LOCUS       NM_013125               8446 bp    mRNA    linear   ROD 27-FEB-2024
DEFINITION  Rattus norvegicus sodium voltage-gated channel alpha subunit 5
            (Scn5a), transcript variant 1, mRNA.
ACCESSION   NM_013125
VERSION     NM_013125.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8446)
  AUTHORS   Durkina,A.V., Bernikova,O.G., Gonotkov,M.A., Mikhaleva,N.J.,
            Sedova,K.A., Malykhina,I.A., Kuzmin,V.S., Velegzhaninov,I.O. and
            Azarov,J.E.
  TITLE     Melatonin treatment improves ventricular conduction via
            upregulation of Nav1.5 channel proteins and sodium current in the
            normal rat heart
  JOURNAL   J Pineal Res 73 (1), e12798 (2022)
   PUBMED   35384053
  REMARK    GeneRIF: Melatonin treatment improves ventricular conduction via
            upregulation of Nav1.5 channel proteins and sodium current in the
            normal rat heart.
REFERENCE   2  (bases 1 to 8446)
  AUTHORS   Jiang,D., Banh,R., Gamal El-Din,T.M., Tonggu,L., Lenaeus,M.J.,
            Pomes,R., Zheng,N. and Catterall,W.A.
  TITLE     Open-state structure and pore gating mechanism of the cardiac
            sodium channel
  JOURNAL   Cell 184 (20), 5151-5162 (2021)
   PUBMED   34520724
  REMARK    GeneRIF: Open-state structure and pore gating mechanism of the
            cardiac sodium channel.
REFERENCE   3  (bases 1 to 8446)
  AUTHORS   Carreras,D., Martinez-Moreno,R., Pinsach-Abuin,M.L., Santafe,M.M.,
            Goma,P., Brugada,R., Scornik,F.S., Perez,G.J. and Pagans,S.
  TITLE     Epigenetic Changes Governing Scn5a Expression in Denervated
            Skeletal Muscle
  JOURNAL   Int J Mol Sci 22 (5), 2755 (2021)
   PUBMED   33803193
  REMARK    GeneRIF: Epigenetic Changes Governing Scn5a Expression in
            Denervated Skeletal Muscle.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8446)
  AUTHORS   Abramochkin,D.V., Filatova,T.S., Pustovit,K.B., Dzhumaniiazova,I.
            and Karpushev,A.V.
  TITLE     Small G-protein RhoA is a potential inhibitor of cardiac fast
            sodium current
  JOURNAL   J Physiol Biochem 77 (1), 13-23 (2021)
   PUBMED   33145656
  REMARK    GeneRIF: Small G-protein RhoA is a potential inhibitor of cardiac
            fast sodium current.
REFERENCE   5  (bases 1 to 8446)
  AUTHORS   Jiang,D., Tonggu,L., Gamal El-Din,T.M., Banh,R., Pomes,R., Zheng,N.
            and Catterall,W.A.
  TITLE     Structural basis for voltage-sensor trapping of the cardiac sodium
            channel by a deathstalker scorpion toxin
  JOURNAL   Nat Commun 12 (1), 128 (2021)
   PUBMED   33397917
  REMARK    GeneRIF: Structural basis for voltage-sensor trapping of the
            cardiac sodium channel by a deathstalker scorpion toxin.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8446)
  AUTHORS   Dhar Malhotra,J., Chen,C., Rivolta,I., Abriel,H., Malhotra,R.,
            Mattei,L.N., Brosius,F.C., Kass,R.S. and Isom,L.L.
  TITLE     Characterization of sodium channel alpha- and beta-subunits in rat
            and mouse cardiac myocytes
  JOURNAL   Circulation 103 (9), 1303-1310 (2001)
   PUBMED   11238277
REFERENCE   7  (bases 1 to 8446)
  AUTHORS   Schott,J.J., Alshinawi,C., Kyndt,F., Probst,V., Hoorntje,T.M.,
            Hulsbeek,M., Wilde,A.A., Escande,D., Mannens,M.M. and Le Marec,H.
  TITLE     Cardiac conduction defects associate with mutations in SCN5A
  JOURNAL   Nat Genet 23 (1), 20-21 (1999)
   PUBMED   10471492
REFERENCE   8  (bases 1 to 8446)
  AUTHORS   Wang,Q., Shen,J., Splawski,I., Atkinson,D., Li,Z., Robinson,J.L.,
            Moss,A.J., Towbin,J.A. and Keating,M.T.
  TITLE     SCN5A mutations associated with an inherited cardiac arrhythmia,
            long QT syndrome
  JOURNAL   Cell 80 (5), 805-811 (1995)
   PUBMED   7889574
REFERENCE   9  (bases 1 to 8446)
  AUTHORS   Sheng,Z.H., Zhang,H., Barchi,R.L. and Kallen,R.G.
  TITLE     Molecular cloning and functional analysis of the promoter of rat
            skeletal muscle voltage-sensitive sodium channel subtype 2 (rSkM2):
            evidence for muscle-specific nuclear protein binding to the core
            promoter
  JOURNAL   DNA Cell Biol 13 (1), 9-23 (1994)
   PUBMED   8286044
REFERENCE   10 (bases 1 to 8446)
  AUTHORS   Rogart,R.B., Cribbs,L.L., Muglia,L.K., Kephart,D.D. and Kaiser,M.W.
  TITLE     Molecular cloning of a putative tetrodotoxin-resistant rat heart
            Na+ channel isoform
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 8170-8174 (1989)
   PUBMED   2554302
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000200.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_013125.4.
            
            On Nov 27, 2020 this sequence version replaced NM_013125.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M27902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JACYVU010000200.1  22277410-22277552   c
            144-473             JACYVU010000200.1  22260164-22260493   c
            474-592             JACYVU010000200.1  22257144-22257262   c
            593-682             JACYVU010000200.1  22247768-22247857   c
            683-811             JACYVU010000200.1  22246520-22246648   c
            812-903             JACYVU010000200.1  22239714-22239805   c
            904-1134            JACYVU010000200.1  22236129-22236359   c
            1135-1198           JACYVU010000200.1  22234335-22234398   c
            1199-1340           JACYVU010000200.1  22232783-22232924   c
            1341-1538           JACYVU010000200.1  22232147-22232344   c
            1539-1718           JACYVU010000200.1  22231353-22231532   c
            1719-2090           JACYVU010000200.1  22230440-22230811   c
            2091-2223           JACYVU010000200.1  22226819-22226951   c
            2224-2462           JACYVU010000200.1  22225741-22225979   c
            2463-2636           JACYVU010000200.1  22218422-22218595   c
            2637-2993           JACYVU010000200.1  22216903-22217259   c
            2994-3434           JACYVU010000200.1  22213159-22213599   c
            3435-3593           JACYVU010000200.1  22211718-22211876   c
            3594-3714           JACYVU010000200.1  22208850-22208970   c
            3715-3869           JACYVU010000200.1  22208074-22208228   c
            3870-4043           JACYVU010000200.1  22196717-22196890   c
            4044-4166           JACYVU010000200.1  22194336-22194458   c
            4167-4448           JACYVU010000200.1  22191255-22191536   c
            4449-4502           JACYVU010000200.1  22189390-22189443   c
            4503-4640           JACYVU010000200.1  22188349-22188486   c
            4641-4745           JACYVU010000200.1  22187706-22187810   c
            4746-5016           JACYVU010000200.1  22186046-22186316   c
            5017-8446           JACYVU010000200.1  22179688-22183117   c
FEATURES             Location/Qualifiers
     source          1..8446
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..8446
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /note="sodium voltage-gated channel alpha subunit 5"
                     /db_xref="GeneID:25665"
                     /db_xref="RGD:3637"
     exon            1..143
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            144..473
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..6257
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium channel, voltage-gated, type V, alpha polypeptide;
                     sodium channel, voltage-gated, type V, alpha subunit;
                     sodium channel protein type 5 subunit alpha; voltage-gated
                     sodium channel Nav1.5c; sodium channel protein type V
                     subunit alpha; voltage-gated sodium channel subunit alpha
                     Nav1.5; sodium channel protein cardiac muscle subunit
                     alpha; sodium channel, voltage-gated, type 5, alpha
                     subunit; skeletal muscle voltage-sensitive sodium channel
                     subtype 2"
                     /codon_start=1
                     /product="sodium channel protein type 5 subunit alpha
                     isoform 1"
                     /protein_id="NP_037257.2"
                     /db_xref="GeneID:25665"
                     /db_xref="RGD:3637"
                     /translation="MANLLLPRGTSSFRRFTRESLAAIEKRMAEKQARGGSATSQESR
                     EGLQEEEAPRPQLDLQASKKLPDLYGNPPRELIGEPLEDLDPFYSTQKTFIVLNKGKT
                     IFRFSATNALYVLSPFHPVRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWTKY
                     VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDLGNVSA
                     LRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGN
                     LRHKCVRNFTELNGTNGSVEADGLVWNSLDVYLNDPANYLLKNGTTDVLLCGNSSDAG
                     TCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMI
                     FFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT
                     IRGVDTVSHSSLEMSPLAPVTNHERKSKRRKRLSSGTEDGGDDRLPKSDSEDGPRALN
                     QLSLTHGLSRTSMRPRSSRGSIFTFRRRDQGSEADFADDENSTAGESESHRTSLLVPW
                     PLRHPSAQGQPGPGASAPGYVLNGKRNSTVDCNGVVSLLGAGDAEATSPGSYLLRPMV
                     LDRPPDTTTPSEEPGGPQMLTPQAPCADGFEEPGARQRALSAVSVLTSALEELEESHR
                     KCPPCWNRFAQHYLIWECCPLWMSIKQKVKFVVMDPFADLTITMCIVLNTLFMALEHY
                     NMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELG
                     LSRMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAV
                     VGMQLFGKNYSELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSG
                     QSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDGEMNNLQLALARIQRG
                     LRFVKRTTWDFCCGILRRRPKKPAALATHSQLPSCITAPRSPPPPEVEKVPPARKETR
                     FEEDKRPGQGTPGDSEPVCVPIAVAESDTEDQEEDEENSLGTEEESSKQESQVVSGGH
                     EPYQEPRAWSQVSETTSSEAGASTSQADWQQEQKTEPQAPGCGETPEDSYSEGSTADM
                     TNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCPCCMVDTTQSPGKVWWRLRKTCYRIV
                     EHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
                     YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFE
                     GMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYT
                     IVNNKSECESFNVTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGY
                     EEQPQWEDNLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQK
                     KYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETD
                     DQSPEKVNILAKINLLFVAIFTGECIVKMAALRHYYFTNSWNIFDFVVVILSIVGTVL
                     SDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFL
                     VMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTG
                     PPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEES
                     TEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSDFADALSEPLRIAKPNQISLINMDL
                     PMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRR
                     KHEEVSATVIQRAFRRHLLQRSVKHASFLFRQQAGGSGLSDEDAPEREGLIAYMMNGN
                     FSRRSAPLSSSSISSTSFPPSYDSVTRATSDNLPVRASDYSRSEDLADFPPSPDRDRE
                     SIV"
     exon            474..592
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            593..682
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            683..811
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            812..903
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1134
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1198
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1340
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1538
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1718
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..2090
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2223
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2462
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2636
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2993
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3434
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3593
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            3594..3714
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            3715..3869
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            3870..4043
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            4044..4166
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4448
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            4449..4502
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            4503..4640
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            4641..4745
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            4746..5016
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
     exon            5017..8446
                     /gene="Scn5a"
                     /gene_synonym="Nav1.5; RATRSKM2X; rSkM2; RSKM2X; SCAL;
                     Scn2x"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagacggcgg cggcgcccgt gggatgcggg gatcgcgccc ccggggccgc tgagcctgag
       61 cccgctgccc caagccctac gccgagccga gcccgcaccg cgctgcagcc gcccaccccg
      121 gggcgcgggc cggggaccat cagcttcctt ccaggcaacc tgaggagagc ctgtgccccc
      181 agaagcagga tgagaagatg gcaaacctcc tgttacctcg gggcaccagc agcttccgta
      241 ggttcacccg ggagtcactg gcggccatcg agaagcgaat ggctgaaaag caagcccgag
      301 gaggttcggc cacctcacag gagagccgtg agggcctgca ggaggaggag gctccccggc
      361 cccagctgga cctacaggcc tccaaaaagc tgccagatct ctatggcaac ccaccccgag
      421 agctcatcgg ggagcccctg gaagacctgg accctttcta tagtacccag aagaccttca
      481 tcgtgctgaa taagggcaaa accatcttcc ggttcagtgc caccaatgcc ttgtatgtcc
      541 tcagcccctt ccaccccgtg cgccgagcgg ccgtgaagat cctggtacac tcgctcttta
      601 gcatgctcat catgtgcacc atcctgacca actgcgtgtt catggcccag cacgaccctc
      661 cgccttggac caaatatgtt gagtacacct tcactgccat ctacaccttt gagtctctgg
      721 tcaagattct agctcgaggc ttctgcctgc atgcattcac cttccttcgg gacccgtgga
      781 actggctaga cttcagtgtg atcgtcatgg catacacaac tgaatttgtg gacctgggca
      841 atgtctcagc cttacgcacc ttccgagtcc tccgggccct gaaaactata tcggtcattt
      901 caggcctgaa gaccatcgtg ggagccctaa tccagtctgt gaagaaactg gccgatgtga
      961 tggtcctcac tgtcttctgc ctcagtgtct ttgccctcat tggcctgcag ctcttcatgg
     1021 gcaacctgag gcacaagtgt gtgcgtaact tcaccgagct caatggcacc aatggttccg
     1081 tggaggccga cggcctagtc tggaactccc tggacgtcta cctcaatgac ccagccaatt
     1141 acctgctcaa gaatggcacc acggatgtgt tactatgtgg gaacagctct gatgccggga
     1201 catgccctga gggctatcgg tgcctgaagg caggtgagaa cccagaccac ggttacacca
     1261 gcttcgactc cttcgcctgg gccttccttg cactcttccg cctgatgaca caggactgct
     1321 gggaacgcct ataccagcag accctgaggt ccgcaggaaa gatctacatg atcttcttca
     1381 tgcttgtcat ctttctgggc tccttctacc tggtgaactt gatcctggct gtggtggcca
     1441 tggcctacga ggagcaaaac caagccacca tcgccgagac ggaagagaag gagaagcgct
     1501 tccaggaggc catggagatg ctcaagaagg aacacgaggc tctcaccatc aggggtgtgg
     1561 ataccgtgtc ccatagctct ctggagatgt ctcctttggc cccagtaacc aaccatgaga
     1621 gaaagagcaa aaggaggaaa cgactatctt cggggacaga ggatggtggg gatgacaggc
     1681 tccccaagtc ggactcagaa gatggtccca gagcattgaa tcagctcagc ctcacccatg
     1741 ggctcagccg gacatccatg aggccccgct cgagccgagg gagcattttc acgttccgaa
     1801 gacgggacca aggctctgag gcggacttcg cagatgacga gaacagcact gcgggggaga
     1861 gtgagagcca ccgcacatcg ctgctggtac cctggcccct gcgccatccc agcgcccaag
     1921 gacagcccgg ccctggagcc tcagctcccg gttacgttct caatggcaaa aggaacagca
     1981 ccgtggactg caatggggtg gtttccttgc tgggggcagg tgacgcagag gccacctccc
     2041 cagggagcta ccttctccgc cctatggtgc tggaccgacc cccagacacg accactccgt
     2101 cagaggagcc cggtgggccc cagatgctga cacctcaggc tccgtgtgca gatggttttg
     2161 aggagcccgg agcacggcaa cgggcactca gcgctgtcag tgtcctcacc agtgccctgg
     2221 aagagttgga ggagtcccat cggaagtgtc caccatgctg gaaccgcttt gcccagcact
     2281 acctcatctg ggagtgctgt ccactctgga tgtccatcaa gcagaaggtg aagtttgtgg
     2341 tcatggaccc atttgccgac ctcactatca ccatgtgcat cgtgctcaat acgctcttca
     2401 tggctctgga gcattacaac atgacggcag agtttgagga gatgctgcag gtcggaaacc
     2461 tggtcttcac gggaatcttc acagcggaga tgaccttcaa gatcatcgcc cttgacccct
     2521 actactactt ccagcagggc tggaatatct tcgacagcat catcgtcatc ctcagtctca
     2581 tggagctggg gctgtcccgc atgggcaact tgtctgtgct acgttccttc cgtctgctgc
     2641 gggtcttcaa gctggccaag tcctggccca ccctgaacac gctcatcaag atcatcggga
     2701 actccgtggg cgccctgggg aacctgaccc tggtgctggc catcatcgtc ttcatcttcg
     2761 ccgtggtggg catgcagctc ttcggcaaga actactcgga gctgaggcac cgcatcagcg
     2821 actccggcct gctgccccgc tggcacatga tggacttttt ccacgccttc ctcatcatct
     2881 tccgcatcct ctgtggggag tggatcgaga ccatgtggga ctgcatggag gtgtctgggc
     2941 agtcgctgtg cttgctggtc ttcctgctcg tcatggtcat tggcaacctt gtggtcctga
     3001 atctcttctt ggccttgctg ctcagctcct tcagcgcaga caacctcaca gcccctgacg
     3061 aggatgggga gatgaacaac ctccagctgg ccctggctcg catccagagg ggcctgcgct
     3121 ttgtcaagcg gaccacctgg gacttctgct gcgggatcct gcggcggcga cctaagaagc
     3181 ccgcggctct tgccacccac agccagctgc ccagctgtat caccgccccc aggtccccac
     3241 cacccccaga ggtggagaag gtgcccccag cccgcaagga aacacgattc gaggaggaca
     3301 agcgacccgg ccagggcacc cctggggatt cggagcctgt gtgtgtgccc atcgccgtgg
     3361 ctgagtcaga cactgaagac caggaagagg atgaagagaa cagccttggc acagaggaag
     3421 agtccagcaa acaggaatcc caagttgtgt ctggtggcca cgagccctac caggagccca
     3481 gggcctggag ccaggtgtca gagaccacgt cctctgaagc tggggccagt acatctcagg
     3541 cagactggca gcaagagcag aaaacggagc cccaggcccc ggggtgcggt gagacccctg
     3601 aggacagtta ctccgagggc agcacagctg acatgaccaa caccgccgac ctcctggagc
     3661 aaatcccaga ccttggtgag gacgtcaagg acccagagga ctgctttact gaaggctgcg
     3721 tccgacgctg tccctgctgc atggtagaca caacccagtc cccagggaag gtctggtggc
     3781 gattgcgcaa gacctgctac cgcatcgtgg agcacagctg gttcgagact ttcatcatct
     3841 tcatgatcct gctcagcagt ggagcgctgg ccttcgagga catctacctg gaggagcgga
     3901 agaccatcaa ggttctgctg gagtacgcgg acaagatgtt cacctacgtc tttgtgttgg
     3961 agatgctgct caagtgggtg gcctacggct tcaagaagta cttcaccaac gcctggtgct
     4021 ggctggactt cctgattgtg gacgtctcgc tggtcagcct cgtggcaaac accttaggct
     4081 tcgccgaaat gggtcccatc aagtcactga ggacactgcg tgcacttcga cccctgaggg
     4141 ccttgtcgag atttgagggc atgcgggtgg tggtcaatgc gctggtgggc gccatcccct
     4201 ccatcatgaa cgtcctcctc gtctgcctca tcttctggct catcttcagc atcatgggtg
     4261 tgaacctctt cgccgggaag ttcggtaggt gcatcaacca gacagaaggg gacctgcctc
     4321 tgaactacac catcgtgaac aacaagagtg agtgcgagtc cttcaacgtg accggagagt
     4381 tgtactggac caaggtgaag gtcaactttg acaacgtggg agccgggtac ctggccctcc
     4441 tgcaggtggc gacatttaaa ggctggatgg acatcatgta tgcggctgtg gactccagag
     4501 ggtatgagga gcagccgcag tgggaagaca acctctacat gtacatctac tttgtcgtct
     4561 tcatcatctt cggctccttc ttcaccctca acctcttcat cggtgtcatc attgacaact
     4621 tcaaccagca gaagaaaaag ttagggggcc aggatatctt catgacggag gagcagaaga
     4681 agtactacaa tgccatgaag aagctgggct ccaagaaacc ccagaagccc atcccacggc
     4741 ccttgaacaa gtaccagggt ttcatattcg acattgtgac caagcaggcc ttcgatgtca
     4801 ccatcatgtt cctcatctgt ttgaacatgg tgaccatgat ggtggagaca gatgaccaga
     4861 gccctgagaa ggtcaacatc ttggccaaga tcaacctgct cttcgtggcc atcttcacag
     4921 gcgagtgtat tgtcaagatg gctgccctgc gccactatta cttcaccaac agctggaaca
     4981 tcttcgactt tgtggtggtc atcctctcca ttgttggcac tgtcctctcc gacatcatcc
     5041 agaagtactt cttctccccg acactcttcc gggtcatccg tctggccagg atcggccgca
     5101 tcctcaggct gatccgcgga gccaagggga ttcgcacgct gctcttcgcc ctcatgatgt
     5161 ccctgcccgc cctcttcaac atcggcctcc tcctcttcct cgtcatgttc atctactcca
     5221 tcttcggcat ggccaacttc gcttacgtca agtgggaggc cggcatcgat gacatgttca
     5281 acttccagac cttcgccaac agcatgctgt gcctgttcca gatcaccaca tcggccggct
     5341 gggacggcct cctcagcccc atcctcaaca cggggcctcc ctactgcgac cccaacctgc
     5401 ccaacagcaa cggctcccgg gggaactgtg ggagcccggc ggtgggcatc ctcttcttca
     5461 ccacctacat catcatctcc ttcctcatcg tggtcaacat gtacatcgcc atcatcctcg
     5521 agaacttcag cgtggccacc gaggagagca cagagcccct gagcgaggac gacttcgaca
     5581 tgttctatga gatctgggag aagttcgacc cggaggccac ccagttcatt gagtatctgg
     5641 ccctgtccga ctttgcagat gccttgtctg agccgctccg catcgccaaa cccaaccaga
     5701 taagcctcat caacatggat ctgcccatgg tgagcggaga ccgtatccac tgtatggaca
     5761 tactgttcgc tttcaccaag agggtgctcg gcgagtctgg ggagatggat gccctgaaga
     5821 tccagatgga ggagaagttc atggcggcca acccttccaa gatctcctac gagcccatca
     5881 ccaccaccct gaggagaaag cacgaggagg tgtcggccac ggtcatccag cgtgccttcc
     5941 ggaggcacct gctgcagcgc tcggtgaagc acgcctcctt tctcttccgc cagcaagcgg
     6001 gcggcagtgg cctctccgat gaggatgccc ctgagcggga gggcctcatc gcctacatga
     6061 tgaatgggaa cttctctcgg cgcagtgctc cgctctccag ctcctccatc tcctccacgt
     6121 ccttcccccc gtcctacgac agcgtcacga gagccaccag tgataacctc ccggtgcgtg
     6181 cgtctgacta tagccgcagc gaagatcttg cagacttccc tccatctcca gatagggacc
     6241 gagagtctat cgtgtgaacc tggccagggt ggccgggacg ttcgccatcg tgccctgatg
     6301 aaccttatgc agttaaaacc agtgtcggcc gaggccttcc tagctctgca gatgagcctc
     6361 cgggtggagg agcctcgagg cagagttccg cgtctctgtg tggaagctgg aggcagccgg
     6421 aggagccctg gctggtggag gcctgaccct ggaggcctgg cacaccctag tagccgggtc
     6481 tggccaggca gcaccgcatg gctctcaaaa gcgactccgt cccagcttct gaggtggaat
     6541 gggaaacaca ctgtacatgt tgtgaacaag cttccataga tttattatat ttgatatttt
     6601 tttacttgag cgaagaacat cttttttcca tgaacatcag cagttcacac tgcctctcct
     6661 taaccctgag caagtgtcaa cggaggtgcc agaactcggc tctcgaagct aacgtgggga
     6721 tccattgtac ccaaggggag ggtcgtgcgt ggctcctgtt gcctgggctg aggaaccagg
     6781 aaggcctaag cactccactc atacacgcgt gtgtgtgcga gcacacttca catgctaggg
     6841 cgggacatag gcctcggggg tcttggggga gccgggatcg cctcaggcaa atgtggtcag
     6901 cggctctgaa ggaggcaggt ttttcttccc agcccccaag cgtggggttc ttccggtgga
     6961 actcagtctg cgctcctgtt ctccccagga ctctgttctc ctgttttcta gtcaggcttc
     7021 acctgaggac agtgctgcca gaattaaaag ctctagagag ctgccccggt ctcagagatg
     7081 aattctgccc ttccttcctc tcctggaaga gtattactgt taggggtacg agggaggcag
     7141 caccccctca cagccaggca cataggtctc ccctagtaca cggcgggccc tgtccaaagg
     7201 ctgagggaag agagggctgt tccacatggg ccgctgaact gtgtccagct gtgggcagct
     7261 gcacagcaga ggaagccatc tccatttccc aggctcccct ggggtctctg cctctgaccg
     7321 agtgtgaagg ggattcccac tgggactcca actcctcttc agacactgtg gaagtgggag
     7381 ggtagcctgg ccctgcctaa gagagaggcc ctgggtggtc aggcatggtt ctgtgccctg
     7441 gaagaggaca agccctccat cccatcggga ggggaggcag tgtggcgtct gggcccagcc
     7501 cggggtctga ctatcccagg cgtcttctga gaaggctttt tcagggaaaa aaaaaaaaaa
     7561 agattttata agtccaatta tccccgtgac ctcttcagct gctgacaatc ctatttagca
     7621 tatgcaaatc ttctaatgta gacaaccatt gtcgctgctg aagtgacagg ctggtggagc
     7681 cagagcaggc aggggcttgg ctgcccaagt ctagctctcc cagcagagcc accctcggct
     7741 gggggcgccc acctcacagg tcacctcagt cgcgcctgcc cactgcaggc tggctgctcc
     7801 tacctacctc gctgagagct gctgtccgag ggctggacgc ccctggcagt gctgaaggag
     7861 gggcactgcg ggggtgagtc aagtattatg tttcttgtca ccttagttcc cttggtggca
     7921 agccggctcc tgccccacct gcccctggag gcttatccag tgtcgggggg gcttggtttt
     7981 aactgtcctg gtgatgcttc tctgagtgaa atcttatttt tgtaggtctg tactttgttc
     8041 tcaaggcttg gagaaatgtg tgtgtccctc cctgccactc aacttcaggc aggaatgtgg
     8101 cctggggctg gctgggctgg cagggctgcc atcccagctg gccggaaaga gactgcggtt
     8161 tggaatatgc agatggcctt gggggctgaa gacaggtgcc tgagctggct gcagacgggg
     8221 cggctgaggg gaggagcaag ctagccccaa gtccttggct tagcatggca tccttttcta
     8281 gaactgcaca ggggggagaa gagagtaggc tgtagacaga aggagggagg ggcgtgcaca
     8341 caggtcaggt gttgtctgga gtaaacgtgc acttctcact aagcttcatg tacaaatgga
     8401 gtacattatt tttcaaacaa acaaataaat ggcttacatg acctgg
//
