LOCUS       NM_001008880            4272 bp    mRNA    linear   ROD 15-DEC-2024
DEFINITION  Rattus norvegicus sodium voltage-gated channel beta subunit 4
            (Scn4b), mRNA.
ACCESSION   NM_001008880 XM_236199
VERSION     NM_001008880.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4272)
  AUTHORS   Xie,W., Zhang,J., Strong,J.A. and Zhang,J.M.
  TITLE     Role of NaV1.6 and NaVbeta4 Sodium Channel Subunits in a Rat Model
            of Low Back Pain Induced by Compression of the Dorsal Root Ganglia
  JOURNAL   Neuroscience 402, 51-65 (2019)
   PUBMED   30699332
  REMARK    GeneRIF: Study found that knockdown of either NaV1.6 or NaVbeta4
            reduced pain behaviors and sensory neuron hyperexcitability in the
            chronic compression dorsal rook ganglia model of low back pain.
REFERENCE   2  (bases 1 to 4272)
  AUTHORS   Xie,W., Tan,Z.Y., Barbosa,C., Strong,J.A., Cummins,T.R. and
            Zhang,J.M.
  TITLE     Upregulation of the sodium channel NaVbeta4 subunit and its
            contributions to mechanical hypersensitivity and neuronal
            hyperexcitability in a rat model of radicular pain induced by local
            dorsal root ganglion inflammation
  JOURNAL   Pain 157 (4), 879-891 (2016)
   PUBMED   26785322
  REMARK    GeneRIF: NaVbeta4 may represent a more specific target for pain
            conditions that depend on myelinated neurons expressing NaV1.6
REFERENCE   3  (bases 1 to 4272)
  AUTHORS   Barbosa,C., Tan,Z.Y., Wang,R., Xie,W., Strong,J.A., Patel,R.R.,
            Vasko,M.R., Zhang,J.M. and Cummins,T.R.
  TITLE     Navbeta4 regulates fast resurgent sodium currents and excitability
            in sensory neurons
  JOURNAL   Mol Pain 11, 60 (2015)
   PUBMED   26408173
  REMARK    GeneRIF: This study identified Navbeta4 as an important regulator
            of excitability in sensory neurons.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4272)
  AUTHORS   Gilchrist,J., Das,S., Van Petegem,F. and Bosmans,F.
  TITLE     Crystallographic insights into sodium-channel modulation by the
            beta4 subunit
  JOURNAL   Proc Natl Acad Sci U S A 110 (51), E5016-E5024 (2013)
   PUBMED   24297919
REFERENCE   5  (bases 1 to 4272)
  AUTHORS   Groome,J., Lehmann-Horn,F. and Holzherr,B.
  TITLE     Open- and closed-state fast inactivation in sodium channels:
            differential effects of a site-3 anemone toxin
  JOURNAL   Channels (Austin) 5 (1), 65-78 (2011)
   PUBMED   21099342
  REMARK    GeneRIF: Anthopleurin elicited opposing effects on the gating mode,
            kinetics and charge immobilized during open- versus closed-state
            fast inactivation of Nav1.4 channels.
REFERENCE   6  (bases 1 to 4272)
  AUTHORS   Kaufmann,S.G., Westenbroek,R.E., Zechner,C., Maass,A.H.,
            Bischoff,S., Muck,J., Wischmeyer,E., Scheuer,T. and Maier,S.K.
  TITLE     Functional protein expression of multiple sodium channel alpha- and
            beta-subunit isoforms in neonatal cardiomyocytes
  JOURNAL   J Mol Cell Cardiol 48 (1), 261-269 (2010)
   PUBMED   19426735
REFERENCE   7  (bases 1 to 4272)
  AUTHORS   Lopez-Santiago,L.F., Meadows,L.S., Ernst,S.J., Chen,C.,
            Malhotra,J.D., McEwen,D.P., Speelman,A., Noebels,J.L., Maier,S.K.,
            Lopatin,A.N. and Isom,L.L.
  TITLE     Sodium channel Scn1b null mice exhibit prolonged QT and RR
            intervals
  JOURNAL   J Mol Cell Cardiol 43 (5), 636-647 (2007)
   PUBMED   17884088
REFERENCE   8  (bases 1 to 4272)
  AUTHORS   Medeiros-Domingo,A., Kaku,T., Tester,D.J., Iturralde-Torres,P.,
            Itty,A., Ye,B., Valdivia,C., Ueda,K., Canizales-Quinteros,S.,
            Tusie-Luna,M.T., Makielski,J.C. and Ackerman,M.J.
  TITLE     SCN4B-encoded sodium channel beta4 subunit in congenital long-QT
            syndrome
  JOURNAL   Circulation 116 (2), 134-142 (2007)
   PUBMED   17592081
REFERENCE   9  (bases 1 to 4272)
  AUTHORS   Ferrera,L. and Moran,O.
  TITLE     Beta1-subunit modulates the Nav1.4 sodium channel by changing the
            surface charge
  JOURNAL   Exp Brain Res 172 (2), 139-150 (2006)
   PUBMED   16432696
  REMARK    GeneRIF: Data suggest that modulation of the sodium current by the
            expression of the highly sialylated beta1-subunit may alter the
            channel gating by increasing the density of surface negative
            charges in the vicinity of the sodium channel voltage sensing
            machinery.
REFERENCE   10 (bases 1 to 4272)
  AUTHORS   Yu,F.H., Westenbroek,R.E., Silos-Santiago,I., McCormick,K.A.,
            Lawson,D., Ge,P., Ferriera,H., Lilly,J., DiStefano,P.S.,
            Catterall,W.A., Scheuer,T. and Curtis,R.
  TITLE     Sodium channel beta4, a new disulfide-linked auxiliary subunit with
            similarity to beta2
  JOURNAL   J Neurosci 23 (20), 7577-7585 (2003)
   PUBMED   12930796
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001008880.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK001030.1, SRR26643299.34870.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000008.1  54343873-54343933
            62-234              JAXUCZ010000008.1  54351808-54351980
            235-463             JAXUCZ010000008.1  54352517-54352745
            464-593             JAXUCZ010000008.1  54354305-54354434
            594-4272            JAXUCZ010000008.1  54355368-54359046
FEATURES             Location/Qualifiers
     source          1..4272
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..4272
                     /gene="Scn4b"
                     /note="sodium voltage-gated channel beta subunit 4"
                     /db_xref="GeneID:315611"
                     /db_xref="RGD:631404"
     CDS             1..687
                     /gene="Scn4b"
                     /note="sodium channel subunit beta-4; sodium channel beta
                     4 subunit; sodium channel accessory subunit; sodium
                     channel, type IV, beta; sodium channel, type 4, beta
                     subunit; sodium channel, voltage-gated, type IV, beta
                     subunit; sodium channel regulatory subunit beta-4"
                     /codon_start=1
                     /product="sodium channel regulatory subunit beta-4
                     precursor"
                     /protein_id="NP_001008880.1"
                     /db_xref="GeneID:315611"
                     /db_xref="RGD:631404"
                     /translation="MSRAGNRGNTQARWLGIGLLGLFLLPMYLSLEVSVGKATTIYAI
                     NGSAILLPCTFSSCYGFENLYFRWSYNNSETSRILIDGIVKNDKSDPKVRVKDDDRIT
                     LEGSTKEKMNNISILLSDLEFSDTGRYTCFVRNPKEKDLNNSATIFLQVVDKLEEVDN
                     TVTLIILAVVGGVIGLLVCILLLKKLITFILKKTREKKKECLVSSSGNDNTENGLPGS
                     KAEEKPPTKV"
     exon            1..61
                     /gene="Scn4b"
                     /inference="alignment:Splign:2.1.0"
     exon            62..234
                     /gene="Scn4b"
                     /inference="alignment:Splign:2.1.0"
     exon            235..463
                     /gene="Scn4b"
                     /inference="alignment:Splign:2.1.0"
     exon            464..593
                     /gene="Scn4b"
                     /inference="alignment:Splign:2.1.0"
     exon            594..4272
                     /gene="Scn4b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtcccggg ctgggaaccg aggcaatact caggcgagat ggctgggcat tgggcttttg
       61 ggtctcttcc tgctccccat gtacctgtcg ttggaggtat ctgtgggaaa ggccaccacc
      121 atctacgcta tcaacggctc agcgatcctg ctaccctgca ccttctccag ctgttatggc
      181 tttgagaacc tctacttcag gtggtcctac aataacagcg aaacatccag gattctcatc
      241 gacgggatcg tgaagaatga taagtctgac cctaaggtga gagtgaagga tgatgaccgc
      301 atcaccctag agggctccac taaggagaag atgaataaca tctccatcct cttgagtgac
      361 ctggagttca gtgacacggg cagatacact tgcttcgtga ggaaccccaa ggagaaggac
      421 ttaaacaact ctgctacgat cttcctccaa gtggttgata aattggaaga agtggacaac
      481 acagtgacgc tcatcatcct ggctgtggta ggcggggtca tcggacttct cgtctgcatc
      541 ctgttgctga agaagctcat cactttcatc ctgaagaaga ccagagagaa gaagaaggag
      601 tgtctcgtga gttcctctgg gaacgacaac acagagaacg ggctgcctgg ttccaaggca
      661 gaagagaagc cacccacaaa agtgtgaggc cctgctcggg gccaagcagg gcagggagcc
      721 tcactttctg atggtgatat tgatgccgag tcctgtctga gatgtgtgct gcttggccca
      781 aactgttctt tctgagcacg aaggacgtgg ccctgcccag ctgccattcc ctccccagcc
      841 ggggcttcct ggggacaagg gttgaccggg ggaggaagcc cacaggagat tggagacagg
      901 gaagggaggg gctggagtgg tgtggaaggt ttggttccag ctcttggaca catggggtct
      961 cctagacttt cacctctgtg aagcctcact ttttcctcag ttttccttct gatctttcac
     1021 caggaaatcg aggtgatcag tgagggctgc tcccaaagct ggggtttgga catgggaaga
     1081 gggtgactcc ttcagaagct ggaaatgcac tagaactctg ggattgaatc ttccgggggt
     1141 ggggtggggc cagtcatgag aggcaagctg ggctttgaag aatatcaggc ttctggaagt
     1201 tcctttagag gggacttctc tcccctccac cctgcccaca ctgtcctggc tccctgacca
     1261 gcctcctgct ctctgggctg cagctgctgg ggaggcttgt ggggaggggc agcctccatc
     1321 cttcctggag ctccagggtg ctatatgcat cttttctggc tttgctcttt gagttccaga
     1381 ggtgggagag caaggcctcg acctcccagc cattggaatg tctaccccag ccctacaaga
     1441 ctgacagccc ttgtacttgg cacggcagga ccatgccacc ctgacacttc cagagctcag
     1501 ttttccacac gtcttccctt ctcttgaaat ggctggcatt gccacattac ctgagcgatg
     1561 gtttcctagg acttcccatc ccataccttt gctcctccta tgtccctcca gcatgcctgg
     1621 ccttcccctg ctcccaggtc tgcccacccc agctctgggt ctacatttgc ctcagggacc
     1681 cttgtttccg ggtgagaagg ggcaactcct cattcagtcc gaggctttct cttctcttta
     1741 cttcttgcag agccggtttg cacacccctt gagtgtgggg ctagattgtg ccttagttcc
     1801 ctgagtcccg attctgagcc ccctttcctt cagctcacac tccctggtta attgcacagt
     1861 ttggtgtgac actggtgggg ctccccagct ccctaaccca aggtcataga ggagaccatg
     1921 aatttggcat tgtgtaaaca atggctccat ggctggtggc agccttggtg acacccaagg
     1981 ggcaccctct ttctcgtcgc tgacatagag ataggatggc atttgatgtg gggccttcag
     2041 gtggatttga tcatgcgggc tcctgtgaca tatgagatgt gataataagg gtacccaaac
     2101 tccctctttc tcatcagatt tctgatatcc tccacttgtc agaagatgga gactacttct
     2161 cttttcagag gttgtaagga ctgctaaagg ctttgcccag gagtagctga aggctcccca
     2221 aagtagaagt tgggggagac taaagaacta aagatctgta ggtacctgtg gctatggcta
     2281 gtgtctgttg cccaagccga ggggctcttg gggttgcctc ctctcctccc attcttcctt
     2341 acccagaact ggctgtgagc tgggcaaaaa ttgcccatct cctgcttttt atatatttat
     2401 ttgagcatag tctcatgtag cccaggcagg ccttcaactc cctgtgtagc caaaactggc
     2461 cttgaactcc cgatctcctg tctccgttgc catagtgctg ggatgacagg tgtgagcgca
     2521 caccctgctt agagtaacct gagaacaaac atggcaccag agcctccagc tattcaggaa
     2581 acttccagct gccttcatgc aaaactgctt tcttccccaa cactggaaga ggcgaagtac
     2641 tgtgggttct tcttgctttc ccgagaggaa gccaacagca tacagcagga gagagggagg
     2701 gactccccct tcccatcttc ctgttcactg tcagcttaga ggcagccctt gcagcttctc
     2761 ccatctcccc aaagggtgaa atgataccta cctcacagga ctgcagtgag gcttggtgat
     2821 gttctctctt ttttcttttt tttctttgtt tttcgcctgt cttggaaagg cactgggaaa
     2881 caaggctaat aactggagag aacgttccgc gtctactcct gtcctcatct ctggatgcgt
     2941 acatgcaaca tgcgtatgcc tcagccctct tcttcttttt gcaaccatag gcatcgtgac
     3001 tcagacgctt aaagcatctt tgtccgtggt acttgtgttt tcatggaggt gcctgaggtg
     3061 atgggggcag tgtttttata ttgtcgttgc cccagtgcct gcgacaatac tggtgtttaa
     3121 tgcatagggg ttaagagcac aagtctcagt cctcttaaca gagaacatct ggtccagtgc
     3181 tagcggcatg cctgtgcaga cattgccatg cattgcagtg ggatgtatat tcgcaaagcc
     3241 atttcctcta ggcagaccct cttgcaggca agtcctcact agcaatctca gggtgttccc
     3301 tgtgccagtg ggcaacagaa cctcttctac aggtgacttt gggaaacctg gacccatgca
     3361 gttgtgtggc atcgacatcc gtgagaccaa agacaaagca caagtccctt atccttgacc
     3421 tccatataaa cttctgcatt cgagggccca gatccctcag tgtagaaact gagcagaagg
     3481 cccctggaat caacctgcag tgccagaggg cccaggagaa tgacagacag ggggcagaac
     3541 tccacacgtc tgaccgacca gtttctgtgg agctagggag gcaagagcgt cctccagctg
     3601 gtgggaggtg agggtgccct tgtgcggagt gctggtggtg tgttggatct cgtagggtgc
     3661 gcctagtcag tctgcaggtg cagaggtatg actgaggagg gtgggctgtg catgcaaggg
     3721 ggtgatgtgg gatgcagggg ctgggggtgc ggctgtgcat cttcagttac ctgaactgga
     3781 aactgaagaa gggtaagaga cagagacgaa cagctgtgct cctggattca actgggtgat
     3841 tccatgtcag gatgacagac aactgccctt gggggggggg tgttggagga aggatgccca
     3901 acggagggat ttgtggggga atcctctagc ttgctgcatt ttattttgtc ccaggttgga
     3961 gtccttgctc acccatctcc cactggatgt gcagtgcttt tgactatctt atgcatggtt
     4021 tattcctctg gcttggataa cagtacccat agtcagtctt cctatctaac tttataggtc
     4081 aaacaataca gtgatgggct gtgggggcct caggtccaca gtgtccccag gaggcaccga
     4141 caggcacatg cccagcactt gtgtttaagc acaggttgaa tgcaattagg ttgtcttgcc
     4201 tctactacac attttgcatt gtaggattgg atttggcttt gctttggatg aaataaaaaa
     4261 ttattttgta at
//
