LOCUS       NM_133383               2018 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus serine carboxypeptidase 1 (Scpep1), mRNA.
ACCESSION   NM_133383
VERSION     NM_133383.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2018)
  AUTHORS   Pan,X., Grigoryeva,L., Seyrantepe,V., Peng,J., Kollmann,K.,
            Tremblay,J., Lavoie,J.L., Hinek,A., Lubke,T. and Pshezhetsky,A.V.
  TITLE     Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary
            roles in regulation of vasoconstriction via inactivation of
            endothelin-1
  JOURNAL   PLoS Genet 10 (2), e1004146 (2014)
   PUBMED   24586188
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2018)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   3  (bases 1 to 2018)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 2018)
  AUTHORS   Chen,J., Streb,J.W., Maltby,K.M., Kitchen,C.M. and Miano,J.M.
  TITLE     Cloning of a novel retinoid-inducible serine carboxypeptidase from
            vascular smooth muscle cells
  JOURNAL   J Biol Chem 276 (36), 34175-34181 (2001)
   PUBMED   11447226
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133383.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF330051.1, SRR22399492.576405.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000010.1  74229949-74230043   c
            96-244              JAXUCZ010000010.1  74227217-74227365   c
            245-334             JAXUCZ010000010.1  74222634-74222723   c
            335-490             JAXUCZ010000010.1  74220053-74220208   c
            491-565             JAXUCZ010000010.1  74219291-74219365   c
            566-638             JAXUCZ010000010.1  74216647-74216719   c
            639-676             JAXUCZ010000010.1  74212412-74212449   c
            677-805             JAXUCZ010000010.1  74211247-74211375   c
            806-899             JAXUCZ010000010.1  74210276-74210369   c
            900-1013            JAXUCZ010000010.1  74209214-74209327   c
            1014-1151           JAXUCZ010000010.1  74205741-74205878   c
            1152-1315           JAXUCZ010000010.1  74204728-74204891   c
            1316-2018           JAXUCZ010000010.1  74200491-74201193   c
FEATURES             Location/Qualifiers
     source          1..2018
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..2018
                     /gene="Scpep1"
                     /gene_synonym="Risc"
                     /note="serine carboxypeptidase 1"
                     /db_xref="GeneID:114861"
                     /db_xref="RGD:620067"
     exon            1..95
                     /gene="Scpep1"
                     /gene_synonym="Risc"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1378
                     /gene="Scpep1"
                     /gene_synonym="Risc"
                     /note="retinoid-inducible serine carboxypeptidase;
                     retinoid-inducible serine caroboxypetidase"
                     /codon_start=1
                     /product="retinoid-inducible serine carboxypeptidase
                     precursor"
                     /protein_id="NP_596874.1"
                     /db_xref="GeneID:114861"
                     /db_xref="RGD:620067"
                     /translation="MELSRRICLVRLWLLLLSFLLGFSAGSALNWREQEGKEVWDYVT
                     VREDARMFWWLYYATNPCKNFSELPLVMWLQGGPGGSSTGFGNFEEIGPLDTRLKPRN
                     TTWLQWASLLFVDNPVGTGFSYVNTTDAYAKDLDTVASDMMVLLKSFFDCHKEFQTVP
                     FYIFSESYGGKMAAGISLELHKAIQQGTIKCNFSGVALGDSWISPVDSVLSWGPYLYS
                     VSLLDNKGLAEVSDIAEQVLNAVNKGFYKEATQLWGKAEMIIEKNTDGVNFYNILTKS
                     TPDTSMESSLEFFRSPLVRLCQRHVRHLQGDALSQLMNGPIKKKLKIIPDDVSWGAQS
                     SSVFISMEEDFMKPVIDIVDTLLELGVNVTVYNGQLDLIVDTIGQESWVQKLKWPQLS
                     RFNQLKWKALYTNPKSSETSAFVKSYENLAFYWILKAGHMVPADQGDMALKMMRLVTQ
                     QE"
     exon            96..244
                     /gene="Scpep1"
                     /gene_synonym="Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            245..334
                     /gene="Scpep1"
                     /gene_synonym="Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            335..490
                     /gene="Scpep1"
                     /gene_synonym="Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            491..565
                     /gene="Scpep1"
                     /gene_synonym="Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            566..638
                     /gene="Scpep1"
                     /gene_synonym="Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            639..676
                     /gene="Scpep1"
                     /gene_synonym="Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            677..805
                     /gene="Scpep1"
                     /gene_synonym="Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            806..899
                     /gene="Scpep1"
                     /gene_synonym="Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1013
                     /gene="Scpep1"
                     /gene_synonym="Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1151
                     /gene="Scpep1"
                     /gene_synonym="Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1315
                     /gene="Scpep1"
                     /gene_synonym="Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..2018
                     /gene="Scpep1"
                     /gene_synonym="Risc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgaggcggg gttttcatca tggagctgtc gcggcggatt tgtctcgtcc gactgtggct
       61 gttgctactg tcgttcttgc tgggcttcag cgcgggatct gccctcaact ggcgggaaca
      121 agaaggcaag gaagtatggg attacgtgac tgttcgagag gatgcacgca tgttctggtg
      181 gctctactat gccaccaacc cttgcaagaa cttctcagag ctgcctctgg tcatgtggct
      241 tcagggtggt ccaggtggtt ctagcactgg atttggaaac tttgaggaaa tcggccctct
      301 tgacacccga ctcaagccac ggaacactac ctggctgcag tgggccagtc tcctgttcgt
      361 ggacaatcct gtgggcacgg gcttcagtta cgtgaacacg acagatgcct acgcaaagga
      421 cctggacacg gtggcttccg acatgatggt cctcctgaaa tccttctttg attgtcataa
      481 agaattccag acggttccgt tctacatttt ctcagaatcc tacggaggaa agatggctgc
      541 tggcatcagt ttagaacttc acaaggctat tcagcaaggg accatcaagt gcaacttctc
      601 tggggttgct ttgggtgact cctggatctc ccctgtggat tcagtgctgt cctggggacc
      661 ttacctgtac agcgtgtctc tccttgataa taaaggcttg gctgaggtgt ccgacattgc
      721 ggagcaagtc ctcaatgctg taaacaaggg cttctacaag gaagccactc agctgtgggg
      781 gaaagcagaa atgatcattg aaaagaacac cgacggggta aacttctata acatcttaac
      841 taaaagcacc cccgacacct ctatggagtc gagcctcgag ttcttccgga gccccttagt
      901 tcgtctctgt cagcgccacg tgagacacct acaaggagac gccttaagtc agctcatgaa
      961 cggtcccatc aaaaagaagc tcaaaattat ccctgacgat gtctcctggg gagcccagtc
     1021 gtcctccgtc ttcataagca tggaagagga cttcatgaag cctgtcatcg acatcgtgga
     1081 tacgttgctg gaactcgggg tcaatgtgac tgtgtacaat gggcagctgg atctcattgt
     1141 ggacaccata ggtcaggagt cctgggttca gaagctgaag tggccacagc tgtccagatt
     1201 caatcagcta aaatggaagg ccctgtacac caatcctaag tcttcagaaa catctgcgtt
     1261 tgtcaagtcc tatgagaacc tagcgttcta ctggatccta aaggcgggtc acatggttcc
     1321 tgctgaccaa ggggacatgg ctctgaagat gatgaggctg gttactcagc aggagtagct
     1381 gagctgagct ggccctggag gccctggagg ccctggagta gggcccagga tgcaggtgct
     1441 aatgtctatc cccggcgctc ttcttcccga ctctaccatg ggatgtaact ccaggagccc
     1501 ctgccatctc ccgtaccaaa agactgtggc ttccgtgtct actcagaaat cagttctact
     1561 tcgtaaacag tgtttaaaac cagactcatt taatcagagt gaaggattgc agtccattgg
     1621 cttcttagca cagaagcagc tgataacaca agtaaacccc agcccttgag aggtagaagc
     1681 aagaggatca gaggttcaag cgcatcctcg gctccatcac aagttcaaaa gccgcctgca
     1741 ccaaatggga gtccttgtct caaaaaaaaa aaaaaaaaaa agcaaagaaa gcaaaggact
     1801 cgatgacatg atttatagac aaaagcagtg ggagaaaata ctaaagcccc actgagctgc
     1861 cagccaggtg tctgtgacta caggtctttt atctgctaca tatatatttt tacaaaaatg
     1921 aaatccatat tgttcgctat tttgctgtct gctttgctcc cgtatcaaca tgacttgcac
     1981 gtcttttccc atcaataaat gtgccatgat atttttaa
//
