LOCUS       NM_012649               2487 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus syndecan 4 (Sdc4), mRNA.
ACCESSION   NM_012649
VERSION     NM_012649.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2487)
  AUTHORS   Valdivia,A., Cardenas,A., Brenet,M., Maldonado,H., Kong,M.,
            Diaz,J., Burridge,K., Schneider,P., San Martin,A., Garcia-Mata,R.,
            Quest,A.F.G. and Leyton,L.
  TITLE     Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in
            mesenchymal cells
  JOURNAL   Cell Commun Signal 18 (1), 129 (2020)
   PUBMED   32811537
  REMARK    GeneRIF: Syndecan-4/PAR-3 signaling regulates focal adhesion
            dynamics in mesenchymal cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2487)
  AUTHORS   Choi,Y., Yun,J.H., Yoo,J., Lee,I., Kim,H., Son,H.N., Kim,I.S.,
            Yoon,H.S., Zimmermann,P., Couchman,J.R., Cho,H.S., Oh,E.S. and
            Lee,W.
  TITLE     New structural insight of C-terminal region of Syntenin-1,
            enhancing the molecular dimerization and inhibitory function
            related on Syndecan-4 signaling
  JOURNAL   Sci Rep 6, 36818 (2016)
   PUBMED   27830760
  REMARK    GeneRIF: syntenin-1 negatively regulates syndecan-4 function via
            oligomerization and/or syndecan-4 interaction, impacting
            cytoskeletal organization and cell migration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2487)
  AUTHORS   Kwon,M.J., Park,J., Jang,S., Eom,C.Y. and Oh,E.S.
  TITLE     The Conserved Phenylalanine in the Transmembrane Domain Enhances
            Heteromeric Interactions of Syndecans
  JOURNAL   J Biol Chem 291 (2), 872-881 (2016)
   PUBMED   26601939
REFERENCE   4  (bases 1 to 2487)
  AUTHORS   Kim,E.Y., Roshanravan,H. and Dryer,S.E.
  TITLE     Syndecan-4 ectodomain evokes mobilization of podocyte TRPC6
            channels and their associated pathways: An essential role for
            integrin signaling
  JOURNAL   Biochim Biophys Acta 1853 (10 Pt A), 2610-2620 (2015)
   PUBMED   26193076
  REMARK    GeneRIF: Locally generated Sdc4 may play a role in regulating TRPC6
            channels, and may contribute to glomerular pathology.
            Erratum:[Biochim Biophys Acta. 2015 Dec;1853(12):3294]
REFERENCE   5  (bases 1 to 2487)
  AUTHORS   Beckett,M.C., Ralphs,J.R., Caterson,B. and Hayes,A.J.
  TITLE     The transmembrane heparan sulphate proteoglycan syndecan-4 is
            involved in establishment of the lamellar structure of the annulus
            fibrosus of the intervertebral disc
  JOURNAL   Eur Cell Mater 30, 69-88;discussion88 (2015)
   PUBMED   26272378
  REMARK    GeneRIF: syndecan-4 is involved in establishment of the lamellar
            structure of the annulus fibrosus of the intervertebral disc
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2487)
  AUTHORS   Kojima,T., Takagi,A., Maeda,M., Segawa,T., Shimizu,A., Yamamoto,K.,
            Matsushita,T. and Saito,H.
  TITLE     Plasma levels of syndecan-4 (ryudocan) are elevated in patients
            with acute myocardial infarction
  JOURNAL   Thromb Haemost 85 (5), 793-799 (2001)
   PUBMED   11372670
REFERENCE   7  (bases 1 to 2487)
  AUTHORS   Woods,A., Longley,R.L., Tumova,S. and Couchman,J.R.
  TITLE     Syndecan-4 binding to the high affinity heparin-binding domain of
            fibronectin drives focal adhesion formation in fibroblasts
  JOURNAL   Arch Biochem Biophys 374 (1), 66-72 (2000)
   PUBMED   10640397
REFERENCE   8  (bases 1 to 2487)
  AUTHORS   Longley,R.L., Woods,A., Fleetwood,A., Cowling,G.J., Gallagher,J.T.
            and Couchman,J.R.
  TITLE     Control of morphology, cytoskeleton and migration by syndecan-4
  JOURNAL   J Cell Sci 112 (Pt 20), 3421-3431 (1999)
   PUBMED   10504291
REFERENCE   9  (bases 1 to 2487)
  AUTHORS   Shworak,N.W., Kojima,T. and Rosenberg,R.D.
  TITLE     Isolation and characterization of ryudocan and syndecan heparan
            sulfate proteoglycans, core proteins, and cDNAs from a rat
            endothelial cell line
  JOURNAL   Haemostasis 23 Suppl 1, 161-176 (1993)
   PUBMED   8495865
REFERENCE   10 (bases 1 to 2487)
  AUTHORS   Kojima,T., Shworak,N.W. and Rosenberg,R.D.
  TITLE     Molecular cloning and expression of two distinct cDNA-encoding
            heparan sulfate proteoglycan core proteins from a rat endothelial
            cell line
  JOURNAL   J Biol Chem 267 (7), 4870-4877 (1992)
   PUBMED   1537865
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000120.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_012649.4.
            
            On Feb 10, 2021 this sequence version replaced NM_012649.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK600963.1, FM029678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN16676784
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JACYVU010000120.1  7745722-7745811     c
            91-226              JACYVU010000120.1  7733987-7734122     c
            227-273             JACYVU010000120.1  7732648-7732694     c
            274-472             JACYVU010000120.1  7731786-7731984     c
            473-2487            JACYVU010000120.1  7727123-7729137     c
FEATURES             Location/Qualifiers
     source          1..2487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2487
                     /gene="Sdc4"
                     /gene_synonym="RATRYUDOCA; RYUDOCA"
                     /note="syndecan 4"
                     /db_xref="GeneID:24771"
                     /db_xref="RGD:3650"
     exon            1..90
                     /gene="Sdc4"
                     /gene_synonym="RATRYUDOCA; RYUDOCA"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..624
                     /gene="Sdc4"
                     /gene_synonym="RATRYUDOCA; RYUDOCA"
                     /note="SYND4; ryudocan core protein; Ryudocan/syndecan 4"
                     /codon_start=1
                     /product="syndecan-4 precursor"
                     /protein_id="NP_036781.1"
                     /db_xref="GeneID:24771"
                     /db_xref="RGD:3650"
                     /translation="MAPVCLFAPLLLLLLGGFPVAPGESIRETEVIDPQDLLEGRYFS
                     GALPDDEDAGGLEQDSDFELSGSGDLDDTEEPRTFPEVISPLVPLDNHIPENAQPGIR
                     VPSEPKELEENEVIPKRVPSDVGDDDVSNKVSMSSTSQGSNIFERTEVLAALIVGGVV
                     GILFAVFLILLLVYRMKKKDEGSYDLGKKPIYKKAPTNEFYA"
     exon            91..226
                     /gene="Sdc4"
                     /gene_synonym="RATRYUDOCA; RYUDOCA"
                     /inference="alignment:Splign:2.1.0"
     exon            227..273
                     /gene="Sdc4"
                     /gene_synonym="RATRYUDOCA; RYUDOCA"
                     /inference="alignment:Splign:2.1.0"
     exon            274..472
                     /gene="Sdc4"
                     /gene_synonym="RATRYUDOCA; RYUDOCA"
                     /inference="alignment:Splign:2.1.0"
     exon            473..2487
                     /gene="Sdc4"
                     /gene_synonym="RATRYUDOCA; RYUDOCA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgctgttg gaaccatggc gcctgtctgc ctgtttgcgc cgctgctgct gttgctcctc
       61 ggaggtttcc ccgtcgcccc aggcgagtcg attcgagaga ctgaggtcat agacccccag
      121 gacctcctgg aaggcagata cttctctgga gccctcccgg acgatgaaga cgctgggggc
      181 cttgagcagg actctgactt tgagctgtcg ggttccggag atctagatga cacggaggag
      241 cccaggacct tccctgaggt gatttcaccc ttggtgccac tagataacca catccccgag
      301 aatgcccagc ctggcatccg tgtcccctca gagcccaagg aactggaaga gaatgaggtc
      361 attcccaaaa gggtcccctc cgacgtgggg gatgacgatg tgtccaacaa agtgtccatg
      421 tccagcactt cccagggcag caacattttt gaaagaactg aggtcttggc agctctgatt
      481 gtgggcggcg tagtgggcat cctcttcgcc gttttcctga tcctgctgct ggtgtaccgc
      541 atgaagaaga aggatgaagg cagttacgac ttgggcaaga aacccatcta caaaaaagcc
      601 cccaccaacg agttctacgc atgaagcttc ttcccatgag tgctgcttgg acttcatggg
      661 gagaggagtt gaggattgtg gacagtggac attggcagag agagggcacc ttaatactga
      721 cttgtatctc catctctggt cacctttctg gtgtcagaag agatatgatc ttctactgtg
      781 ctgcctcaga gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga
      841 gatgggatgg ggtgcggagg gagtgtccgt gtgtgtgtgt gtccgtgtgt gtgtgtgtgt
      901 gtgtgtgtgt gtgtctgtct gtctgagttg ccctggcaga aaaatggggt taaacttgtt
      961 ctttcttgaa ggcaagcctg gaattgggtc tttttgttgt tgtttcaaat ttctagaata
     1021 gaatgtagga ccagtttagt tcctgccgtt aacatgtctc atttatgact gcctttattc
     1081 tagaggcaag gagttggggg caaggagccg gaacccgctg caccttgaga tgtgttcacc
     1141 cgagtacttc ctcacactac agggtctctg tggtgtatct cggggcattc taggctcagt
     1201 gacttttgaa attcaacctt tttttttttt tttttaaatc cagggagggt gggactgaag
     1261 tgctgacagc tcatgctgaa gtacacttgt agaagatttg taaaatgtaa ggtttttttt
     1321 tttttttttt ttaatggtcc attccttcat gggagcgtgt gcgcctgggc tgagagcgtg
     1381 gggatgcaca gatgttcttt ctagaacata tccgttgcaa cagctaactt tgtgttttca
     1441 tggtttttta tgttttgttt tgtttttttg aaaatgagag aagagctgga gagatgattt
     1501 ttatgatttt ttttgttttg ttttttacta tttatagctt cagacggggc tgcttttctc
     1561 tacctttctg tctttactgt ttcccactat ttttttttaa tgttctgtgc tcttgttttt
     1621 gaccctggcc ctttctgaag ttgctttatc ttaaaaagta gctacagtgt tctagcagat
     1681 tccagaatat aatgtagggg gtagcgggat atttgtgttc ttgtaatata tattatcctt
     1741 cctcggttct aggagaatag ataaatatat ttttttagga tatagaatga tactacaggt
     1801 ctcatgttgg ctgggtggct gcgtgagtga gttttcgtgc ggctgagtaa gctgttgccc
     1861 tcttctcttg ccctgctcct ggtgccttct cgagatcgag ctggagtgac tgagggtacc
     1921 tgactctaac ctcactgtgc cttctgccgg gggctctgcc caggagcctc tgggtttgct
     1981 ttctccaggc tctctagatg cacgatccaa tacagtgacc tcctgtggct gtatcaatca
     2041 gttcacttga ctatgtgatt ggaaatcatt cctctgttgc actggccaca caatttaagt
     2101 gcctagtcac catccaccga gcacagagat tgaggctggt ttagcaggtt acggttcagt
     2161 tttgcttgtc tccccgggca agagaagggg acttaggagg aaggtgatga ggtcccaggg
     2221 actcctgtca cccaggactc tccctcttac agaggaaaga cctagtagct taaaaggtct
     2281 gggctgtgtg ggggtggggc ggtcatacca ctccctcaac catgccctat gcctgtaagc
     2341 ccccatcacc acctccgtgc agggtcctag ctggctgggt cctcttctag ccttgtgcct
     2401 gctccttttc tgtatccctt actctgtcgt ctgttactga tttttttgat aaaaagataa
     2461 taaaacctgg tactttctag atcgcca
//
