LOCUS       NM_012877               4448 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus sodium voltage-gated channel beta subunit 2
            (Scn2b), mRNA.
ACCESSION   NM_012877
VERSION     NM_012877.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4448)
  AUTHORS   Cho,I.H., Panzera,L.C., Chin,M. and Hoppa,M.B.
  TITLE     Sodium Channel beta2 Subunits Prevent Action Potential Propagation
            Failures at Axonal Branch Points
  JOURNAL   J Neurosci 37 (39), 9519-9533 (2017)
   PUBMED   28871036
  REMARK    GeneRIF: Navbeta2 is a critical regulator of axonal excitability
            and synaptic function.
REFERENCE   2  (bases 1 to 4448)
  AUTHORS   Shimada,Y., Sato,T., Yajima,T., Fujita,M., Hashimoto,N., Shoji,N.,
            Sasano,T. and Ichikawa,H.
  TITLE     SCN2B in the Rat Trigeminal Ganglion and Trigeminal Sensory Nuclei
  JOURNAL   Cell Mol Neurobiol 36 (8), 1399-1408 (2016)
   PUBMED   26852328
  REMARK    GeneRIF: distribution of SCN2B-containing neurons in the trigeminal
            ganglion
REFERENCE   3  (bases 1 to 4448)
  AUTHORS   Sun,L.H., Yan,M.L., Hu,X.L., Peng,L.W., Che,H., Bao,Y.N., Guo,F.,
            Liu,T., Chen,X., Zhang,R., Ban,T., Wang,N., Liu,H.L., Hou,X. and
            Ai,J.
  TITLE     MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by
            targeting Navbeta2 protein coding region in rat with chronic brain
            hypoperfusion
  JOURNAL   Mol Neurodegener 10, 36 (2015)
   PUBMED   26259688
  REMARK    GeneRIF: miR-9 suppressed the trafficking of Nav1.1/Nav1.2 from
            cytoplasm to cell membrane. miR-9 overexpression inhibited Navbeta2
            expression by targeting its coding sequence domain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4448)
  AUTHORS   Chen,C., Calhoun,J.D., Zhang,Y., Lopez-Santiago,L., Zhou,N.,
            Davis,T.H., Salzer,J.L. and Isom,L.L.
  TITLE     Identification of the cysteine residue responsible for disulfide
            linkage of Na+ channel alpha and beta2 subunits
  JOURNAL   J Biol Chem 287 (46), 39061-39069 (2012)
   PUBMED   22992729
REFERENCE   5  (bases 1 to 4448)
  AUTHORS   Watanabe,H., Darbar,D., Kaiser,D.W., Jiramongkolchai,K., Chopra,S.,
            Donahue,B.S., Kannankeril,P.J. and Roden,D.M.
  TITLE     Mutations in sodium channel beta1- and beta2-subunits associated
            with atrial fibrillation
  JOURNAL   Circ Arrhythm Electrophysiol 2 (3), 268-275 (2009)
   PUBMED   19808477
REFERENCE   6  (bases 1 to 4448)
  AUTHORS   Li,H.S., Doyle,W.J., Swarts,J.D. and Hebda,P.A.
  TITLE     Suppression of epithelial ion transport transcripts during
            pneumococcal acute otitis media in the rat
  JOURNAL   Acta Otolaryngol 122 (5), 488-494 (2002)
   PUBMED   12206256
REFERENCE   7  (bases 1 to 4448)
  AUTHORS   Dhar Malhotra,J., Chen,C., Rivolta,I., Abriel,H., Malhotra,R.,
            Mattei,L.N., Brosius,F.C., Kass,R.S. and Isom,L.L.
  TITLE     Characterization of sodium channel alpha- and beta-subunits in rat
            and mouse cardiac myocytes
  JOURNAL   Circulation 103 (9), 1303-1310 (2001)
   PUBMED   11238277
REFERENCE   8  (bases 1 to 4448)
  AUTHORS   Srinivasan,J., Schachner,M. and Catterall,W.A.
  TITLE     Interaction of voltage-gated sodium channels with the extracellular
            matrix molecules tenascin-C and tenascin-R
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15753-15757 (1998)
   PUBMED   9861042
REFERENCE   9  (bases 1 to 4448)
  AUTHORS   Gastaldi,M., Robaglia-Schlupp,A., Massacrier,A., Planells,R. and
            Cau,P.
  TITLE     mRNA coding for voltage-gated sodium channel beta2 subunit in rat
            central nervous system: cellular distribution and changes following
            kainate-induced seizures
  JOURNAL   Neurosci Lett 249 (1), 53-56 (1998)
   PUBMED   9672387
REFERENCE   10 (bases 1 to 4448)
  AUTHORS   Isom,L.L., Ragsdale,D.S., De Jongh,K.S., Westenbroek,R.E.,
            Reber,B.F., Scheuer,T. and Catterall,W.A.
  TITLE     Structure and function of the beta 2 subunit of brain sodium
            channels, a transmembrane glycoprotein with a CAM motif
  JOURNAL   Cell 83 (3), 433-442 (1995)
   PUBMED   8521473
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 20, 2020 this sequence version replaced NM_012877.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1043957.1,
                                           SRR26360176.2198521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               JAXUCZ010000008.1  54322383-54322633
            252-418             JAXUCZ010000008.1  54329607-54329773
            419-629             JAXUCZ010000008.1  54330005-54330215
            630-4448            JAXUCZ010000008.1  54330701-54334519
FEATURES             Location/Qualifiers
     source          1..4448
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..4448
                     /gene="Scn2b"
                     /gene_synonym="SCNB2"
                     /note="sodium voltage-gated channel beta subunit 2"
                     /db_xref="GeneID:25349"
                     /db_xref="RGD:3633"
     exon            1..251
                     /gene="Scn2b"
                     /gene_synonym="SCNB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..829
                     /gene="Scn2b"
                     /gene_synonym="SCNB2"
                     /note="sodium channel subunit beta-2; Sodium channel beta
                     2; sodium channel, voltage-gated, type II, beta
                     polypeptide; sodium channel, voltage-gated, type II, beta
                     subunit; sodium channel regulatory subunit beta-2"
                     /codon_start=1
                     /product="sodium channel regulatory subunit beta-2
                     precursor"
                     /protein_id="NP_037009.1"
                     /db_xref="GeneID:25349"
                     /db_xref="RGD:3633"
                     /translation="MHRDAWLPRPAFSLTGLSLFFSLVPSGRSMEVTVPTTLSVLNGS
                     DTRLPCTFNSCYTVNHKQFSLNWTYQECSNCSEEMFLQFRMKIINLKLERFGDRVEFS
                     GNPSKYDVSVTLKNVQLEDEGIYNCYITNPPDRHRGHGKIYLQVLLEVPPERDSTVAV
                     IVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNAEDGAK"
     exon            252..418
                     /gene="Scn2b"
                     /gene_synonym="SCNB2"
                     /inference="alignment:Splign:2.1.0"
     exon            419..629
                     /gene="Scn2b"
                     /gene_synonym="SCNB2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..4448
                     /gene="Scn2b"
                     /gene_synonym="SCNB2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccacatac aagtcggcca tattagagag atggaaataa agcttcctta atgttgcata
       61 tgtctttgaa gtacatccct gcattttctt ttttagcatc taaccattcc tcccttgtgg
      121 tccttggtcc ctcaatcacc ctttcccaca gcccacccgc ctaacatcac agtctctgaa
      181 aatgcacagg gatgcctggc tacctcgccc tgccttcagt ctcacggggc tcagtctgtt
      241 tttctctttg gtgccctcgg ggcggagcat ggaagtcaca gtccccacca ctcttagtgt
      301 cctcaacggg tctgataccc gcctgccctg taccttcaac tcctgctata ccgtgaacca
      361 caagcagttc tctctgaact ggacttacca ggagtgtagc aattgctcag aggagatgtt
      421 cctccagttc cgaatgaaga tcatcaacct gaagctggag cggtttggag accgcgtaga
      481 gttctcgggg aaccccagta agtacgacgt gtcagtgact ctaaagaacg tgcagctaga
      541 agacgaaggc atttacaact gctacatcac caaccctcca gaccgccacc gtggccatgg
      601 caagatctac ctgcaggtcc ttctagaagt gcccccagag cgggactcca cggtggcagt
      661 catcgtgggt gcctcagtgg ggggtttcct ggctgtggtc atcttggtgc tgatggtggt
      721 caaatgtgtg aggaggaaaa aagagcagaa gctgagcacg gatgacctga agaccgaaga
      781 ggaaggcaag acggatggcg agggcaacgc ggaagatggc gccaagtaac cggaagcttg
      841 ccctgaagcc ccttcctgtg tcctgtctcc tctcactctc tgccctgtac agtgtgaccc
      901 tgcctgctct cacttggtgt gcttctcttg aataggaccc caggatcgac ctggggcctc
      961 ccttccaatg cccccactcc cataccaagg acgacctccc tccccttcat ctgaaaactg
     1021 ccttggtatc tgagatacgc gcgagtccca gggagaacag agagggctct agcctgtcag
     1081 tctttgagga agaaagacct gtgtggtccc aaagacagga ttggggaagg agggcagtgg
     1141 gagaagaggc cgtctgcccg tcttgtctag ggtttggtct tgtggtgatt taaaccgtgg
     1201 gaatggcagt gtgtgtggtg ggggattctg tgctgatcag aggcaccatg ggaatgactc
     1261 gtgatgataa tggctttgct gtattcctct ggctactcct agccaggaac agccatcagc
     1321 tggggatgaa ggtggggtcc taccatttgt gaaagtatta tttaaaggga tgactgtgca
     1381 tttccagggc actcaagaaa agatagggct gaggcatttc tgggcagagc cttggcccag
     1441 agaactctgt tctggcctca tttctatcac tagccactcc cagagaggcc ctggtttact
     1501 gttggctact gctcccttgg ggatgctggc aagagcgcta ctggaaaagc ggcatcaggt
     1561 aagatcatat gctaccctag ggatgctcct taagagacct gtgagggcct gaggggtacg
     1621 ggcttcactg cgtacatgtg gctgccttct ccaacaagat gattaccttg gtttcagcca
     1681 gcagctgcca aacctcagaa tgggggtgtg ttttgtgtgt gtgtgtgtgt atgggcaact
     1741 tcctgcaggg ctttagtttg ggggtttctg gctgcccttg gcaggggttc tgtctggctt
     1801 ttggcaagaa ggaagagaag gctggagagc atgtaatatg agagcattct ggaggagcct
     1861 gtgagctctg cccctccccc acccccagag ctccctttat aggggagaaa gtcgctcctg
     1921 tgggaaaaca actttcactg ccattttact atcattataa gggacttgtt aagtccagaa
     1981 atgggagaaa ggcagggcag aaatggctaa tcggagagca ccgtgttagg acatgctcag
     2041 agaactggca cagagcctcc tgcagactga agttccaagt gaccgacaga agctaaaagt
     2101 attgcccatg ttctggctcc ctggtccctg gttagaacaa acagagcttc ctggtgggag
     2161 aaccttgagc ctaggaggtg tttgtacatg gtagtggtgg ggtccgtcta gccctgctcc
     2221 ccttcccaga aactcagccc ccacaagctc agggtaagta agctgttcag ggtagggaaa
     2281 gagtgtggta gagacaagac caagacagtc tcagggacca atacttgcct ctgcttatca
     2341 gatagccact cgaagagaca atgacagcag atggaaggtt cagcttaatt catttcaacc
     2401 caacaaccat ttaccgagtt tatgctgtat tccaggcact gtgctgggtg ccaggggtgc
     2461 atacaaagcc ataacagagt cagggactgc caaatctgca ctgtaggacc aagagtagat
     2521 ttttcttcct tcctttcttt ctttttcttt tcttttcttt ctttctttcc tttttttttt
     2581 tgatgcatct acttccgcct ccatagccac tgcttccaca agaggtcagg aggatgagac
     2641 ttttgatttg ggggtttggg aaaataaggc tgcaagggga ggggggaagg tactgttgga
     2701 gagggtacag aggtcatgta ggttgggcat ggagtagggg atgggtaagc agccagagga
     2761 ctcctgggta aggtgaatct aacccttctg gaagttctaa ctctttggct cagaacctaa
     2821 ctgccagaga acacactgcc aatgggagtg ggcgaaacca ccagggtgcc tggagcaggt
     2881 ggatactgcc tatccttcca gcaagcccac taggggtaga gagatgggtc atgggctcct
     2941 caagccagct gaagccaagg gtggtggtgt ttggtagctt ggagcagcca gttttcatta
     3001 cctggcacgt gccgtcttct ttcacggtgc acagacaagg gacttggctt ttgcaaagtc
     3061 tcctaacatt ttggggggag tggttacttg ggcgattccc ccagagggtt gtactaataa
     3121 gtggcctctt aaagaggtaa agtttctagg ggtctctttc ttttctgtcc tgacggaatg
     3181 gggtccaggg aaagcaacgc ctgtctctgg atctcatggg ctgggtcagg ggccattttg
     3241 ccccaggtac ttgcccccat gcgcactttc ttaaacccta cgtgagggcc tctgggcttg
     3301 aggttgggaa caaaaccagg cttctgtgag gtggggtggg aaactgtgag atgtaactac
     3361 aggagccgtt gctcaagctt gcttcttagc ttacgccagc gaactgctct cttgctgcag
     3421 tgtgggctcc gagctctgct cttggctatg tgctcccacc gctgtgctcc ccgtctctcc
     3481 tgcctctcct gctctcccag atccccctcc tcaggtccta tctgcctctg cctcctaatt
     3541 aagggccact gcaaagaaag attggcaggc taacccgagg ggttcagctc aggagaacaa
     3601 agcacaatat ttcaggactg aaaatgcctt gcggtgcctt ggaactggct ttggaagaga
     3661 gttgtctgcc cctccagcta tgggctcgtc agctagtccc gctttatcaa atggaaaagc
     3721 tgattgggtc cgtggttgcc tgtgagtctc cttgggaaag ttgggctgct acctacctat
     3781 aagatcaggt taagcaggta ggcaggtaga aataccgacc aggtccaaag atgttagtcc
     3841 caggccatag gaatggcttg gtgcagttgg aacgggtgac aaattaagaa aacttttttt
     3901 tttcctacat atgtcttaag aatagacagc cttgctgtgc ctcttgctga tgtcttcctt
     3961 tattgaagct tgctgatgcg actgtacata gcctttctat ataggtagag atatattata
     4021 catacatata aaacatctca ctggggctgg ggatttagct cagtggtaga gcgcttacct
     4081 aggaagcaca aggccctggg ttcggtcccc agctccgaca aaaagaacaa caacaacaaa
     4141 aaaatctcac tatgcccacc ccaaaagtta cactgtgggg ggagggtgta atcacttctc
     4201 agtgtttccg agtaccaaag gttccttagg caacgttctg tatggttttt cagggggaga
     4261 acccagctgc atagcaaggg ctcacgctcg tgcaggttct acgtcctgtt tggtggttgg
     4321 gaggggagag aagcttaaac aaatggcctt ctgtgacctg gctgctggga gcaggctgga
     4381 tttctttagc agtttgtcgg attgcttggg gctgttggct gcaataaaca cactgtctcc
     4441 ccccggaa
//
