LOCUS       NM_001388508            6837 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Rattus norvegicus sodium voltage-gated channel alpha subunit 7
            (Scn7a), mRNA.
ACCESSION   NM_001388508 XM_006234296
VERSION     NM_001388508.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6837)
  AUTHORS   Salgado-Mozo,S., Thirouin,Z.S., Wyrosdic,J.C., Garcia-Hernandez,U.
            and Bourque,C.W.
  TITLE     NaX Channel Is a Physiological [Na+] Detector in Oxytocin- and
            Vasopressin-Releasing Magnocellular Neurosecretory Cells of the Rat
            Supraoptic Nucleus
  JOURNAL   J Neurosci 43 (49), 8306-8316 (2023)
   PUBMED   37783507
  REMARK    GeneRIF: NaX Channel Is a Physiological [Na[+]] Detector in
            Oxytocin- and Vasopressin-Releasing Magnocellular Neurosecretory
            Cells of the Rat Supraoptic Nucleus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6837)
  AUTHORS   Bogdanovic,E., Potet,F., Marszalec,W., Iyer,H., Galiano,R.,
            Hong,S.J., Leung,K.P., Wasserstrom,J.A., George,A.L. Jr. and
            Mustoe,T.A.
  TITLE     The sodium channel NaX : Possible player in excitation-contraction
            coupling
  JOURNAL   IUBMB Life 72 (4), 601-606 (2020)
   PUBMED   32027092
  REMARK    GeneRIF: The sodium channel NaX : Possible player in
            excitation-contraction coupling.
REFERENCE   3  (bases 1 to 6837)
  AUTHORS   Ke,C.B., He,W.S., Li,C.J., Shi,D., Gao,F. and Tian,Y.K.
  TITLE     Enhanced SCN7A/Nax expression contributes to bone cancer pain by
            increasing excitability of neurons in dorsal root ganglion
  JOURNAL   Neuroscience 227, 80-89 (2012)
   PUBMED   23026072
  REMARK    GeneRIF: The results of this study demonstrated that enhanced
            expression of SCN7A/Nax channel within distinct subpopulation of
            DRG neurons contributes to bone cancer pain by increasing the
            excitability of these neurons
REFERENCE   4  (bases 1 to 6837)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   5  (bases 1 to 6837)
  AUTHORS   Buga,A.M., Scholz,C.J., Kumar,S., Herndon,J.G., Alexandru,D.,
            Cojocaru,G.R., Dandekar,T. and Popa-Wagner,A.
  TITLE     Identification of new therapeutic targets by genome-wide analysis
            of gene expression in the ipsilateral cortex of aged rats after
            stroke
  JOURNAL   PLoS One 7 (12), e50985 (2012)
   PUBMED   23251410
REFERENCE   6  (bases 1 to 6837)
  AUTHORS   Fryatt,A.G., Vial,C., Mulheran,M., Gunthorpe,M.J. and Grubb,B.D.
  TITLE     Voltage-gated sodium channel expression in rat spiral ganglion
            neurons
  JOURNAL   Mol Cell Neurosci 42 (4), 399-407 (2009)
   PUBMED   19765660
  REMARK    GeneRIF: Data demonstrate predominant localisation of Na(V)1.6 and
            Na(V)1.7 on SGN cell bodies and Na(V)1.1 on axonal processes in rat
            brain.
REFERENCE   7  (bases 1 to 6837)
  AUTHORS   Watanabe,E., Hiyama,T.Y., Shimizu,H., Kodama,R., Hayashi,N.,
            Miyata,S., Yanagawa,Y., Obata,K. and Noda,M.
  TITLE     Sodium-level-sensitive sodium channel Na(x) is expressed in glial
            laminate processes in the sensory circumventricular organs
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 290 (3), R568-R576 (2006)
   PUBMED   16223844
REFERENCE   8  (bases 1 to 6837)
  AUTHORS   Grob,M., Drolet,G. and Mouginot,D.
  TITLE     Specific Na+ sensors are functionally expressed in a neuronal
            population of the median preoptic nucleus of the rat
  JOURNAL   J Neurosci 24 (16), 3974-3984 (2004)
   PUBMED   15102913
  REMARK    GeneRIF: This study shows that a neuronal population of the median
            preoptic nucleus acts as functional Na+ sensors and that the Na(X)
            channel might represent the molecular basis for the extracellular
            sodium level sensing in these neurons.
REFERENCE   9  (bases 1 to 6837)
  AUTHORS   Akopian,A.N., Souslova,V., Sivilotti,L. and Wood,J.N.
  TITLE     Structure and distribution of a broadly expressed atypical sodium
            channel
  JOURNAL   FEBS Lett 400 (2), 183-187 (1997)
   PUBMED   9001394
REFERENCE   10 (bases 1 to 6837)
  AUTHORS   Gautron,S., Dos Santos,G., Pinto-Henrique,D., Koulakoff,A., Gros,F.
            and Berwald-Netter,Y.
  TITLE     The glial voltage-gated sodium channel: cell- and tissue-specific
            mRNA expression
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 7272-7276 (1992)
   PUBMED   1379737
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 25, 2020 this sequence version replaced XM_006234296.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN12840105, SAMN12840106
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               JAXUCZ010000003.1  71846068-71846284   c
            218-465             JAXUCZ010000003.1  71819116-71819363   c
            466-584             JAXUCZ010000003.1  71814512-71814630   c
            585-674             JAXUCZ010000003.1  71814183-71814272   c
            675-803             JAXUCZ010000003.1  71812434-71812562   c
            804-895             JAXUCZ010000003.1  71811420-71811511   c
            896-1102            JAXUCZ010000003.1  71810481-71810687   c
            1103-1172           JAXUCZ010000003.1  71807060-71807129   c
            1173-1314           JAXUCZ010000003.1  71804505-71804646   c
            1315-1521           JAXUCZ010000003.1  71799388-71799594   c
            1522-1618           JAXUCZ010000003.1  71780274-71780370   c
            1619-1857           JAXUCZ010000003.1  71777107-71777345   c
            1858-2028           JAXUCZ010000003.1  71771028-71771198   c
            2029-2385           JAXUCZ010000003.1  71770155-71770511   c
            2386-2820           JAXUCZ010000003.1  71767843-71768277   c
            2821-2926           JAXUCZ010000003.1  71765112-71765217   c
            2927-3081           JAXUCZ010000003.1  71762694-71762848   c
            3082-3255           JAXUCZ010000003.1  71759767-71759940   c
            3256-3363           JAXUCZ010000003.1  71757375-71757482   c
            3364-3642           JAXUCZ010000003.1  71752828-71753106   c
            3643-3696           JAXUCZ010000003.1  71751953-71752006   c
            3697-3834           JAXUCZ010000003.1  71751443-71751580   c
            3835-3939           JAXUCZ010000003.1  71750514-71750618   c
            3940-4210           JAXUCZ010000003.1  71749701-71749971   c
            4211-6837           JAXUCZ010000003.1  71743873-71746499   c
FEATURES             Location/Qualifiers
     source          1..6837
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..6837
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /note="sodium voltage-gated channel alpha subunit 7"
                     /db_xref="GeneID:64155"
                     /db_xref="RGD:61922"
     exon            1..217
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            218..465
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..5274
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /note="sodium channel, voltage-gated, type 6, alpha
                     polypeptide; sodium channel voltage-gated type VI alpha
                     polypeptide; sodium channel, voltage-gated, type VII,
                     alpha subunit; nax channel; glial sodium channel alpha
                     subunit; voltage-gated sodium channel-like protein"
                     /codon_start=1
                     /product="sodium channel protein type 7 subunit alpha"
                     /protein_id="NP_001375437.1"
                     /db_xref="GeneID:64155"
                     /db_xref="RGD:61922"
                     /translation="MLTSPEPKGLVPFTAESLELIKNHIAKKCNEEHEEEDLKPSWGL
                     EAGKKLPFAYGTLPQGTVSEPLEDVDPYYYVKRNTFMVLNRNRVIFRFNAVSILCTLS
                     PLSSLRRAVIKVLVHPLFRLLILISVLTDSILMCMSNLPEWILAVENTLLGIYTFEIL
                     VKVIARGIWAGSFSFLGDLWNWLDFSVTLFELITRSSPLSSLPMFKTIRTLRILKIIP
                     LNHGLQSIVVTLVQCLKKLLGAIALALFFLTVSSLFGMGLFMGNLKHKCVRWPQEDGN
                     DVMYNGTGSQYHILERENFYYMEGARYALLCGNKTDAGLCPEGYMCVKEGSNPDNGFT
                     SFDNFGWALLAMFRLMTQDYPELLYHQILYASGKIYMIFFVLISFWFAFYMASLFLGI
                     LTMAYEQEKQRASEESRDMDSKCHQTVKEFEEEHEGAEMETTQIEMKKRSPTSINTTL
                     DILEDTALGHKEEPETSRKECPLCWYKFTKTCFIWKCSPCWIKLNEFADRIITHPLFD
                     LFLVICIILNICFLALEHFPMSEELMSLLAIGNLVFIGIYTIEMILKIIAMHPYGYFQ
                     ISWHIFDSILVVLGLTEMLLADIEEITVFILVPLIFIKLGKYAPPFKNLMRILGRALV
                     ALKDLVLLVSIFIYFSAVFGMKLFGRSYKDCVCHVDQDCQRQRWHMSDFLHAYVTVFR
                     ILCGEWIETLWECMEVAGEAWCIPFYMMVILIGNLLILYLFVALVSSFASYDATTEVS
                     KEAKNLQLAVAWIKMVINCVLLKILCKEKTVSTEATDQTCDPSVKENISGHTLSELSN
                     TQTFLRYKDQSSGTEKTPVTESESQSLIASPSVSETVPIASGESDIENLDNKETRSKS
                     ANGSSKEKMKQSSSSECSTVDIAISEEEEMVYEHEKSKLHKNGYERKSSAGQVSRESR
                     NGKIWRNIRKTCCKIVENSWFECFIGLVTLLCTGTLALEDIYIDQRKTIKIFLEYGDM
                     IFAYIFILEMLLKWVAYGFKAYFSNNWYKLDFMVVIVLCLSLIGKTREDLNPLASIKF
                     LRALRVLSQFERMKVVLRALIKTTLPAVSVFLVCLMIWLLFSVMGVFLFAGKFYECID
                     PTRGERFSVFEVMNKSQCENLVFNESMPWENAKLNFDNVGNGFLSLFQVATFNGWISI
                     MNSAIDSVGVYMQPSFEHSLHMYTYFIIFVVFGLFLPLCMLIGVIIRNFNKQKIKQGG
                     SNIFITVKQKKQYRALKKLLYADSQKPAARPRNKFQGFICDVVTHRVFNVIIILLICF
                     QATTIMIQNDEQSPQIETAVFWMNSLFTMLFTLECILKLTAFRCHYFTSAWNVHDFMV
                     VVFSITGLLLPLSIGQYFVPPSLVQLLLLSRIIHVLRPGKGPKVFHDLMLPLMLSLPA
                     LLNIALLIFLVMFIYAIFGMYNFAYVKKEAGINDVSNFETFGSSMLCLFQVTTFSGWD
                     GMLDAIFNSQWSDCDPDKINPGTQVRGDCGSPSVGIFYFVSYILISWLIIVNMYVVLI
                     MEFLSIPSKRKNRTLSEDDFRRFFKVWNRFDPDRTQYIDSTKLSDFAAALDPPLFMAK
                     PNKGQLVAMDLPMAAGDRIHCLDILLAFTKRVMGKDERVEKILSEIESGFMLANPFKI
                     TYEPITTTLKRKQEAVSATIIQRAYKSYRLRQSDKKIQDIPEIDDGREDPNSKGVHSG
                     QIEEKASIQTQI"
     exon            466..584
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            585..674
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            675..803
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            804..895
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1102
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1172
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1314
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1521
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1618
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1857
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..2028
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2385
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2820
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2926
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3081
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3255
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3363
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3642
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..3696
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            3697..3834
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            3835..3939
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4210
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
     exon            4211..6837
                     /gene="Scn7a"
                     /gene_synonym="Na-G; SCL-11; Scn6a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctgtctgt aggtggtctc tgggtctgtg actgaggaga cagccaggtg acagagtgtc
       61 tagctggcaa aagcagtgga cagcaagctc agtgccacaa ccccctaagc agagagatct
      121 gggaagaaaa acaagcccag gagagcaaag ggctctcatg agccttgctt ctgggtttcc
      181 tgctggagtt ttagtgaaga ctatcatttg gcaacaagta caaaattgaa aatgttgact
      241 tcgccagagc cgaagggcct tgtcccattc acggcagagt cacttgaact tataaaaaat
      301 cacattgcta aaaaatgcaa cgaagagcat gaagaagaag atttaaaacc aagctggggt
      361 ttagaagcag gcaaaaaact tccatttgcc tatggaaccc ttcctcaagg aaccgtgtca
      421 gagcccttgg aagatgtgga tccatactac tatgttaaga gaaatacttt catggtctta
      481 aacagaaaca gagtcatctt caggttcaat gcggtttcca tcctctgcac gttgtctcct
      541 ttaagctctc tcagaagagc tgttatcaag gttttggtgc accccctttt tcgcctgctg
      601 attttaatta gtgttctcac cgacagcata cttatgtgca tgagtaatct accggaatgg
      661 atattggcag tagagaatac tttgcttggg atttacacat tcgaaatact tgtaaaagtc
      721 attgcaagag gtatctgggc agggtcattt tccttccttg gggatctttg gaactggctt
      781 gatttcagtg taactttgtt cgagcttatc acaaggtctt cacctctaag ctcccttcca
      841 atgtttaaaa caataagaac cttgcgaatt ttgaagatca ttcctttgaa ccatggcctg
      901 cagtctattg tggtgacgct ggtccagtgt ttgaagaaac tactcggagc cattgcccta
      961 gctctgtttt ttctgactgt gtcttcgcta ttcgggatgg gtctcttcat gggcaacctg
     1021 aagcacaaat gtgtgcgatg gccccaagaa gatggaaatg atgtgatgta caatggaact
     1081 ggaagccagt accatattct agaaagagaa aacttctact atatggaagg cgcgagatac
     1141 gctctcctct gcggcaacaa gacagatgcc ggcctgtgtc cagaaggtta tatgtgtgta
     1201 aaagagggct caaatcctga caatggcttc acaagttttg acaattttgg ctgggctcta
     1261 ctggctatgt ttcgattgat gactcaggat taccctgaat tactttatca ccagatcctt
     1321 tatgcttcag gaaagatcta catgatattt tttgttctga tcagtttctg gtttgccttc
     1381 tatatggcaa gtttgttctt gggcatcctc actatggcct atgaacagga gaagcagaga
     1441 gcttctgagg agtctagaga catggattct aaatgtcatc agactgtgaa agaattcgag
     1501 gaagaacatg aaggagctga gatggaaact acacaaatag aaatgaagaa aagatcacca
     1561 acctctataa acaccacatt ggatatactg gaagacactg cccttggaca caaagaagaa
     1621 ccagaaacat ccaggaagga atgcccactc tgttggtata agtttactaa aacctgcttt
     1681 atctggaaat gctctccctg ttggataaaa ctgaatgagt ttgctgacag aattataaca
     1741 cacccattgt ttgatctttt ccttgttata tgcatcattt taaacatatg cttcctggcc
     1801 ctagaacact ttccaatgag tgaggagctc atgtcactcc ttgccattgg aaacttggtt
     1861 tttattggaa tttacacaat agaaatgatt ttgaagataa tcgctatgca tccatatggg
     1921 tatttccaaa taagctggca tatttttgac agtattcttg tggttttggg attaacagaa
     1981 atgttactag cagatattga agaaataact gtttttatat tagtcccatt gatatttata
     2041 aaattgggaa aatatgcacc accatttaag aatttgatgc gtattcttgg tagagcattg
     2101 gtggccctga aagacttggt cctgttggtc tccattttca tttacttctc tgccgtgttt
     2161 ggcatgaagc tgtttggtcg aagttacaaa gattgtgtct gccacgtaga tcaagactgt
     2221 caacgccaac gttggcacat gagtgacttc ctccacgcct acgtgactgt gttccgaatc
     2281 ctctgcggag agtggataga gacattatgg gagtgtatgg aggttgcagg cgaggcctgg
     2341 tgtattccat tttacatgat ggtcatttta attggaaatt tattgatact ttacctcttt
     2401 gtggcattgg tgagctcatt tgcttcatac gatgctacca cagaagtgag caaagaagcc
     2461 aaaaaccttc agcttgcagt ggcatggata aaaatggtaa taaactgtgt gcttcttaaa
     2521 atactgtgca aagaaaaaac tgtttctaca gaagcaacag accaaacatg tgatccaagt
     2581 gttaaagaga atatttctgg tcatactctt tctgaactga gcaacaccca aacattcctc
     2641 agatacaagg accagagcag tggtactgag aaaactccag tgactgagtc tgagagccaa
     2701 tccctgattg ctagtcccag tgtatcagaa actgtgccaa ttgcttcagg agaatccgat
     2761 atagaaaacc tggataacaa ggagactcgg agcaagtctg caaatggaag cagtaaagag
     2821 aaaatgaagc aatctagttc atctgagtgc agcacggttg atattgctat ttctgaagaa
     2881 gaagaaatgg tctatgaaca tgaaaagtcg aagcttcata aaaatggtta tgaacgcaaa
     2941 tcttcagctg gccaagtcag tagagaatct aggaatggaa agatttggag gaacataagg
     3001 aaaacttgct gcaagatagt ggagaacagc tggtttgagt gtttcattgg cctggtcact
     3061 ctgctctgca caggcactct ggctctggaa gacatatata ttgatcagcg gaaaaccatt
     3121 aaaatcttcc tggagtatgg agacatgata tttgcttaca tcttcattct ggagatgctt
     3181 ctcaagtggg tggcctacgg ctttaaagcc tacttctcta acaactggta caagctggac
     3241 ttcatggtcg ttatcgtgtt gtgtcttagc ttaataggca aaactcgaga ggacctgaac
     3301 cctctggctt ccataaagtt ccttcgagca cttagagttc tgtctcagtt tgaaagaatg
     3361 aaggtggttc tgagagcttt gataaaaaca accttacccg ctgtgagcgt gtttctggtc
     3421 tgcctaatga tctggctgct tttcagtgtt atgggagtgt tcttattcgc tggcaagttc
     3481 tatgaatgca ttgacccaac aaggggagaa agattctctg tatttgaagt tatgaataag
     3541 agtcagtgtg aaaacctggt atttaatgaa tcaatgccat gggagaatgc aaaactgaac
     3601 tttgataatg ttggaaatgg ttttctttct ttgttccaag tggcaacatt taatgggtgg
     3661 atcagtatta tgaattcagc aattgactct gttggtgtgt acatgcagcc tagttttgag
     3721 cacagcctcc acatgtacac ttactttatc atctttgttg tgtttggatt atttcttccc
     3781 ttgtgtatgc tgattggtgt tattatcagg aatttcaaca agcagaaaat taagcaggga
     3841 ggatcaaata tctttataac ggtaaagcag aagaaacagt accgggcact gaagaagctc
     3901 ttgtatgcag actctcagaa accagcagcc cgccctagaa acaagttcca aggcttcatt
     3961 tgtgacgtag taacacatcg tgtctttaat gtcatcatca tacttcttat ctgtttccaa
     4021 gcaacaacca ttatgataca aaatgatgag cagagtccac aaattgaaac cgctgtcttc
     4081 tggatgaact ccctttttac catgctgttc actctggaat gcatactgaa gctcaccgcc
     4141 ttccgctgcc actatttcac cagcgcatgg aatgttcatg actttatggt ggtcgttttc
     4201 tccattacag gactgctgct gcctttgtca ataggacaat actttgtgcc tccttcactg
     4261 gtgcagctgc ttcttctctc tcgcatcatc catgtcctgc gtcctgggaa aggaccaaag
     4321 gtgttccatg atctgatgct tcccttgatg ctgtcactcc cagcactgct caacattgct
     4381 cttctcatct tcctggtcat gttcatctac gccatctttg gaatgtacaa cttcgcctac
     4441 gtaaagaaag aagccggaat taatgatgtg tccaactttg agacctttgg aagcagtatg
     4501 ctttgtctct ttcaagttac aacattttct ggttgggacg ggatgctgga tgcaattttc
     4561 aacagtcagt ggtctgactg cgatcctgat aaaattaacc cagggactca ggtcagggga
     4621 gactgtggga gcccttctgt tgggattttt tattttgtca gttacatcct catatcatgg
     4681 ttgatcattg ttaatatgta cgttgttttg atcatggagt tcttaagtat tccttctaag
     4741 agaaaaaaca ggaccttgag cgaagatgac tttaggagat tcttcaaggt atggaacagg
     4801 tttgaccctg acaggaccca gtacatagac tctactaagc tttctgattt tgcagctgct
     4861 ctcgatcctc ctcttttcat ggcaaaacca aacaagggcc agcttgtagc catggatctc
     4921 cccatggctg caggagacag aatccattgc cttgatattt tgcttgcctt tacgaaaaga
     4981 gtgatgggaa aggatgagcg ggtggagaag atcctttcag agatagaatc tgggtttatg
     5041 ttagcgaacc ctttcaaaat tacgtatgag ccgattacaa cgactttgaa acgcaaacaa
     5101 gaggcagtct cagccactat catccagcgg gcatacaaaa gttaccgctt aaggcaaagt
     5161 gacaaaaaga tacaagatat cccggaaata gatgatggca gggaggatcc taactctaaa
     5221 ggtgtccact ctggtcaaat cgaggaaaag gcatctattc agacccagat ctaaccgtac
     5281 ttcccaattc ttctttcttt acatattccc acacacacta aaaacgctta actaagcagg
     5341 agatcggaga ctagagataa tggtcacatc tgtgtgccca cacatctcca tgacaagctc
     5401 tgctttatgt ccagtctcgt gatacctcag gaaagacaga gcctcagtat tgctgcaggt
     5461 agctaaagtg ggtcacactt gtcatttggc tatttaaaat gtttctctgt ggcttgtcta
     5521 gtgttgccta tagtggaaga tgtgtaagaa gaaaagagag gagagggaaa taaagttcag
     5581 cagttataca gttttcctca tatattttat atttaatttt acaggccggg tcaccacccc
     5641 tggggcctag ttgcaaatat gaggtatttc cttaaagtgg attgtgcttc aaaaattcgg
     5701 gaagcctgcc ttcaatcatg agcatgccta aataaacact actgggtggg aaaggagaat
     5761 gcaggtcttc agaaagtgcc tttcagttct acatttctta aaatgtttaa ctggcccctc
     5821 cccctctttt tgctttcttc ctgatggctt tttgaatttt tgtttcattt tttgtttgtt
     5881 tgctcgcttt gttttgctgt tgttctttgg tgtttcgttg tccctcgtga ctatgcaggt
     5941 tctacaagag ctccaggtca gaaagaactg agatttatgg agcaagaagc gtaggagtca
     6001 cacttaacaa tgagcacatt ttctgtattt cattcacatt tatacctttt tataagtaca
     6061 catttactaa aaggatacaa tagagttaat ggactggagc tttaccttgt tctaaaaact
     6121 ggtttatttt ttaccattta tccatagcag gtgcatgctg tcatataaat tagaagagtt
     6181 gggggcaacc agcatgttta ggggttttca gtgccctgat ccttaattta aaaactggtc
     6241 acttgaaagt tcttcccatt gtacgttgta tttcttgcaa cttgaagaaa atgacccttc
     6301 aaacaatagg ggtagtgagg aagcagatga aagttaagtt ggcattttat aacatcatta
     6361 tatgcaaatt agctcactta tgtttccctt atttctttta tatcttctca tacatactca
     6421 tgcaaatgtt ttatatttga gaatctataa aataacaaac attagtttta actactgata
     6481 ttatttttgt taatataaat agttggtttt gatttcttca catagttgtt tacttccact
     6541 catgtagttt gagaatctga tattttctcc atttgtataa agactgatta caccgtgcct
     6601 atgaagccct ccagaattga aaagaaaaaa tatatatata tatatatatt ctactggctt
     6661 aaataagaag ctttaaatgg gttttatgat actcaatgcc attgtattct cgagactgta
     6721 ttttgtaatg aacgcatgga ctcgagcctt aactcttgtt atctactttc gatcctcaga
     6781 aactcaatga atttaccaac ttgccttgga caatcaagta aacgtaattt cagagtc
//
