LOCUS       NM_130412               1455 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus stromal cell derived factor 4 (Sdf4), mRNA.
ACCESSION   NM_130412
VERSION     NM_130412.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1455)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 1455)
  AUTHORS   Zhang,Y., Kang,Y.H., Chang,N., Lam,P.P., Liu,Y., Olkkonen,V.M. and
            Gaisano,H.Y.
  TITLE     Cab45b, a Munc18b-interacting partner, regulates exocytosis in
            pancreatic beta-cells
  JOURNAL   J Biol Chem 284 (31), 20840-20847 (2009)
   PUBMED   19487699
  REMARK    GeneRIF: The results suggest a mechanism for Cab45b action that
            involves regulating the dynamic association of Munc18b with SNAREs
            to impact beta-cell granule exocytosis.
REFERENCE   3  (bases 1 to 1455)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 1455)
  AUTHORS   Zhu,Y., Wang,Q., Xu,W. and Li,S.
  TITLE     The ethanol response gene Cab45 can modulate the impairment
            elicited by ethanol and ultraviolet in PC12 cells
  JOURNAL   J Genet Genomics 35 (3), 153-161 (2008)
   PUBMED   18355758
REFERENCE   5  (bases 1 to 1455)
  AUTHORS   Lam,P.P., Hyvarinen,K., Kauppi,M., Cosen-Binker,L., Laitinen,S.,
            Keranen,S., Gaisano,H.Y. and Olkkonen,V.M.
  TITLE     A cytosolic splice variant of Cab45 interacts with Munc18b and
            impacts on amylase secretion by pancreatic acini
  JOURNAL   Mol Biol Cell 18 (7), 2473-2480 (2007)
   PUBMED   17442889
  REMARK    GeneRIF: In a yeast two-hybrid screen the EF-hand Ca(2+)-binding
            protein Cab45 was identified as an interaction partner of Munc18b.
REFERENCE   6  (bases 1 to 1455)
  AUTHORS   Scherer,P.E., Lederkremer,G.Z., Williams,S., Fogliano,M.,
            Baldini,G. and Lodish,H.F.
  TITLE     Cab45, a novel (Ca2+)-binding protein localized to the Golgi lumen
  JOURNAL   J Cell Biol 133 (2), 257-268 (1996)
   PUBMED   8609160
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086996.1.
            
            On Oct 26, 2005 this sequence version replaced NM_130412.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086996.1, FQ218523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1455
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1455
                     /gene="Sdf4"
                     /note="stromal cell derived factor 4"
                     /db_xref="GeneID:155173"
                     /db_xref="RGD:621521"
     exon            1..83
                     /gene="Sdf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1176
                     /gene="Sdf4"
                     /note="SDF-4; cab45"
                     /codon_start=1
                     /product="45 kDa calcium-binding protein"
                     /protein_id="NP_569096.2"
                     /db_xref="GeneID:155173"
                     /db_xref="RGD:621521"
                     /translation="MTSRAPNCAPQTRRIRKPGSPVVWLAAMTSRQRSLCGLAAHGLW
                     FLGLVLLMDATARPANHSFSRERAANRDENEIIPPDHLNGVKLEMDGHLNKDFHQEVF
                     LGKDMDGFDEDSEPRRSRRKLMVIFSKVDVNTDRRISAKEMQHWIMEKTAEHFQEAVK
                     ENKLHFRAVDPDGDGHVSWDEYKVKFLASKGHNEREIADAIKNHEELKVDEETQEVLG
                     NLRDRWYQADNPPADLLLTEDEFLSFLHPEHSRGMLKFMVKEIVRDLDQDGDKQLSLP
                     EFISLPVGTVENQQGQDIDDNWVKDRKKEFEELIDSNHDGIVTMEELENYMDPMNEYN
                     ALNEAKQMIAIADENQNHHLEPEEILKYSEFFTGSKLMDYARNVHEEF"
     exon            84..413
                     /gene="Sdf4"
                     /inference="alignment:Splign:2.1.0"
     exon            414..550
                     /gene="Sdf4"
                     /inference="alignment:Splign:2.1.0"
     exon            551..664
                     /gene="Sdf4"
                     /inference="alignment:Splign:2.1.0"
     exon            665..823
                     /gene="Sdf4"
                     /inference="alignment:Splign:2.1.0"
     exon            824..999
                     /gene="Sdf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1431
                     /gene="Sdf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcggcc tgagccgagt tccgcgtatg acttcgcggg cgcccaactg cgctccccag
       61 acccggcgta tcagaaagcc ggggagtccc gtggtctggc tggcggcaat gacgtccagg
      121 cagaggtccc tctgtggtct ggctgctcat ggcctctggt tcttgggcct tgtccttctg
      181 atggatgcaa ctgctagacc tgccaaccac tcattttctc gggaaagagc agccaacagg
      241 gatgaaaatg agatcatacc cccagaccac ttgaatgggg tgaagctgga gatggatgga
      301 cacctcaata aggacttcca tcaggaggtt ttcctgggaa aggacatgga tgggtttgat
      361 gaggactcag agccacggag aagcaggagg aagctaatgg tcatcttttc caaggtagat
      421 gtgaacactg accggaggat cagcgctaag gagatgcagc actggattat ggagaaaaca
      481 gcagagcact tccaggaggc tgtcaaggag aacaaactac acttcagggc tgtggacccc
      541 gatggtgatg gccatgtgtc ctgggatgaa tataaagtga agtttttggc aagcaaaggc
      601 cacaatgaaa gggagattgc cgatgccatc aagaatcacg aggagctcaa agtggatgag
      661 gagacacagg aagtccttgg gaacctcaga gatcgctggt atcaggcaga caatcctcct
      721 gcagacctgc tgctgactga ggacgagttc ctgtcattcc ttcaccctga gcacagccgg
      781 ggcatgctca agttcatggt caaagagatc gttcgggact tggaccagga tggtgataag
      841 cagttgtctc tgcctgagtt catctctctg cctgtgggta ctgttgagaa ccagcaaggc
      901 caagacattg acgacaactg ggtgaaagac aggaagaaag agtttgagga actgattgat
      961 tctaaccatg atgggattgt gaccatggag gagttggaga actacatgga ccccatgaat
     1021 gaatacaatg ccctcaatga agcaaaacag atgattgcca ttgctgatga gaaccagaat
     1081 caccatctgg agcctgagga gatcctcaag tacagtgagt tcttcacggg cagcaagctg
     1141 atggactatg cccgcaatgt gcatgaagag ttctgagcag acccctcaac tgggaccagg
     1201 tcgccagtat gctgtctgcc ccttcccaca cttggaggag gctatggtcc agtgagacct
     1261 gtagatgact gggtccagat cgggtctaaa atgctaccta ccctgtgtct gagggctacc
     1321 ataagtccct caaagtgctg ttccagaacc ttccttcttc tgttgtgtcc atatgctctg
     1381 gcttagctcc tgccatggca tggcccaggt tcattaaaga tatgctcaat aaaaaaaaaa
     1441 aaaaaaaaaa aaaaa
//
