LOCUS       NM_001100539            1007 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Rattus norvegicus succinate dehydrogenase complex iron sulfur
            subunit B (Sdhb), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001100539 XM_001071846 XM_216558
VERSION     NM_001100539.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1007)
  AUTHORS   Eprintsev,A.T., Fedorin,D.N. and Bakarev,M.Y.
  TITLE     [Molecular and biochemical studies of succinate dehydrogenase in
            rat liver under conditions of alloxan diabetes]
  JOURNAL   Biomed Khim 68 (4), 272-278 (2022)
   PUBMED   36005845
  REMARK    GeneRIF: [Molecular and biochemical studies of succinate
            dehydrogenase in rat liver under conditions of alloxan diabetes].',
            trans 'Molekuliarnye i biokhimicheskie issledovaniia
            suktsinatdegidrogenazy v pecheni krys v usloviiakh alloksanovogo
            diabeta.
REFERENCE   2  (bases 1 to 1007)
  AUTHORS   Kang,K.W., Ko,J.Y., Lee,H., Shin,S.Y., Lee,W.S., Hong,J., Kim,S.W.,
            Lee,S.K. and Oak,M.H.
  TITLE     Surgically Metabolic Resection of Pericardial Fat to Ameliorate
            Myocardial Mitochondrial Dysfunction in Acute Myocardial Infarction
            Obese Rats
  JOURNAL   J Korean Med Sci 37 (9), e55 (2022)
   PUBMED   35257523
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1007)
  AUTHORS   Signes,A. and Fernandez-Vizarra,E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1007)
  AUTHORS   Peralta,S., Torraco,A., Wenz,T., Garcia,S., Diaz,F. and Moraes,C.T.
  TITLE     Partial complex I deficiency due to the CNS conditional ablation of
            Ndufa5 results in a mild chronic encephalopathy but no increase in
            oxidative damage
  JOURNAL   Hum Mol Genet 23 (6), 1399-1412 (2014)
   PUBMED   24154540
REFERENCE   5  (bases 1 to 1007)
  AUTHORS   Bardella,C., Pollard,P.J. and Tomlinson,I.
  TITLE     SDH mutations in cancer
  JOURNAL   Biochim Biophys Acta 1807 (11), 1432-1443 (2011)
   PUBMED   21771581
  REMARK    Review article
REFERENCE   6  (bases 1 to 1007)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1007)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 1007)
  AUTHORS   Bjorkman,J., Gould,S.J. and Crane,D.I.
  TITLE     Pex13, the mouse ortholog of the human peroxisome biogenesis
            disorder PEX13 gene: gene structure, tissue expression, and
            localization of the protein to peroxisomes
  JOURNAL   Genomics 79 (2), 162-168 (2002)
   PUBMED   11829486
REFERENCE   9  (bases 1 to 1007)
  AUTHORS   Astuti,D., Latif,F., Dallol,A., Dahia,P.L., Douglas,F., George,E.,
            Skoldberg,F., Husebye,E.S., Eng,C. and Maher,E.R.
  TITLE     Gene mutations in the succinate dehydrogenase subunit SDHB cause
            susceptibility to familial pheochromocytoma and to familial
            paraganglioma
  JOURNAL   Am J Hum Genet 69 (1), 49-54 (2001)
   PUBMED   11404820
  REMARK    Erratum:[Am J Hum Genet 2002 Feb;70(2):565]
REFERENCE   10 (bases 1 to 1007)
  AUTHORS   Gould,S.J., Subramani,S. and Scheffler,I.E.
  TITLE     Use of the DNA polymerase chain reaction for homology probing:
            isolation of partial cDNA or genomic clones encoding the
            iron-sulfur protein of succinate dehydrogenase from several species
  JOURNAL   Proc Natl Acad Sci U S A 86 (6), 1934-1938 (1989)
   PUBMED   2494655
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1993 Mar 15;90(6):2556]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158620.1.
            
            On or before Oct 24, 2008 this sequence version replaced
            XM_216558.3, XM_001071846.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158620.1, FQ215046.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1007
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1007
                     /gene="Sdhb"
                     /note="succinate dehydrogenase complex iron sulfur subunit
                     B"
                     /db_xref="GeneID:298596"
                     /db_xref="RGD:1308598"
     exon            1..92
                     /gene="Sdhb"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..869
                     /gene="Sdhb"
                     /EC_number="1.3.5.1"
                     /note="succinate dehydrogenase [ubiquinone] iron-sulfur
                     subunit, mitochondrial; ip; iron-sulfur subunit of complex
                     II; succinate dehydrogenase complex, subunit B, iron
                     sulfur (Ip); malate dehydrogenase [quinone] iron-sulfur
                     subunit"
                     /codon_start=1
                     /product="succinate dehydrogenase [ubiquinone] iron-sulfur
                     subunit, mitochondrial precursor"
                     /protein_id="NP_001094009.1"
                     /db_xref="GeneID:298596"
                     /db_xref="RGD:1308598"
                     /translation="MAAVVGVSLKRGFSATALGRVGLQFQACREAQTAAAAAPRIKTF
                     AIYRWDPDKAGDKPRMQTYKVDLNKCGPMVLDALIKIKNEIDSTLTFRRSCREGICGS
                     CAMNINGGNTLACTRRIDTDLGKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLK
                     KKDESQEGKQQYLQSIEDREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAY
                     RWMIDSRDEFTEERLAKLQDPFSLYRCHTIMNCTQTCPKGLNPGKAIAEIKKMMATYK
                     EKRALA"
     exon            93..226
                     /gene="Sdhb"
                     /inference="alignment:Splign:2.1.0"
     exon            227..312
                     /gene="Sdhb"
                     /inference="alignment:Splign:2.1.0"
     exon            313..449
                     /gene="Sdhb"
                     /inference="alignment:Splign:2.1.0"
     exon            450..566
                     /gene="Sdhb"
                     /inference="alignment:Splign:2.1.0"
     exon            567..668
                     /gene="Sdhb"
                     /inference="alignment:Splign:2.1.0"
     exon            669..791
                     /gene="Sdhb"
                     /inference="alignment:Splign:2.1.0"
     exon            792..971
                     /gene="Sdhb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgacgtc aggagccaaa atggcggcgg tggtcggggt ctccttgaag cgcggctttt
       61 cggctacggc tctcggcaga gtcggcctgc agtttcaggc ctgccgagag gcacagacag
      121 ctgctgctgc agctcccaga atcaaaacct tcgccattta ccgatgggac ccggacaagg
      181 ctggagataa acctcgaatg cagacataca aggtggatct gaataagtgt ggaccgatgg
      241 tgctggatgc tctaatcaag attaagaatg aaatcgattc tactttgacc ttccgaagat
      301 catgcagaga agggatctgt ggctcttgtg ccatgaacat caacggaggc aacacgctgg
      361 catgcacgcg caggatcgac acagaccttg gcaaagtctc gaaaatatac cctcttccgc
      421 atatgtatgt gatcaaggat ctagtccctg acttgagtaa cttctatgca caatacaaat
      481 ccattgagcc ctatctgaag aagaaggatg agtcccagga gggcaagcaa cagtatctgc
      541 aatccatcga ggaccgggag aagctggacg gattgtatga gtgcatcctg tgtgcctgct
      601 gcagcaccag ctgtcccagt tactggtgga acggagacaa gtacctgggg cctgcagttc
      661 tcatgcaggc ttatcgctgg atgatcgact ccagagatga attcacagag gagcgcctgg
      721 ccaagctgca ggaccccttc tctctctacc gctgccacac catcatgaac tgtacacaga
      781 cctgccccaa gggtctgaat ccaggaaaag caattgcaga aatcaagaag atgatggcga
      841 cctacaagga gaagcgggca ttggcttaac cctgtccatg ctgagtgtgg ctgtcagctc
      901 tggcgtgagt cccttcaagc ccccggagtg tctctgagta cagcctatgt aataaacatt
      961 taggagataa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
