LOCUS       NM_053801               2614 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SEC14-like lipid binding 2 (Sec14l2), mRNA.
ACCESSION   NM_053801
VERSION     NM_053801.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2614)
  AUTHORS   Liu,J., Dong,W., Wong,T.Y., Qiu,C., Wu,J., Zhao,J., Xia,J., Xie,S.
            and Song,X.
  TITLE     Proteome-wide analysis of protein alterations in response to
            aristolochic acids in rat kidney and liver tissues
  JOURNAL   Mol Omics 17 (3), 405-412 (2021)
   PUBMED   34008672
  REMARK    GeneRIF: Proteome-wide analysis of protein alterations in response
            to aristolochic acids in rat kidney and liver tissues.
REFERENCE   2  (bases 1 to 2614)
  AUTHORS   Ribeiro,F.M., Ferreira,L.T., Marion,S., Fontes,S., Gomez,M.,
            Ferguson,S.S., Prado,M.A. and Prado,V.F.
  TITLE     SEC14-like protein 1 interacts with cholinergic transporters
  JOURNAL   Neurochem Int 50 (2), 356-364 (2007)
   PUBMED   17092608
  REMARK    GeneRIF: overexpression of SEC14L1 modestly decreases high affinity
            choline transport activity
REFERENCE   3  (bases 1 to 2614)
  AUTHORS   Mokashi,V. and Porter,T.D.
  TITLE     Supernatant protein factor requires phosphorylation and interaction
            with Golgi to stimulate cholesterol synthesis in hepatoma cells
  JOURNAL   Arch Biochem Biophys 435 (1), 175-181 (2005)
   PUBMED   15680919
  REMARK    GeneRIF: The activation of SPF by PKA suggests that cholesterol
            synthesis can be rapidly modulated in response to external stimuli
            by changes in cAMP levels, and that this regulation is dependent on
            an as yet undefined interaction with Golgi.
REFERENCE   4  (bases 1 to 2614)
  AUTHORS   Mokashi,V., Singh,D.K. and Porter,T.D.
  TITLE     Supernatant protein factor stimulates HMG-CoA reductase in cell
            culture and in vitro
  JOURNAL   Arch Biochem Biophys 433 (2), 474-480 (2005)
   PUBMED   15581604
  REMARK    GeneRIF: Sec14l2 stimulates HMG-CoA reductase in hepatoma cell
            cultures.
REFERENCE   5  (bases 1 to 2614)
  AUTHORS   Yamauchi,J., Iwamoto,T., Kida,S., Masushige,S., Yamada,K. and
            Esashi,T.
  TITLE     Tocopherol-associated protein is a ligand-dependent transcriptional
            activator
  JOURNAL   Biochem Biophys Res Commun 285 (2), 295-299 (2001)
   PUBMED   11444841
REFERENCE   6  (bases 1 to 2614)
  AUTHORS   Shibata,N., Arita,M., Misaki,Y., Dohmae,N., Takio,K., Ono,T.,
            Inoue,K. and Arai,H.
  TITLE     Supernatant protein factor, which stimulates the conversion of
            squalene to lanosterol, is a cytosolic squalene transfer protein
            and enhances cholesterol biosynthesis
  JOURNAL   Proc Natl Acad Sci U S A 98 (5), 2244-2249 (2001)
   PUBMED   11226224
REFERENCE   7  (bases 1 to 2614)
  AUTHORS   Zimmer,S., Stocker,A., Sarbolouki,M.N., Spycher,S.E., Sassoon,J.
            and Azzi,A.
  TITLE     A novel human tocopherol-associated protein: cloning, in vitro
            expression, and characterization
  JOURNAL   J Biol Chem 275 (33), 25672-25680 (2000)
   PUBMED   10829015
REFERENCE   8  (bases 1 to 2614)
  AUTHORS   Caras,I.W., Friedlander,E.J. and Bloch,K.
  TITLE     Interactions of supernatant protein factor with components of the
            microsomal squalene epoxidase system. Binding of supernatant
            protein factor to anionic phospholipids
  JOURNAL   J Biol Chem 255 (8), 3575-3580 (1980)
   PUBMED   7364757
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089785.1.
            
            On Feb 20, 2005 this sequence version replaced NM_053801.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089785.1, AF309558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2614
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2614
                     /gene="Sec14l2"
                     /gene_synonym="Spf"
                     /note="SEC14-like lipid binding 2"
                     /db_xref="GeneID:116486"
                     /db_xref="RGD:621779"
     exon            1..102
                     /gene="Sec14l2"
                     /gene_synonym="Spf"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1260
                     /gene="Sec14l2"
                     /gene_synonym="Spf"
                     /note="TAP; squalene transfer protein; supernatant protein
                     factor; alpha-tocopherol-associated protein"
                     /codon_start=1
                     /product="SEC14-like protein 2"
                     /protein_id="NP_446253.2"
                     /db_xref="GeneID:116486"
                     /db_xref="RGD:621779"
                     /translation="MSGRVGDLSPKQEEALAKFRENVQDVLPALPNPDDYFLLRWLRA
                     RSFDLQKSEAMLRKHVEFRKQKDIDKIISWQPPEVIQQYLSGGRCGYDLDGCPVWYDI
                     IGPLDAKGLLFSASKQDLLRTKMRDCELLLQECTHQTAKLGKKIETITMIYDCEGLGL
                     KHLWKPAVEAYGEFLTMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIM
                     VLGANWKEVLLKHISPDQLPVEYGGTMTDPDGNPKCKSKINYGGDIPKQYYVRDQVKQ
                     QYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSEGSDVGFGIFLKTKMGERQRAGEMT
                     EVLPNQRYNSHMVPEDGTLTCSEPGIYVLRFDNTYSFIHAKKVSFTVEVLLPDKAAEE
                     KLNQQGTVTPK"
     exon            103..178
                     /gene="Sec14l2"
                     /gene_synonym="Spf"
                     /inference="alignment:Splign:2.1.0"
     exon            179..222
                     /gene="Sec14l2"
                     /gene_synonym="Spf"
                     /inference="alignment:Splign:2.1.0"
     exon            223..282
                     /gene="Sec14l2"
                     /gene_synonym="Spf"
                     /inference="alignment:Splign:2.1.0"
     exon            283..471
                     /gene="Sec14l2"
                     /gene_synonym="Spf"
                     /inference="alignment:Splign:2.1.0"
     exon            472..567
                     /gene="Sec14l2"
                     /gene_synonym="Spf"
                     /inference="alignment:Splign:2.1.0"
     exon            568..628
                     /gene="Sec14l2"
                     /gene_synonym="Spf"
                     /inference="alignment:Splign:2.1.0"
     exon            629..712
                     /gene="Sec14l2"
                     /gene_synonym="Spf"
                     /inference="alignment:Splign:2.1.0"
     exon            713..819
                     /gene="Sec14l2"
                     /gene_synonym="Spf"
                     /inference="alignment:Splign:2.1.0"
     exon            820..959
                     /gene="Sec14l2"
                     /gene_synonym="Spf"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1129
                     /gene="Sec14l2"
                     /gene_synonym="Spf"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..2592
                     /gene="Sec14l2"
                     /gene_synonym="Spf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcttcat cagctgccgc aggcgccgcg ccccgaggct gagccacgat gagcgggaga
       61 gtcggtgacc tgagccccaa acaggaggag gcactggcca agtttcgaga aaatgtccag
      121 gacgtgctgc ctgccctgcc caatccagat gactactttc tccttcgatg gctccgagcc
      181 cgaagctttg acctgcagaa gtcggaggcc atgctccgga agcatgtgga attccggaag
      241 caaaaggaca ttgacaaaat catcagctgg cagccaccag aggtgatcca acagtatctg
      301 tcaggcggcc ggtgtgggta tgacctggac ggctgccctg tctggtatga catcatcggc
      361 ccactggatg ccaagggtct gctgttctcc gcctccaagc aagacctgct caggaccaag
      421 atgagagatt gtgagctgct tctgcaggag tgcacccatc agaccgcaaa gctagggaag
      481 aagatagaga ccatcaccat gatttacgac tgtgagggac tcggcctcaa gcacctctgg
      541 aaacctgcag tggaggccta tggagagttt ctcaccatgt ttgaggagaa ctatcctgaa
      601 acgctgaagc ggctgttcgt cgttaaagcc cccaagctgt ttccagtggc ctacaacctc
      661 atcaagccct tcctgagtga ggacactagg aagaagatca tggttctggg agcaaactgg
      721 aaggaggttt tactcaaaca catcagcccc gaccagttgc ctgtggagta tggaggcacc
      781 atgacggacc ctgatggaaa ccccaagtgt aaatccaaga tcaactatgg gggtgacatc
      841 cccaagcagt attacgtgcg agaccaggtg aagcagcagt atgaacacag tgtgcagatc
      901 tcccgaggct cctcccacca agtagagtat gagattcttt tccccggctg cgtcctcagg
      961 tggcagttta tgtcggaggg atcagacgtg ggttttggga ttttcctgaa gaccaagatg
     1021 ggggaacggc agcgggcagg ggagatgacg gaggtgctgc ctaaccagag atacaattcc
     1081 cacatggtcc ctgaggatgg gaccctcacc tgcagtgagc caggcatcta tgtcctacgg
     1141 tttgacaaca cctacagctt catccatgcc aagaaagtca gtttcactgt ggaggtcctg
     1201 cttccagaca aagcagcaga agagaagttg aatcagcagg ggacagtcac ccccaaataa
     1261 catctccctc ctgcagcagg cctggccccc ctcagtgtct tcctgtcagt ttctttatag
     1321 tcattttcct acaacctatt agcccaaaga aactgggctg gagggaagac ttcagactgg
     1381 acggagcacc cgttcagagt cagaagcgga taaatagcta gaggggtcct cctcatcaga
     1441 atactaaagg gtctccagag acgggatgta acaatgtcta ccctgtagac cttgccaact
     1501 tcacctgccc agggacagtt gagacgagag ggtaaggtta cataggatgg cggcagggaa
     1561 ggaattagaa gtaagagatt gggatgtcat actcagggaa gccagctgct ggggagaaac
     1621 ttgctcctaa atgaacgtgg aataagcctc cactactgta atgatggttg caaggtagca
     1681 ggctgctaga atggtgggta gctgaagctc ttcgaaactt ttgtcataag ccttgaatat
     1741 ctcttgtctt cctcacccct ctccaacccc aaatctcagg agtggcccaa gtcagcactg
     1801 gaaggctaac agaaggcctc tcttcccccc cttgagaacc tcactaactc ctgggcttca
     1861 ctggctgcct gcttaactac taatggttgc cagtgcccca gagctctgtg ggactttggt
     1921 acctagccac tgttctccag tgaaagaaac cctccacaag cacaagggta attaatttca
     1981 gggatcatag ataggaaagg gccaaggagg ctgtgggtgg gccacaagcc tctaagtaaa
     2041 ccttcacttg agcaacccta cacaaaaatg acaagtgggg ctgaaacagc actgagtgta
     2101 cttcccagtc tagtctccca cagtgcctga gaagcagtct ccttactgac atgagcaagg
     2161 gcttggcagg cccttcgctg tggaggcgtg taatggaagc agtggcttcc tcttccctgg
     2221 ggacgcaggt tgccagggaa ggtggccata ggttaggcaa gcatttgagc caggggaaag
     2281 agccaggcac aggcgacctt gcaatagcag ctcttgaccc cacacaagtt gtgagccagg
     2341 ttacaggctg cccagaattc gggaaggaag ctccaggccc ttgcggggac tgccttttcc
     2401 tcggaatgag gcctcgccca gcctgcggac tcgtttcatg aagcggaggg agctctgggt
     2461 agggctagca accagagagg gccgaggcta cccaggatct agtcacatat ctcaggagca
     2521 tatcctggcc ttggtttaca atgttgttag gtacattaac caatgaataa ataaatcaat
     2581 tttcaaagca aaaaaaaaaa aaaaaaaaaa aaaa
//
