LOCUS       NM_138508               2569 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus sterol carrier protein 2 (Scp2), mRNA.
ACCESSION   NM_138508
VERSION     NM_138508.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2569)
  AUTHORS   Nishioka,Y., Yamaguchi,M., Kawakami,A., Munehiro,M., Masuda,S.,
            Tomaru,U. and Ishizu,A.
  TITLE     Type II Natural Killer T Cells that Recognize Sterol Carrier
            Protein 2 Are Implicated in Vascular Inflammation in the Rat Model
            of Systemic Connective Tissue Diseases
  JOURNAL   Am J Pathol 187 (1), 176-186 (2017)
   PUBMED   27863214
  REMARK    GeneRIF: that type II natural killer T cells reactive with
            autologous SCP2 are implicated in vascular inflammation in the rat
            model.
REFERENCE   2  (bases 1 to 2569)
  AUTHORS   Williams,C.P., Schueller,N., Thompson,C.A., van den Berg,M., Van
            Haren,S.D., Erdmann,R., Bond,C.S., Distel,B., Schliebs,W.,
            Wilmanns,M. and Stanley,W.A.
  TITLE     The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is
            autonomous and essential for receptor recognition
  JOURNAL   BMC Biochem 12, 12 (2011)
   PUBMED   21375735
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2569)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   4  (bases 1 to 2569)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2569)
  AUTHORS   Shiozawa,K., Konarev,P.V., Neufeld,C., Wilmanns,M. and Svergun,D.I.
  TITLE     Solution structure of human Pex5.Pex14.PTS1 protein complexes
            obtained by small angle X-ray scattering
  JOURNAL   J Biol Chem 284 (37), 25334-25342 (2009)
   PUBMED   19584060
REFERENCE   6  (bases 1 to 2569)
  AUTHORS   van Haren,L., Teerds,K.J., Ossendorp,B.C., van Heusden,G.P.,
            Orly,J., Stocco,D.M., Wirtz,K.W. and Rommerts,F.F.
  TITLE     Sterol carrier protein 2 (non-specific lipid transfer protein) is
            localized in membranous fractions of Leydig cells and Sertoli cells
            but not in germ cells
  JOURNAL   Biochim Biophys Acta 1124 (3), 288-296 (1992)
   PUBMED   1374267
REFERENCE   7  (bases 1 to 2569)
  AUTHORS   Heikoop,J.C., Ossendorp,B.C., Wanders,R.J., Wirtz,K.W. and
            Tager,J.M.
  TITLE     Subcellular localisation and processing of non-specific lipid
            transfer protein are not aberrant in Rhizomelic Chondrodysplasia
            Punctata fibroblasts
  JOURNAL   FEBS Lett 299 (2), 201-204 (1992)
   PUBMED   1347505
REFERENCE   8  (bases 1 to 2569)
  AUTHORS   Ossendorp,B.C., Van Heusden,G.P., De Beer,A.L., Bos,K.,
            Schouten,G.L. and Wirtz,K.W.
  TITLE     Identification of the cDNA clone which encodes the 58-kDa protein
            containing the amino acid sequence of rat liver non-specific
            lipid-transfer protein (sterol-carrier protein 2). Homology with
            rat peroxisomal and mitochondrial 3-oxoacyl-CoA thiolases
  JOURNAL   Eur J Biochem 201 (1), 233-239 (1991)
   PUBMED   1915369
REFERENCE   9  (bases 1 to 2569)
  AUTHORS   Yamamoto,R., Kallen,C.B., Babalola,G.O., Rennert,H.,
            Billheimer,J.T. and Strauss,J.F. 3rd.
  TITLE     Cloning and expression of a cDNA encoding human sterol carrier
            protein 2
  JOURNAL   Proc Natl Acad Sci U S A 88 (2), 463-467 (1991)
   PUBMED   1703300
REFERENCE   10 (bases 1 to 2569)
  AUTHORS   Seedorf,U. and Assmann,G.
  TITLE     Cloning, expression, and nucleotide sequence of rat liver sterol
            carrier protein 2 cDNAs
  JOURNAL   J Biol Chem 266 (1), 630-636 (1991)
   PUBMED   1985920
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138508.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M57453.1, M62763.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000005.1  128109931-128110015 c
            86-143              JAXUCZ010000005.1  128103472-128103529 c
            144-215             JAXUCZ010000005.1  128099175-128099246 c
            216-347             JAXUCZ010000005.1  128097367-128097498 c
            348-412             JAXUCZ010000005.1  128094872-128094936 c
            413-539             JAXUCZ010000005.1  128091531-128091657 c
            540-603             JAXUCZ010000005.1  128084652-128084715 c
            604-690             JAXUCZ010000005.1  128083208-128083294 c
            691-841             JAXUCZ010000005.1  128078361-128078511 c
            842-989             JAXUCZ010000005.1  128076411-128076558 c
            990-1097            JAXUCZ010000005.1  128067552-128067659 c
            1098-1251           JAXUCZ010000005.1  128064503-128064656 c
            1252-1354           JAXUCZ010000005.1  128056767-128056869 c
            1355-1484           JAXUCZ010000005.1  128047939-128048068 c
            1485-1564           JAXUCZ010000005.1  128039327-128039406 c
            1565-2569           JAXUCZ010000005.1  128035714-128036718 c
FEATURES             Location/Qualifiers
     source          1..2569
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..2569
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /note="sterol carrier protein 2"
                     /db_xref="GeneID:25541"
                     /db_xref="RGD:3642"
     exon            1..85
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1660
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /EC_number="2.3.1.16"
                     /EC_number="2.3.1.176"
                     /EC_number="2.3.1.155"
                     /note="non-specific lipid-transfer protein; SCP-2; SCP-X;
                     NSL-TP; SCP-chi; sterol carrier protein X; propanoyl-CoA
                     C-acyltransferase; Sterol carrier protein 2, liver;
                     SCP-2/thiolase; SCP-2/3-oxoacyl-CoA thiolase;
                     straight-chain acyl-CoA oxidase; acetyl-CoA
                     C-myristoyltransferase"
                     /codon_start=1
                     /product="sterol carrier protein 2"
                     /protein_id="NP_612517.3"
                     /db_xref="GeneID:25541"
                     /db_xref="RGD:3642"
                     /translation="MPSVALNSPRLRRVFVVGVGMTKFMKPGGENSRDYPDLAKEAGQ
                     KALADAQIPYSAVEQACVGYVYGESTCGQRAIYHSLGLTGIPIINVNNNCSTGSTALF
                     MAQQLVQGGLANCVLALGFEKMEKGSLGTKYSDRSNPLEKHIDVLINKYGMSACPFAP
                     QLFGSAGKEHMETYGTKVEHFAKIGWKNHKHSVNNPYSQFQDEYSLDEIMKSRPVFDF
                     LTVLQCCPTSDGAAAAIVSSEEFVQKHGLQSKAVEIVAQEMVTDMPSTFEEKSVIKMV
                     GYDMSKEAARKCYEKSGLGPSDVDVIELHDCFSTNELLTYEALGLCPEGQGGALVDRG
                     DNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQVPGAKVALQHNL
                     GLGGAAVVTLYRMGFPEAASSFRTHQISAAPTSSAGDGFKANLIFKEIEKKLEEEGEE
                     FVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPDSDKKADCTITMADSDLLALM
                     TGKMNPQSAFFQGKLKIAGNMGLAMKLQSLQLQPDKAKL"
     exon            86..143
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /inference="alignment:Splign:2.1.0"
     exon            144..215
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /inference="alignment:Splign:2.1.0"
     exon            216..347
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /inference="alignment:Splign:2.1.0"
     exon            348..412
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /inference="alignment:Splign:2.1.0"
     exon            413..539
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /inference="alignment:Splign:2.1.0"
     exon            540..603
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /inference="alignment:Splign:2.1.0"
     exon            604..690
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /inference="alignment:Splign:2.1.0"
     exon            691..841
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /inference="alignment:Splign:2.1.0"
     exon            842..989
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1097
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1251
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1354
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1484
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1564
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..2569
                     /gene="Scp2"
                     /gene_synonym="NSLIPTR; SCPx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttgctgct agagccatgc cttcagtcgc gttgaactct ccgcgcctgc gccgggtgtt
       61 cgtggtcgga gttggcatga ccaagttcat gaagcctgga ggtgagaatt caagagacta
      121 tcctgatttg gcaaaagaag caggccagaa ggcattggcg gacgcgcaga tcccttactc
      181 cgcagtggag caggcgtgcg ttggctatgt gtacggtgaa tccacctgcg ggcagagggc
      241 catctatcac agcctggggc tgactggcat ccctatcatt aatgtcaaca ataactgctc
      301 taccggttct actgctttgt ttatggccca gcaactggtt cagggaggtt tagcaaattg
      361 cgtgttagct cttgggtttg agaagatgga aaagggatcc cttggtacca aatattcaga
      421 tcggtcaaat ccactggaaa aacatattga cgtcttgatc aataagtatg gaatgtctgc
      481 ctgtccattt gctcctcagc tgtttgggag cgctgggaaa gaacatatgg aaacatatgg
      541 aacaaaggtt gaacactttg caaaaattgg atggaaaaat cataaacact cagttaataa
      601 cccgtattcc cagttccaag atgaatacag cttagatgag ataatgaaat caaggccagt
      661 tttcgatttt ctgactgtct tacaatgctg tcccacctca gatggtgccg cagcagcaat
      721 tgtgtctagt gaggagtttg tgcagaagca tggcctgcag tccaaagctg tggaaattgt
      781 ggcacaggag atggtgactg acatgcccag tacatttgaa gaaaaaagtg ttattaaaat
      841 ggttggctat gatatgagta aagaagctgc caggaagtgc tatgagaagt ccggcctggg
      901 tcccagtgat gtcgacgtga tagagcttca cgattgcttc tctaccaatg aactcctgac
      961 ttacgaagca ctggggctct gtccagaagg acaaggtgga gcactggtgg acagagggga
     1021 caacacttac ggaggaaagt gggtcataaa ccctagtgga ggcctcatct ccaagggaca
     1081 cccactgggt gccacaggtc tggctcagtg cgcggagctc tgctggcagc tgagaggtga
     1141 agccggaaag aggcaggttc ctggggcaaa ggtggctctg cagcacaatt taggccttgg
     1201 aggagctgct gttgtcaccc tctacagaat gggttttccc gaagctgcca gctccttcag
     1261 aacgcaccag atttcagctg ctcccaccag ctctgcaggg gatggattca aggcaaatct
     1321 catttttaag gaaatcgaga agaagcttga agaggaaggg gaagagttcg tgaagaaaat
     1381 cggtggcatt tttgccttca aagtgaagga tggccccggg ggcaaagaag ctacgtgggt
     1441 ggtggacgtg aagaacggca aaggatcggt gcttccggat tcagataaga aggctgactg
     1501 cacaatcacc atggctgact cagacttgct ggctttgatg actggtaaaa tgaaccctca
     1561 gtcggccttc tttcaaggta aactgaaaat tgccggtaac atgggcctgg ccatgaaact
     1621 gcaaagcctg cagcttcagc cggacaaagc taagctgtga agagtccctt tggcaacctc
     1681 aggacatcaa gatgagatgt gtggatacgt agaaatccac gtctccctgt caggacttag
     1741 actgacactt cctgaatagc atgagataga tttcttgcta ggtggctatg gccaattgta
     1801 tttcccccaa gctgggggtg caaagggcct cccaggctac actgctgctt tgaggacttg
     1861 cattctactg tgcttcatga agctactatg ttaatgatgg tttggggtaa acttgagttt
     1921 cagaataaag ttcagaatag taaaatctaa agactgtgta aacagagccc ttgttttgct
     1981 taggagtaca tttaaggatc gtcgtgttgg acactcggtg tgacagtttc cccttagagg
     2041 gactggagaa gaaacagatt tccagagttg accaggaatt agtgcctcac acttaattac
     2101 ctgcatcagt ttctcactaa tagttcttaa aataaaattc tgtactgagt gtttaaaaaa
     2161 aaactttaaa aatgttcttt tcatgccatc agaaacagtt cttttcttcc caaataaaat
     2221 acaagaatta tggtcagagc ttaagagaga atttacagct gaacagagct gtttttaaaa
     2281 tatttttaaa gtgggcatct tttaaaaaaa atcagcatcg gagctatggg atgccattgc
     2341 taaaaataat tgaataaagt ttcttccaga gatacaggct tcaaattata ttttcatact
     2401 agtaagttta taaactgggt ctcacaaatt tcctctttca tgcatttggt tgtctgcatt
     2461 tatctttctt cctggttttt ctaactctaa cgctgtttgt tataatttag gtttgggata
     2521 aaaatatgct tttggaagat ttaaaaagaa aattaaaaca gctcttcct
//
