LOCUS       NM_053962               1296 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus serine dehydratase (Sds), mRNA.
ACCESSION   NM_053962
VERSION     NM_053962.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1296)
  AUTHORS   Montez,P., Vazquez-Medina,J.P., Rodriguez,R., Thorwald,M.A.,
            Viscarra,J.A., Lam,L., Peti-Peterdi,J., Nakano,D., Nishiyama,A. and
            Ortiz,R.M.
  TITLE     Angiotensin receptor blockade recovers hepatic UCP2 expression and
            aconitase and SDH activities and ameliorates hepatic oxidative
            damage in insulin resistant rats
  JOURNAL   Endocrinology 153 (12), 5746-5759 (2012)
   PUBMED   23087176
  REMARK    GeneRIF: Angiotensin receptor blockade recovers hepatic UCP2
            expression and aconitase and SDH activities and ameliorates hepatic
            oxidative damage in insulin resistant rats
REFERENCE   2  (bases 1 to 1296)
  AUTHORS   Nagao,K., Bannai,M., Seki,S., Mori,M. and Takahashi,M.
  TITLE     Adaptational modification of serine and threonine metabolism in the
            liver to essential amino acid deficiency in rats
  JOURNAL   Amino Acids 36 (3), 555-562 (2009)
   PUBMED   18584286
REFERENCE   3  (bases 1 to 1296)
  AUTHORS   Zhang,B. and Lin,S.
  TITLE     Effects of 3,4-dichloroaniline on testicle enzymes as biological
            markers in rats
  JOURNAL   Biomed Environ Sci 22 (1), 40-43 (2009)
   PUBMED   19462686
REFERENCE   4  (bases 1 to 1296)
  AUTHORS   Yamada,T., Komoto,J., Kasuya,T., Takata,Y., Ogawa,H., Mori,H. and
            Takusagawa,F.
  TITLE     A catalytic mechanism that explains a low catalytic activity of
            serine dehydratase like-1 from human cancer cells: crystal
            structure and site-directed mutagenesis studies
  JOURNAL   Biochim Biophys Acta 1780 (5), 809-818 (2008)
   PUBMED   18342636
REFERENCE   5  (bases 1 to 1296)
  AUTHORS   Zhong,B., Sakai,S., Saeki,T. and Kanamoto,R.
  TITLE     Excess leucine intake induces serine dehydratase in rat liver
  JOURNAL   Biosci Biotechnol Biochem 71 (10), 2614-2617 (2007)
   PUBMED   17928680
  REMARK    GeneRIF: Excess leucine intake induces Sdh in rat liver.
REFERENCE   6  (bases 1 to 1296)
  AUTHORS   Noda,C., Ohguri,M., Matsuda,K., Nakamura,T., Hasegawa,A., Yagi,S.
            and Ichihara,A.
  TITLE     Organization and structure of the 5' flanking region of the rat
            serine dehydratase gene
  JOURNAL   J Biochem 108 (4), 622-628 (1990)
   PUBMED   2292591
REFERENCE   7  (bases 1 to 1296)
  AUTHORS   Ogawa,H., Fujioka,M., Date,T., Mueckler,M., Su,Y. and Pitot,H.C.
  TITLE     Rat serine dehydratase gene codes for two species of mRNA of which
            only one is translated into serine dehydratase
  JOURNAL   J Biol Chem 265 (24), 14407-14413 (1990)
   PUBMED   2387860
REFERENCE   8  (bases 1 to 1296)
  AUTHORS   Leoncini,R., Henschen,A., Krieglstein,K., Calvete,J., Pagani,R. and
            Marinello,E.
  TITLE     Amino acid sequence around the pyridoxal 5'-phosphate binding site
            of rat liver L-threonine deaminase
  JOURNAL   Ital J Biochem 39 (4), 235-241 (1990)
   PUBMED   2228555
REFERENCE   9  (bases 1 to 1296)
  AUTHORS   Leoncini,R., Henschen,A., Krieglstein,K., Calvete,J., Pagani,R. and
            Marinello,E.
  TITLE     Primary structure of rat liver L-threonine deaminase
  JOURNAL   Ital J Biochem 39 (4), 228-234 (1990)
   PUBMED   2228554
REFERENCE   10 (bases 1 to 1296)
  AUTHORS   Ogawa,H., Konishi,K. and Fujioka,M.
  TITLE     The peptide sequences near the bound pyridoxal phosphate are
            conserved in serine dehydratase from rat liver, and threonine
            dehydratases from yeast and Escherichia coli
  JOURNAL   Biochim Biophys Acta 996 (1-2), 139-141 (1989)
   PUBMED   2660911
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088110.1.
            
            On Oct 19, 2007 this sequence version replaced NM_053962.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088110.1, Y00752.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5756307,
                                           SAMEA5760393 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1296
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1296
                     /gene="Sds"
                     /gene_synonym="RATSDHE1; Sdh; SDH2; Sdhe1; TDH"
                     /note="serine dehydratase"
                     /db_xref="GeneID:25044"
                     /db_xref="RGD:67376"
     exon            1..55
                     /gene="Sds"
                     /gene_synonym="RATSDHE1; Sdh; SDH2; Sdhe1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            56..129
                     /gene="Sds"
                     /gene_synonym="RATSDHE1; Sdh; SDH2; Sdhe1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            130..284
                     /gene="Sds"
                     /gene_synonym="RATSDHE1; Sdh; SDH2; Sdhe1; TDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1115
                     /gene="Sds"
                     /gene_synonym="RATSDHE1; Sdh; SDH2; Sdhe1; TDH"
                     /EC_number="4.3.1.17"
                     /EC_number="4.3.1.19"
                     /note="L-serine deaminase; L-threonine dehydratase"
                     /codon_start=1
                     /product="L-serine dehydratase/L-threonine deaminase"
                     /protein_id="NP_446414.3"
                     /db_xref="GeneID:25044"
                     /db_xref="RGD:67376"
                     /translation="MAAQESLHVKTPLRDSMALSKVAGTSVFLKMDSSQPSGSFKIRG
                     IGHLCKMKAKQGCKHFVCSSAGNAGMATAYAARRLGLPATIVVPSTTPALTIERLKNE
                     GATVEVVGEMLDEAIQLAKALEKNNPGWVYISPFDDPLIWEGHTSLVKELKETLSAKP
                     GAIVLSVGGGGLLCGVVQGLREVGWEDVPIIAMETFGAHSFHAAVKEGKLVTLPKITS
                     VAKALGVNTVGAQTLKLFYEHPIFSEVISDQEAVTAIEKFVDDEKILVEPACGAALAA
                     VYSGVVCRLQAEGRLQTPLASLVVIVCGGSNISLAQLQALKAQLGLNELLK"
     exon            285..324
                     /gene="Sds"
                     /gene_synonym="RATSDHE1; Sdh; SDH2; Sdhe1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            325..464
                     /gene="Sds"
                     /gene_synonym="RATSDHE1; Sdh; SDH2; Sdhe1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            465..556
                     /gene="Sds"
                     /gene_synonym="RATSDHE1; Sdh; SDH2; Sdhe1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            557..784
                     /gene="Sds"
                     /gene_synonym="RATSDHE1; Sdh; SDH2; Sdhe1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            785..909
                     /gene="Sds"
                     /gene_synonym="RATSDHE1; Sdh; SDH2; Sdhe1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1274
                     /gene="Sds"
                     /gene_synonym="RATSDHE1; Sdh; SDH2; Sdhe1; TDH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacacagaca aaatctaccc ttctcgctcg ctctgtccag ctcctcctgt gccgggtgcg
       61 gcggggcata cctgtgatcc cagcaattgg gagactgaga caggaggatc caaccttcaa
      121 agctacatgc catggctgcc caggagtccc tgcacgtgaa gaccccacta cgtgacagca
      181 tggcattgtc caaagtggcc ggcactagtg tgttccttaa gatggacagc tctcagccct
      241 ctggctcctt caagatccga ggcattgggc atctctgcaa gatgaaggca aaacaaggct
      301 gtaaacattt cgtctgctct tcagcgggca acgcgggcat ggcgactgcc tatgctgcca
      361 ggaggctggg cctcccagcc actattgttg tgccaagcac cacacctgcc ctcaccattg
      421 agcggctgaa gaacgaaggg gccacagttg aagtggtggg agagatgctg gatgaggcca
      481 tccaactggc caaggctctg gaaaagaaca acccaggttg ggtgtacatc tcccccttcg
      541 atgaccctct catctgggaa ggccacactt cccttgtgaa ggagctgaag gagacactga
      601 gcgccaagcc cggggccatt gtgctgtctg tgggcggtgg aggcctgctg tgcggagtgg
      661 tccaggggct gcgggaggtg ggctgggagg atgtgcccat catcgccatg gagaccttcg
      721 gcgcccacag cttccacgct gccgtcaagg aaggaaagct ggtcaccctg cccaagatca
      781 ccagtgttgc caaggccttg ggtgtgaaca ctgtgggggc acagaccctg aagctgtttt
      841 acgaacaccc cattttctct gaggtcatct cagaccagga ggctgtgact gctatcgaga
      901 agttcgtaga cgatgagaag atcctggtgg agcccgcgtg tggcgctgcc ctggctgcag
      961 tgtacagcgg tgtggtgtgc aggctgcagg ctgagggccg actgcaaacc ccactggcct
     1021 cgctggttgt cattgtgtgt ggtggcagca acatcagcct ggcacagctg caggcactca
     1081 aggcacagct gggcctgaat gagctactca agtgatatct gctgctgccc tggccaccct
     1141 gaggggtcac cagcacccct gagtaggctg ggtgggcgtc cgcctgacag tggcccaccc
     1201 tcctttatcc atgtttataa tatgcacttt ttcattgtaa ataaaaatta atatatatat
     1261 gtttataaag caaaaaaaaa aaaaaaaaaa aaaaaa
//
