LOCUS       NM_130428               2277 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Rattus norvegicus succinate dehydrogenase complex flavoprotein
            subunit A (Sdha), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_130428
VERSION     NM_130428.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2277)
  AUTHORS   Eprintsev,A.T., Fedorin,D.N. and Bakarev,M.Y.
  TITLE     [Molecular and biochemical studies of succinate dehydrogenase in
            rat liver under conditions of alloxan diabetes]
  JOURNAL   Biomed Khim 68 (4), 272-278 (2022)
   PUBMED   36005845
  REMARK    GeneRIF: [Molecular and biochemical studies of succinate
            dehydrogenase in rat liver under conditions of alloxan diabetes].',
            trans 'Molekuliarnye i biokhimicheskie issledovaniia
            suktsinatdegidrogenazy v pecheni krys v usloviiakh alloksanovogo
            diabeta.
REFERENCE   2  (bases 1 to 2277)
  AUTHORS   Signes,A. and Fernandez-Vizarra,E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2277)
  AUTHORS   Grunewald,A., Rygiel,K.A., Hepplewhite,P.D., Morris,C.M., Picard,M.
            and Turnbull,D.M.
  TITLE     Mitochondrial DNA Depletion in Respiratory Chain-Deficient
            Parkinson Disease Neurons
  JOURNAL   Ann Neurol 79 (3), 366-378 (2016)
   PUBMED   26605748
REFERENCE   4  (bases 1 to 2277)
  AUTHORS   Guo,X., Li,D., Wu,Y., Chen,Y., Zhou,X., Wang,X., Huang,X., Li,X.,
            Yang,H. and Xing,J.
  TITLE     Genetic variants in genes of tricarboxylic acid cycle key enzymes
            are associated with prognosis of patients with non-small cell lung
            cancer
  JOURNAL   Lung Cancer 87 (2), 162-168 (2015)
   PUBMED   25576295
REFERENCE   5  (bases 1 to 2277)
  AUTHORS   Claycombe,K.J., Roemmich,J.N., Johnson,L., Vomhof-DeKrey,E.E. and
            Johnson,W.T.
  TITLE     Skeletal muscle Sirt3 expression and mitochondrial respiration are
            regulated by a prenatal low-protein diet
  JOURNAL   J Nutr Biochem 26 (2), 184-189 (2015)
   PUBMED   25483313
  REMARK    GeneRIF: Data suggest activation/acetylation of Sdha in skeletal
            muscle can be regulated by diet; maternal low-protein leads to
            inactivation of Sdha; postnatal high-fat leads to further
            inactivation of Sdha; this increases susceptibility to type 2
            diabetes.
REFERENCE   6  (bases 1 to 2277)
  AUTHORS   Schilling,B., Murray,J., Yoo,C.B., Row,R.H., Cusack,M.P.,
            Capaldi,R.A. and Gibson,B.W.
  TITLE     Proteomic analysis of succinate dehydrogenase and
            ubiquinol-cytochrome c reductase (Complex II and III) isolated by
            immunoprecipitation from bovine and mouse heart mitochondria
  JOURNAL   Biochim Biophys Acta 1762 (2), 213-222 (2006)
   PUBMED   16120479
REFERENCE   7  (bases 1 to 2277)
  AUTHORS   Sun,F., Huo,X., Zhai,Y., Wang,A., Xu,J., Su,D., Bartlam,M. and
            Rao,Z.
  TITLE     Crystal structure of mitochondrial respiratory membrane protein
            complex II
  JOURNAL   Cell 121 (7), 1043-1057 (2005)
   PUBMED   15989954
REFERENCE   8  (bases 1 to 2277)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 2277)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 2277)
  AUTHORS   Bourgeron,T., Rustin,P., Chretien,D., Birch-Machin,M.,
            Bourgeois,M., Viegas-Pequignot,E., Munnich,A. and Rotig,A.
  TITLE     Mutation of a nuclear succinate dehydrogenase gene results in
            mitochondrial respiratory chain deficiency
  JOURNAL   Nat Genet 11 (2), 144-149 (1995)
   PUBMED   7550341
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB072907.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB072907.1, SRR8487231.147407.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2277
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..2277
                     /gene="Sdha"
                     /note="succinate dehydrogenase complex flavoprotein
                     subunit A"
                     /db_xref="GeneID:157074"
                     /db_xref="RGD:621557"
     exon            1..104
                     /gene="Sdha"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2012
                     /gene="Sdha"
                     /EC_number="1.3.5.1"
                     /note="succinate dehydrogenase [ubiquinone] flavoprotein
                     subunit, mitochondrial; fp; flavoprotein subunit of
                     complex II; succinate dehydrogenase complex, subunit A,
                     flavoprotein (Fp); malate dehydrogenase [quinone]
                     flavoprotein subunit"
                     /codon_start=1
                     /product="succinate dehydrogenase [ubiquinone]
                     flavoprotein subunit, mitochondrial precursor"
                     /protein_id="NP_569112.1"
                     /db_xref="GeneID:157074"
                     /db_xref="RGD:621557"
                     /translation="MAGVGAVSRLLRGRRLALAGATRGFHFSVGESKKASAKVSDAIS
                     TQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACLTKLFPTRSHTVAAQGGINAA
                     LGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPASVVELENYGMPFSRTEDGRI
                     YQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLM
                     ENGECRGVIALCIEDGSIHRIRAKNTIIATGGYGRTYFSCTSAHTSTGDGTAMVTRAG
                     LPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDV
                     VSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPI
                     PVLPTVHYNMGGIPTNYKGQVLKHVNGQDQIVPGLYACGEAACASVHGANRLGANSLL
                     DLVVFGRACALSIAESCRPGDKVPPIKANAGEESVMNLDKLRFADGSVRTSELRLSMQ
                     KSMQSHAAVFRVGSVLQEGCEKVSQLYGDLQHLKTFDRGMVWNTDLVETLELQNLMLC
                     ALQTIYGAEARKESRGAHAREDYKVRIDEYDYSKPIEGQQKKPFAEHWRKHTLSYVDT
                     KTGKVTLDYRPVIDKTLNEADCATVPPAIRSY"
     exon            105..167
                     /gene="Sdha"
                     /inference="alignment:Splign:2.1.0"
     exon            168..329
                     /gene="Sdha"
                     /inference="alignment:Splign:2.1.0"
     exon            330..473
                     /gene="Sdha"
                     /inference="alignment:Splign:2.1.0"
     exon            474..638
                     /gene="Sdha"
                     /inference="alignment:Splign:2.1.0"
     exon            639..787
                     /gene="Sdha"
                     /inference="alignment:Splign:2.1.0"
     exon            788..912
                     /gene="Sdha"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1081
                     /gene="Sdha"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1277
                     /gene="Sdha"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1449
                     /gene="Sdha"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1568
                     /gene="Sdha"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1680
                     /gene="Sdha"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1811
                     /gene="Sdha"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1925
                     /gene="Sdha"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2277
                     /gene="Sdha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcaagcgca gtctatcgct gaggcttgcg ggaaggcaaa catggccggg gttggcgcag
       61 tttcgagact tcttcgcggg cggcgcttgg ctctagctgg ggcgactcgt ggctttcact
      121 tctctgttgg tgagagcaag aaggcatccg ctaaagtttc agacgcgatt tctacccagt
      181 accccgtggt ggaccatgag tttgatgctg tggttgtagg tgcaggcggg gcaggcttgc
      241 gagctgcatt cggcctttct gaggcaggct ttaacacggc atgccttaca aagctctttc
      301 ctacccgctc acatactgtt gcagcacagg gaggtatcaa tgctgccctg gggaacatgg
      361 aagaggacaa ctggagatgg catttctatg acaccgtgaa aggctctgac tggctggggg
      421 atcaggatgc catccattac atgacagagc aagctcctgc ctccgtggtt gagctagaaa
      481 attacggtat gccgtttagc aggactgaag atgggaggat ttatcagcgt gcatttggtg
      541 gacagagcct caagttcggg aaaggcgggc aggcccatcg gtgttgctgt gtcgctgatc
      601 ggacgggcca ctcactctta cacaccttgt atggacgatc tctgcggtat gacaccagtt
      661 attttgtgga gtatttcgca ctggatcttc tgatggaaaa tggggagtgc cgtggtgtca
      721 ttgcactgtg catagaagat gggtccatac accgaataag agcaaagaac actattattg
      781 ctactggggg ctatgggcga acctacttca gctgtacttc tgcccacacc agcacagggg
      841 acggcacagc catggtcact cgggctggtt taccttgcca ggacttagaa tttgttcagt
      901 tccaccccac aggtatctat ggtgctggct gcctcatcac agaagggtgc cgtggagagg
      961 gaggcattct catcaacagc caaggcgaaa ggttcatgga gagatatgcc cctgttgcca
     1021 aggacctagc atcaagagat gttgtgtctc gatccatgac tctcgagatc cgtgaaggaa
     1081 gaggctgtgg ccctgagaag gatcacgtct acctgcagtt gcaccatctg ccccctgagc
     1141 agctggccac gcgtctgcct gggatctcag agacggccat gatcttcgcc ggcgtggatg
     1201 tcaccaagga gcccattcca gtccttccca ctgtgcatta caacatgggc gggattccca
     1261 ctaactacaa gggacaggtg ctgaagcacg tgaacggcca ggatcagatt gtgcctggtc
     1321 tgtacgcctg tggggaggct gcctgcgcct cagtgcatgg tgccaaccgg cttggagcaa
     1381 actctctttt ggaccttgtc gtctttggcc gagcctgtgc cctgagcatt gcagaatctt
     1441 gcaggcctgg agataaagtt cctccgatta aggcaaatgc tggagaagag tcggttatga
     1501 atcttgacaa gttgagattt gctgatggaa gtgtaagaac atcagagctg cgcctcagca
     1561 tgcagaagtc gatgcagagc catgccgccg tgttccgtgt gggaagtgtg ctgcaagaag
     1621 gctgtgaaaa agtcagccag ctctatggag acctacagca tctgaagacg tttgacaggg
     1681 gaatggtctg gaacacagac ctggtggaga cgctggagct gcagaatctg atgctgtgcg
     1741 cactgcagac catatatggt gcggaagcac ggaaggagtc acggggagct catgccaggg
     1801 aagattacaa ggtgcggatt gatgagtatg attactccaa gcccatcgag ggccagcaga
     1861 agaagccatt tgcggaacac tggaggaagc acaccctctc atatgtggac accaagactg
     1921 ggaaggttac tttggattac agacctgtta ttgacaagac cttgaatgag gctgactgtg
     1981 ctactgtacc tcctgctatc cgttcctact gaaaaacctg acagctacag gaccagctta
     2041 tgtgattata catcatagct tacctaggtt tcctctcata ctcgtcttgt taaaaatctg
     2101 ctctcatgaa caaggagtca cttcacagat tatgatcaac agcttggcag tacttgatgt
     2161 gagggactcg agttgcacca ttgtctctca ttcttgtgca gtgataaact ggtataattc
     2221 ttaaatgatg tacaaacgaa caatctttta tttctaaata aaaccacata gtatttg
//
