LOCUS       NM_001011938            2644 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus SCY1 like pseudokinase 1 (Scyl1), mRNA.
ACCESSION   NM_001011938 XM_215190
VERSION     NM_001011938.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2644)
  AUTHORS   Kuliyev,E., Gingras,S., Guy,C.S., Howell,S., Vogel,P. and
            Pelletier,S.
  TITLE     Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron
            Viability
  JOURNAL   J Neurosci 38 (10), 2615-2630 (2018)
   PUBMED   29437892
REFERENCE   2  (bases 1 to 2644)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2644)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2644)
  AUTHORS   Burman,J.L., Bourbonniere,L., Philie,J., Stroh,T., Dejgaard,S.Y.,
            Presley,J.F. and McPherson,P.S.
  TITLE     Scyl1, mutated in a recessive form of spinocerebellar
            neurodegeneration, regulates COPI-mediated retrograde traffic
  JOURNAL   J Biol Chem 283 (33), 22774-22786 (2008)
   PUBMED   18556652
  REMARK    GeneRIF: Data demonstrate a function for Scyl1 as an accessory
            factor in COPI trafficking and suggest that alterations in the COPI
            pathway result in neurodegenerative disease.
REFERENCE   5  (bases 1 to 2644)
  AUTHORS   Di,Y., Li,J., Fang,J., Xu,Z., He,X., Zhang,F., Ling,J., Li,X.,
            Xu,D., Li,L., Li,Y.Y. and Huo,K.
  TITLE     Cloning and characterization of a novel gene which encodes a
            protein interacting with the mitosis-associated kinase-like protein
            NTKL
  JOURNAL   J Hum Genet 48 (6), 315-321 (2003)
   PUBMED   12783284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 8, 2021 this sequence version replaced NM_001011938.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217187.1, BC087141.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000001.1  212488677-212488860 c
            185-325             JAXUCZ010000001.1  212488184-212488324 c
            326-675             JAXUCZ010000001.1  212487664-212488013 c
            676-766             JAXUCZ010000001.1  212487176-212487266 c
            767-922             JAXUCZ010000001.1  212486924-212487079 c
            923-1081            JAXUCZ010000001.1  212483479-212483637 c
            1082-1189           JAXUCZ010000001.1  212482668-212482775 c
            1190-1303           JAXUCZ010000001.1  212481680-212481793 c
            1304-1459           JAXUCZ010000001.1  212478391-212478546 c
            1460-1648           JAXUCZ010000001.1  212477322-212477510 c
            1649-1724           JAXUCZ010000001.1  212477129-212477204 c
            1725-1889           JAXUCZ010000001.1  212476721-212476885 c
            1890-2032           JAXUCZ010000001.1  212476377-212476519 c
            2033-2104           JAXUCZ010000001.1  212476006-212476077 c
            2105-2311           JAXUCZ010000001.1  212475710-212475916 c
            2312-2372           JAXUCZ010000001.1  212475570-212475630 c
            2373-2644           JAXUCZ010000001.1  212475198-212475469 c
FEATURES             Location/Qualifiers
     source          1..2644
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2644
                     /gene="Scyl1"
                     /note="SCY1 like pseudokinase 1"
                     /db_xref="GeneID:293684"
                     /db_xref="RGD:1307330"
     exon            1..184
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..2497
                     /gene="Scyl1"
                     /note="SCY1-like protein 1; SCY1-like, kinase-like 1"
                     /codon_start=1
                     /product="N-terminal kinase-like protein"
                     /protein_id="NP_001011938.1"
                     /db_xref="GeneID:293684"
                     /db_xref="RGD:1307330"
                     /translation="MWFFARDPVRDFPFELNPEPPEGGPPGPWVLHRGRKKATGSAVS
                     IFVYDVKPGAEEQTQVAKAAFKRLKTLRHPNILAYIDGLETEKCLHIVTEAVTPLGTY
                     LKARAEAGGLKEQELSWGLHQIVKALSFLVNDCNLIHNNVCMAAVFVDKAGEWKLGGL
                     DYMYSAQGNGGGPPNKGIPELEQYDPPELADSSSRAVKEKWSADMWRLGCLIWEVFNG
                     SLPRATALRNPGKIPKSLVTHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETN
                     LFLEEIQIKEPAEKQKFFQELSKSLDSFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPL
                     FKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRVRLLQQMEQFIQYLDEPTVNTQIFPH
                     VTHGFLDTNPAIREQTVKSMLLLAPKLSETNLNVELLKHFARLQAKDDQGPIRCNTTV
                     CLGKIGSYLSASTRHRVLTSAFSRATKDPFAPSRVAGVLGFAATHNLYSMDDCAHKIL
                     PVLCGLTVDPEKSVRDQAFKTIRSFLSKLESVSEDPTQLAEIEKDVHAASSPGTGGAA
                     ASWAGWAVTGVSSLTSKLIRTHPTPVPSEAAVPQRPVPEGDPAPAPAPASATPATSGH
                     RETQEEDKDAAEDSATADRWDDEDWGSLEQEAESVLAQQDDWSTKGQGNRAGQVSHSD
                     HKSLDSHWSSWEVEGSWDQGWQEPSSVEPPPEGTRLASEYNWGGAEPSDKGDPFAALS
                     VRPSTQPRPDPDSWGEDNWEGLEAESRQVKAELARKKREERRREMEAKRAEKKATKGP
                     MKLGARKLD"
     exon            185..325
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
     exon            326..675
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
     exon            676..766
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..922
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1081
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1189
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1303
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1459
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1648
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1724
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1889
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2032
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2104
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2311
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2372
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2644
                     /gene="Scyl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accccgcccc gccccggctc gggcggccgg aggacccgga gtggaggctc ccgagccctt
       61 ggcggcggcg acgatgtggt tctttgcccg ggacccggtc cgggacttcc cgttcgagct
      121 gaaccctgag ccccccgaag gcggaccgcc cgggccctgg gtcctgcacc gaggccgcaa
      181 aaaggccaca ggcagtgcgg tgtccatctt cgtgtacgat gtgaaacccg gagccgaaga
      241 gcagacccag gtggccaaag ctgccttcaa acgcctcaaa actctccgac accccaacat
      301 cctggcctat atcgatgggt tggagacaga aaagtgcctc cacatcgtga cagaggctgt
      361 gaccccactg ggaacatacc tcaaggcacg agcagaagca ggtggtctga aggagcagga
      421 gctgtcatgg gggttacacc agatcgtgaa agccctcagc ttcctggtca acgactgcaa
      481 cctcatccac aacaatgtct gcatggctgc tgtgtttgtg gacaaggctg gcgagtggaa
      541 acttgggggt ctggactaca tgtactcagc acagggcaac ggtgggggac cacccaacaa
      601 ggggatccct gagcttgagc agtatgatcc tccggagttg gctgatagca gcagcagagc
      661 agtcaaagag aagtggtcag cagacatgtg gcgcttgggc tgcctcatct gggaagtttt
      721 caatgggtct ctacctcggg caactgccct gcgcaaccct gggaagatcc ccaaatccct
      781 ggtcacccat tactgcgagc tggtgggagc taaccccaaa gtacgtccca acccggcccg
      841 cttcctgcag aactgccggg cacctggtgg cttcatgagc aaccgctttg tggagaccaa
      901 cctgttcctg gaggagattc agatcaaaga gccagctgag aagcagaagt tcttccaaga
      961 gctgagcaag agtctagact cgtttcctga agatttctgt cgacacaagg tgctgcccca
     1021 gctgctgact gcctttgagt ttggcaatgc tggggccgtg gtcctcacac ctctcttcaa
     1081 ggtggggaaa ttcctcagtg ctgaagaata ccagcagaag atcatccccg tggtggttaa
     1141 gatgttctca tccactgacc gtgccatgcg cgtccgcctc ctccagcaga tggagcagtt
     1201 catccaatac cttgatgagc cgacagtcaa cacccagatc ttcccccacg tcactcatgg
     1261 ctttctggac accaaccctg ccatccggga gcagactgtc aagtccatgc tgctcttggc
     1321 cccaaagctg agtgagacca acctcaatgt ggagctgctg aagcacttcg caaggctgca
     1381 agccaaggac gaccagggtc ccatccgctg caacaccacg gtctgcttgg gcaaaatcgg
     1441 ctcctacctc agtgctagta ctagacacag ggtcctcacc tctgccttca gccgggccac
     1501 taaggaccca tttgcaccat cccgggttgc gggtgtcctg ggcttcgctg ctacacacaa
     1561 tctctactca atggatgact gtgcccataa gatcctgcct gtgctctgcg gccttactgt
     1621 agaccctgaa aaatctgtgc gggaccaggc ctttaagacc attcgaagct tcctgtccaa
     1681 attagagtct gtgtcggagg atcctaccca gttggcagaa atagagaagg acgtccatgc
     1741 agcatccagc cctggaacag gaggagctgc agccagctgg gcaggctggg ctgtgaccgg
     1801 ggtgtcatct ctcacctcca agctgatccg aacacacccc acacctgtgc cgtctgaggc
     1861 cgctgtgccc cagagaccag tgccagaggg agaccctgct ccagctccag cccctgcctc
     1921 tgccacccct gcgacctcag gccaccggga aacacaggaa gaagacaagg acgctgcaga
     1981 agacagcgcc actgccgaca gatgggatga tgaggactgg ggcagcttgg agcaggaagc
     2041 cgagtctgtg ttggcgcagc aggatgactg gagcaccaag ggccaaggga atcgagctgg
     2101 acaggtcagc cattcagacc acaaatctct ggactcacac tggagcagct gggaagttga
     2161 gggctcctgg gaccagggct ggcaggaacc cagttctgtg gagccacccc cagaaggaac
     2221 ccggctagcc agcgagtata actggggtgg tgcagagccc agtgacaagg gtgacccctt
     2281 tgctgccctg tctgttcgtc ccagcaccca gcccaggcca gacccagact cctggggtga
     2341 ggacaactgg gaaggcttgg aggctgaaag caggcaggtg aaggcagagc tagcccgaaa
     2401 aaagcgagag gaaaggagaa gagaaatgga agccaagcgg gcggagaaaa aggccaccaa
     2461 ggggcccatg aagctgggag cccggaagct ggactgacaa ccctaccccc agacccctgg
     2521 gcatttccaa ccactggaaa gcaggcccgg aggatgtatt tattgtacaa accatgtcag
     2581 cctggtcagc aggtcaggca catctagtgt acataatcag agccacaata aattctattt
     2641 caca
//
