LOCUS       NP_001263346            2346 aa            linear   ROD 27-MAR-2024
DEFINITION  protein transport protein Sec16A [Rattus norvegicus].
ACCESSION   NP_001263346 XP_002729192 XP_003753734
VERSION     NP_001263346.1
DBSOURCE    REFSEQ: accession NM_001276417.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 2346)
  AUTHORS   Wu,Y., Guo,X.P., Kanemoto,S., Maeoka,Y., Saito,A., Asada,R.,
            Matsuhisa,K., Ohtake,Y., Imaizumi,K. and Kaneko,M.
  TITLE     Sec16A, a key protein in COPII vesicle formation, regulates the
            stability and localization of the novel ubiquitin ligase RNF183
  JOURNAL   PLoS One 13 (1), e0190407 (2018)
   PUBMED   29300766
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 2346)
  AUTHORS   Maeda,M., Katada,T. and Saito,K.
  TITLE     TANGO1 recruits Sec16 to coordinately organize ER exit sites for
            efficient secretion
  JOURNAL   J Cell Biol 216 (6), 1731-1743 (2017)
   PUBMED   28442536
REFERENCE   3  (residues 1 to 2346)
  AUTHORS   Piao,H., Kim,J., Noh,S.H., Kweon,H.S., Kim,J.Y. and Lee,M.G.
  TITLE     Sec16A is critical for both conventional and unconventional
            secretion of CFTR
  JOURNAL   Sci Rep 7, 39887 (2017)
   PUBMED   28067262
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 2346)
  AUTHORS   Bruno,J., Brumfield,A., Chaudhary,N., Iaea,D. and McGraw,T.E.
  TITLE     SEC16A is a RAB10 effector required for insulin-stimulated GLUT4
            trafficking in adipocytes
  JOURNAL   J Cell Biol 214 (1), 61-76 (2016)
   PUBMED   27354378
REFERENCE   5  (residues 1 to 2346)
  AUTHORS   Cho,H.J., Yu,J., Xie,C., Rudrabhatla,P., Chen,X., Wu,J.,
            Parisiadou,L., Liu,G., Sun,L., Ma,B., Ding,J., Liu,Z. and Cai,H.
  TITLE     Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to
            allow ER-Golgi export
  JOURNAL   EMBO J 33 (20), 2314-2331 (2014)
   PUBMED   25201882
REFERENCE   6  (residues 1 to 2346)
  AUTHORS   Yonekawa,S., Furuno,A., Baba,T., Fujiki,Y., Ogasawara,Y.,
            Yamamoto,A., Tagaya,M. and Tani,K.
  TITLE     Sec16B is involved in the endoplasmic reticulum export of the
            peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in
            mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 108 (31), 12746-12751 (2011)
   PUBMED   21768384
REFERENCE   7  (residues 1 to 2346)
  AUTHORS   Budnik,A., Heesom,K.J. and Stephens,D.J.
  TITLE     Characterization of human Sec16B: indications of specialized,
            non-redundant functions
  JOURNAL   Sci Rep 1, 77 (2011)
   PUBMED   22355596
REFERENCE   8  (residues 1 to 2346)
  AUTHORS   Hughes,H., Budnik,A., Schmidt,K., Palmer,K.J., Mantell,J.,
            Noakes,C., Johnson,A., Carter,D.A., Verkade,P., Watson,P. and
            Stephens,D.J.
  TITLE     Organisation of human ER-exit sites: requirements for the
            localisation of Sec16 to transitional ER
  JOURNAL   J Cell Sci 122 (Pt 16), 2924-2934 (2009)
   PUBMED   19638414
REFERENCE   9  (residues 1 to 2346)
  AUTHORS   Iinuma,T., Shiga,A., Nakamoto,K., O'Brien,M.B., Aridor,M.,
            Arimitsu,N., Tagaya,M. and Tani,K.
  TITLE     Mammalian Sec16/p250 plays a role in membrane traffic from the
            endoplasmic reticulum
  JOURNAL   J Biol Chem 282 (24), 17632-17639 (2007)
   PUBMED   17428803
REFERENCE   10 (residues 1 to 2346)
  AUTHORS   Cros,N., Tkatchenko,A.V., Pisani,D.F., Leclerc,L., Leger,J.J.,
            Marini,J.F. and Dechesne,C.A.
  TITLE     Analysis of altered gene expression in rat soleus muscle atrophied
            by disuse
  JOURNAL   J Cell Biochem 83 (3), 508-519 (2001)
   PUBMED   11596118
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Feb 10, 2013 this sequence version replaced
            XP_002729192.2, XP_003753734.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.11972.1,
                                           SRR26643292.11644.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2346
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     Protein         1..2346
                     /product="protein transport protein Sec16A"
                     /EC_number="3.1.3.36"
                     /note="SEC16 homolog A-like"
                     /calculated_mol_wt=253163
     Region          <3..313
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1500..1862
                     /region_name="ACE1-Sec16-like"
                     /note="Ancestral coatomer element 1 (ACE1) of COPII coat
                     complex assembly protein Sec16; cd09233"
                     /db_xref="CDD:187750"
     Site            order(1619..1620,1622..1623,1625..1629,1631,1633,1643,
                     1645,1647..1648,1650..1651,1655,1661,1668,1677,1682,1685,
                     1713..1714)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:187750"
     Site            order(1785,1807..1808,1810..1811,1814..1815,1818,
                     1845..1846,1849..1850,1853,1857)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:187750"
     Region          <1958..2301
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..2346
                     /gene="Sec16a"
                     /coded_by="NM_001276417.1:392..7432"
                     /db_xref="GeneID:100360302"
                     /db_xref="RGD:2322350"
ORIGIN      
        1 mqpppqavps gvagpppagn prssfwansp yrkpannnap vapitrplqp vtdpfafnrq
       61 tlqntpvgss skssppnlpg palpvfsqwp glpvpptnag dsstglhepl pgtlsqprad
      121 pslfppastp sslpglevnr saevdsssgp evqmlphpph yipgvgpeqp hgghlndsga
      181 gpdqsmnrha phdgavahaa spffpqpqmp gqwgpvhggp ppsyhhhspc legpvqdmgp
      241 qaaslphfps psslhegpgh esrvpqtftp aslasgegne ivhqqsknyp sssfppkhsf
      301 eqnsrvgnmw asaefrqnpg vnkehlldpa hvnpftqgns penqvhhppv aatnhalqea
      361 asgalsmffq geeteneenl ssekaglddr ldsgsfssts rlghpplpga ggvyqaaqeg
      421 dvqpyfsqfv girhdkqttm tpandawgdi pgagthcasg pqcenvenle fvqnqevlpr
      481 etvnvdpfsp sdqfrygplp gpaasrpvts gltrggglnl eapdmplhpt rpdsvsssys
      541 nhshrsppgs arpqelvgtf iqqevgkled dtsgsffkqi dsspvggetd emtrsqnycs
      601 slsqpstpsp pkptgvfqts anssfepvks hlvgvkpvea dranmvvevr gtqncqkhga
      661 avlppdatpg nleqppdnme tlcapqacpl plsttgeagq lvshtagppl dtvrpmpdkr
      721 ssaraqgpvk cespattlwa qnelpdfggn vllapaapal yvpvkpkpse vvhhpekgms
      781 gqqswksgsv pplqnqdppg asenlenppk vgeeealplq assgyaslls sppteslhnq
      841 pvliaqpdqs ynlaqpinfs vslpnpnekn qcwgdavvge ksmvstralg adheehaals
      901 aipastvtgs slpnsvtqnc aprgsgssem iasqpaswlv qqlspqipqs qhpnaekgps
      961 efvnspangs vmlappansa vipnsnkgyh srnpeeaiga ldftlsrtle npvrmcspsh
     1021 snspasqqpl anhprqsgpg lhnqdhfyqq vtkdaqdhrs lergqselvp pppqnspqqv
     1081 pqaacpepsn pespptqgqs eglvqpsasp apvntgqqpq ppqsssasvt stnsnqaavr
     1141 seqpwlhppp ttfgpapqdl asyyyyrppy eayqspypsp ypsdpgaasl yyqdiyglye
     1201 pryrpydssa sayaenhrys eperpssras hysdqltprq gypegyynsk sgwsshsdyy
     1261 anyysgqydy gdpgrwdryy gsrfrdprtw drrywydsdh dpyrkdnyay sdrpekcddh
     1321 wrydprftgs fdddtelhrd pygeevdrrs ihsehsarsl rsthslpsrr sslsshshqs
     1381 qiyrshhvtg gsfeaphapg sfhgdyaygt yasnfsgahg fpeysypadt swpaaeqvps
     1441 rptspekftv phvcarfgpg gqllkvipnl psegqpalve ihsletllqh tpeqeemrsf
     1501 pgplgkddth kvdvinfaqn katkclqnes lidkesasll wnfiillcrq ngtvvgtdia
     1561 elllrdhrtv wlpgkspnea nlidftneav eqveeeesge aqlsfltdsq tvtssvleke
     1621 terfrellly grkkdalesa mknglwghal llaskmdsrt harvmtrfan slpindplqt
     1681 vyqlmsgrmp aastccgdek wgdwrphlam vlsnlnnnmd vesrtmatmg dtlaskglld
     1741 aahfcylmaq vgfgvytkkt tklvligsnh slpflkfatn eaiqrteaye yaqslgahtc
     1801 slpnfqvfkf iylcrlaemg latqafhyce viaksvltqp tayspvlisq liqmasqlrl
     1861 fdpqlkekpe eesfvepawl vqlqhverqi qegtvlwnqd gtepqqchit sgseveqpdg
     1921 pglnqqagpr adnpllmpst eplvhsvqll ptapqtlpdg qpahlarvpm fpvpmsrppl
     1981 elsaaygppg svlgfpessr sdpavlhpgq alppatpglq esgpplqear spdpemvpqg
     2041 spvrhsppep reeefgknva dlgssrtaqd setspvwdlg sssltrapsl tpdsegkkpa
     2101 qavkkepkep kkteswfsrw lpgkkrteay lpddknksiv wdekknqwvn lnepeeekka
     2161 ppppptsfpr vpqaaptgpa gppmasvnvf srkaggsrar yvdvlnpsgt qrsepalapa
     2221 dffaplaplp ipsnlfvpnp daeesqpadg tgcrgqapag tqskaeptle akvvsstvsa
     2281 pgpelspskp adgsqggeap gdhcpagatp ggsvpfynpa qlvqasvtsg tsrpgrigqr
     2341 kyaaln
//
