ010000003.1  29643448-29643553   c
            5810-5950           JAXUCZ010000003.1  29642700-29642840   c
            5951-6064           JAXUCZ010000003.1  29642155-29642268   c
            6065-6248           JAXUCZ010000003.1  29641728-29641911   c
            6249-6494           JAXUCZ010000003.1  29640277-29640522   c
            6495-6577           JAXUCZ010000003.1  29639652-29639734   c
            6578-6727           JAXUCZ010000003.1  29638057-29638206   c
            6728-6805           JAXUCZ010000003.1  29635145-29635222   c
            6806-6862           JAXUCZ010000003.1  29634888-29634944   c
            6863-6974           JAXUCZ010000003.1  29634636-29634747   c
            6975-7112           JAXUCZ010000003.1  29634165-29634302   c
            7113-7207           JAXUCZ010000003.1  29633830-29633924   c
            7208-7285           JAXUCZ010000003.1  29633101-29633178   c
            7286-7363           JAXUCZ010000003.1  29631446-29631523   c
            7364-8889           JAXUCZ010000003.1  29627779-29629304   c
FEATURES             Location/Qualifiers
     source          1..8889
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..8889
                     /gene="Sec16a"
                     /note="SEC16 homolog A, endoplasmic reticulum export
                     factor"
                     /db_xref="GeneID:100360302"
                     /db_xref="RGD:2322350"
     exon            1..323
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            324..3970
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..7432
                     /gene="Sec16a"
                     /EC_number="3.1.3.36"
                     /note="SEC16 homolog A-like"
                     /codon_start=1
                     /product="protein transport protein Sec16A"
                     /protein_id="NP_001263346.1"
                     /db_xref="GeneID:100360302"
                     /db_xref="RGD:2322350"
                     /translation="MQPPPQAVPSGVAGPPPAGNPRSSFWANSPYRKPANNNAPVAPI
                     TRPLQPVTDPFAFNRQTLQNTPVGSSSKSSPPNLPGPALPVFSQWPGLPVPPTNAGDS
                     STGLHEPLPGTLSQPRADPSLFPPASTPSSLPGLEVNRSAEVDSSSGPEVQMLPHPPH
                     YIPGVGPEQPHGGHLNDSGAGPDQSMNRHAPHDGAVAHAASPFFPQPQMPGQWGPVHG
                     GPPPSYHHHSPCLEGPVQDMGPQAASLPHFPSPSSLHEGPGHESRVPQTFTPASLASG
                     EGNEIVHQQSKNYPSSSFPPKHSFEQNSRVGNMWASAEFRQNPGVNKEHLLDPAHVNP
                     FTQGNSPENQVHHPPVAATNHALQEAASGALSMFFQGEETENEENLSSEKAGLDDRLD
                     SGSFSSTSRLGHPPLPGAGGVYQAAQEGDVQPYFSQFVGIRHDKQTTMTPANDAWGDI
                     PGAGTHCASGPQCENVENLEFVQNQEVLPRETVNVDPFSPSDQFRYGPLPGPAASRPV
                     TSGLTRGGGLNLEAPDMPLHPTRPDSVSSSYSNHSHRSPPGSARPQELVGTFIQQEVG
                     KLEDDTSGSFFKQIDSSPVGGETDEMTRSQNYCSSLSQPSTPSPPKPTGVFQTSANSS
                     FEPVKSHLVGVKPVEADRANMVVEVRGTQNCQKHGAAVLPPDATPGNLEQPPDNMETL
                     CAPQACPLPLSTTGEAGQLVSHTAGPPLDTVRPMPDKRSSARAQGPVKCESPATTLWA
                     QNELPDFGGNVLLAPAAPALYVPVKPKPSEVVHHPEKGMSGQQSWKSGSVPPLQNQDP
                     PGASENLENPPKVGEEEALPLQASSGYASLLSSPPTESLHNQPVLIAQPDQSYNLAQP
                     INFSVSLPNPNEKNQCWGDAVVGEKSMVSTRALGADHEEHAALSAIPASTVTGSSLPN
                     SVTQNCAPRGSGSSEMIASQPASWLVQQLSPQIPQSQHPNAEKGPSEFVNSPANGSVM
                     LAPPANSAVIPNSNKGYHSRNPEEAIGALDFTLSRTLENPVRMCSPSHSNSPASQQPL
                     ANHPRQSGPGLHNQDHFYQQVTKDAQDHRSLERGQSELVPPPPQNSPQQVPQAACPEP
                     SNPESPPTQGQSEGLVQPSASPAPVNTGQQPQPPQSSSASVTSTNSNQAAVRSEQPWL
                     HPPPTTFGPAPQDLASYYYYRPPYEAYQSPYPSPYPSDPGAASLYYQDIYGLYEPRYR
                     PYDSSASAYAENHRYSEPERPSSRASHYSDQLTPRQGYPEGYYNSKSGWSSHSDYYAN
                     YYSGQYDYGDPGRWDRYYGSRFRDPRTWDRRYWYDSDHDPYRKDNYAYSDRPEKCDDH
                     WRYDPRFTGSFDDDTELHRDPYGEEVDRRSIHSEHSARSLRSTHSLPSRRSSLSSHSH
                     QSQIYRSHHVTGGSFEAPHAPGSFHGDYAYGTYASNFSGAHGFPEYSYPADTSWPAAE
                     QVPSRPTSPEKFTVPHVCARFGPGGQLLKVIPNLPSEGQPALVEIHSLETLLQHTPEQ
                     EEMRSFPGPLGKDDTHKVDVINFAQNKATKCLQNESLIDKESASLLWNFIILLCRQNG
                     TVVGTDIAELLLRDHRTVWLPGKSPNEANLIDFTNEAVEQVEEEESGEAQLSFLTDSQ
                     TVTSSVLEKETERFRELLLYGRKKDALESAMKNGLWGHALLLASKMDSRTHARVMTRF
                     ANSLPINDPLQTVYQLMSGRMPAASTCCGDEKWGDWRPHLAMVLSNLNNNMDVESRTM
                     ATMGDTLASKGLLDAAHFCYLMAQVGFGVYTKKTTKLVLIGSNHSLPFLKFATNEAIQ
                     RTEAYEYAQSLGAHTCSLPNFQVFKFIYLCRLAEMGLATQAFHYCEVIAKSVLTQPTA
                     YSPVLISQLIQMASQLRLFDPQLKEKPEEESFVEPAWLVQLQHVERQIQEGTVLWNQD
                     GTEPQQCHITSGSEVEQPDGPGLNQQAGPRADNPLLMPSTEPLVHSVQLLPTAPQTLP
                     DGQPAHLARVPMFPVPMSRPPLELSAAYGPPGSVLGFPESSRSDPAVLHPGQALPPAT
                     PGLQESGPPLQEARSPDPEMVPQGSPVRHSPPEPREEEFGKNVADLGSSRTAQDSETS
                     PVWDLGSSSLTRAPSLTPDSEGKKPAQAVKKEPKEPKKTESWFSRWLPGKKRTEAYLP
                     DDKNKSIVWDEKKNQWVNLNEPEEEKKAPPPPPTSFPRVPQAAPTGPAGPPMASVNVF
                     SRKAGGSRARYVDVLNPSGTQRSEPALAPADFFAPLAPLPIPSNLFVPNPDAEESQPA
                     DGTGCRGQAPAGTQSKAEPTLEAKVVSSTVSAPGPELSPSKPADGSQGGEAPGDHCPA
                     GATPGGSVPFYNPAQLVQASVTSGTSRPGRIGQRKYAALN"
     exon            3971..4107
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            4108..4205
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            4206..4329
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            4330..4528
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            4529..4703
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            4704..4846
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            4847..4908
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            4909..5047
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            5048..5293
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            5294..5391
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            5392..5473
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            5474..5591
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            5592..5703
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            5704..5809
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            5810..5950
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            5951..6064
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            6065..6248
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            6249..6494
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            6495..6577
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            6578..6727
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            6728..6805
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            6806..6862
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            6863..6974
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            6975..7112
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            7113..7207
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            7208..7285
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            7286..7363
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
     exon            7364..8889
                     /gene="Sec16a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggagccgg atgtggcaag atggctgcgg ctgctgctgg atacgcgcta gttcccacta
       61 ctgccgccgc cgtcgccggc taggtttcag ttcgcggctc ctgagaagcc aaccgcagct
      121 gagcgggtga gggctgagta tatggagcac ggtggaagcc cgagtgcggg cgaggctgcg
      181 gaggtcaggc aggctcagtg agcatcgggc ctagcccgaa gtggcgagcg catttaaaga
      241 gacaccgtca ggccagggga gaacgacagt accgggccgc ctggtgctga gacaccggac
      301 aggttacagc ccgtgtcgcc ttgcacaaat tacagaaaag acctaccctg cctcctttat
      361 aagcagcatc tcctgcagga aagactccac catgcagcca ccacctcagg cagtcccgtc
      421 tggtgtggct ggcccacccc cagctgggaa tcctcgaagc tcgttctggg ccaacagccc
      481 ttacaggaag ccagccaata ataatgcacc agtggctccc ataacacgcc cactgcagcc
      541 agtaacggat ccgtttgctt ttaacagaca gactcttcaa aacacaccag tgggcagttc
      601 atccaaaagc agcccaccta atttgcctgg cccagccctc cctgtttttt ctcagtggcc
      661 tggtttgcct gtgcctccca caaatgctgg ggatagctcc acaggacttc atgagcctct
      721 gccaggaact ctgtcacagc ctagagcaga ccccagtcta tttcctcctg catctacccc
      781 ttcttcattg cctgggctgg aggtgaacag gagtgctgag gttgattcca gctcaggacc
      841 tgaagtccag atgctgccac atccacctca ctacattcca ggagtgggtc ctgagcagcc
      901 tcacggaggc catctgaatg acagtggggc tgggcctgac caatccatga ataggcacgc
      961 cccacatgat ggtgctgtgg cccatgcagc atctcctttc ttccctcagc cccagatgcc
     1021 aggtcagtgg gggcctgtgc atggaggccc tccgccctcc tatcatcatc actcaccctg
     1081 cctggagggc cctgttcagg acatggggcc ccaggctgcc agcttgcccc atttcccctc
     1141 tccatctagt ctacacgagg gacctggcca tgagtcccgt gtcccacaaa cgtttactcc
     1201 agcatccttg gccagtggtg aaggaaatga gatagtccac cagcaaagta aaaattaccc
     1261 atcgagtagc ttccccccta aacacagttt tgagcagaat tccagagttg ggaatatgtg
     1321 ggcaagcgcg gagttcaggc agaatccagg agttaataaa gagcatctgc tagaccctgc
     1381 ccatgtgaat cccttcactc agggaaacag ccctgagaac caggtgcacc atcccccagt
     1441 ggccgcaact aaccatgccc tgcaagaagc agcctccgga gcgctctcaa tgttttttca
     1501 aggggaggag acagagaacg aggaaaatct ctcatctgaa aaagcaggcc ttgatgacag
     1561 attagactcg ggtagcttct cttctacctc cagactgggc catccaccac tccctggagc
     1621 tggtggtgtc taccaggccg ctcaggaagg agatgtgcaa ccttattttt ctcagtttgt
     1681 gggcatccgt catgacaaac agaccactat gactcctgct aatgatgcgt ggggtgatat
     1741 tccgggtgct gggacccact gtgctagtgg gccacagtgt gagaatgtag agaacctaga
     1801 atttgttcag aatcaagaag ttttgccacg tgagaccgtg aatgtggatc ccttttcccc
     1861 gagtgatcag tttcgatatg ggccccttcc tgggccagct gcctccaggc ctgttacttc
     1921 gggcctcact agaggaggag ggctaaatct tgaggcccct gacatgccac tgcaccctac
     1981 acgacctgac agtgtgtcat ccagctacag caaccatagt cacagaagtc ctcctgggtc
     2041 agccagaccc caagaattgg tgggcacatt cattcagcaa gaagttggaa aactcgaaga
     2101 tgatacgtca gggagttttt ttaagcaaat tgattcttct ccggttggag gtgaaacaga
     2161 tgagatgacc aggagtcaaa attactgcag cagcctgtcc cagccttcaa ctccaagccc
     2221 tccaaaacct acgggagtct tccagacaag tgcaaatagt tcttttgagc cagtaaaatc
     2281 ccacttggtt ggagtgaaac cagttgaagc agatcgtgcc aacatggtgg ttgaagtgag
     2341 agggacccag aactgccaga agcacggggc cgctgttcta ccacctgatg ccaccccagg
     2401 aaacctggaa cagccaccag acaacatgga gaccctgtgt gcacctcagg cctgcccttt
     2461 gcctcttagc accactggag aggctgggca actggtttca cacacagcag ggccaccctt
     2521 ggatactgtg cgccccatgc ctgacaagag gtcctcagcc agggcccagg ggcctgtgaa
     2581 atgtgagagc ccagccacaa ctctgtgggc acaaaacgaa ctgccagatt ttgggggcaa
     2641 tgtccttcta gcccctgctg cccctgcact ttatgttcct gtaaaaccaa aaccttcaga
     2701 ggttgttcat catccagaaa agggcatgtc tggacagcag tcatggaaat cagggtctgt
     2761 gccccctttg cagaaccaag accctcctgg tgcttctgag aaccttgaga accctcccaa
     2821 ggtaggagaa gaggaggccc ttccattgca ggcaagttct ggttatgcga gtttgctgtc
     2881 ctcaccaccc actgaatctt tacacaatca acctgtcctg attgcccagc ctgatcaaag
     2941 ctataatttg gctcagccca ttaatttttc tgtgtcctta ccgaatccta atgagaagaa
     3001 tcagtgctgg ggagatgctg tggtggggga gaaatccatg gtgagcaccc gggctcttgg
     3061 tgctgaccat gaagaacatg ctgccttgtc tgcaattcca gccagtactg tcactggctc
     3121 gtctttgcct aacagtgtca cccagaactg tgcccctcga ggttctgggt cttctgaaat
     3181 gattgctagc cagcctgcca gttggttggt tcaacagctg tcccctcaga ttcctcaaag
     3241 tcagcacccc aatgcagaga agggtccttc tgagtttgtt aatagccctg ctaatggaag
     3301 tgtgatgcta gctccacctg caaacagtgc tgtgatacct aacagtaata aggggtatca
     3361 ctctagaaac ccggaagaag ccatcggtgc cctagacttc acattgagta gaactttgga
     3421 aaatcctgtg agaatgtgta gcccatctca ttcaaacagc ccagcttctc agcagcctct
     3481 tgccaatcat cccagacaat ctgggcctgg gctgcataac caggatcatt tctaccagca
     3541 ggtaacaaaa gatgctcagg atcaccgtag cctagaaaga ggccagtcag agctggtgcc
     3601 tcctccgcca cagaattctc cccaacaagt accccaagct gcgtgtccag agccttcaaa
     3661 tccagaaagc ccacccacac aaggacagtc tgaaggcttg gtccagccat cagcaagtcc
     3721 agctccagtc aacacaggcc agcagcctca gccaccgcag tcctccagtg catcggttac
     3781 atctaccaac tccaaccagg cagctgtgcg gtcagaacag ccatggctac acccacctcc
     3841 cactactttt ggcccagcac ctcaagactt ggcatcctac tactattata gacccccgta
     3901 tgaagcctac cagtctccgt acccttcacc gtacccatca gatcctggag cagcctcttt
     3961 atactaccaa gatatctatg gcctgtatga gcctcgttac agaccctatg acagctcggc
     4021 atctgcttat gccgagaacc accgctactc tgaacctgag cggcccagct cccgtgcaag
     4081 tcactattct gaccagctca ctcccaggca aggatatcct gaaggatact acaattctaa
     4141 gagtggatgg agcagtcaca gtgactacta cgcaaattac tactctggcc agtatgatta
     4201 tggagaccca ggccgctggg accgttacta tgggtctcga tttagggacc ctcgcacctg
     4261 ggaccggagg tactggtatg actctgacca tgacccatac aggaaggaca actatgctta
     4321 cagtgacagg cctgagaaat gtgatgatca ctggaggtat gaccctcgct tcactgggag
     4381 cttcgatgat gacactgagc tccacaggga cccctatgga gaagaagtag acagacgcag
     4441 catccacagc gagcactcag cccggagcct gcgcagtact cacagcctgc ccagccgccg
     4501 cagcagcctc agctcccatt cacaccagag tcagatttac agaagccacc atgtgactgg
     4561 cggttccttt gaggcccccc atgccccagg ctcatttcat ggtgattatg cctatggtac
     4621 ctatgccagc aatttcagcg gtgcccatgg ttttccagag tacagctacc ctgcagacac
     4681 ctcctggcct gctgcggagc aagttccatc aagaccgacc tctcctgaga agtttacagt
     4741 gcctcacgtc tgtgccaggt ttggtcctgg tggtcagctc ctcaaagtga tacccaacct
     4801 gccttcagaa ggacagcccg cattggtgga gatccacagc ttagagacct tgctgcagca
     4861 cacacctgag caggaagaaa tgcgctcctt cccaggacct ctcggcaaag atgacactca
     4921 caaagtagat gttattaact ttgcacaaaa caaagcgaca aaatgtttgc agaatgaaag
     4981 tttaattgac aaagagtctg caagtcttct ttggaacttc attattctgt tatgcagaca
     5041 gaatgggacc gtcgtgggaa cagacatcgc agagctcttg ttacgggacc atagaactgt
     5101 gtggcttcct gggaagtcac ccaacgaggc aaacctgata gattttacca atgaggctgt
     5161 ggagcaagtg gaagaggagg agtcagggga ggcccagctc tcatttctca cagacagtca
     5221 gacagtgacc agcagtgtgc tggagaagga gactgagcgg ttccgtgaac tcttgctgta
     5281 cggtcggaag aaggatgctc tggagtctgc catgaaaaat ggcttatggg gtcacgccct
     5341 gctgcttgca agtaagatgg acagccggac acatgcccgt gtcatgacca ggtttgccaa
     5401 cagtcttccg atcaatgacc ccctgcagac tgtctaccag ctcatgtctg gacggatgcc
     5461 tgctgcatcc acgtgttgtg gagatgagaa atggggagat tggaggccac atcttgcaat
     5521 ggttttgtcc aacctgaaca acaacatgga tgtggaatct cggaccatgg ctaccatggg
     5581 tgatacccta gcatcaaaag gcctgctgga tgccgcacat ttttgctacc tcatggccca
     5641 ggttggattt ggggtttata caaagaaaac taccaaactt gttttgatag gctcaaatca
     5701 cagtttgcca tttttaaagt ttgccactaa tgaagccatt caaaggacgg aggcttatga
     5761 gtacgctcag tcccttgggg cgcatacctg ttccttacct aacttccagg tgtttaaatt
     5821 catctacttg tgccgcctgg ctgaaatggg actcgctaca caggccttcc actactgtga
     5881 agtaatagcc aagagtgtcc tgacacagcc tactgcatac tccccagtgc tgattagcca
     5941 gttgattcag atggcttccc agttacgcct cttcgatcct caactgaagg agaagccaga
     6001 ggaggagtcc tttgtggagc ctgcctggtt ggtgcagctg cagcacgtgg agaggcagat
     6061 ccaggagggc actgtgctgt ggaaccagga tggaactgaa ccccagcagt gtcacatcac
     6121 atcgggctct gaggtggagc agccagatgg ccctggactc aaccagcagg cagggccaag
     6181 ggccgacaac cctctcctga tgccaagcac tgagcctttg gtgcacagcg tgcagctgct
     6241 gcccacagct cctcagacat tgcctgatgg ccagcctgct caccttgcca gggtgcccat
     6301 gttcccagta ccaatgtctc gtccccccct ggagctgagt gctgcctatg gacccccggg
     6361 gtctgtactt ggcttcccag aatcctccag atctgatcct gcagtgctgc atcctgggca
     6421 ggccctacca cccgctacac caggtctcca ggaaagtggg ccaccactcc aggaggccag
     6481 aagcccagat ccagaaatgg tgccacaggg ctcacctgtc agacactccc ctcctgagcc
     6541 ccgtgaagag gagtttggca agaacgtcgc tgacctgggc tcctctagaa cagcacagga
     6601 ctcggaaacc tccccagtgt gggatcttgg cagctccagt ctgacacgtg ccccatcttt
     6661 gacacctgat tctgaaggga agaaacctgc acaagctgtc aaaaaggagc ccaaggagcc
     6721 caagaagacc gagtcctggt tctctcgctg gctgcctggg aagaaaagga cagaagctta
     6781 tctaccagat gacaagaaca aatcaattgt ttgggatgaa aagaaaaacc agtgggtgaa
     6841 tctgaatgaa ccggaggagg agaagaaggc tccaccccca cctccaacat cgttccccag
     6901 ggttccccag gcggctccca ctgggcctgc aggaccaccc atggcctccg tgaatgtgtt
     6961 ttctagaaaa gcaggtgggt ccagagctcg ctatgtggat gttctcaacc caagtggaac
     7021 acagcggagt gaaccagctc ttgctcctgc ggatttcttt gctcctcttg ccccgctgcc
     7081 aatcccttct aacttatttg taccaaaccc agatgcagaa gagtcacaac ctgcagatgg
     7141 gactggctgt aggggacagg caccagctgg gactcaatct aaggcagagc ccaccctgga
     7201 agccaaggtg gtaagctcta cagtatcagc ccctgggcct gaactctcac cctccaaacc
     7261 agcagatggc tcccagggag gagaggctcc tggagaccac tgtcctgcag gggccactcc
     7321 tggtgggtct gtgccctttt acaaccctgc gcagttggtg caggcgtctg tcacctcggg
     7381 gacttcaagg ccaggaagga ttggccaaag aaaatatgcg gcactgaact aggattgctg
     7441 ctggattctt acttggcacc ctgagaggat tcgataactg ttcttcaaca agaaccaaac
     7501 tagctgcctc aggtcctgcg gatcccagat gggcgtggca gcactcagag ccggtcatac
     7561 tgtgtgtctc cctccttgca gcctatgtat atgaattatt gaaaaatcaa tttcaaggtt
     7621 tctttcagat gctggataga atgaatctaa ttcaaagtct tttatgtaaa agaacggtgt
     7681 ttctttttta gttactttag acaaattaag gtttgagtca cttgagaaaa cccctgaaga
     7741 gaggctagac agggcttcac tacaggagag cacagttcct tggaaaccag ggcctctctc
     7801 acctgagaaa tggtgcagac caaccagggc cccttaggtt gctgagagaa gagtgactac
     7861 ttgcctggag aggactgact actgagctgc ctggcctaag aggagcccca agctgcagtg
     7921 ggcaactatg ccctgtcctg tgaaccaggg aatacatgcc agctcctcta agggcaccag
     7981 atggccaagg ctcacagact gggagggaag tggttacaag ggcatgtctc tcagagaatt
     8041 cccagcctca ctccattttc tgtggcctga ttagagctgg gtgactttta ctgctcagag
     8101 cttccggtca tggaccagtc actgggcaga gttccaggga gctgacatgc taaagctgct
     8161 gatctgatta accaggtcaa aaactggatg catgctgcaa agtcctgccc ttctagccaa
     8221 gggtttgtgt gaagccttct agctgactca tgtcacctgc agacagcact tagagacttg
     8281 gtggtatctt ggagtggctt acggtgtcct agcagatact ctggaacctt gcatctctac
     8341 cccaaagccc accaaggacc ttgagcagct actcactgac tcacccatat cacttcaagg
     8401 agctgccacc acgttcaaac tcagagcttt aaggcttcac tgactgttcc taaaactatc
     8461 cttacactct aaagaggagg ggaaagagat ttaaaatatt tatacaaatc agcaggtaat
     8521 ttgggtagaa aacataaatg gtttgttatt aaatttagaa attgtagcac atggaattat
     8581 acagcccttc ctggttttct ggttccccac atcatctagg gaaggaagac tcacagaatg
     8641 gtttccagaa tgttccgtag atgagtgtac ttggagcctc ctgttcctgt cattaagaaa
     8701 ggcctgtccc tgggtcatta gcaacgtgtt tccttgctgg gaccaggcag gacccttgcc
     8761 tctggtgcaa ccttgcccag gctctgtgtt gactgccaac cacttttgat tcaagaagct
     8821 tcttccctgg gagctgctat ttttccaaaa ttcacattgt taaataaaat attttgggct
     8881 ctcgagtaa
//
