LOCUS       NM_001008371            1890 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus succinate dehydrogenase complex assembly factor 2
            (Sdhaf2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001008371 XM_342019
VERSION     NM_001008371.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1890)
  AUTHORS   Wu,H., Zhang,D., Xia,H., Li,Y., Mao,F. and Liao,Y.
  TITLE     SDH5 down-regulation mitigates the damage of osteoporosis via
            inhibiting the MyD88/NF-kappaB signaling pathway
  JOURNAL   Immunopharmacol Immunotoxicol 45 (3), 317-327 (2023)
   PUBMED   36326104
  REMARK    GeneRIF: SDH5 down-regulation mitigates the damage of osteoporosis
            via inhibiting the MyD88/NF-kappaB signaling pathway.
REFERENCE   2  (bases 1 to 1890)
  AUTHORS   Liu,J., Gao,L., Zhang,H., Wang,D., Wang,M., Zhu,J., Pang,C. and
            Wang,C.
  TITLE     Succinate dehydrogenase 5 (SDH5) regulates glycogen synthase kinase
            3beta-beta-catenin-mediated lung cancer metastasis
  JOURNAL   J Biol Chem 288 (41), 29965-29973 (2013)
   PUBMED   23983127
REFERENCE   3  (bases 1 to 1890)
  AUTHORS   Hao,H.X., Khalimonchuk,O., Schraders,M., Dephoure,N., Bayley,J.P.,
            Kunst,H., Devilee,P., Cremers,C.W., Schiffman,J.D., Bentz,B.G.,
            Gygi,S.P., Winge,D.R., Kremer,H. and Rutter,J.
  TITLE     SDH5, a gene required for flavination of succinate dehydrogenase,
            is mutated in paraganglioma
  JOURNAL   Science 325 (5944), 1139-1142 (2009)
   PUBMED   19628817
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086542.1.
            
            On Dec 16, 2004 this sequence version replaced XM_342019.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086542.1, EV769073.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1890
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1890
                     /gene="Sdhaf2"
                     /gene_synonym="RGD1309216"
                     /note="succinate dehydrogenase complex assembly factor 2"
                     /db_xref="GeneID:361726"
                     /db_xref="RGD:1309216"
     exon            1..86
                     /gene="Sdhaf2"
                     /gene_synonym="RGD1309216"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..545
                     /gene="Sdhaf2"
                     /gene_synonym="RGD1309216"
                     /note="SDH assembly factor 2; succinate dehydrogenase
                     assembly factor 2, mitochondrial; succinate dehydrogenase
                     subunit 5, mitochondrial"
                     /codon_start=1
                     /product="succinate dehydrogenase assembly factor 2,
                     mitochondrial precursor"
                     /protein_id="NP_001008372.1"
                     /db_xref="GeneID:361726"
                     /db_xref="RGD:1309216"
                     /translation="MAVVTLIPTLARVLSKHSLLSPLLSVTSFRRFYRGDSPTDSQKD
                     MIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFAKEYLHNMTEKQLNL
                     YDRLINEPSNDWDIYYWATEAKPAPEIFENEVMELLREFTKNKNKEQRLRAPDLEYLF
                     EKPR"
     exon            87..304
                     /gene="Sdhaf2"
                     /gene_synonym="RGD1309216"
                     /inference="alignment:Splign:2.1.0"
     exon            305..414
                     /gene="Sdhaf2"
                     /gene_synonym="RGD1309216"
                     /inference="alignment:Splign:2.1.0"
     exon            415..1856
                     /gene="Sdhaf2"
                     /gene_synonym="RGD1309216"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagttcccg gaagagggtc ggttgctagc ttcctgtact atagggagaa atggcggtgg
       61 tcaccttgat cccgacgctg gcgcgggtat tgtcaaagca cagtctgctg tctcctttgc
      121 ttagtgtgac atcgttcaga cgcttctaca gaggtgacag cccaacagat tctcaaaaag
      181 acatgattga aatccctttg cctccgtggc aggagagaac tgatgaatcc atagaaacca
      241 aaagagcccg cttactgtat gagagcagaa agagggggat gctggagaac tgcattctcc
      301 tgagcctctt tgctaaagaa tatctgcaca acatgacaga gaagcagctg aacctctacg
      361 atcgtctgat taatgagcct agcaatgact gggatattta ctactgggcc acagaagcaa
      421 aaccagctcc agaaatattt gaaaatgaag tcatggaact actgagagaa ttcaccaaaa
      481 acaaaaacaa agagcagaga ctgcgtgccc cagatctgga atatctcttt gaaaagcctc
      541 gttaagccgg gtgccactgc ctgttgtggt ggtcattata tggatagaaa ctgcttctgg
      601 tactgacctt ggcttcctgc ttctccttag acacttgaac ctctcccagg acagacatgt
      661 aatgtgtaag atgactcatc taacctgtgc ttgtctgtaa aacccaagtc agacccctta
      721 cctggctgat atgtgctgtg ctgcaggtct gccacaagag ggcactgtag ggaagcgagt
      781 ccactgcctc agcgccaaca atgcaaaaga cactgctgct gtaggaagag ctgaccccat
      841 cctcctccac ccagtggccc tggacttttt taagataaaa ccaccccaac ctgatagttc
      901 caccaaagaa tgtcgattca ggcctctaaa ctgagcccat caaaggtaca gcaagctgaa
      961 tgagggcacc aaagcaggaa tattgtgggc atactgctta agtcaacatc ctcatcagct
     1021 tttcacaaca tacatgtttt aaactgaaag atagttgaat gttgaagact atcgagaaga
     1081 aagtcaacag ttcactaacc ctcacagtta tcttcatttt tgtctgattc tctgctacat
     1141 atagtcctat aatggggttt tacaagctta tagtcataag ttttctgacc ttctggtatt
     1201 gtggcaaact ttcctctcat tctgacagcc atcaaattat tttagttgac caaataataa
     1261 tggcatataa gaagtaacat attaactgtg tcataggtcc taccctcggg gaactgaggt
     1321 aggaacagca ctaagaattt gaagctagcc tagatcacac tgtagagtga ggcagctagg
     1381 agagctgtgc actcctgaag gattctttct gcaggagctc tggctggtat gtgaaggtgc
     1441 tggctggaga gaaaactggc cagcactgag agacttgggt gggtaactac aggagctata
     1501 ggaaaacggg aaagatacct gtccagggag ggaagagggg aaccagcctt cacttacctc
     1561 agagcacttc cacagacaga tagcattagg cctgtttatg gacaagagat tagcttggaa
     1621 ggagtcagta atacagccat gatcaaaaac cagaatttgg gcctggagag atggcttggt
     1681 ggttaagagc aatggctggc tgttcttcca gaggacctgg gttcaatttc tagtacctac
     1741 aaagcagctc acaacggtct atagctccat ttcagaggat ctgacacaga cacagaaaca
     1801 ccaatgaaca taaaaatata aacataaaaa agtaaataaa aagatgaaag ctggaaaaaa
     1861 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
