LOCUS       NM_013026               3021 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus syndecan 1 (Sdc1), mRNA.
ACCESSION   NM_013026
VERSION     NM_013026.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3021)
  AUTHORS   Qin,L.L., Xue,F., Yin,F., Zhao,J. and Zhang,K.Y.
  TITLE     Expression of syndecan-1, PKC and VEGF in rats with acute kidney
            injury and correlation between syndecan-1 and renal function
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (24), 12794-12801 (2020)
   PUBMED   33378064
  REMARK    GeneRIF: Expression of syndecan-1, PKC and VEGF in rats with acute
            kidney injury and correlation between syndecan-1 and renal
            function.
REFERENCE   2  (bases 1 to 3021)
  AUTHORS   Jing,Z., Wei-Jie,Y., Yi-Feng,Z.G. and Jing,H.
  TITLE     Downregulation of Syndecan-1 induce glomerular endothelial cell
            dysfunction through modulating internalization of VEGFR-2
  JOURNAL   Cell Signal 28 (8), 826-837 (2016)
   PUBMED   27075925
  REMARK    GeneRIF: down-regulation of Syndecan-1 could inhibit VEGF-VEGFR-2
            signaling through regulating internalization of VEGFR-2.
REFERENCE   3  (bases 1 to 3021)
  AUTHORS   Torres Filho,I.P., Torres,L.N., Salgado,C. and Dubick,M.A.
  TITLE     Plasma syndecan-1 and heparan sulfate correlate with microvascular
            glycocalyx degradation in hemorrhaged rats after different
            resuscitation fluids
  JOURNAL   Am J Physiol Heart Circ Physiol 310 (11), H1468-H1478 (2016)
   PUBMED   27037369
  REMARK    GeneRIF: Plasma syndecan-1 and heparan sulfate correlate with
            microvascular glycocalyx degradation in hemorrhaged rats after
            different resuscitation fluids.
REFERENCE   4  (bases 1 to 3021)
  AUTHORS   Kwon,M.J., Park,J., Jang,S., Eom,C.Y. and Oh,E.S.
  TITLE     The Conserved Phenylalanine in the Transmembrane Domain Enhances
            Heteromeric Interactions of Syndecans
  JOURNAL   J Biol Chem 291 (2), 872-881 (2016)
   PUBMED   26601939
REFERENCE   5  (bases 1 to 3021)
  AUTHORS   Adepu,S., Rosman,C.W., Dam,W., van Dijk,M.C., Navis,G., van
            Goor,H., Bakker,S.J. and van den Born,J.
  TITLE     Incipient renal transplant dysfunction associates with tubular
            syndecan-1 expression and shedding
  JOURNAL   Am J Physiol Renal Physiol 309 (2), F137-F145 (2015)
   PUBMED   25972509
  REMARK    GeneRIF: expression upregulated two months after renal
            transplantation
REFERENCE   6  (bases 1 to 3021)
  AUTHORS   Larrain,J., Cizmeci-Smith,G., Troncoso,V., Stahl,R.C., Carey,D.J.
            and Brandan,E.
  TITLE     Syndecan-1 expression is down-regulated during myoblast terminal
            differentiation. Modulation by growth factors and retinoic acid
  JOURNAL   J Biol Chem 272 (29), 18418-18424 (1997)
   PUBMED   9218485
REFERENCE   7  (bases 1 to 3021)
  AUTHORS   Nakanishi,T., Kadomatsu,K., Okamoto,T., Ichihara-Tanaka,K.,
            Kojima,T., Saito,H., Tomoda,Y. and Muramatsu,T.
  TITLE     Expression of syndecan-1 and -3 during embryogenesis of the central
            nervous system in relation to binding with midkine
  JOURNAL   J Biochem 121 (2), 197-205 (1997)
   PUBMED   9089390
REFERENCE   8  (bases 1 to 3021)
  AUTHORS   Shworak,N.W., Kojima,T. and Rosenberg,R.D.
  TITLE     Isolation and characterization of ryudocan and syndecan heparan
            sulfate proteoglycans, core proteins, and cDNAs from a rat
            endothelial cell line
  JOURNAL   Haemostasis 23 Suppl 1, 161-176 (1993)
   PUBMED   8495865
REFERENCE   9  (bases 1 to 3021)
  AUTHORS   Cizmeci-Smith,G., Asundi,V., Stahl,R.C., Teichman,L.J.,
            Chernousov,M., Cowan,K. and Carey,D.J.
  TITLE     Regulated expression of syndecan in vascular smooth muscle cells
            and cloning of rat syndecan core protein cDNA
  JOURNAL   J Biol Chem 267 (22), 15729-15736 (1992)
   PUBMED   1639809
REFERENCE   10 (bases 1 to 3021)
  AUTHORS   Kojima,T., Shworak,N.W. and Rosenberg,R.D.
  TITLE     Molecular cloning and expression of two distinct cDNA-encoding
            heparan sulfate proteoglycan core proteins from a rat endothelial
            cell line
  JOURNAL   J Biol Chem 267 (7), 4870-4877 (1992)
   PUBMED   1537865
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061834.1.
            
            On Dec 20, 2003 this sequence version replaced NM_013026.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061834.1, M81785.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3021
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..3021
                     /gene="Sdc1"
                     /gene_synonym="HSPG; Synd1; SYNDECA; Syndecan"
                     /note="syndecan 1"
                     /db_xref="GeneID:25216"
                     /db_xref="RGD:3648"
     exon            1..274
                     /gene="Sdc1"
                     /gene_synonym="HSPG; Synd1; SYNDECA; Syndecan"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1150
                     /gene="Sdc1"
                     /gene_synonym="HSPG; Synd1; SYNDECA; Syndecan"
                     /codon_start=1
                     /product="syndecan-1 precursor"
                     /protein_id="NP_037158.1"
                     /db_xref="GeneID:25216"
                     /db_xref="RGD:3648"
                     /translation="MRRAALWLWLCALALRLQPALPQIVTANVPPEDQDGSGDDSDNF
                     SGSGTGALPDMTLSRQTPSTWKDVWLLTATPTAPEPTSRDTEATLTSILPAGEKPEEG
                     EPVAHVEAEPDFTARDKEKEATTRPRETTQLPVTQQASTAARATTAQASVTSHPHGDV
                     QPGLHETLAPTAPGQPDHQPPSVEDGGTSVIKEVVEDETTNQLPAGEGSGEQDFTFET
                     SGENTAVAGVEPDLRNQSPVDEGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVAF
                     MLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA"
     exon            275..356
                     /gene="Sdc1"
                     /gene_synonym="HSPG; Synd1; SYNDECA; Syndecan"
                     /inference="alignment:Splign:2.1.0"
     exon            357..844
                     /gene="Sdc1"
                     /gene_synonym="HSPG; Synd1; SYNDECA; Syndecan"
                     /inference="alignment:Splign:2.1.0"
     exon            845..980
                     /gene="Sdc1"
                     /gene_synonym="HSPG; Synd1; SYNDECA; Syndecan"
                     /inference="alignment:Splign:2.1.0"
     exon            981..3008
                     /gene="Sdc1"
                     /gene_synonym="HSPG; Synd1; SYNDECA; Syndecan"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagcctgg cgctgaggaa ggaatctggc agtcgagagc tgactccagc cgacggaacc
       61 tgcagccctt gctccggaca gcagcgcgcc gggcaggagt ccgggatagc gaagcgcaga
      121 gcaatcagca gagcctgccc ggagctccgt gcaaccggca actccgaccc acatagcccg
      181 ccgagctccc gccgccggtc cgggcagcat gagacgtgcg gcgctctggc tttggctctg
      241 cgcgctggcg ctgcgcctgc agcctgccct cccgcaaatt gtcaccgcaa atgtgcctcc
      301 tgaagaccaa gatggctctg gggacgactc agacaacttc tctggctcag gcacaggtgc
      361 tttgccagat atgactttgt cacggcagac accttccact tggaaggatg tgtggctcct
      421 gacagctaca cccacagctc cagaacccac cagcagggat accgaggcca ccctcacctc
      481 tatcctgccg gctggagaga agcctgagga gggagagccc gtggcccacg tggaagcaga
      541 gcctgacttc actgctcggg acaaggagaa ggaggccacc accaggccta gggagaccac
      601 acagctccca gtcacccaac aggcctcaac agcagccaga gccaccacgg cccaggcatc
      661 tgtcacgtct catccccacg gggatgtgca acctggcctc cacgagacct tggctcccac
      721 agcacccggc caacctgacc atcagcctcc aagtgtggag gatggaggca cttctgtcat
      781 caaagaggtt gtggaggatg aaactaccaa tcagcttcct gcaggagagg gctctggaga
      841 acaagacttc acctttgaaa catctgggga gaacacagct gtggctggcg tcgagcctga
      901 ccttcggaat cagtccccag tggatgaagg agccacaggt gcttctcagg gccttttgga
      961 caggaaggaa gtgctgggag gtgtcattgc tggaggcctg gtgggcctca tctttgctgt
     1021 gtgcctggtg gctttcatgc tataccggat gaagaagaag gacgaaggca gttactcctt
     1081 ggaggagccc aaacaagcca atggcggtgc ctaccagaaa cccaccaagc aggaagagtt
     1141 ctacgcctga tggggaaata gttctccccc cacaacccct gccactcact aggctcccat
     1201 ttgcctcttc tgtgaaaaac ttcaagccct ggcctcccta ccgctgtgcc gtctcctctg
     1261 cacccagacc cttctgcccg agcggtctca gggtgtgctg ggaattcctt ctcctctgac
     1321 ttctgctaga agcttgggtg cagagggttt cttgcatttt gtctttctac cacagccacg
     1381 cctgttgtcc actcttctga cttggcttct ccaaatggga ggagactcag ctctggacag
     1441 aaagggaacc caactgcttt ggacctagat ggcctattgt gactggagga tcctgaggac
     1501 aggagagggg cttcaacaga cacgccatag cacttaccca tagagaccat tagggttggc
     1561 tgtgctgtgg tagggaagga gtccagggct ccttggaatt cacttctcat tgtggggagg
     1621 tctactttag acaacttggt tttgcacatg tttcctctaa tttttctgtt ttagagcccc
     1681 agcagacctt acttctgggg taaggcaagt cagttgactg gtgtccccac ctcgcttccc
     1741 taatctacat tcgggagacc gcatcggggt taaataagac ttttcatttt cgtttttgtt
     1801 tttaacctag aagaaccaaa tccggacacc aaaacgtagg cttagtttgt gtgttgtctc
     1861 tgagtttgtc gctcatgcgt gcaacagggt atggactatc tgtttggtgc cccatttttg
     1921 gtggcccata agtaggctgg ctagcccagg atgccatgga gtagccacct cttgaccagt
     1981 catgcctgtg tgcatagact cagggccatg gcctttgtga cattggaaga gcctgtgtga
     2041 gaacttcctc ctagattagt ctagggatgg aggggaggag actgtatagt ttgggaggag
     2101 gggtgacaag ggtgtccaag actctcccac ctttggtact aactctggtc accctttctc
     2161 ctggaagttg acaagacaca tcttgagtat ggctggcact ggctcctcca tcaagaacca
     2221 agttcacctt cagctcctgt ggccctgttc ccaggctgga gtcagaaatg tttcccaaag
     2281 agtgagagtc ttttgctttt ggcaaaacgc tacttaatcc aatgggttct gtacagtaga
     2341 ttttgcagat gtaataaact ttaatataaa ggagtcctat gaactctact gtttctgctt
     2401 cttattctct gggctggtgg tacagacgta gccagcctct gcccaaaccc gggtagctca
     2461 gagaagcttg gctcaaggct acgtgcctcc agtcctctga ggggtaggat cctggatcca
     2521 gggttccgct ggtttgttgt tttgttttgt ttttcttttg gctaaacttc ttttggaagt
     2581 tggtaggttc agccaaggtt ctgcaggacc tgacgtctgt tcttctagat ggtttaagta
     2641 atcgggactc tagcacatct tgacctgggg tcactacagc taagcttgct ttgcagagca
     2701 gatacctggg acagccttca tccctcatgg ttgctgggac acttctgagg actccttgct
     2761 tacttagctc agcgatgttc cagctgctgg ctaggctgct cagtggcgcg gctagacaaa
     2821 agatctgtgc cctgtgtttc atcccagaat ttgctgccag atcgtacggc tggatgtgat
     2881 gtggggtggg gtggggtcag atctgagaca gcactcaact gagggcttgt gagacagtgt
     2941 ccaagtctca ggctggggcc attcatataa ttgcaataaa tggtacgtgt ccatttggac
     3001 agcagacaaa aaaaaaaaaa a
//
