LOCUS       NM_022670                522 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus secretin (Sct), mRNA.
ACCESSION   NM_022670
VERSION     NM_022670.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 522)
  AUTHORS   Li,Y., Schnabl,K., Gabler,S.M., Willershauser,M., Reber,J.,
            Karlas,A., Laurila,S., Lahesmaa,M., U Din,M.,
            Bast-Habersbrunner,A., Virtanen,K.A., Fromme,T., Bolze,F.,
            O'Farrell,L.S., Alsina-Fernandez,J., Coskun,T., Ntziachristos,V.,
            Nuutila,P. and Klingenspor,M.
  TITLE     Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to
            Induce Satiation
  JOURNAL   Cell 175 (6), 1561-1574 (2018)
   PUBMED   30449620
REFERENCE   2  (bases 1 to 522)
  AUTHORS   Fuchs,J.R., Robinson,G.M., Dean,A.M., Schoenberg,H.E.,
            Williams,M.R., Morielli,A.D. and Green,J.T.
  TITLE     Cerebellar secretin modulates eyeblink classical conditioning
  JOURNAL   Learn Mem 21 (12), 668-675 (2014)
   PUBMED   25403455
  REMARK    GeneRIF: propose that eyeblink conditioning (EBC)-induced secretin
            release from Purkinje cells modulates EBC acquisition by reducing
            surface expression of Kv1.2 at one or both of these sites
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 522)
  AUTHORS   Sekar,R. and Chow,B.K.
  TITLE     Lipolytic actions of secretin in mouse adipocytes
  JOURNAL   J Lipid Res 55 (2), 190-200 (2014)
   PUBMED   24273196
REFERENCE   4  (bases 1 to 522)
  AUTHORS   Williams,M.R., Fuchs,J.R., Green,J.T. and Morielli,A.D.
  TITLE     Cellular mechanisms and behavioral consequences of Kv1.2 regulation
            in the rat cerebellum
  JOURNAL   J Neurosci 32 (27), 9228-9237 (2012)
   PUBMED   22764231
  REMARK    GeneRIF: Secretin decreases cell surface Kv1.2 alpha-subunit levels
            by modulating Kv1.2 alpha- subunit endocytic trafficking.
REFERENCE   5  (bases 1 to 522)
  AUTHORS   Uriz,M., Saez,E., Prieto,J., Medina,J.F. and Banales,J.M.
  TITLE     Ursodeoxycholic acid is conjugated with taurine to promote
            secretin-stimulated biliary hydrocholeresis in the normal rat
  JOURNAL   PLoS One 6 (12), e28717 (2011)
   PUBMED   22194894
  REMARK    GeneRIF: Ursodeoxycholic acid is conjugated in order to promote
            secretin-stimulated hydrocholeresis in rats through Ae2,
            microtubules, intracellular Ca(2+), PKCalpha, PI3K, PKA, and MEK.
REFERENCE   6  (bases 1 to 522)
  AUTHORS   Itoh,N., Furuya,T., Ozaki,K., Ohta,M. and Kawasaki,T.
  TITLE     The secretin precursor gene. Structure of the coding region and
            expression in the brain
  JOURNAL   J Biol Chem 266 (19), 12595-12598 (1991)
   PUBMED   2061329
REFERENCE   7  (bases 1 to 522)
  AUTHORS   Kopin,A.S., Wheeler,M.B., Nishitani,J., McBride,E.W., Chang,T.M.,
            Chey,W.Y. and Leiter,A.B.
  TITLE     The secretin gene: evolutionary history, alternative splicing, and
            developmental regulation
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5335-5339 (1991)
   PUBMED   1711228
REFERENCE   8  (bases 1 to 522)
  AUTHORS   Kopin,A.S., Wheeler,M.B. and Leiter,A.B.
  TITLE     Secretin: structure of the precursor and tissue distribution of the
            mRNA
  JOURNAL   Proc Natl Acad Sci U S A 87 (6), 2299-2303 (1990)
   PUBMED   2315322
REFERENCE   9  (bases 1 to 522)
  AUTHORS   Gossen,D., Vandermeers,A., Vandermeers-Piret,M.C., Rathe,J.,
            Cauvin,A., Robberecht,P. and Christophe,J.
  TITLE     Isolation and primary structure of rat secretin
  JOURNAL   Biochem Biophys Res Commun 160 (2), 862-867 (1989)
   PUBMED   2719704
REFERENCE   10 (bases 1 to 522)
  AUTHORS   Murthy,S.N. and Ganiban,G.
  TITLE     Effect of the secretin family of peptides on gastric emptying and
            small intestinal transit in rats
  JOURNAL   Peptides 9 (3), 583-588 (1988)
   PUBMED   3047699
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 13, 2022 this sequence version replaced NM_022670.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF394786.1, M31495.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676811 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000001.1  205813128-205813246 c
            120-221             JAXUCZ010000001.1  205812945-205813046 c
            222-326             JAXUCZ010000001.1  205812735-205812839 c
            327-522             JAXUCZ010000001.1  205812435-205812630 c
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..522
                     /gene="Sct"
                     /gene_synonym="Secr"
                     /note="secretin"
                     /db_xref="GeneID:24769"
                     /db_xref="RGD:3643"
     exon            1..119
                     /gene="Sct"
                     /gene_synonym="Secr"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..438
                     /gene="Sct"
                     /gene_synonym="Secr"
                     /codon_start=1
                     /product="secretin precursor"
                     /protein_id="NP_073161.1"
                     /db_xref="GeneID:24769"
                     /db_xref="RGD:3643"
                     /translation="MEPLLPTPPLLLLLLLLLSSSFVLPAPPRTPRHSDGTFTSELSR
                     LQDSARLQRLLQGLVGKRSEEDTENIPENSVARPKPLEDQLCLLWSNTQALQDWLLPR
                     LSLDGSLSLWLPPGPRPAVDHSEWTETTRQPR"
     exon            120..221
                     /gene="Sct"
                     /gene_synonym="Secr"
                     /inference="alignment:Splign:2.1.0"
     exon            222..326
                     /gene="Sct"
                     /gene_synonym="Secr"
                     /inference="alignment:Splign:2.1.0"
     exon            327..522
                     /gene="Sct"
                     /gene_synonym="Secr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtgcagca tttatcacac ccagaacccg accatggagc ctctactgcc cacgccgccg
       61 ctactgctgc tgctgctgct gctgctctca agttctttcg tgcttcctgc acctcccagg
      121 accccaagac actcggacgg gacgttcacc agcgagctca gccgcttgca ggacagtgcc
      181 aggctgcagc gcctgctgca gggtctggtg gggaagcgca gcgaggagga cacagaaaat
      241 attccagaga acagcgtggc ccgtcccaag ccattagagg accaactctg cttgctgtgg
      301 tcgaacactc aggccctaca ggattggctt ctgcccaggc tgtccctgga tgggtccctg
      361 tctctctggc tgcctcctgg accaaggcct gctgtcgacc attcagagtg gactgaaaca
      421 accaggcagc ccagatgagg gaggaagggg agtctccagg agcctgactg gagtagggat
      481 tggttgtcct tggcatcaat aaagaaggaa tttagaccct gg
//
