LOCUS       NM_031986               2088 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus syndecan binding protein (Sdcbp), mRNA.
ACCESSION   NM_031986
VERSION     NM_031986.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2088)
  AUTHORS   Choi,Y., Yun,J.H., Yoo,J., Lee,I., Kim,H., Son,H.N., Kim,I.S.,
            Yoon,H.S., Zimmermann,P., Couchman,J.R., Cho,H.S., Oh,E.S. and
            Lee,W.
  TITLE     New structural insight of C-terminal region of Syntenin-1,
            enhancing the molecular dimerization and inhibitory function
            related on Syndecan-4 signaling
  JOURNAL   Sci Rep 6, 36818 (2016)
   PUBMED   27830760
  REMARK    GeneRIF: syntenin-1 negatively regulates syndecan-4 function via
            oligomerization and/or syndecan-4 interaction, impacting
            cytoskeletal organization and cell migration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2088)
  AUTHORS   Egea-Jimenez,A.L., Gallardo,R., Garcia-Pino,A., Ivarsson,Y.,
            Wawrzyniak,A.M., Kashyap,R., Loris,R., Schymkowitz,J., Rousseau,F.
            and Zimmermann,P.
  TITLE     Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports
            Frizzled 7 trafficking and signalling
  JOURNAL   Nat Commun 7, 12101 (2016)
   PUBMED   27386966
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2088)
  AUTHORS   Hwangbo,C., Tae,N., Lee,S., Kim,O., Park,O.K., Kim,J., Kwon,S.H.
            and Lee,J.H.
  TITLE     Syntenin regulates TGF-beta1-induced Smad activation and the
            epithelial-to-mesenchymal transition by inhibiting
            caveolin-mediated TGF-beta type I receptor internalization
  JOURNAL   Oncogene 35 (3), 389-401 (2016)
   PUBMED   25893292
REFERENCE   4  (bases 1 to 2088)
  AUTHORS   Kashyap,R., Roucourt,B., Lembo,F., Fares,J., Carcavilla,A.M.,
            Restouin,A., Zimmermann,P. and Ghossoub,R.
  TITLE     Syntenin controls migration, growth, proliferation, and cell cycle
            progression in cancer cells
  JOURNAL   Front Pharmacol 6, 241 (2015)
   PUBMED   26539120
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2088)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2088)
  AUTHORS   Koroll,M., Rathjen,F.G. and Volkmer,H.
  TITLE     The neural cell recognition molecule neurofascin interacts with
            syntenin-1 but not with syntenin-2, both of which reveal
            self-associating activity
  JOURNAL   J Biol Chem 276 (14), 10646-10654 (2001)
   PUBMED   11152476
REFERENCE   7  (bases 1 to 2088)
  AUTHORS   Zimmermann,P., Tomatis,D., Rosas,M., Grootjans,J., Leenaerts,I.,
            Degeest,G., Reekmans,G., Coomans,C. and David,G.
  TITLE     Characterization of syntenin, a syndecan-binding PDZ protein, as a
            component of cell adhesion sites and microfilaments
  JOURNAL   Mol Biol Cell 12 (2), 339-350 (2001)
   PUBMED   11179419
REFERENCE   8  (bases 1 to 2088)
  AUTHORS   Fernandez-Larrea,J., Merlos-Suarez,A., Urena,J.M., Baselga,J. and
            Arribas,J.
  TITLE     A role for a PDZ protein in the early secretory pathway for the
            targeting of proTGF-alpha to the cell surface
  JOURNAL   Mol Cell 3 (4), 423-433 (1999)
   PUBMED   10230395
REFERENCE   9  (bases 1 to 2088)
  AUTHORS   Torres,R., Firestein,B.L., Dong,H., Staudinger,J., Olson,E.N.,
            Huganir,R.L., Bredt,D.S., Gale,N.W. and Yancopoulos,G.D.
  TITLE     PDZ proteins bind, cluster, and synaptically colocalize with Eph
            receptors and their ephrin ligands
  JOURNAL   Neuron 21 (6), 1453-1463 (1998)
   PUBMED   9883737
REFERENCE   10 (bases 1 to 2088)
  AUTHORS   Grootjans,J.J., Zimmermann,P., Reekmans,G., Smets,A., Degeest,G.,
            Durr,J. and David,G.
  TITLE     Syntenin, a PDZ protein that binds syndecan cytoplasmic domains
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13683-13688 (1997)
   PUBMED   9391086
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 30, 2020 this sequence version replaced NM_031986.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064651.1, AF248548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000005.1  24287499-24287565
            68-133              JAXUCZ010000005.1  24298673-24298738
            134-218             JAXUCZ010000005.1  24301299-24301383
            219-328             JAXUCZ010000005.1  24302792-24302901
            329-490             JAXUCZ010000005.1  24307143-24307304
            491-666             JAXUCZ010000005.1  24308417-24308592
            667-838             JAXUCZ010000005.1  24311872-24312043
            839-930             JAXUCZ010000005.1  24312669-24312760
            931-2088            JAXUCZ010000005.1  24313555-24314712
FEATURES             Location/Qualifiers
     source          1..2088
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..2088
                     /gene="Sdcbp"
                     /gene_synonym="mda-9; TACIP18"
                     /note="syndecan binding protein"
                     /db_xref="GeneID:83841"
                     /db_xref="RGD:621497"
     exon            1..67
                     /gene="Sdcbp"
                     /gene_synonym="mda-9; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     exon            68..133
                     /gene="Sdcbp"
                     /gene_synonym="mda-9; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..985
                     /gene="Sdcbp"
                     /gene_synonym="mda-9; TACIP18"
                     /note="sdc binding protein; syndecan-binding protein 1;
                     syntenin"
                     /codon_start=1
                     /product="syntenin-1"
                     /protein_id="NP_114192.1"
                     /db_xref="GeneID:83841"
                     /db_xref="RGD:621497"
                     /translation="MSLYPSLEDLKVDKVIQAQTASSANPASQAFFLNVVDSAAFPPG
                     GNLYPKLYPELSQYMGLSLSEAEICENMPVVSGAPTQGQLVARPSSVNYMVAPVTGND
                     AGIRRAEIKQGIREVILCKDQDGKIGLRLKSVDNGIFVQLVQANSPASLVGLRFGDQV
                     LQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTVTMHKDSSGHVGFIFKSG
                     KITSIVKDSSAARNGLLTDHHICEINGQNVIGLKDAQIADILSTAGTVVTITIMPAFI
                     FEHIIKRMAPSIMKSLMDHTIPEV"
     exon            134..218
                     /gene="Sdcbp"
                     /gene_synonym="mda-9; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     exon            219..328
                     /gene="Sdcbp"
                     /gene_synonym="mda-9; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     exon            329..490
                     /gene="Sdcbp"
                     /gene_synonym="mda-9; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     exon            491..666
                     /gene="Sdcbp"
                     /gene_synonym="mda-9; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     exon            667..838
                     /gene="Sdcbp"
                     /gene_synonym="mda-9; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     exon            839..930
                     /gene="Sdcbp"
                     /gene_synonym="mda-9; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     exon            931..2088
                     /gene="Sdcbp"
                     /gene_synonym="mda-9; TACIP18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggccctg aggttcggtt gtgtggagcc ggagcgagcg gcaggaacaa cgcggtgttc
       61 ggggcagaaa acacctgcaa aaatgtctct ctatccatct cttgaagatt tgaaggtaga
      121 caaagtaatt caggctcaaa ctgcctcttc tgctaatcct gccagccagg cctttttttt
      181 aaatgtggtc gattctgctg ccttccctcc aggtggaaat ctctatccta aactgtatcc
      241 agaactctct caatacatgg gactgtcttt aagtgaagct gaaatatgtg aaaacatgcc
      301 tgtggtctct ggagcgccaa cccaagggca gttggtagca aggccatcca gtgtgaacta
      361 catggtagca cctgtgacag gtaacgatgc ggggattagg agagcagaga ttaagcaagg
      421 gattcgggaa gtcattttgt gtaaggatca agatggaaaa attgggctca gactgaagtc
      481 agtagataat ggtatatttg ttcaactagt ccaggctaat tccccagcct ccttggttgg
      541 gctgcgattt ggggaccagg tgctccagat caatggtgaa aactgtgccg gctggagctc
      601 cgataaggca cacaaggtgc tcaagcaggc ctttggagag aagattacca tgaccattcg
      661 tgatagaccc tttgaacgga cagttaccat gcataaggac agcagtggac atgttggctt
      721 tatctttaaa agtggaaaaa tcacatccat agtgaaagac agttctgctg ccagaaacgg
      781 ccttctcact gatcaccaca tctgtgagat caacggacag aacgtcattg gcttgaagga
      841 tgctcagatt gcagatatac tgtcaacagc tgggactgtg gtcaccatca caatcatgcc
      901 tgcctttatc ttcgaacata ttattaaacg gatggctccc agcattatga aaagcctgat
      961 ggatcacacc attcctgaag tttaaacctt gtacagtgca tcaccgccga acgcttccag
     1021 tcttcctctt cggcaacttc tctatttcac cgcacatgaa gctttcccgg atccagggag
     1081 actgtgctgc atggagacct gtctatcttc caccatggct gggaacctca ctctatctga
     1141 gagcgtcttc agattttaag ataggtgtag ccttatcctg gttttacaga tgtgaaactc
     1201 tcaaaagatt ccctgacttt ctagacttgg ttctttactg ggaacctgat gtttttctat
     1261 aagccattgt gattaggatg actggtgtag gcttagctgt gtccgagaac tggtctgctt
     1321 tctccgagaa gtgcacagtg ctaggcacgt gcttcagttc tgtggcatat gtggattgta
     1381 gtacatcagc atagtacctg taggatgatt gcctttgatc gctacttttt aagtttgtgt
     1441 gtgagtgtgt aaaattccag ttaatcaaca cttccattcc acaaaagcat tatacagttc
     1501 tgtgtaggtg gcaagagact aatgattgtc actaaattct aactaccttc acttaatgtg
     1561 cttcagttgt cgccttaact acagtaagca tttagaataa aagccaaaat agaattattg
     1621 ctgccttctg aaacctgaga ggttagctct ctatcaagct gttctatgct agccctgagc
     1681 agcttactgg tgtcgcagag ctgcctagct gtaccaagat tttctagtca ctgcataaag
     1741 gaaacgccta agagttgccg tattgctttc tgagatacaa attgctatat atttcatgta
     1801 aaagttgtta tactaaatag gataaatttt ggagtctctt tttcactcgt agattaagtg
     1861 ggtaatatct aatttggcac ttgagtccta acattatgta actttagcta ggttggggtg
     1921 ggtttagaat gtttccctag tcatctcagt ttgttccatt ttctgactct atcctgcaaa
     1981 caaaaatggc aatgacactt tatcctgact ctttccttct tagtttgtgc ctatcttatt
     2041 attttatgtg atattatcct attaaatgta taaaaatatt aaatgtca
//
