LOCUS       NM_139097               3910 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus sodium voltage-gated channel beta subunit 3
            (Scn3b), mRNA.
ACCESSION   NM_139097
VERSION     NM_139097.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3910)
  AUTHORS   Farago,N., Kocsis,A.K., Brasko,C., Lovas,S., Rozsa,M., Baka,J.,
            Kovacs,B., Mikite,K., Szemenyei,V., Molnar,G., Ozsvar,A., Olah,G.,
            Piszar,I., Zvara,A., Patocs,A., Barzo,P., Puskas,L.G. and Tamas,G.
  TITLE     Human neuronal changes in brain edema and increased intracranial
            pressure
  JOURNAL   Acta Neuropathol Commun 4 (1), 78 (2016)
   PUBMED   27487831
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3910)
  AUTHORS   Huang,X., Du,Y., Yang,P., Lin,S., Xi,Y., Yang,Z. and Ma,A.
  TITLE     Age-dependent alterations of voltage-gated Na(+) channel isoforms
            in rat sinoatrial node
  JOURNAL   Mech Ageing Dev 152, 80-90 (2015)
   PUBMED   26528804
  REMARK    GeneRIF: the presences of Nav1.1, Nav1.6, Navbeta1 and Navbeta3
            mRNA and their reduced levels in rat SAN during aging.
REFERENCE   3  (bases 1 to 3910)
  AUTHORS   Olesen,M.S., Jespersen,T., Nielsen,J.B., Liang,B., Moller,D.V.,
            Hedley,P., Christiansen,M., Varro,A., Olesen,S.P., Haunso,S.,
            Schmitt,N. and Svendsen,J.H.
  TITLE     Mutations in sodium channel beta-subunit SCN3B are associated with
            early-onset lone atrial fibrillation
  JOURNAL   Cardiovasc Res 89 (4), 786-793 (2011)
   PUBMED   21051419
REFERENCE   4  (bases 1 to 3910)
  AUTHORS   Cusdin,F.S., Nietlispach,D., Maman,J., Dale,T.J., Powell,A.J.,
            Clare,J.J. and Jackson,A.P.
  TITLE     The sodium channel {beta}3-subunit induces multiphasic gating in
            NaV1.3 and affects fast inactivation via distinct intracellular
            regions
  JOURNAL   J Biol Chem 285 (43), 33404-33412 (2010)
   PUBMED   20675377
  REMARK    GeneRIF: The sodium channel {beta}3-subunit induces multiphasic
            gating in NaV1.3 and affects fast inactivation via distinct
            intracellular regions.
REFERENCE   5  (bases 1 to 3910)
  AUTHORS   Tan,B.H., Pundi,K.N., Van Norstrand,D.W., Valdivia,C.R.,
            Tester,D.J., Medeiros-Domingo,A., Makielski,J.C. and Ackerman,M.J.
  TITLE     Sudden infant death syndrome-associated mutations in the sodium
            channel beta subunits
  JOURNAL   Heart Rhythm 7 (6), 771-778 (2010)
   PUBMED   20226894
REFERENCE   6  (bases 1 to 3910)
  AUTHORS   Vijayaragavan,K., Powell,A.J., Kinghorn,I.J. and Chahine,M.
  TITLE     Role of auxiliary beta1-, beta2-, and beta3-subunits and their
            interaction with Na(v)1.8 voltage-gated sodium channel
  JOURNAL   Biochem Biophys Res Commun 319 (2), 531-540 (2004)
   PUBMED   15178439
REFERENCE   7  (bases 1 to 3910)
  AUTHORS   Takahashi,N., Kikuchi,S., Dai,Y., Kobayashi,K., Fukuoka,T. and
            Noguchi,K.
  TITLE     Expression of auxiliary beta subunits of sodium channels in primary
            afferent neurons and the effect of nerve injury
  JOURNAL   Neuroscience 121 (2), 441-450 (2003)
   PUBMED   14522002
REFERENCE   8  (bases 1 to 3910)
  AUTHORS   Qu,Y., Curtis,R., Lawson,D., Gilbride,K., Ge,P., DiStefano,P.S.,
            Silos-Santiago,I., Catterall,W.A. and Scheuer,T.
  TITLE     Differential modulation of sodium channel gating and persistent
            sodium currents by the beta1, beta2, and beta3 subunits
  JOURNAL   Mol Cell Neurosci 18 (5), 570-580 (2001)
   PUBMED   11922146
REFERENCE   9  (bases 1 to 3910)
  AUTHORS   Ratcliffe,C.F., Westenbroek,R.E., Curtis,R. and Catterall,W.A.
  TITLE     Sodium channel beta1 and beta3 subunits associate with neurofascin
            through their extracellular immunoglobulin-like domain
  JOURNAL   J Cell Biol 154 (2), 427-434 (2001)
   PUBMED   11470829
REFERENCE   10 (bases 1 to 3910)
  AUTHORS   Morgan,K., Stevens,E.B., Shah,B., Cox,P.J., Dixon,A.K., Lee,K.,
            Pinnock,R.D., Hughes,J., Richardson,P.J., Mizuguchi,K. and
            Jackson,A.P.
  TITLE     beta 3: an additional auxiliary subunit of the voltage-sensitive
            sodium channel that modulates channel gating with distinct kinetics
  JOURNAL   Proc Natl Acad Sci U S A 97 (5), 2308-2313 (2000)
   PUBMED   10688874
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070899.1.
            
            On May 24, 2004 this sequence version replaced NM_139097.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070899.1, AF378093.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3910
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..3910
                     /gene="Scn3b"
                     /gene_synonym="Scnb3"
                     /note="sodium voltage-gated channel beta subunit 3"
                     /db_xref="GeneID:245956"
                     /db_xref="RGD:621657"
     exon            1..350
                     /gene="Scn3b"
                     /gene_synonym="Scnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            351..432
                     /gene="Scn3b"
                     /gene_synonym="Scnb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..1025
                     /gene="Scn3b"
                     /gene_synonym="Scnb3"
                     /note="sodium channel subunit beta-3; sodium channel beta
                     3 subunit; sodium channel, voltage-gated, type III, beta
                     subunit; sodium channel regulatory subunit beta-3"
                     /codon_start=1
                     /product="sodium channel regulatory subunit beta-3
                     precursor"
                     /protein_id="NP_620797.1"
                     /db_xref="GeneID:245956"
                     /db_xref="RGD:621657"
                     /translation="MPAFNRLLPLASLVLIYWVRVCFPVCVEVPSETEAVQGNPMKLR
                     CISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQD
                     VSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEI
                     MMYILLVFLTLWLFIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSVVPVEE"
     exon            433..596
                     /gene="Scn3b"
                     /gene_synonym="Scnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            597..822
                     /gene="Scn3b"
                     /gene_synonym="Scnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..961
                     /gene="Scn3b"
                     /gene_synonym="Scnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1041
                     /gene="Scn3b"
                     /gene_synonym="Scnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..3887
                     /gene="Scn3b"
                     /gene_synonym="Scnb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacattcagc cacggggtgg ccctggagag ggacggtttt gaccacctaa tcgtccagca
       61 tcggggcttc gcaagatcca ggaacgcgcc ccacggaaag gggtccctcg gtctacccat
      121 cctccacctc tgagatcacc caccccaccg gaggtcccac ctctttccac ccctgaagga
      181 cctcctgtga gcccgggacc ctgtgtacag gactgaagtg gaacaaattc tgtagcccag
      241 acgacggctg gagtggggac acgcccaact gaagaagcct gccccgccgt agaagcccga
      301 gatcctgagt ctcggtggat tgaagtcgtt gtccctgggg gaggcaagag cttcagaaat
      361 cgcttacggt ggaaaagatg cctgccttca acagattgct tcccctagct tctctagtgc
      421 tcatctactg ggtcagagtc tgcttccctg tgtgtgtgga agtaccctcg gagacagaag
      481 cggtgcaggg taatcccatg aagctgaggt gcatctcctg catgaagagg gaggaggtgg
      541 aggccaccac tgtggtggag tggttctaca ggcctgaggg cggtaaagat ttccttatat
      601 atgagtatcg gaatggccac caggaagtgg agagcccctt ccaaggccgt ctgcagtgga
      661 atgggagcaa agacctgcag gacgtatcca tcactgtact caatgtcact ttgaatgact
      721 ctggcctcta cacatgcaat gtgtccaggg agttcgaatt cgaggcacac aggccttttg
      781 tgaagaccac gagactgata cctttgcgag tcactgaaga ggcgggagaa gacttcacct
      841 ccgtggtctc ggaaatcatg atgtacatcc tcctggtctt cctcaccttg tggctgttta
      901 ttgagatgat ctattgctac agaaaggtct ctaaggccga agaggcagca caggaaaatg
      961 cgtctgacta ccttgctatc ccttcagaga acaaggagaa ctctgtggta cctgtggagg
     1021 aataatgtgg tgtgacttga ggtgatctga gtgctgaggg actggatatc cccagttcag
     1081 tgatgccagc aatatcagga agtgccccag gtgtcccaac acatccatct tttctattca
     1141 tcaaccacca acccaatgtg agattttcac ctgacttccg aactctatca gaactctaca
     1201 catctttacc ttgcctgaac cgaagagcca acatctatct ctacacggac taaacctcac
     1261 tctgttcttg cttccaacca agtaactccc aacttaacta gagttgttcc ctatgttcca
     1321 aatgatttag acaagtactg gagagtagta ttacctctgc cctgactgtc tgtgactggg
     1381 tcattctcca ctgcagcaaa aggatggata taaatcggaa gaaagccctg actagtttgt
     1441 cttaaagcca aagcgtgcca cgtacgtact ttgattcatt gaagtcagtt tttcctgctt
     1501 ctcagagcgc cagaaagcag catgccccta atgcttgcag ggacatcatc tgtgtgcact
     1561 ggaacgcttt ctggagctca gtgtttggag gctgtatccc cataatcctg aagacctgga
     1621 gcaaacccag aacttccagg aagtcccaag gaaggatcca ggacagtttc agtaggtctc
     1681 gaaaatgata taacacactc ctgatattgg aaacatggat gagtgacctt tctggattga
     1741 aactcctcag ttcttcatgt ctcagtgtct gtggatcagt attagtcctc gttttacagg
     1801 aggaaactga gactcacaca aggctgaaca ggacatttag gggattaaac tgggccagag
     1861 atgactttcc tgccaccaac ctcacactcc ctgggatgag aggtattttt gaggactcta
     1921 acattcagca tgccatttgc ccagcggaag ctgactgcca cagatctgag gaactggaaa
     1981 ccaggtaaga aaacacagac ggcatgagat agacttcagg atttcacaca aagatttgtg
     2041 aatctgaagc atcctccagg agagacggca cccgagggca atatctctgt gatgaaaaat
     2101 ggttttagtc tgaaatggac agtcaacaga gagacaaaga tgggcgtgta gcttctaaat
     2161 acctcacctg tagatgtcac gtttgggtac tggtgtttgt aaagtccccc acctctaccc
     2221 tcatccccac ccaagagaac agggaaccag tgacaagatg cttagtcaat atctcttttt
     2281 aatgactgtt ctaaatgcaa tattctttag cccctccaga tagcaagggc agaaggcctt
     2341 atgatgtata aaaaggtaaa agtgagactc cataggagaa atgtcctcac ctctggggag
     2401 atctgtaaga aagaacattc tccaccccta cctggctttg tatgaaaagc tcacctttca
     2461 ctcccaacat ttccttcttg gtggatgcca gacatgcgct ttgggaaccc catcccaccc
     2521 tacctttatc tagcttgttt atacatggtg gcttatctgg aatcacaatc gcatttcctt
     2581 ataggagatc atgactataa cctacaaggc acggcactca ccagccaatt aaaatctttg
     2641 ccatctccat ttcttcccat aattccactt agaatcctgg actagacatg tgtgactctg
     2701 gagcctttcc tggtgtgcta tggcttacta aagggcttag aagagttctc aagggctata
     2761 atcatccaga aaccccattg tttgtcttgg tgctgggtat ttgcccggac tgattctcaa
     2821 taatttactg aaggtcaaac taagctgagt ctagttttcc ccttatccct gcctaacagc
     2881 tgtgaacttg gttactcagt tggtcctgag agcatcttgc cctgttggct tggacggtca
     2941 gccaggggtt gttaccgagc cccaatccct aagcgcttgc tatctcaggc tttactttca
     3001 atctgtttac acattattct ttggtttctc caccctcggt caaccgcaca ccccagctat
     3061 cttttgagtt tctgggtttg ctctagacat cgaaatagaa ttgcaagtag aaagggaact
     3121 ttccagagca agattatgct gagaacgaca ggggtgaggt taaaaggcgt tagggctaag
     3181 gtgatagccc agtgggtaaa atgcttgcca cccaagcgtg agagtctcag tgtgatctcc
     3241 agaatccatg tgaacagaca gacattgtgg cacacattgg tcatcccaga gctggggagg
     3301 cagagacagg aagatctgag cctcactaac caggccacct ggcctaactt acttacttgg
     3361 caagctccag gagagtgaga cgctgtctca aaaaaaaaaa aaacacaaat aaaaaaacca
     3421 acaaaggtgg atagtgcctg aggaatgaca cccgaggttg acttctggcc tccacatata
     3481 catgtgcaca agttaaggcc catatttata tttacataaa gatgcacgtg agcaatacac
     3541 acacatacac acacaccgag agagagagag agagagagag agagagagag agagagagag
     3601 agagagagag agagagagag agagaaagct tcctctcact tgttttataa acgaaaaagc
     3661 cctggttctg tgacttcacc cagtcactgc aaatgtatgt gaccaggacc ttggagtgcc
     3721 tgcttatcat tctgaccatc caatcccatt gactcaacgc tctctgtgtc aagtactagg
     3781 ttagactcta gctagacccc ttggtcttag gcctgtagaa atgtgcacag gcccatggtt
     3841 ccaataaagt ctctctgttc gtgtcaataa agtatctctg aagaccaaaa aaaaaaaaaa
     3901 aaaaaaaaaa
//
