LOCUS       NM_001134884            4237 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus signal peptide, CUB domain and EGF like domain
            containing 1 (Scube1), mRNA.
ACCESSION   NM_001134884 XM_235529
VERSION     NM_001134884.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4237)
  AUTHORS   Lin,Y.C., Roffler,S.R., Yan,Y.T. and Yang,R.B.
  TITLE     Disruption of Scube2 Impairs Endochondral Bone Formation
  JOURNAL   J Bone Miner Res 30 (7), 1255-1267 (2015)
   PUBMED   25639508
REFERENCE   2  (bases 1 to 4237)
  AUTHORS   Turkmen,S., Mentese,S., Mentese,A., Sumer,A.U., Saglam,K.,
            Yulug,E., Turedi,S. and Gunduz,A.
  TITLE     The value of signal peptide-CUB-EGF domain-containing protein 1 and
            oxidative stress parameters in the diagnosis of acute mesenteric
            ischemia
  JOURNAL   Acad Emerg Med 20 (3), 257-264 (2013)
   PUBMED   23517257
  REMARK    GeneRIF: A pronounced rise in SCUBE-1 levels was determined with
            6-hour acute mesenteric ischemia in rats.
REFERENCE   3  (bases 1 to 4237)
  AUTHORS   Vanpoucke,G., Orr,B., Grace,O.C., Chan,R., Ashley,G.R.,
            Williams,K., Franco,O.E., Hayward,S.W. and Thomson,A.A.
  TITLE     Transcriptional profiling of inductive mesenchyme to identify
            molecules involved in prostate development and disease
  JOURNAL   Genome Biol 8 (10), R213 (2007)
   PUBMED   17922897
  REMARK    GeneRIF: Scube1 encodes a novel stromal molecule that is involved
            in prostate development and tumorigenesis.
REFERENCE   4  (bases 1 to 4237)
  AUTHORS   Yang,R.B., Ng,C.K., Wasserman,S.M., Colman,S.D., Shenoy,S.,
            Mehraban,F., Komuves,L.G., Tomlinson,J.E. and Topper,J.N.
  TITLE     Identification of a novel family of cell-surface proteins expressed
            in human vascular endothelium
  JOURNAL   J Biol Chem 277 (48), 46364-46373 (2002)
   PUBMED   12270931
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Sep 11, 2008 this sequence version replaced XM_235529.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000007.1  116760774-116760944 c
            172-303             JAXUCZ010000007.1  116757652-116757783 c
            304-432             JAXUCZ010000007.1  116739108-116739236 c
            433-567             JAXUCZ010000007.1  116713964-116714098 c
            568-693             JAXUCZ010000007.1  116695373-116695498 c
            694-810             JAXUCZ010000007.1  116690178-116690294 c
            811-900             JAXUCZ010000007.1  116687643-116687732 c
            901-1017            JAXUCZ010000007.1  116674777-116674893 c
            1018-1140           JAXUCZ010000007.1  116670817-116670939 c
            1141-1257           JAXUCZ010000007.1  116665487-116665603 c
            1258-1380           JAXUCZ010000007.1  116664107-116664229 c
            1381-1500           JAXUCZ010000007.1  116658109-116658228 c
            1501-1605           JAXUCZ010000007.1  116657732-116657836 c
            1606-1722           JAXUCZ010000007.1  116656682-116656798 c
            1723-1860           JAXUCZ010000007.1  116655459-116655596 c
            1861-2064           JAXUCZ010000007.1  116653282-116653485 c
            2065-2226           JAXUCZ010000007.1  116650540-116650701 c
            2227-2394           JAXUCZ010000007.1  116649066-116649233 c
            2395-2556           JAXUCZ010000007.1  116648035-116648196 c
            2557-2754           JAXUCZ010000007.1  116646164-116646361 c
            2755-2907           JAXUCZ010000007.1  116644713-116644865 c
            2908-2987           JAXUCZ010000007.1  116644211-116644290 c
            2988-4237           JAXUCZ010000007.1  116642231-116643480 c
FEATURES             Location/Qualifiers
     source          1..4237
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4237
                     /gene="Scube1"
                     /note="signal peptide, CUB domain and EGF like domain
                     containing 1"
                     /db_xref="GeneID:315174"
                     /db_xref="RGD:1309015"
     exon            1..171
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..3140
                     /gene="Scube1"
                     /note="signal peptide, CUB and EGF-like domain-containing
                     protein 1; signal peptide, CUB domain, EGF-like 1"
                     /codon_start=1
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 1 precursor"
                     /protein_id="NP_001128356.1"
                     /db_xref="GeneID:315174"
                     /db_xref="RGD:1309015"
                     /translation="MGAAAVRWHLCLLLALGARGQLVGGSGLPGAVDVDECSEGTDDC
                     HIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYYNGGCVHDCINIPGNYRCTC
                     FDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRS
                     NEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCE
                     DTDTGPMCGCHQKYALHADGRTCIEKDEAAIERSQFNATSVADVDKRVKRRLLMETCA
                     VNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLMNNGGCDHFCRNTVGSF
                     ECGCQKGHKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTHCGD
                     VDECSMNNGSCDQGCVNTKGSYECVCPPGRRLHWNRKDCVEMSGCLSRSKASAQAQLS
                     CGKVGGVENCFLSCLGQSLFMPDSETSYILSCGVPGLQGKAPPKRNGTSSSVGPGCSD
                     APTTPIRQKARFKIRDAKCHLRPRSQERAKDTLRHPLLDNCHVTFVTLKCDSSKKRRR
                     GRKSPSKEVSHITAEFEVEMKVEEASGSCEADCMRKRAEQSLQAAIKTLRKSIGRHQF
                     YVQVSGTEYEVAQRPAKAPEGTGTCGIGQILQDGKCVPCAPGTYFSSEPGQCVPCVSG
                     TYQDMEGQLSCTPCPSSEGLGLAGARNVSECGGQCSPGFFSEDGFKPCQACPVGTYQP
                     EPGRTGCFPCGGGLLTKQTGTASFQECEAKVHCSPGHHYNTTTHRCIRCPVGTYQPEF
                     GQNHCISCPGNTSTDFDGSTNVTHCKNQHCGGELGDYTGYIESPNYPGDYPANAECVW
                     HIAPPPKRRILIVVPEIFLPIEDECGDVLVMRKSASPTSVTTYETCQTYERPIAFTSR
                     SRKLWIQFKSNEANSGKGFQVPYVTYDEDYQQLIEDIVRDGRLYASENHQEILKDKKL
                     IKALFDVLAHPQNYFKYTAQESKEMFPRSFIKLLRSKVSRFLRPYK"
     exon            172..303
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..432
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..567
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..693
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..810
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..900
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1017
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1140
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1257
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1380
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1500
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1605
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1722
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1860
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2064
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2226
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2394
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2556
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2754
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2907
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..2987
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..4237
                     /gene="Scube1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcttgct gcagacagga gcgctcgcag agcggccgct ctgagcgtcc cgtgccccgc
       61 acccagcgcg gcccgcagcg agcatgggcg cggcggccgt gcgctggcac ttgtgcctgc
      121 tgctcgctct gggagcgcga gggcagctgg tggggggcag cgggctgcca ggagccgtgg
      181 atgtggatga gtgctcagag ggcacagatg actgccacat agatgccatc tgtcagaaca
      241 cacccaagtc ttacaaatgt ctctgcaagc cgggctacaa gggggaaggg aagcagtgcg
      301 aagacatcga tgagtgtgag aatgactact acaacggggg ctgtgtccat gactgcatca
      361 acatccctgg gaactacagg tgcacctgct ttgacggctt catgctggcc cacgatggac
      421 acaactgtct ggatgtagat gagtgccaag acaacaacgg tggctgccag cagatctgtg
      481 tcaatgccat gggcagctat gagtgccagt gccacagcgg cttttttctc agtgacaacc
      541 aacacacctg catacaccgc tccaacgagg gtatgaactg catgaacaaa gaccatggct
      601 gtgcccacat ctgccgggag acgcccaaag gtggggtagc ctgtgactgc aggcccggct
      661 ttgaccttgc ccaaaaccag aaggactgca cactaacctg taactatgga aacggaggct
      721 gtcagcacag ctgcgaggac acggacacgg gccccatgtg tggctgccac cagaagtacg
      781 ccctacacgc cgatggtcgg acgtgcatcg agaaggatga ggctgcaatt gagcgctctc
      841 agttcaatgc cacgtcagta gctgatgtgg acaagcgtgt gaaacggcgg ctcctcatgg
      901 agacgtgtgc ggtgaacaac ggaggctgtg accggacgtg taaggacact gccaccggcg
      961 tgagatgcag ctgcccagtt ggattcacgc tacagccgga tggaaagaca tgcaaagaca
     1021 tcaacgagtg cttgatgaac aacggaggct gcgaccactt ctgccgaaac actgtgggca
     1081 gctttgaatg cggctgccaa aagggccaca agctactgac ggacgagcgg acatgccaag
     1141 acattgacga gtgttccttt gagcggacct gtgaccacat ctgcatcaac tcccccggca
     1201 gcttccagtg cctgtgtcac cgaggctaca tactctacgg gacaacccac tgcggagacg
     1261 tggatgagtg cagcatgaac aacggcagct gtgatcaggg ctgcgtcaac accaagggca
     1321 gctacgagtg tgtgtgccca ccagggagga ggctgcactg gaatcggaag gactgtgtgg
     1381 agatgagcgg gtgcctgtct cggtccaagg cctctgccca ggcccagctg tcctgtggca
     1441 aggtgggtgg agtggaaaac tgcttcctgt cctgcctggg ccagagtctc ttcatgccag
     1501 actcagaaac cagctacatc ctgagctgtg gtgttccagg tctccagggc aaggcaccac
     1561 cgaagcgcaa tggcaccagc tccagtgtgg ggcccggctg ctcagatgcc cccaccaccc
     1621 ccatcagaca gaaggcccgc ttcaagatca gagatgccaa gtgccacctg cggccccgca
     1681 gccaggagcg agcgaaggat accctgaggc atcccctttt agacaactgc cacgtgactt
     1741 tcgtgaccct caagtgcgac tcctccaaga agaggcgtcg aggccgcaag tccccctcca
     1801 aggaggtgtc ccacatcacg gcagagtttg aggtagagat gaaggtggaa gaggcctcag
     1861 gctcctgcga agcagactgc atgcggaagc gtgccgagca gagcctgcag gctgccatca
     1921 agactctgcg gaagtccatc ggccggcacc agttctacgt ccaggtctcc ggcactgagt
     1981 acgaggtggc ccagcggcca gccaaggcac cggaggggac cgggacatgt ggcataggcc
     2041 aaatactaca ggatggcaag tgtgtaccat gtgctcctgg cacctacttc agtagtgagc
     2101 caggccaatg cgtgccgtgt gtgtcgggaa cctaccagga catggaaggc cagctcagct
     2161 gcacgccgtg ccccagcagc gaagggctgg gtctggctgg tgcccgcaac gtatccgaat
     2221 gtggaggcca gtgttctcca ggcttcttct cagaggatgg gttcaagcct tgtcaggcct
     2281 gccctgtggg cacataccag cctgagcctg ggcgtaccgg ctgcttcccc tgtggaggtg
     2341 ggctgctcac caagcagacg ggtactgcct ctttccagga atgtgaggcc aaagtacact
     2401 gctctcccgg ccaccactac aataccacta cccaccggtg catccgatgt cctgtgggta
     2461 cctatcaacc cgagtttggc cagaaccatt gcatctcctg tccgggcaac accagcaccg
     2521 attttgatgg ttccaccaat gtcacacact gcaaaaacca gcactgcggt ggcgagcttg
     2581 gtgactacac aggctatatc gagtccccca actaccctgg agactaccca gccaatgcgg
     2641 agtgtgtgtg gcacattgcg cctcccccca agcgcaggat cctcattgtg gtccctgaga
     2701 tcttcctgcc catcgaggat gagtgtggcg atgttctggt catgaggaag agcgcctcgc
     2761 ccacgtcagt caccacctat gagacgtgcc agacctacga gcggcctatc gccttcacct
     2821 cccgctcccg caaactctgg atccagttca aatccaacga ggccaacagt ggcaaagggt
     2881 ttcaagtgcc ctacgtcacc tatgacgagg actaccagca gctaatagaa gacatcgtgc
     2941 gcgatgggcg cttgtatgcc tcggagaacc atcaggagat tttgaaagac aagaagctga
     3001 tcaaggccct ctttgatgtg ttggcacacc cacaaaacta cttcaaatac acagcccagg
     3061 agtcaaagga gatgttcccc cggtccttta tcaaacttct gcgttccaaa gtgtctcggt
     3121 tcctgcggcc ctacaaataa ccagccagct gtcctgcgtg gggacagtgg gaaccaagtg
     3181 ggaggggaat gtgccttccc tccacagcac gagatgaaag gaggctccat gggccttcag
     3241 gctgccttga gaaacccatg atacctgcct ctggcaaagc cgtccagcct ggaccacccc
     3301 catggaaggc ctagacccag cacagacccc ttggtggggc tgccactcct gggtggaagc
     3361 agtgcttcag aaagccttca cctaccctct gcctcccagg acacctagag tactccctcc
     3421 tgaaccaccg cagtgggatc tgcctgggcc aggacatact gtccccacca tgtggggagc
     3481 aggacgactg tgcccttggc ccgatccgtt tgttgagaga gaggagtgtg tccagctccc
     3541 tgcaggctct ggaaagcatg ggccattgtc acccacacag ggccaggcca gggcaggagg
     3601 ggtgtgtggt ggtgccatct ggggagttga taagcctgtg ccagtgcctg tggaaccaac
     3661 acaccctgcc agctcttctg ggcacagccg ggtcatggag ctcaagggac tctgtaagag
     3721 atggaatagg tcctccagga gaggagtcca cgtgcttgtg cttcgcctta atagaccatc
     3781 taaagaagtt ctatatatat atatataaat atataaatat taaatatatt cacttctcta
     3841 tgtgggtggg tatttcagaa gggttctcct cagcaactgt aacactaacc actgttgcca
     3901 gcctcccctg gtgattaaac tgcgcctccc agcgcttgcc acctctggcc ccatccccca
     3961 tcccctcccc ccgccccccc cgccccccgc cggcctgggg agagcacaga gatatgcttg
     4021 gacatgccgt tgaatgtgac ttgttgagga ctggactagg tgttgtgttg aagcattgac
     4081 ggggtgcggg ggggagggtg cttcacaagc aacatcacca ctgtcaacag aacacagtgg
     4141 aaagcacccc cacccactgt gggtcctagc gctcactgac tctgcactgt gcgtgcaggt
     4201 caccagaaac aaggccttcc tcagggatgt gcaggct
//
