LOCUS       NM_001271045            1667 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus sodium voltage-gated channel beta subunit 1
            (Scn1b), transcript variant 1, mRNA.
ACCESSION   NM_001271045
VERSION     NM_001271045.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1667)
  AUTHORS   Al-Ward,H., Liu,N., Omorou,M., Huang,Y., Chen,W., Liu,C.Y., Lv,S.,
            Murshed,A., Shaher,F., Li,Y., Zhang,Y., Lu,L., Gao,W., Sun,Y.E. and
            Xu,H.
  TITLE     The relationship between miRNA-210 and SCN1B in fetal rats with
            hypoxic-ischemic brain injury
  JOURNAL   Biosci Rep 43 (1) (2023)
   PUBMED   36541246
  REMARK    GeneRIF: The relationship between miRNA-210 and SCN1B in fetal rats
            with hypoxic-ischemic brain injury.
REFERENCE   2  (bases 1 to 1667)
  AUTHORS   Pan,X., Li,Z., Zhou,Q., Shen,H., Wu,K., Huang,X., Chen,J.,
            Zhang,J., Zhu,X., Lei,J., Xiong,W., Gong,H., Xiao,B. and Yan,N.
  TITLE     Structure of the human voltage-gated sodium channel Nav1.4 in
            complex with beta1
  JOURNAL   Science 362 (6412) (2018)
   PUBMED   30190309
REFERENCE   3  (bases 1 to 1667)
  AUTHORS   Johnson,K.W., Herold,K.F., Milner,T.A., Hemmings,H.C. Jr. and
            Platholi,J.
  TITLE     Sodium channel subtypes are differentially localized to pre- and
            post-synaptic sites in rat hippocampus
  JOURNAL   J Comp Neurol 525 (16), 3563-3578 (2017)
   PUBMED   28758202
  REMARK    GeneRIF: Nav1.1 and Nav1.2 are highly expressed in axon terminals
            in central hilus compared to stratum radiatum and in dendrites and
            spines in stratum radiatum compared to central hilus
REFERENCE   4  (bases 1 to 1667)
  AUTHORS   Sanchez-Solano,A., Islas,A.A., Scior,T., Paiz-Candia,B.,
            Millan-PerezPena,L. and Salinas-Stefanon,E.M.
  TITLE     Characterization of specific allosteric effects of the Na+ channel
            beta1 subunit on the Nav1.4 isoform
  JOURNAL   Eur Biophys J 46 (5), 485-494 (2017)
   PUBMED   28012039
  REMARK    GeneRIF: the role of the intracellular IFM motif of rNav1.4
            (skeletal muscle isoform of the rat Na(+) channel) on the
            alpha-beta1 functional interaction
REFERENCE   5  (bases 1 to 1667)
  AUTHORS   Huang,X., Du,Y., Yang,P., Lin,S., Xi,Y., Yang,Z. and Ma,A.
  TITLE     Age-dependent alterations of voltage-gated Na(+) channel isoforms
            in rat sinoatrial node
  JOURNAL   Mech Ageing Dev 152, 80-90 (2015)
   PUBMED   26528804
  REMARK    GeneRIF: the presences of Nav1.1, Nav1.6, Navbeta1 and Navbeta3
            mRNA and their reduced levels in rat SAN during aging.
REFERENCE   6  (bases 1 to 1667)
  AUTHORS   Kazen-Gillespie,K.A., Ragsdale,D.S., D'Andrea,M.R., Mattei,L.N.,
            Rogers,K.E. and Isom,L.L.
  TITLE     Cloning, localization, and functional expression of sodium channel
            beta1A subunits
  JOURNAL   J Biol Chem 275 (2), 1079-1088 (2000)
   PUBMED   10625649
REFERENCE   7  (bases 1 to 1667)
  AUTHORS   Dib-Hajj,S.D. and Waxman,S.G.
  TITLE     Genes encoding the beta 1 subunit of voltage-dependent Na+ channel
            in rat, mouse and human contain conserved introns
  JOURNAL   FEBS Lett 377 (3), 485-488 (1995)
   PUBMED   8549781
REFERENCE   8  (bases 1 to 1667)
  AUTHORS   Oh,Y. and Waxman,S.G.
  TITLE     The beta 1 subunit mRNA of the rat brain Na+ channel is expressed
            in glial cells
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9985-9989 (1994)
   PUBMED   7937931
REFERENCE   9  (bases 1 to 1667)
  AUTHORS   Makita,N., Bennett,P.B. Jr. and George,A.L. Jr.
  TITLE     Voltage-gated Na+ channel beta 1 subunit mRNA expressed in adult
            human skeletal muscle, heart, and brain is encoded by a single gene
  JOURNAL   J Biol Chem 269 (10), 7571-7578 (1994)
   PUBMED   8125980
REFERENCE   10 (bases 1 to 1667)
  AUTHORS   Isom,L.L., De Jongh,K.S., Patton,D.E., Reber,B.F., Offord,J.,
            Charbonneau,H., Walsh,K., Goldin,A.L. and Catterall,W.A.
  TITLE     Primary structure and functional expression of the beta 1 subunit
            of the rat brain sodium channel
  JOURNAL   Science 256 (5058), 839-842 (1992)
   PUBMED   1375395
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 11, 2022 this sequence version replaced NM_001271045.1.
            
            Transcript Variant: This variant (1) and variant 2 encode the
            longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094523.1, SRR22399481.331769.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               JAXUCZ010000001.1  95490852-95491197   c
            347-513             JAXUCZ010000001.1  95489304-95489470   c
            514-754             JAXUCZ010000001.1  95487611-95487851   c
            755-896             JAXUCZ010000001.1  95482464-95482605   c
            897-1667            JAXUCZ010000001.1  95481298-95482068   c
FEATURES             Location/Qualifiers
     source          1..1667
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1667
                     /gene="Scn1b"
                     /note="sodium voltage-gated channel beta subunit 1"
                     /db_xref="GeneID:29686"
                     /db_xref="RGD:3631"
     exon            1..346
                     /gene="Scn1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..963
                     /gene="Scn1b"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sodium channel subunit beta-1; sodium channel,
                     voltage-gated, type 1, beta polypeptide; sodium channel,
                     voltage-gated, type I, beta polypeptide; sodium channel,
                     voltage-gated, type I, beta subunit; sodium channel
                     regulatory subunit beta-1"
                     /codon_start=1
                     /product="sodium channel regulatory subunit beta-1 isoform
                     1 precursor"
                     /protein_id="NP_001257974.1"
                     /db_xref="GeneID:29686"
                     /db_xref="RGD:3631"
                     /translation="MGTLLALVVGAVLVSSAWGGCVEVDSETEAVYGMTFKILCISCK
                     RRSETTAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQ
                     DLSIFITNVTYNHSGDYECHVYRLLFFDNYEHNTSVVKKIHLEVVDKANRDMASIVSE
                     IMMYVLIVVLTIWLVAEMVYCYKKIAAATEAAAQENASEYLAITSESKENCTGVQVAE
                     "
     exon            347..513
                     /gene="Scn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            514..754
                     /gene="Scn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            755..896
                     /gene="Scn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1667
                     /gene="Scn1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtgcgca ggagcccgcg gtccgcaccc cagcgccggg agcccgagcg cgagcagcgt
       61 ccggagccag acaggggtcg ccgcagcctg gatgcgccct gtggcgcgca cgcacgcagc
      121 atcccgagcc tcccgccgcg cggcggggat gcctgctctc cgggccccgg ggcttggccc
      181 ccggcggtaa ccggagcggg ggggcgcgcc cccccagcag cagctgcggc gcccgcgccc
      241 gggccagtcg ccgccggggc ccatctcctg tcgccgcgct ctgcgcaccc accgccttgc
      301 gcggccatgg ggacgctgct ggctctcgtg gtgggcgcgg tgctggtatc ctcagcctgg
      361 gggggctgcg tggaggtgga ttctgagacc gaggcagtgt atgggatgac cttcaaaatc
      421 ctgtgtatct cctgtaagcg tcgtagtgag accaccgccg agaccttcac ggagtggacc
      481 ttccgccaga agggcacaga ggaatttgtc aagatcctac gctatgagaa tgaggtgctg
      541 cagctggagg aagatgagcg ctttgagggc cgtgtggtgt ggaacggtag tcggggcacc
      601 aaggacctgc aggacctgtc catcttcatc accaatgtca cctacaacca ctctggcgac
      661 tacgaatgtc acgtctaccg tctcctcttc tttgataatt acgagcacaa caccagcgtc
      721 gtcaagaaga tccacctgga ggtggtggac aaggccaaca gagatatggc atccatcgtg
      781 tcagagatca tgatgtacgt gctcattgtg gtgttaacca tatggctcgt ggcggagatg
      841 gtgtactgct acaagaagat tgctgctgcc acggaagctg ctgcacaaga gaatgcctcg
      901 gaatacctgg ccattacttc cgagagcaaa gagaactgta caggcgtcca ggtggctgaa
      961 tagcgctggt aaggttgatg gacctacacg tctgcgcatc gccagcctgc agggttcagg
     1021 gacacactct aagtctccac ttcttaccct gcaggctctg ggctccgcct caaggaagag
     1081 ccagccccta cgggtaccct ccagccctgc agtggggatc agcccctggt gggtaccctc
     1141 ccctggcagt ggggatcagc ccatcggtct ccccagcctc acagttctgc agtggagcca
     1201 ccagggtggg agcgggcagg gactgatccc acctcaccca ccgcctccca cctaccctcc
     1261 caccgccatg catgatgggt gaagcaatat ggccgcccca ccctgctttt gctgcctgtt
     1321 tgggggaggg ggcggtgagg cgagggggca ggccccgccc cttctttttg ctgatttgca
     1381 cataggccac ttcccacacg cactgccagg ccagccggcc ccacccctgc ttgatggggt
     1441 gaagaggggt cgggacaggg acagtagtgg gcagggggtt ctgggcctca tctcccctcc
     1501 gcttcctccg gctggacctg gggttccctt cctgtgacac ctcctagccc tggcccaccc
     1561 gccctctctc accagccttc aattgtggtc tcttgggaag ggcctcttcg gcctcctatc
     1621 tttacagaag tagtttttgt tcatgaaata aagattcttg gactcga
//
