LOCUS       NM_031723               1228 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SEC11 homolog A, signal peptidase complex subunit
            (Sec11a), mRNA.
ACCESSION   NM_031723 XM_346545
VERSION     NM_031723.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1228)
  AUTHORS   Kalies,K.U. and Hartmann,E.
  TITLE     Membrane topology of the 12- and the 25-kDa subunits of the
            mammalian signal peptidase complex
  JOURNAL   J Biol Chem 271 (7), 3925-3929 (1996)
   PUBMED   8632014
REFERENCE   2  (bases 1 to 1228)
  AUTHORS   Signs,S.A. and Jacquet,R.
  TITLE     Induction of ethanol dependence increases signal peptidase mRNA
            levels in rat brain
  JOURNAL   Mol Cell Biochem 139 (1), 21-26 (1994)
   PUBMED   7854339
REFERENCE   3  (bases 1 to 1228)
  AUTHORS   Shelness,G.S., Lin,L. and Nicchitta,C.V.
  TITLE     Membrane topology and biogenesis of eukaryotic signal peptidase
  JOURNAL   J Biol Chem 268 (7), 5201-5208 (1993)
   PUBMED   8444896
REFERENCE   4  (bases 1 to 1228)
  AUTHORS   Evans,E.A., Gilmore,R. and Blobel,G.
  TITLE     Purification of microsomal signal peptidase as a complex
  JOURNAL   Proc Natl Acad Sci U S A 83 (3), 581-585 (1986)
   PUBMED   3511473
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC060554.1.
            
            On Aug 31, 2012 this sequence version replaced NM_031723.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060554.1, FQ220501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1228              BC060554.1         5-1232
FEATURES             Location/Qualifiers
     source          1..1228
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..1228
                     /gene="Sec11a"
                     /gene_synonym="Sec11l1; Spc18"
                     /note="SEC11 homolog A, signal peptidase complex subunit"
                     /db_xref="GeneID:65166"
                     /db_xref="RGD:69360"
     exon            1..138
                     /gene="Sec11a"
                     /gene_synonym="Sec11l1; Spc18"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..627
                     /gene="Sec11a"
                     /gene_synonym="Sec11l1; Spc18"
                     /EC_number="3.4.21.89"
                     /note="endopeptidase SP18; SEC11-like protein 1; SPase 18
                     kDa subunit; microsomal signal peptidase 18 kDa subunit;
                     Sec11-like 1; signal peptidase complex 18kD"
                     /codon_start=1
                     /product="signal peptidase complex catalytic subunit
                     SEC11A"
                     /protein_id="NP_113911.2"
                     /db_xref="GeneID:65166"
                     /db_xref="RGD:69360"
                     /translation="MLSLDFLDDVRRMNKRQLYYQVLNFGMIVSSALMIWKGLMVITG
                     SESPIVVVLSGSMEPAFHRGDLLFLTNRVEDPIRVGEIVVFRIEGREIPIVHRVLKIH
                     EKQDGHIKFLTKGDNNAVDDRGLYKQGQHWLEKKDVVGRARGFVPYIGIVTILMNDYP
                     KFKYAVLFLLGLFVLVHRE"
     exon            139..248
                     /gene="Sec11a"
                     /gene_synonym="Sec11l1; Spc18"
                     /inference="alignment:Splign:2.1.0"
     exon            249..398
                     /gene="Sec11a"
                     /gene_synonym="Sec11l1; Spc18"
                     /inference="alignment:Splign:2.1.0"
     exon            399..518
                     /gene="Sec11a"
                     /gene_synonym="Sec11l1; Spc18"
                     /inference="alignment:Splign:2.1.0"
     exon            519..576
                     /gene="Sec11a"
                     /gene_synonym="Sec11l1; Spc18"
                     /inference="alignment:Splign:2.1.0"
     exon            577..1104
                     /gene="Sec11a"
                     /gene_synonym="Sec11l1; Spc18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagcccgg cccgtgtggc agcggttcct cttggtgatt gtatcgcgcc ctctttgctg
       61 ctaattaccg cgttctccat tctcaccatg ctgtctctag actttctaga tgatgtacgg
      121 cggatgaaca agaggcagct gtactaccaa gtcctaaatt ttggaatgat tgtctcctcg
      181 gcactaatga tctggaaggg gctgatggtg ataaccggaa gtgagagtcc cattgtagtg
      241 gtgctcagtg gcagcatgga gcctgcgttt cacagagggg atctcctttt cctcacgaac
      301 cgagttgaag atcctatacg tgtgggggaa atcgttgttt tcaggataga aggaagagag
      361 attcccatag tgcatcgagt cttgaagatc catgaaaagc aagatgggca tatcaagttt
      421 ttaaccaaag gagataataa tgccgttgat gaccgaggcc tctataaaca aggacaacac
      481 tggctggaga agaaagatgt tgtagggaga gcaagagggt ttgttccgta cattggaatc
      541 gtgacgatcc tcatgaatga ctatcctaaa tttaagtatg cagtactgtt tctgctgggt
      601 ttatttgtgc tggtccatcg tgagtaagaa gccggcctcg ctggtcctgg gaggatgctg
      661 tcttgttgtt actgaatgtt ggagtagacc ctggcctgtg actggcgggt atccggagga
      721 cacatatggc ggcacttctg ggtagcactg ctttgcatta ctttgtgttt ccacacccga
      781 ggatgtgtgg gcgggtgcat gtgcaccatg gcgtgcacac aaggggactg tcaatcacag
      841 gctttcatat gttgtcattg tcactctttc acatttttgt acatcagtga attttttata
      901 ttaaaaggtt gagccaaagc ccccagtgtt tgtattttga agccaagctt cacttttaaa
      961 gtgcctacag agctctgtgc atgcaaacac agctctgcat gagttcaaac ctgtcgttcc
     1021 tccttaacgt gggaagggca cataatgagg cggtcataag tcttaacttt tcaaaatttt
     1081 aaataaaaga ctttgcacat tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1141 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1201 aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
