LOCUS       NM_013082               2155 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus syndecan 2 (Sdc2), mRNA.
ACCESSION   NM_013082
VERSION     NM_013082.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2155)
  AUTHORS   Jang,B., Jung,H., Choi,S., Lee,Y.H., Lee,S.T. and Oh,E.S.
  TITLE     Syndecan-2 cytoplasmic domain up-regulates matrix
            metalloproteinase-7 expression via the protein kinase
            Cgamma-mediated FAK/ERK signaling pathway in colon cancer
  JOURNAL   J Biol Chem 292 (39), 16321-16332 (2017)
   PUBMED   28821612
  REMARK    GeneRIF: Data suggest that the cytoplasmic domain of Sdc2 is
            involved in regulation of expression of MMP7 in colon
            carcinoma/adenocarcinoma cells; induction of MMP7 involves protein
            kinase C gamma-mediated FAK/ERK signaling. (Sdc2 = syndecan-2; MMP7
            = matrix metalloproteinase-7; FAK = focal adhesion kinase 1)
REFERENCE   2  (bases 1 to 2155)
  AUTHORS   Hu,H.T., Umemori,H. and Hsueh,Y.P.
  TITLE     Postsynaptic SDC2 induces transsynaptic signaling via FGF22 for
            bidirectional synaptic formation
  JOURNAL   Sci Rep 6, 33592 (2016)
   PUBMED   27627962
  REMARK    GeneRIF: postsynaptic SDC2 uses its ectodomain to interact with and
            facilitate dendritic filopodial targeting of FGF22, triggering
            presynaptic maturation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2155)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (bases 1 to 2155)
  AUTHORS   Kwon,M.J., Park,J., Jang,S., Eom,C.Y. and Oh,E.S.
  TITLE     The Conserved Phenylalanine in the Transmembrane Domain Enhances
            Heteromeric Interactions of Syndecans
  JOURNAL   J Biol Chem 291 (2), 872-881 (2016)
   PUBMED   26601939
REFERENCE   5  (bases 1 to 2155)
  AUTHORS   Choi,Y., Kwon,M.J., Lim,Y., Yun,J.H., Lee,W. and Oh,E.S.
  TITLE     Trans-regulation of Syndecan Functions by Hetero-oligomerization
  JOURNAL   J Biol Chem 290 (27), 16943-16953 (2015)
   PUBMED   25979339
  REMARK    GeneRIF: Syndecan-2 and -4 form heterdimer and this interaction
            regulates syndecan-mediated cellular functions.
REFERENCE   6  (bases 1 to 2155)
  AUTHORS   Hsueh,Y.P., Roberts,A.M., Volta,M., Sheng,M. and Roberts,R.G.
  TITLE     Bipartite interaction between neurofibromatosis type I protein
            (neurofibromin) and syndecan transmembrane heparan sulfate
            proteoglycans
  JOURNAL   J Neurosci 21 (11), 3764-3770 (2001)
   PUBMED   11356864
  REMARK    Erratum:[J Neurosci. 2017 Feb 1;37(5):1374. doi:
            10.1523/JNEUROSCI.3824-16.2016.. PMID: 28148807]
REFERENCE   7  (bases 1 to 2155)
  AUTHORS   Hsueh,Y.P. and Sheng,M.
  TITLE     Regulated expression and subcellular localization of syndecan
            heparan sulfate proteoglycans and the syndecan-binding protein
            CASK/LIN-2 during rat brain development
  JOURNAL   J Neurosci 19 (17), 7415-7425 (1999)
   PUBMED   10460248
REFERENCE   8  (bases 1 to 2155)
  AUTHORS   Ethell,I.M. and Yamaguchi,Y.
  TITLE     Cell surface heparan sulfate proteoglycan syndecan-2 induces the
            maturation of dendritic spines in rat hippocampal neurons
  JOURNAL   J Cell Biol 144 (3), 575-586 (1999)
   PUBMED   9971750
REFERENCE   9  (bases 1 to 2155)
  AUTHORS   Hsueh,Y.P., Yang,F.C., Kharazia,V., Naisbitt,S., Cohen,A.R.,
            Weinberg,R.J. and Sheng,M.
  TITLE     Direct interaction of CASK/LIN-2 and syndecan heparan sulfate
            proteoglycan and their overlapping distribution in neuronal
            synapses
  JOURNAL   J Cell Biol 142 (1), 139-151 (1998)
   PUBMED   9660869
REFERENCE   10 (bases 1 to 2155)
  AUTHORS   Pierce,A., Lyon,M., Hampson,I.N., Cowling,G.J. and Gallagher,J.T.
  TITLE     Molecular cloning of the major cell surface heparan sulfate
            proteoglycan from rat liver
  JOURNAL   J Biol Chem 267 (6), 3894-3900 (1992)
   PUBMED   1740437
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_013082.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M81687.1, FQ222974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-443               JAXUCZ010000007.1  66012405-66012847
            444-555             JAXUCZ010000007.1  66109621-66109732
            556-689             JAXUCZ010000007.1  66115911-66116044
            690-825             JAXUCZ010000007.1  66122366-66122501
            826-2155            JAXUCZ010000007.1  66123772-66125101
FEATURES             Location/Qualifiers
     source          1..2155
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2155
                     /gene="Sdc2"
                     /gene_synonym="HSPG"
                     /note="syndecan 2"
                     /db_xref="GeneID:25615"
                     /db_xref="RGD:3649"
     exon            1..443
                     /gene="Sdc2"
                     /gene_synonym="HSPG"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..989
                     /gene="Sdc2"
                     /gene_synonym="HSPG"
                     /note="SYND2; fibroglycan; heparan sulfate proteoglycan
                     core protein; Ryudocan/syndecan 2"
                     /codon_start=1
                     /product="syndecan-2 precursor"
                     /protein_id="NP_037214.1"
                     /db_xref="GeneID:25615"
                     /db_xref="RGD:3649"
                     /translation="MRVRATSPGNMQRAWILLTLGLMACVSAETRAELTSDKDMYLDS
                     SSIEEASGLYPIDDDDYSSASGSGAYEDKGSPDLTTSQLIPRISLTSAAPEVETMTLK
                     TQSITPTQTESPEETDKKEFEISEAEEKQDPAVKSTDVYTEKHSDNLFKRTEVLAAVI
                     AGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA"
     exon            444..555
                     /gene="Sdc2"
                     /gene_synonym="HSPG"
                     /inference="alignment:Splign:2.1.0"
     exon            556..689
                     /gene="Sdc2"
                     /gene_synonym="HSPG"
                     /inference="alignment:Splign:2.1.0"
     exon            690..825
                     /gene="Sdc2"
                     /gene_synonym="HSPG"
                     /inference="alignment:Splign:2.1.0"
     exon            826..2155
                     /gene="Sdc2"
                     /gene_synonym="HSPG"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtcccctcc gttctgcatc cccaaacttc agccgcagct ctgtttcaac ccatcggctg
       61 cttgcttcaa atcagacagc accgcgaccc agacacccga gtccgcggag tgaaagcaca
      121 acgccgagta ggaccagacc aggaaaatag actcgtgaag cagcaactct ggattgggag
      181 ggcagaagcc aacaagtgag aaggcgcggc gtttccgggg cgctgtgcga aagctagagc
      241 aggcgccaga gaagacagct cgagctcaga acccgagacc aagcctctct cccggaggca
      301 gctcagctcc tatcttctct aggcccgctg cagcgtgcgc tgggcttcgt tttatgcggg
      361 tacgagccac gtccccgggg aatatgcagc gtgcgtggat cctgctcacc ttgggcttga
      421 tggcctgtgt gtcggcagag acgagagcag agctgacatc tgataaggac atgtaccttg
      481 acagcagctc cattgaggaa gcttcaggat tatatcctat tgatgatgat gactattctt
      541 ctgcctctgg ctcaggagct tatgaagaca aagggagtcc agatctgaca acatcccaac
      601 tgattccaag gatctccctc actagtgctg ctcccgaagt ggaaaccatg acgttgaaga
      661 cacaaagcat cacacccact cagaccgagt cacccgaaga aactgacaag aaggagtttg
      721 aaatctctga ggcagaagaa aagcaggacc ctgctgtaaa aagcacagac gtgtacaccg
      781 agaaacattc agacaatctg ttcaagcgga cggaagttct agcagctgtc attgctggcg
      841 gtgtgattgg ctttctcttt gccattttcc tcatcctgtt gttggtgtac cgcatgcgga
      901 agaaagacga aggaagctac gaccttggag aacgcaaacc gtccagcgca gcttaccaga
      961 aggcacccac taaggagttt tatgcataaa actcccactt agtgtctcta tttaagagat
     1021 cactgaactt ttcaaaataa agctttagca tagaataatg aatatctttg ttatctgttt
     1081 tgttcattac agagccatgc tggcccttta atgatgaaga tcccattgta tttaaaattt
     1141 ttcatatatt tctttagaat gacttaaaag taaaaattta acatctgcag tgttctgtga
     1201 atagcagtgg caaaatattt tgttacaaaa acccttgaca ttcatggaat tgatttgaac
     1261 atctatgtgc aaatacaaaa tgattgtgtt tgtcctctgg ttcaaagatg actgctgttc
     1321 ccctcatcag cagatctcca gttgacctta ccgagttgat ctttgttaat ttatctcttg
     1381 ttcctcttct ctgccctccc ttcttgtctc ctcccttaaa aacaaaacct tatgcctttt
     1441 gtagctgtca tggtgcaatt tgtctttgaa tgattacaat aatggtaatt tagtgtatat
     1501 gtgatttttt tcaattatgt aaactttaac ctcctcttta tgtaattttt ttaaatgtca
     1561 gactacccat tttacacttg ctttaatttc cattccctgt agcttcaggc agatttgcaa
     1621 aggcaaatta taaaattgga ttattactac gaaactgtta gtcctagtta tctaagcaga
     1681 tcttctcttg gaggatttga catcactgac aagcctcagc aaacccaaag atgctaacag
     1741 tatttgagaa gttgctacag actcctttgg ccactgtact tgctagttta caatttgaag
     1801 gtacaaggaa gagtttaaag gaaaaaaaag atcagttttt gttcttaaaa atgcatttaa
     1861 gttgtaaaca tctttttaag cctttgaagt gcctatgatt ctatgtaact tgttgcagac
     1921 tggtgttaat gagtatatat aacagttttt aaaaagttgg tattttataa gcacagacaa
     1981 ttctaatggt aacttttgta gtcttatgaa tagacataaa ttgtaatttg ggaacaagca
     2041 aactactgaa taaatcacat ggcctaatat tgaaaatgtc actgttataa attttgtaca
     2101 tttcttatca aatgtacagc ttccctttgc tatgactgac tgtctgttct cagtg
//
