LOCUS       NM_001173374            1600 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus synthesis of cytochrome C oxidase 1 (Sco1), mRNA.
ACCESSION   NM_001173374 XM_001078805 XM_573117
VERSION     NM_001173374.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1600)
  AUTHORS   Hlynialuk CJ, Ling B, Baker ZN, Cobine PA, Yu LD, Boulet A, Wai T,
            Hossain A, El Zawily AM, McFie PJ, Stone SJ, Diaz F, Moraes CT,
            Viswanathan D, Petris MJ and Leary SC.
  TITLE     The Mitochondrial Metallochaperone SCO1 Is Required to Sustain
            Expression of the High-Affinity Copper Transporter CTR1 and
            Preserve Copper Homeostasis
  JOURNAL   Cell Rep 10 (6), 933-943 (2015)
   PUBMED   25683716
REFERENCE   2  (bases 1 to 1600)
  AUTHORS   Baertling F, A M van den Brand M, Hertecant JL, Al-Shamsi A, P van
            den Heuvel L, Distelmaier F, Mayatepek E, Smeitink JA, Nijtmans LG
            and Rodenburg RJ.
  TITLE     Mutations in COA6 cause cytochrome c oxidase deficiency and
            neonatal hypertrophic cardiomyopathy
  JOURNAL   Hum Mutat 36 (1), 34-38 (2015)
   PUBMED   25339201
REFERENCE   3  (bases 1 to 1600)
  AUTHORS   Brosel S, Yang H, Tanji K, Bonilla E and Schon EA.
  TITLE     Unexpected vascular enrichment of SCO1 over SCO2 in mammalian
            tissues: implications for human mitochondrial disease
  JOURNAL   Am J Pathol 177 (5), 2541-2548 (2010)
   PUBMED   20864674
REFERENCE   4  (bases 1 to 1600)
  AUTHORS   Yang H, Brosel S, Acin-Perez R, Slavkovich V, Nishino I, Khan R,
            Goldberg IJ, Graziano J, Manfredi G and Schon EA.
  TITLE     Analysis of mouse models of cytochrome c oxidase deficiency owing
            to mutations in Sco2
  JOURNAL   Hum Mol Genet 19 (1), 170-180 (2010)
   PUBMED   19837698
REFERENCE   5  (bases 1 to 1600)
  AUTHORS   Leary SC, Kaufman BA, Pellecchia G, Guercin GH, Mattman A, Jaksch M
            and Shoubridge EA.
  TITLE     Human SCO1 and SCO2 have independent, cooperative functions in
            copper delivery to cytochrome c oxidase
  JOURNAL   Hum Mol Genet 13 (17), 1839-1848 (2004)
   PUBMED   15229189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK359925.1 and BC158882.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_001078805.2, XM_573117.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158882.1, FQ209701.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                CK359925.1         1-65
            66-1600             BC158882.1         1-1535
FEATURES             Location/Qualifiers
     source          1..1600
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1600
                     /gene="Sco1"
                     /gene_synonym="RGD1559538"
                     /note="synthesis of cytochrome C oxidase 1"
                     /db_xref="GeneID:497930"
                     /db_xref="RGD:1559538"
     exon            1..259
                     /gene="Sco1"
                     /gene_synonym="RGD1559538"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..892
                     /gene="Sco1"
                     /gene_synonym="RGD1559538"
                     /note="SCO1 cytochrome c oxidase assembly protein; SCO
                     cytochrome c oxidase assembly protein 1"
                     /codon_start=1
                     /product="SCO cytochrome oxidase deficient homolog 1"
                     /protein_id="NP_001166845.1"
                     /db_xref="GeneID:497930"
                     /db_xref="RGD:1559538"
                     /translation="MAALVRLAVVRSQCRQLWHLFPRGHGLRGMAERPRPEEARCSLG
                     SRNFSARPPPPGAGPEPKGSQAGSHRPKLGPVSWKSLALTFAIGGSLLAGMKYFKKEK
                     IEKLEKQRHRSIGKPLLGGPFSLTTHNGEPKTDKDFLGQWVLIYFGFTHCPDICPEEL
                     EKMIEVVEEIDSIPSLPNLTPLFITIDPERDTKEAIATYVKEFSPKLVGLTGTKEEID
                     GVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKKKAEIAGSIAAH
                     MRSHMRKR"
     exon            260..350
                     /gene="Sco1"
                     /gene_synonym="RGD1559538"
                     /inference="alignment:Splign:2.1.0"
     exon            351..548
                     /gene="Sco1"
                     /gene_synonym="RGD1559538"
                     /inference="alignment:Splign:2.1.0"
     exon            549..641
                     /gene="Sco1"
                     /gene_synonym="RGD1559538"
                     /inference="alignment:Splign:2.1.0"
     exon            642..757
                     /gene="Sco1"
                     /gene_synonym="RGD1559538"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1580
                     /gene="Sco1"
                     /gene_synonym="RGD1559538"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaggcggc cctaaggagg cgcggtctcc taaattcatg gcggctcttg tacggttagc
       61 ggtggtgcgt tcacagtgtc gccagctttg gcatctgttc cctcgcggcc atgggctcag
      121 gggtatggcg gagaggccga gaccggagga ggcgcgctgc tccctgggga gccgaaactt
      181 cagcgccagg ccgccaccgc cgggtgccgg gccggagccc aagggcagtc aagcggggtc
      241 tcaccgcccg aagcttgggc ctgtttcttg gaagtcttta gcactcactt ttgccattgg
      301 aggatcttta ttggctggaa tgaagtactt caagaaagag aagatagaaa agctggagaa
      361 acagcggcat cgcagcattg ggaagccttt actaggggga ccattttccc tcacaactca
      421 caatggagag cccaaaactg acaaggactt cctgggtcaa tgggtattga tttattttgg
      481 cttcactcat tgccctgata tctgtccaga agaactggaa aaaatgattg aagttgtgga
      541 ggaaatagac agtattccat ccctgccaaa tttaactcca cttttcatca ccattgaccc
      601 agaaagggac acaaaagaag ccatcgcaac ttatgtgaaa gaattttctc ccaaattggt
      661 tggtttgact ggcacaaagg aagagattga tggagtggcc agagcataca gggtgtatta
      721 cagtcctggc cctaaggacg aggatgagga ctacatagtg gatcatacaa taataatgta
      781 cttgattgga ccagatggag aatttcttga ttattttgga caaaacaaga agaaggcaga
      841 aatagctggc tcaatagctg cacatatgag gtcacacatg aggaagaggt agccagagcc
      901 atgtcacctg atgcaggatt gtcttgctgg caaggaagct ttgtctccca gaggaacctc
      961 tatattatgt aacatacagc gtggactgca taccctgaga gcatcattct acatgagatg
     1021 ttaccctggg gctcagccag cccagtctgc cacgaagcta ccatgagtcc aaaggatcag
     1081 cgcaggcaga accagtggag aacaggcacc cagaagcatc agagaggcac acgaatgcac
     1141 atctgtaggc acggcactct tggaatagtg ttgctgcctc gccagtgtct gcttgctcag
     1201 gcctgtgggg ccaaattcta caggaaagag tgtcacttcc ataatgctct cattgtttca
     1261 actcgtgtgc tcgcgtgctc atagtcagca taggcgtcta cgtcatcttc atactggaga
     1321 gtggacgctc agcttctttg aaaaggcatg tcaccatcag gtctgcatct cattcccaca
     1381 gcagctgctg ctttgagggc tggaagagaa aacttactgt ttgcacataa ctgttggctc
     1441 agtccccacc tttttatttt aatagctaag tgatttggtt tggtagacca aatggaaatg
     1501 aaaatattta tcatgactat aatctggtac tttttatgta ccaggttaca cagtgtatga
     1561 aataaaagat gtcagtctaa aaaaaaaaaa aaaaaaaaaa
//
