LOCUS       NM_013119               6822 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Rattus norvegicus sodium voltage-gated channel alpha subunit 3
            (Scn3a), mRNA.
ACCESSION   NM_013119 XM_346657
VERSION     NM_013119.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6822)
  AUTHORS   Li,X., Liu,Y., Shao,M., Wang,J., Wang,L., Wang,Y. and Xu,W.
  TITLE     Exploring the mechanism of Nav1.3 in the ION-CCI rat model based on
            the TLR4/TRAF6/NF-kappaB pathway
  JOURNAL   Neurosci Lett 832, 137806 (2024)
   PUBMED   38714229
  REMARK    GeneRIF: Exploring the mechanism of Nav1.3 in the ION-CCI rat model
            based on the TLR4/TRAF6/NF-kappaB pathway.
REFERENCE   2  (bases 1 to 6822)
  AUTHORS   Huang,X.J., Su,G.J., Wu,C.W., Sha,X.S., Zou,J.F., Liu,X.S., Li,M.
            and He,Y.
  TITLE     Knockdown of rno_circRNA_009194 Improves Outcomes in Traumatic
            Brain Injury Rats through Inhibiting Voltage-Gated Sodium Channel
            Nav1.3
  JOURNAL   J Neurotrauma 39 (1-2), 196-210 (2022)
   PUBMED   34726508
  REMARK    GeneRIF: Knockdown of rno_circRNA_009194 Improves Outcomes in
            Traumatic Brain Injury Rats through Inhibiting Voltage-Gated Sodium
            Channel Nav1.3.
REFERENCE   3  (bases 1 to 6822)
  AUTHORS   Pang,B., Qiao,L., Wang,S., Guo,X., Xie,Y. and Han,L.
  TITLE     MiR-214-3p plays a protective role in diabetic neuropathic rats by
            regulating Nav1.3 and TLR4
  JOURNAL   Cell Biol Int 45 (11), 2294-2303 (2021)
   PUBMED   34296787
  REMARK    GeneRIF: MiR-214-3p plays a protective role in diabetic neuropathic
            rats by regulating Nav1.3 and TLR4.
REFERENCE   4  (bases 1 to 6822)
  AUTHORS   Martinez-Espinosa,P.L., Yang,C., Xia,X.M. and Lingle,C.J.
  TITLE     Nav1.3 and FGF14 are primary determinants of the TTX-sensitive
            sodium current in mouse adrenal chromaffin cells
  JOURNAL   J Gen Physiol 153 (4) (2021)
   PUBMED   33651884
  REMARK    GeneRIF: Nav1.3 and FGF14 are primary determinants of the
            TTX-sensitive sodium current in mouse adrenal chromaffin cells.
REFERENCE   5  (bases 1 to 6822)
  AUTHORS   Liu,M., Zhong,J., Xia,L., Dou,N. and Li,S.
  TITLE     The expression of voltage-gated sodium channels in trigeminal nerve
            following chronic constriction injury in rats
  JOURNAL   Int J Neurosci 129 (10), 955-962 (2019)
   PUBMED   30889362
  REMARK    GeneRIF: Chronic constriction injury gives rise to an up-regulation
            of Nav1.3 in trigeminal nerve and C-type neurons at the trigeminal
            ganglion.
REFERENCE   6  (bases 1 to 6822)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   7  (bases 1 to 6822)
  AUTHORS   Shah,B.S., Rush,A.M., Liu,S., Tyrrell,L., Black,J.A., Dib-Hajj,S.D.
            and Waxman,S.G.
  TITLE     Contactin associates with sodium channel Nav1.3 in native tissues
            and increases channel density at the cell surface
  JOURNAL   J Neurosci 24 (33), 7387-7399 (2004)
   PUBMED   15317864
REFERENCE   8  (bases 1 to 6822)
  AUTHORS   Hains,B.C., Saab,C.Y., Klein,J.P., Craner,M.J. and Waxman,S.G.
  TITLE     Altered sodium channel expression in second-order spinal sensory
            neurons contributes to pain after peripheral nerve injury
  JOURNAL   J Neurosci 24 (20), 4832-4839 (2004)
   PUBMED   15152043
  REMARK    GeneRIF: results show changed sodium channel expression in
            higher-order spinal sensory neurons after peripheral nerve injury
            and suggest a link between misexpression of Na(v)1.3 sodium
            channels and central mechanisms of neuropathic pain after injury.
REFERENCE   9  (bases 1 to 6822)
  AUTHORS   Hains,B.C., Klein,J.P., Saab,C.Y., Craner,M.J., Black,J.A. and
            Waxman,S.G.
  TITLE     Upregulation of sodium channel Nav1.3 and functional involvement in
            neuronal hyperexcitability associated with central neuropathic pain
            after spinal cord injury
  JOURNAL   J Neurosci 23 (26), 8881-8892 (2003)
   PUBMED   14523090
  REMARK    GeneRIF: Upregulation of Nav1.3 in dorsal horn nociceptive neurons
            after experimental spinal cord injury was noted suggesting a
            functional link between Nav1.3 expression and neuronal
            hyperexcitability associated with central neuropathic pain
REFERENCE   10 (bases 1 to 6822)
  AUTHORS   Kayano,T., Noda,M., Flockerzi,V., Takahashi,H. and Numa,S.
  TITLE     Primary structure of rat brain sodium channel III deduced from the
            cDNA sequence
  JOURNAL   FEBS Lett 228 (1), 187-194 (1988)
   PUBMED   2449363
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013119.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y00766.1, SRR26360176.1139142.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               JAXUCZ010000003.1  70665837-70666198   c
            363-676             JAXUCZ010000003.1  70635192-70635505   c
            677-795             JAXUCZ010000003.1  70629692-70629810   c
            796-885             JAXUCZ010000003.1  70628306-70628395   c
            886-1014            JAXUCZ010000003.1  70625797-70625925   c
            1015-1106           JAXUCZ010000003.1  70624994-70625085   c
            1107-1379           JAXUCZ010000003.1  70623902-70624174   c
            1380-1443           JAXUCZ010000003.1  70623443-70623506   c
            1444-1585           JAXUCZ010000003.1  70621057-70621198   c
            1586-1792           JAXUCZ010000003.1  70620136-70620342   c
            1793-2083           JAXUCZ010000003.1  70611967-70612257   c
            2084-2284           JAXUCZ010000003.1  70605177-70605377   c
            2285-2417           JAXUCZ010000003.1  70603881-70604013   c
            2418-2656           JAXUCZ010000003.1  70602832-70603070   c
            2657-2830           JAXUCZ010000003.1  70595591-70595764   c
            2831-3187           JAXUCZ010000003.1  70594145-70594501   c
            3188-3658           JAXUCZ010000003.1  70591555-70592025   c
            3659-3779           JAXUCZ010000003.1  70580851-70580971   c
            3780-3934           JAXUCZ010000003.1  70579520-70579674   c
            3935-4108           JAXUCZ010000003.1  70578663-70578836   c
            4109-4231           JAXUCZ010000003.1  70569198-70569320   c
            4232-4504           JAXUCZ010000003.1  70565465-70565737   c
            4505-4558           JAXUCZ010000003.1  70564586-70564639   c
            4559-4696           JAXUCZ010000003.1  70563651-70563788   c
            4697-4801           JAXUCZ010000003.1  70562529-70562633   c
            4802-5072           JAXUCZ010000003.1  70560144-70560414   c
            5073-6822           JAXUCZ010000003.1  70556224-70557973   c
FEATURES             Location/Qualifiers
     source          1..6822
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..6822
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /note="sodium voltage-gated channel alpha subunit 3"
                     /db_xref="GeneID:497770"
                     /db_xref="RGD:3635"
     exon            1..362
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            363..676
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..6268
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /note="voltage-gated sodium channel subtype III; sodium
                     channel protein type III subunit alpha; sodium channel
                     protein, brain III subunit alpha; voltage-gated sodium
                     channel subunit alpha Nav1.3; sodium channel,
                     voltage-gated, type 3, alpha subunit; sodium channel,
                     voltage-gated, type III, alpha subunit; sodium channel
                     protein type 3 subunit alpha-like; rCG26412-like"
                     /codon_start=1
                     /product="sodium channel protein type 3 subunit alpha"
                     /protein_id="NP_037251.2"
                     /db_xref="GeneID:497770"
                     /db_xref="RGD:3635"
                     /translation="MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDID
                     DENKPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYVSKKTFVVLNKGKAIFRF
                     SATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYT
                     FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTF
                     RVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNK
                     CLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIADDSHFYVLDGQKDP
                     LLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLT
                     LRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLE
                     QLKKQQEEAQAVAAASAASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQ
                     REHLEGNHRADGDRFPKSESEDSVKRRSFLLSLDGNPLTGDKKLCSPHQSLLSIRGSL
                     FSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSESRRDSLFVPHRPGERRNSN
                     GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAMSIASILTNTMEELEESRQKCPPCWY
                     RFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTQQFS
                     SVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLANVEGL
                     SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG
                     KSYKECVCKINVDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIV
                     FMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKNK
                     IRECFRKAFFRKPKVIEIQEGNKIDSCMSNNTGIEISKELNYLKDGNGTTSGVGTGSS
                     VEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATS
                     SSEGSTVDVAPPREGEQAEIEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNL
                     RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL
                     EMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRP
                     LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNTTT
                     GNMFEIKEVNNFSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAV
                     DSRDVKLQPIYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM
                     TEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTM
                     MVETDDQSKYMTLVLSRINLVFIVLFTGEFLLKLISLRYYYFTIGWNIFDFVVVILSI
                     VGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIG
                     LLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP
                     ILNSAPPDCDPDAIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFS
                     VATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQ
                     LIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPI
                     TTTLKRKQEEVSAAIIQRNYRCYLLKQRLKNISSKYDKETIKGRIDLPIKGDMVIDKL
                     NGNSTPEKTDGSSSTTSPPSYDSVTKPDKEKFEKDKPEKEIKGKEVRENQK"
     exon            677..795
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            796..885
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1014
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1106
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1379
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1443
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1585
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1792
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..2083
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2284
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2417
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2656
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2830
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..3187
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3188..3658
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3779
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3780..3934
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3935..4108
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            4109..4231
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            4232..4504
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            4505..4558
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            4559..4696
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            4697..4801
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            4802..5072
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
     exon            5073..6822
                     /gene="Scn3a"
                     /gene_synonym="Nav1.3; SCIII; Scn2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtgttttg tcgtttgcgc aatggcgtgt gtctgccagt agatggcagt gacacgttga
       61 gtgccgccaa ccttttcttt tttctttctt tttttttttt tttcccttcc agggccgttt
      121 tctgatatat gttgggtacc atagagtgaa tctcagaaca ggaagcggag gcataagcag
      181 agaggattct ggaaaggtct ctttgttttc atgtccacag agaaagcaag ggggaaaaat
      241 tgaatgtaat ttgcaaatcc ctgtggccca aatctgaaga actacagggg gtggcaccgt
      301 ccattctaac catcttggat gctgtccttt gttgagctgt gattcctaag gctctccatc
      361 aggcaattct tatgcaagaa gctaaacgta attaaatgtg caggatgaaa agatggccca
      421 ggcactgctg gtacccccgg gacctgagag cttccgcctt ttcactcgag aatctcttgc
      481 tgctatcgaa aagcgtgctg cagaagagaa agccaagaaa cccaagaaag agcaagacat
      541 tgacgatgag aacaaaccaa agccaaacag cgacttggaa gctgggaaga accttccatt
      601 tatctatgga gacattcctc cagagatggt gtcggagccc ctggaggacc tggaccccta
      661 ctatgtcagt aagaaaactt ttgtagtgtt gaataaaggg aaggcgattt ttcgattcag
      721 cgccacctcc gccctgtata ttttaactcc gctaaaccct gttaggaaaa ttgccattaa
      781 gattttggta cactctttgt tcagcatgct tatcatgtgc actattttga ccaactgtgt
      841 atttatgacg ttgagtaatc ctcccgactg gacaaagaat gtagagtata cgttcactgg
      901 gatctatacc tttgagtcac ttataaagat cttggcaaga gggttttgct tagaagattt
      961 cactttcctc cgtgacccat ggaactggct ggatttcagt gtcatcgtga tggcatatgt
     1021 gacagagttt gtggacctgg gcaatgtctc agcgctgaga acgttcagag ttctccgagc
     1081 attgaaaaca atatcagtca ttccaggttt aaagaccatc gtgggggccc tgatccagtc
     1141 cgtgaagaag ctgtccgacg tcatgatcct caccgtgttc tgtctcagtg tctttgctct
     1201 aatcgggctg cagctcttca tgggcaacct gaggaataaa tgcttgcagt ggcccccgag
     1261 cgattcggct tttgaaacca acactacttc ctacttcaat ggcacaatgg attcaaatgg
     1321 gacatttgtt aatgtaacaa tgagcacttt caactggaag gattatatcg cagatgacag
     1381 tcacttttat gtcttggatg gacaaaaaga tcctttactc tgtggaaatg gctccgatgc
     1441 aggacaatgt ccagaagggt acatctgtgt gaaggctgga cgaaacccca actacggcta
     1501 cacaagcttt gacaccttca gctgggcctt cttgtccctg tttcgactca tgactcagga
     1561 ctactgggag aatctttacc agttgacatt gcgtgcagct gggaaaacct acatgatatt
     1621 tttcgtcctg gtaattttct tgggctcgtt ttatttggtg aacttgatcc tggctgtggt
     1681 ggccatggcc tatgaggagc agaaccaggc cacactggag gaggctgaac agaaggaggc
     1741 agagtttcag cagatgctgg agcaactgaa gaagcagcag gaggaggctc aggcagtggc
     1801 tgcagcctcc gcggcatcca gagacttcag tggaatagga gggttaggag aacttctgga
     1861 gagttcttca gaagcttcca agttgagctc caagagtgct aaggagtgga ggaaccggag
     1921 gaagaagagg agacagaggg aacacttgga gggaaaccac agagccgatg gagacaggtt
     1981 tcccaagtcg gaatcggaag acagtgtcaa acgaagaagc ttcctgctct ccctggatgg
     2041 caacccgctg actggtgaca agaagctgtg ctctccccac cagtctctct tgagtatccg
     2101 tggctccctg ttttccccaa gacgcaatag caaaacgagc attttcagct tcagaggtcg
     2161 ggcgaaggac gtggggtctg agaatgactt tgcagacgat gagcacagca ccttcgagga
     2221 cagcgagagc aggagagact ccctgtttgt gccgcacaga cctggagagc gacgcaacag
     2281 taacggtacc accactgaaa cggaagtcag gaagagaagg ctaagttctt accagatttc
     2341 gatggaaatg ctggaggatt cctctggaag acaaagagcc atgagcatag ccagtatcct
     2401 gaccaacacc atggaggaac ttgaagaatc tagacagaag tgcccaccat gctggtatag
     2461 attcgccaat gtgtttttga tctgggactg ctgtgatgca tggttaaaag tgaagcatct
     2521 tgtgaattta attgtgatgg atccatttgt tgatcttgcc ataacaattt gcatcgtatt
     2581 aaatacactg ttcatggcca tggagcacta tcccatgacc cagcagttca gcagtgtgct
     2641 gactgtggga aacctggtct tcactgggat cttcacagcc gaaatggtcc ttaaaatcat
     2701 tgccatggac ccctattatt atttccaaga gggctggaat attttcgatg gaattattgt
     2761 tagcctgagt ttaatggagc taggcctggc aaatgtggag gggctgtctg tgcttcggtc
     2821 cttcagactg ctccgagtct tcaagttggc aaagtcctgg cccacactga acatgctcat
     2881 taagatcatc ggcaactcgg tgggcgcact gggcaacctg accctggtgc tggccatcat
     2941 cgtcttcatt tttgccgtgg tcggcatgca gctgtttgga aagagctaca aggagtgtgt
     3001 ctgcaagatc aatgtggact gcaagctgcc gcgctggcac atgaacgact tcttccactc
     3061 cttcctgatc gtgttccgag tgctgtgtgg ggagtggata gagaccatgt gggactgcat
     3121 ggaggtcgcg ggccagacca tgtgccttat tgtgttcatg ttggtcatgg tgattgggaa
     3181 ccttgtggtt ctgaacctct ttctggcctt attgttgagt tcctttagtt cagataacct
     3241 tgctgctact gacgatgata acgaaatgaa caacctccag atcgcggtgg gaaggatgca
     3301 aaagggaatt gattttgtga aaaataagat acgggagtgc ttccgaaaag cgtttttcag
     3361 aaagccgaaa gtgatagaaa tccaagaagg caacaaaata gacagctgca tgtccaataa
     3421 cacgggcatc gaaataagca aagagcttaa ctaccttaaa gacggtaatg gaaccaccag
     3481 cggcgtggga accggaagca gtgtggaaaa atacgtaatc gatgaaaatg actacatgtc
     3541 attcataaac aatcccagcc tcaccgtgac tgtgccaatt gctgtgggag agtctgactt
     3601 tgaaaattta aatacggaag agttcagcag tgagtcagaa ttggaagaaa gtaaggagaa
     3661 attaaatgca accagctctt ctgaaggaag cacagttgat gttgctccac cccgagaagg
     3721 tgaacaagca gaaattgaac ctgaggagga ccttaagcca gaagcttgtt ttactgaagg
     3781 gtgcattaaa aaattcccct tctgtcaagt aagtacagaa gaaggtaaag gaaaaatatg
     3841 gtggaatctt aggaagacat gctacagcat tgtggagcac aactggtttg aaacgttcat
     3901 tgtgttcatg attctcctca gtagtggcgc tttggccttt gaggatatat acattgagca
     3961 acgaaagacg atcaagacca tgctggagta tgcagacaag gtcttcacgt acatcttcat
     4021 cctggagatg ctcctcaaat gggtggccta tggatttcaa acctatttca ccaatgcctg
     4081 gtgctggttg gacttcctga tcgttgatgt ttctttggtt agcctggtag ccaatgctct
     4141 tggttactca gaacttggtg ccatcaaatc cctacggaca ctgagagctc tgaggccact
     4201 ccgagcctta tcccgctttg aaggcatgag ggtggttgtg aatgctcttg ttggtgcaat
     4261 tccctccatc atgaatgtgt tattggtgtg tctcatcttc tggctgattt ttagcatcat
     4321 gggtgtgaat ctgtttgctg gaaagttcta tcactgtgtt aacacgacaa caggcaacat
     4381 gtttgaaata aaagaagtga acaatttcag tgactgtcag gctcttggca agcaagcccg
     4441 gtggaagaat gtgaaagtca actttgacaa cgttggggct ggctacctgg cattgctgca
     4501 agtggccaca ttcaaaggct ggatggacat catgtatgca gctgttgatt cgcgggacgt
     4561 caaactgcag cccatatatg aagaaaacct gtacatgtac ctgtactttg tcatcttcat
     4621 catcttcggc tcgttcttca ctctaaatct attcatcggt gtcatcatag acaacttcaa
     4681 ccagcagaag aagaagtttg gaggtcaaga catctttatg acagaagaac agaagaaata
     4741 ctacaatgca atgaagaagc tcggctcaaa gaaacctcag aagcccatcc ctcggcctgc
     4801 aaacaaattt caagggatgg tctttgattt tgtaaccaga caagtgtttg acatcagcat
     4861 catgatcctc atctgcctca acatggtgac catgatggtg gaaacggatg accagagcaa
     4921 atacatgacc ctggttttgt cccgaatcaa cctagtgttc attgtcctct tcactgggga
     4981 gtttctgctg aagctcatct ccctcagata ctactacttc acgatagggt ggaacatctt
     5041 tgactttgtg gtggtgattc tctcgattgt aggaatgttt ctcgcggagc tgatagagaa
     5101 gtatttcgtg tcccctaccc tgttccgagt catccgcctg gccaggattg gacgaatcct
     5161 acgcctgatc aaaggcgcca aggggatccg cactctgctc tttgctttga tgatgtccct
     5221 tcctgcgctg ttcaacatcg gcctcctgct tttcctggtc atgttcatct acgccatctt
     5281 tgggatgtcc aactttgcct acgttaaaaa agaggctgga attgatgaca tgttcaactt
     5341 tgagactttt ggcaacagca tgatctgctt gttccaaatc accacctctg ccggctggga
     5401 cggactgctg gcccccatcc tcaacagcgc acctcccgac tgtgaccccg atgcaattca
     5461 ccctggaagc tcggtgaagg gggactgtgg gaacccatcc gtggggattt tcttttttgt
     5521 cagctacatc atcatatcct tcctggtggt ggtgaacatg tacatcgctg tcatcctgga
     5581 gaacttcagc gtcgccaccg aagaaagtgc agagcccctg agtgaggacg actttgagat
     5641 gttctacgag gtctgggaga agttcgaccc tgacgccact cagttcatag agttctgcaa
     5701 gctctctgac tttgcagctg ccctggatcc tcccctcctc atcgcaaagc caaacaaagt
     5761 ccagctcatt gccatggacc tgcccatggt gagtggagac cgcatccact gcctggacat
     5821 cttgtttgct tttacaaagc gggtcctggg cgagagtgga gagatggacg ctcttcgaat
     5881 ccagatggaa gaaaggttca tggcttccaa cccctccaag gtctcttatg agcccattac
     5941 caccaccctg aaacggaaac aagaggaggt gtctgctgct atcattcagc gtaattatag
     6001 atgttatctt ttaaagcaac ggttaaaaaa catatcgagt aaatacgaca aagagacaat
     6061 caagggaagg attgacttgc ctataaaagg agatatggtt attgacaaat tgaatgggaa
     6121 ttccacccca gaaaagacgg atgggagttc ctccacaacc tctcctcctt cctatgacag
     6181 tgtaacaaaa ccagataagg aaaagtttga gaaagacaaa ccagaaaaag aaatcaaagg
     6241 gaaagaggtc cgagagaatc aaaagtaaaa agagacaaag aaatgtcttt gtaatcaatt
     6301 gtttacagcc tctgaaggta aagtatccgt gtcaactgga ctctaaggag aggtccatgc
     6361 caaactgact gtttcaacaa atactcaagg tcagtgccta taccagacag tgacctctgt
     6421 cactgccact ctgtgagaca gggtatcaac attgacaaga ggttgctgct tccattacca
     6481 gctgacactg ctgaggagaa ctccattgtg caagtgaccc gtcatcacgc ccccaaactc
     6541 cattagtaca acgctcctgt catctatttt taacattcac atttgccata tttttacaaa
     6601 atctgtccca gtgtatcttc ctggtcccca cttcatagtc tgttcataat actatgtcac
     6661 tatttttgta aatgaagttt acgttaaggg aaaatatata tataagaatc ccatgttgct
     6721 aagtccacaa gtttctccag taatcataaa aaaatatttt gcctgagaga tgaaattatt
     6781 gctcaaaaca aaaaaaaaat aaattctaat gttaacagtt tc
//
