LOCUS       NM_001005534            1186 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus succinate dehydrogenase complex subunit C (Sdhc),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001005534 XM_213936
VERSION     NM_001005534.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1186)
  AUTHORS   Signes A and Fernandez-Vizarra E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1186)
  AUTHORS   Guo X, Li D, Wu Y, Chen Y, Zhou X, Wang X, Huang X, Li X, Yang H
            and Xing J.
  TITLE     Genetic variants in genes of tricarboxylic acid cycle key enzymes
            are associated with prognosis of patients with non-small cell lung
            cancer
  JOURNAL   Lung Cancer 87 (2), 162-168 (2015)
   PUBMED   25576295
REFERENCE   3  (bases 1 to 1186)
  AUTHORS   Forner F, Kumar C, Luber CA, Fromme T, Klingenspor M and Mann M.
  TITLE     Proteome differences between brown and white fat mitochondria
            reveal specialized metabolic functions
  JOURNAL   Cell Metab 10 (4), 324-335 (2009)
   PUBMED   19808025
REFERENCE   4  (bases 1 to 1186)
  AUTHORS   Huo X, Su D, Wang A, Zhai Y, Xu J, Li X, Bartlam M, Sun F and Rao
            Z.
  TITLE     Preliminary molecular characterization and crystallization of
            mitochondrial respiratory complex II from porcine heart
  JOURNAL   FEBS J 274 (6), 1524-1529 (2007)
   PUBMED   17480203
REFERENCE   5  (bases 1 to 1186)
  AUTHORS   Briere JJ, Favier J, El Ghouzzi V, Djouadi F, Benit P, Gimenez AP
            and Rustin P.
  TITLE     Succinate dehydrogenase deficiency in human
  JOURNAL   Cell Mol Life Sci 62 (19-20), 2317-2324 (2005)
   PUBMED   16143825
  REMARK    Review article
REFERENCE   6  (bases 1 to 1186)
  AUTHORS   Sun F, Huo X, Zhai Y, Wang A, Xu J, Su D, Bartlam M and Rao Z.
  TITLE     Crystal structure of mitochondrial respiratory membrane protein
            complex II
  JOURNAL   Cell 121 (7), 1043-1057 (2005)
   PUBMED   15989954
REFERENCE   7  (bases 1 to 1186)
  AUTHORS   Ishii T, Yasuda K, Akatsuka A, Hino O, Hartman PS and Ishii N.
  TITLE     A mutation in the SDHC gene of complex II increases oxidative
            stress, resulting in apoptosis and tumorigenesis
  JOURNAL   Cancer Res 65 (1), 203-209 (2005)
   PUBMED   15665296
REFERENCE   8  (bases 1 to 1186)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 1186)
  AUTHORS   Niemann S and Muller U.
  TITLE     Mutations in SDHC cause autosomal dominant paraganglioma, type 3
  JOURNAL   Nat Genet 26 (3), 268-270 (2000)
   PUBMED   11062460
REFERENCE   10 (bases 1 to 1186)
  AUTHORS   Hirawake H, Taniwaki M, Tamura A, Kojima S and Kita K.
  TITLE     Cytochrome b in human complex II (succinate-ubiquinone
            oxidoreductase): cDNA cloning of the components in liver
            mitochondria and chromosome assignment of the genes for the large
            (SDHC) and small (SDHD) subunits to 1q21 and 11q23
  JOURNAL   Cytogenet Cell Genet 79 (1-2), 132-138 (1997)
   PUBMED   9533030
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082027.1.
            
            On Oct 8, 2004 this sequence version replaced XM_213936.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082027.1, FQ215990.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1186
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1186
                     /gene="Sdhc"
                     /note="succinate dehydrogenase complex subunit C"
                     /db_xref="GeneID:289217"
                     /db_xref="RGD:1359454"
     exon            1..26
                     /gene="Sdhc"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..516
                     /gene="Sdhc"
                     /note="succinate dehydrogenase complex, subunit C,
                     integral membrane protein"
                     /codon_start=1
                     /product="succinate dehydrogenase cytochrome b560 subunit,
                     mitochondrial"
                     /protein_id="NP_001005534.1"
                     /db_xref="GeneID:289217"
                     /db_xref="RGD:1359454"
                     /translation="MAALLLRHIGRHCLRAHLSSQLCIRNAAPLGTTAKEEMARFWNK
                     NTSSNRPVSPHLTIYRWSLPMAMSVCHRGSGIAMSGGVSLFGLSALLLPGNFESYLML
                     VKSLCLGPALIHAAKFVLVFPLMYHSLNGVRHLMWDLGKGLSISQVQLSGVTVLVLAV
                     LSSAGLAAI"
     exon            27..83
                     /gene="Sdhc"
                     /inference="alignment:Splign:2.1.0"
     exon            84..185
                     /gene="Sdhc"
                     /inference="alignment:Splign:2.1.0"
     exon            186..247
                     /gene="Sdhc"
                     /inference="alignment:Splign:2.1.0"
     exon            248..411
                     /gene="Sdhc"
                     /inference="alignment:Splign:2.1.0"
     exon            412..1149
                     /gene="Sdhc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcaagatgg ctgcgctctt gctgagacac atcggccgcc attgcctccg agcccacctt
       61 agttctcagc tctgtatcag aaatgctgct cctttgggaa ccacagctaa ggaagaaatg
      121 gcacggttct ggaataagaa cacgagttcc aaccgtcctg tctctcccca tttgactatc
      181 tacaggtggt ctcttcccat ggcaatgtct gtttgccacc gaggctctgg gatagccatg
      241 agtggagggg tctctctttt tggcctgtcg gcactgctgc ttcctgggaa ctttgagtcg
      301 tatctgatgc ttgtgaagtc cctgtgtttg gggccagcgc tgatccatgc agccaagttc
      361 gtgcttgtct ttcctctcat gtaccactca ttgaatgggg tccgacactt gatgtgggac
      421 ctagggaaag gcctgtcgat ttcccaggtc cagttgtctg gagtgacggt cttggttctt
      481 gcagtgctgt cctctgcagg actggcagcc atatgaagag ctgggattcc cacatccgtc
      541 ctgtgcatca tcacactgat ctctattcct gtttgtcact cctccctcca gccaccaagg
      601 ttctcctgat ttgtttagat gtcatgtgct tccgatcccc tgggggcaca gtagagaagc
      661 ttacagaact gtaatagtag aaagaatcct tttccctagg cctaggagcc ctcattcctc
      721 tccacttttg actctgattt gtgctgaggg tcagctttgt gctgcttctt gctgagacag
      781 tggaaacaat gccagttctg tggctgccct gagtgccact gcctgtgggc tgcaggctta
      841 aaggacactt ctgttcattg gtcagctcag ggcctttagc acccacacag cgtgactgag
      901 agaagagaaa tggaggtgga ggggatcatc ctgcccagct agagggagat aaagagcagc
      961 gtggatcttg ggagctcatg cttgggggaa agacagacag ctttccatgt atgaggaaga
     1021 tcaaaaaaaa attgtattaa gattgtttca tttttcattt ctaggaacat acacctttaa
     1081 tgtcattttt tctaatctaa attcatgtac catctttctt tggaaatgat taaagtacta
     1141 ctcattttaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
