LOCUS       NM_001130508            1134 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus scleraxis bHLH transcription factor (Scx), mRNA.
ACCESSION   NM_001130508 XM_001060414
VERSION     NM_001130508.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1134)
  AUTHORS   Kishimoto,Y., Ohkawara,B., Sakai,T., Ito,M., Masuda,A.,
            Ishiguro,N., Shukunami,C., Docheva,D. and Ohno,K.
  TITLE     Wnt/beta-catenin signaling suppresses expressions of Scx, Mkx, and
            Tnmd in tendon-derived cells
  JOURNAL   PLoS One 12 (7), e0182051 (2017)
   PUBMED   28750046
  REMARK    GeneRIF: Wnt/beta-catenin decreased Mkx and Tnmd expressions
            without suppressing Scx expression in Scx-programmed tendon
            progenitors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1134)
  AUTHORS   Kanazawa,T., Gotoh,M., Ohta,K., Shiba,N. and Nakamura,K.
  TITLE     Three-dimensional ultrastructural analysis of development at the
            supraspinatus insertion by using focused ion beam/scanning electron
            microscope tomography in rats
  JOURNAL   J Orthop Res 34 (6), 969-976 (2016)
   PUBMED   26599103
  REMARK    GeneRIF: morphological change and SOX9/SCX expression of the cells
            at the supraspinatus tendon insertion drastically changed during
            endochondral ossification
REFERENCE   3  (bases 1 to 1134)
  AUTHORS   Zeglinski,M.R., Roche,P., Hnatowich,M., Jassal,D.S., Wigle,J.T.,
            Czubryt,M.P. and Dixon,I.M.
  TITLE     TGFbeta1 regulates Scleraxis expression in primary cardiac
            myofibroblasts by a Smad-independent mechanism
  JOURNAL   Am J Physiol Heart Circ Physiol 310 (2), H239-H249 (2016)
   PUBMED   26566727
  REMARK    GeneRIF: Scleraxis expression is induced by TGFbeta1 through a
            Smad-independent pathway in the cardiac myofibroblast
REFERENCE   4  (bases 1 to 1134)
  AUTHORS   Tan,C., Lui,P.P., Lee,Y.W. and Wong,Y.M.
  TITLE     Scx-transduced tendon-derived stem cells (tdscs) promoted better
            tendon repair compared to mock-transduced cells in a rat patellar
            tendon window injury model
  JOURNAL   PLoS One 9 (5), e97453 (2014)
   PUBMED   24831949
  REMARK    GeneRIF: Scx has a role in expression of lineage markers in
            tendon-derived stem cells and the effect of the resulting cell line
            in the promotion of tendon repair
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1134)
  AUTHORS   Killian,M.L., Lim,C.T., Thomopoulos,S., Charlton,N., Kim,H.M. and
            Galatz,L.M.
  TITLE     The effect of unloading on gene expression of healthy and injured
            rotator cuffs
  JOURNAL   J Orthop Res 31 (8), 1240-1248 (2013)
   PUBMED   23508698
  REMARK    GeneRIF: The expression of scleraxis, a transcription factor
            necessary for tendon development, was upregulated in response to
            rotator cuff injury and repair.
REFERENCE   6  (bases 1 to 1134)
  AUTHORS   Perez,A.V., Perrine,M., Brainard,N. and Vogel,K.G.
  TITLE     Scleraxis (Scx) directs lacZ expression in tendon of transgenic
            mice
  JOURNAL   Mech Dev 120 (10), 1153-1163 (2003)
   PUBMED   14568104
REFERENCE   7  (bases 1 to 1134)
  AUTHORS   Carlberg,A.L., Tuan,R.S. and Hall,D.J.
  TITLE     Regulation of scleraxis function by interaction with the bHLH
            protein E47
  JOURNAL   Mol Cell Biol Res Commun 3 (2), 82-86 (2000)
   PUBMED   10775504
REFERENCE   8  (bases 1 to 1134)
  AUTHORS   Brown,D., Wagner,D., Li,X., Richardson,J.A. and Olson,E.N.
  TITLE     Dual role of the basic helix-loop-helix transcription factor
            scleraxis in mesoderm formation and chondrogenesis during mouse
            embryogenesis
  JOURNAL   Development 126 (19), 4317-4329 (1999)
   PUBMED   10477299
REFERENCE   9  (bases 1 to 1134)
  AUTHORS   Liu,Y., Nifuji,A., Tamura,M., Wozney,J.M., Olson,E.N. and Noda,M.
  TITLE     Scleraxis messenger ribonucleic acid is expressed in C2C12
            myoblasts and its level is down-regulated by bone morphogenetic
            protein-2 (BMP2)
  JOURNAL   J Cell Biochem 67 (1), 66-74 (1997)
   PUBMED   9328840
REFERENCE   10 (bases 1 to 1134)
  AUTHORS   Cserjesi,P., Brown,D., Ligon,K.L., Lyons,G.E., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Olson,E.N.
  TITLE     Scleraxis: a basic helix-loop-helix protein that prefigures
            skeletal formation during mouse embryogenesis
  JOURNAL   Development 121 (4), 1099-1110 (1995)
   PUBMED   7743923
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On Jul 27, 2008 this sequence version replaced XM_001060414.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1134
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1134
                     /gene="Scx"
                     /note="scleraxis bHLH transcription factor"
                     /db_xref="GeneID:680712"
                     /db_xref="RGD:1588254"
     exon            1..756
                     /gene="Scx"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..795
                     /gene="Scx"
                     /note="scleraxis basic helix-loop-helix transcription
                     factor"
                     /codon_start=1
                     /product="basic helix-loop-helix transcription factor
                     scleraxis"
                     /protein_id="NP_001123980.1"
                     /db_xref="GeneID:680712"
                     /db_xref="RGD:1588254"
                     /translation="MSFAMLRSAPPPGRYLYPEVSPLSEDEDRGSESSGSDEKPCRVH
                     AARCGLQGARRRAGGRRAAGSGPGPGGRPGREPRQRHTANARERDRTNSVNTAFTALR
                     TLIPTEPADRKLSKIETLRLASSYISHLGNVLLVGEACGDGQPCHSGPAFFHSGRAGS
                     PLPPPPPPPPLPLARDGGENTQPKQICTFCLSNQRKLSKDRDRKTAIRS"
     exon            757..1134
                     /gene="Scx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatccgctgg cggccccact ccagtccgaa cacatgtgcc cgcctcgccc ggcagccacc
       61 accgcggggc gcagcggaga cccctggccc ggcggcctgt ggggacctaa agaggcggca
      121 tgagcagcgc accgtggagc tgacgccgcg ccccctgccc ggcccatgtc cttcgccatg
      181 ctgcgttcag cgccaccgcc gggccgctac ctgtaccctg aggtgagccc gctgtccgag
      241 gatgaggacc gcggaagcga gagctcgggc tccgacgaaa aaccctgtcg tgttcatgct
      301 gcgcgctgcg gcctccaggg cgcccggcgg cgggcaggag gacggagggc cgcgggtagt
      361 gggccaggac ccggggggcg gccaggccgc gagccccggc agcggcacac agcgaatgcg
      421 cgcgagcggg accgcaccaa cagcgtgaac acggccttca ctgcgctgcg cacactcatc
      481 ccgaccgagc cagcagatcg caagctctcc aagattgaga cgctgcgcct ggcctccagc
      541 tacatttctc acctgggcaa cgtgctactg gtgggtgaag cctgcggtga cgggcagccc
      601 tgccactcgg gacccgcttt cttccacagc ggtcgtgcgg gcagcccact accaccgcca
      661 ccgccgccgc ccccactacc actggccaga gacggcggcg agaacaccca gcccaaacag
      721 atctgcacct tctgcctcag caaccagaga aagttgagca aagaccgtga cagaaagacg
      781 gcgattcgaa gttagaagga ggagggtcca cagcagccaa gaggtgatgc cactagtgaa
      841 ggtggaagcc actgaagagt catggagagc cccaccttgg acctgatctg agcacaggtc
      901 cccaagagcg cgctcaccag gccagacctg ccccagctct gagcagggcc tgtgaacaga
      961 gagatggaca ggcgggctat ggcttgactc taagtagctg aacacttgta cccaggccca
     1021 ctggaacttt ccatgctggc tctctacctg ggccaagtgt tggcatcttg tgtctttaat
     1081 atgataatat aaagtctgga aattttgtat aattaaagtg aaacagtatc ttcc
//
