LOCUS       NP_001128356            1018 aa            linear   ROD 29-MAR-2024
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 1
            precursor [Rattus norvegicus].
ACCESSION   NP_001128356 XP_235529
VERSION     NP_001128356.1
DBSOURCE    REFSEQ: accession NM_001134884.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1018)
  AUTHORS   Lin,Y.C., Roffler,S.R., Yan,Y.T. and Yang,R.B.
  TITLE     Disruption of Scube2 Impairs Endochondral Bone Formation
  JOURNAL   J Bone Miner Res 30 (7), 1255-1267 (2015)
   PUBMED   25639508
REFERENCE   2  (residues 1 to 1018)
  AUTHORS   Turkmen,S., Mentese,S., Mentese,A., Sumer,A.U., Saglam,K.,
            Yulug,E., Turedi,S. and Gunduz,A.
  TITLE     The value of signal peptide-CUB-EGF domain-containing protein 1 and
            oxidative stress parameters in the diagnosis of acute mesenteric
            ischemia
  JOURNAL   Acad Emerg Med 20 (3), 257-264 (2013)
   PUBMED   23517257
  REMARK    GeneRIF: A pronounced rise in SCUBE-1 levels was determined with
            6-hour acute mesenteric ischemia in rats.
REFERENCE   3  (residues 1 to 1018)
  AUTHORS   Vanpoucke,G., Orr,B., Grace,O.C., Chan,R., Ashley,G.R.,
            Williams,K., Franco,O.E., Hayward,S.W. and Thomson,A.A.
  TITLE     Transcriptional profiling of inductive mesenchyme to identify
            molecules involved in prostate development and disease
  JOURNAL   Genome Biol 8 (10), R213 (2007)
   PUBMED   17922897
  REMARK    GeneRIF: Scube1 encodes a novel stromal molecule that is involved
            in prostate development and tumorigenesis.
REFERENCE   4  (residues 1 to 1018)
  AUTHORS   Yang,R.B., Ng,C.K., Wasserman,S.M., Colman,S.D., Shenoy,S.,
            Mehraban,F., Komuves,L.G., Tomlinson,J.E. and Topper,J.N.
  TITLE     Identification of a novel family of cell-surface proteins expressed
            in human vascular endothelium
  JOURNAL   J Biol Chem 277 (48), 46364-46373 (2002)
   PUBMED   12270931
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Sep 11, 2008 this sequence version replaced XP_235529.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1018
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     Protein         1..1018
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 1 precursor"
                     /note="signal peptide, CUB and EGF-like domain-containing
                     protein 1; signal peptide, CUB domain, EGF-like 1"
                     /calculated_mol_wt=108967
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2534
     Region          37..72
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          84..115
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          121..156
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          166..202
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          206..241
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          275..310
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          316..351
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <348..384
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          396..431
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          666..713
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          720..767
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          776..823
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          828..939
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(836,838,840,867,872,910,934,936,938..939)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..1018
                     /gene="Scube1"
                     /coded_by="NM_001134884.1:84..3140"
                     /db_xref="GeneID:315174"
                     /db_xref="RGD:1309015"
ORIGIN      
        1 mgaaavrwhl clllalgarg qlvggsglpg avdvdecseg tddchidaic qntpksykcl
       61 ckpgykgegk qcedidecen dyynggcvhd cinipgnyrc tcfdgfmlah dghncldvde
      121 cqdnnggcqq icvnamgsye cqchsgffls dnqhtcihrs negmncmnkd hgcahicret
      181 pkggvacdcr pgfdlaqnqk dctltcnygn ggcqhscedt dtgpmcgchq kyalhadgrt
      241 ciekdeaaie rsqfnatsva dvdkrvkrrl lmetcavnng gcdrtckdta tgvrcscpvg
      301 ftlqpdgktc kdineclmnn ggcdhfcrnt vgsfecgcqk ghklltdert cqdidecsfe
      361 rtcdhicins pgsfqclchr gyilygtthc gdvdecsmnn gscdqgcvnt kgsyecvcpp
      421 grrlhwnrkd cvemsgclsr skasaqaqls cgkvggvenc flsclgqslf mpdsetsyil
      481 scgvpglqgk appkrngtss svgpgcsdap ttpirqkarf kirdakchlr prsqerakdt
      541 lrhplldnch vtfvtlkcds skkrrrgrks pskevshita efevemkvee asgsceadcm
      601 rkraeqslqa aiktlrksig rhqfyvqvsg teyevaqrpa kapegtgtcg igqilqdgkc
      661 vpcapgtyfs sepgqcvpcv sgtyqdmegq lsctpcpsse glglagarnv secggqcspg
      721 ffsedgfkpc qacpvgtyqp epgrtgcfpc ggglltkqtg tasfqeceak vhcspghhyn
      781 ttthrcircp vgtyqpefgq nhciscpgnt stdfdgstnv thcknqhcgg elgdytgyie
      841 spnypgdypa naecvwhiap ppkrrilivv peiflpiede cgdvlvmrks asptsvttye
      901 tcqtyerpia ftsrsrklwi qfksneansg kgfqvpyvty dedyqqlied ivrdgrlyas
      961 enhqeilkdk klikalfdvl ahpqnyfkyt aqeskemfpr sfikllrskv srflrpyk
//
