LOCUS       NM_030875               8397 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Rattus norvegicus sodium voltage-gated channel alpha subunit 1
            (Scn1a), mRNA.
ACCESSION   NM_030875
VERSION     NM_030875.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8397)
  AUTHORS   Prakash,C., Mishra,M., Kumar,P., Kumar,V. and Sharma,D.
  TITLE     Response of Voltage-Gated Sodium and Calcium Channels Subtypes on
            Dehydroepiandrosterone Treatment in Iron-Induced Epilepsy
  JOURNAL   Cell Mol Neurobiol 41 (2), 279-292 (2021)
   PUBMED   32318899
  REMARK    GeneRIF: Response of Voltage-Gated Sodium and Calcium Channels
            Subtypes on Dehydroepiandrosterone Treatment in Iron-Induced
            Epilepsy.
REFERENCE   2  (bases 1 to 8397)
  AUTHORS   Ohmori,I., Kobayashi,K. and Ouchida,M.
  TITLE     Scn1a and Cacna1a mutations mutually alter their original
            phenotypes in rats
  JOURNAL   Neurochem Int 141, 104859 (2020)
   PUBMED   33045260
  REMARK    GeneRIF: Scn1a and Cacna1a mutations mutually alter their original
            phenotypes in rats.
REFERENCE   3  (bases 1 to 8397)
  AUTHORS   Sakkaki,S., Barriere,S., Bender,A.C., Scott,R.C. and
            Lenck-Santini,P.P.
  TITLE     Focal Dorsal Hippocampal Nav1.1 Knock Down Alters Place Cell
            Temporal Coordination and Spatial Behavior
  JOURNAL   Cereb Cortex 30 (9), 5049-5066 (2020)
   PUBMED   32377688
  REMARK    GeneRIF: Focal Dorsal Hippocampal Nav1.1 Knock Down Alters Place
            Cell Temporal Coordination and Spatial Behavior.
REFERENCE   4  (bases 1 to 8397)
  AUTHORS   Osteen,J.D., Herzig,V., Gilchrist,J., Emrick,J.J., Zhang,C.,
            Wang,X., Castro,J., Garcia-Caraballo,S., Grundy,L., Rychkov,G.Y.,
            Weyer,A.D., Dekan,Z., Undheim,E.A., Alewood,P., Stucky,C.L.,
            Brierley,S.M., Basbaum,A.I., Bosmans,F., King,G.F. and Julius,D.
  TITLE     Selective spider toxins reveal a role for the Nav1.1 channel in
            mechanical pain
  JOURNAL   Nature 534 (7608), 494-499 (2016)
   PUBMED   27281198
REFERENCE   5  (bases 1 to 8397)
  AUTHORS   Syam,N., Chatel,S., Ozhathil,L.C., Sottas,V., Rougier,J.S.,
            Baruteau,A., Baron,E., Amarouch,M.Y., Daumy,X., Probst,V.,
            Schott,J.J. and Abriel,H.
  TITLE     Variants of Transient Receptor Potential Melastatin Member 4 in
            Childhood Atrioventricular Block
  JOURNAL   J Am Heart Assoc 5 (5), e001625 (2016)
   PUBMED   27207958
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8397)
  AUTHORS   Planells-Cases,R., Caprini,M., Zhang,J., Rockenstein,E.M.,
            Rivera,R.R., Murre,C., Masliah,E. and Montal,M.
  TITLE     Neuronal death and perinatal lethality in voltage-gated sodium
            channel alpha(II)-deficient mice
  JOURNAL   Biophys J 78 (6), 2878-2891 (2000)
   PUBMED   10827969
REFERENCE   7  (bases 1 to 8397)
  AUTHORS   Escayg,A., MacDonald,B.T., Meisler,M.H., Baulac,S., Huberfeld,G.,
            An-Gourfinkel,I., Brice,A., LeGuern,E., Moulard,B., Chaigne,D.,
            Buresi,C. and Malafosse,A.
  TITLE     Mutations of SCN1A, encoding a neuronal sodium channel, in two
            families with GEFS+2
  JOURNAL   Nat Genet 24 (4), 343-345 (2000)
   PUBMED   10742094
REFERENCE   8  (bases 1 to 8397)
  AUTHORS   Sarao,R., Gupta,S.K., Auld,V.J. and Dunn,R.J.
  TITLE     Developmentally regulated alternative RNA splicing of rat brain
            sodium channel mRNAs
  JOURNAL   Nucleic Acids Res 19 (20), 5673-5679 (1991)
   PUBMED   1658739
REFERENCE   9  (bases 1 to 8397)
  AUTHORS   Noda,M. and Numa,S.
  TITLE     Structure and function of sodium channel
  JOURNAL   J Recept Res 7 (1-4), 467-497 (1987)
   PUBMED   2442385
REFERENCE   10 (bases 1 to 8397)
  AUTHORS   Noda,M., Ikeda,T., Kayano,T., Suzuki,H., Takeshima,H., Kurasaki,M.,
            Takahashi,H. and Numa,S.
  TITLE     Existence of distinct sodium channel messenger RNAs in rat brain
  JOURNAL   Nature 320 (6058), 188-192 (1986)
   PUBMED   3754035
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_030875.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X03638.1, M22253.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JAXUCZ010000003.1  71479542-71479743   c
            203-515             JAXUCZ010000003.1  71432094-71432406   c
            516-634             JAXUCZ010000003.1  71418945-71419063   c
            635-724             JAXUCZ010000003.1  71416586-71416675   c
            725-853             JAXUCZ010000003.1  71414823-71414951   c
            854-945             JAXUCZ010000003.1  71412844-71412935   c
            946-1215            JAXUCZ010000003.1  71412107-71412376   c
            1216-1279           JAXUCZ010000003.1  71410058-71410121   c
            1280-1421           JAXUCZ010000003.1  71409420-71409561   c
            1422-1628           JAXUCZ010000003.1  71408631-71408837   c
            1629-1913           JAXUCZ010000003.1  71406503-71406787   c
            1914-2294           JAXUCZ010000003.1  71405217-71405597   c
            2295-2427           JAXUCZ010000003.1  71403788-71403920   c
            2428-2666           JAXUCZ010000003.1  71402821-71403059   c
            2667-2840           JAXUCZ010000003.1  71401406-71401579   c
            2841-3197           JAXUCZ010000003.1  71399974-71400330   c
            3198-3680           JAXUCZ010000003.1  71399110-71399592   c
            3681-3801           JAXUCZ010000003.1  71389978-71390098   c
            3802-3956           JAXUCZ010000003.1  71388462-71388616   c
            3957-4130           JAXUCZ010000003.1  71386407-71386580   c
            4131-4253           JAXUCZ010000003.1  71384804-71384926   c
            4254-4535           JAXUCZ010000003.1  71377037-71377318   c
            4536-4589           JAXUCZ010000003.1  71374908-71374961   c
            4590-4727           JAXUCZ010000003.1  71373246-71373383   c
            4728-4832           JAXUCZ010000003.1  71369361-71369465   c
            4833-5103           JAXUCZ010000003.1  71367026-71367296   c
            5104-8397           JAXUCZ010000003.1  71360841-71364134   c
FEATURES             Location/Qualifiers
     source          1..8397
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..8397
                     /gene="Scn1a"
                     /note="sodium voltage-gated channel alpha subunit 1"
                     /db_xref="GeneID:81574"
                     /db_xref="RGD:69364"
     exon            1..202
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            203..515
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..6281
                     /gene="Scn1a"
                     /note="sodium channel, voltage-gated, type I, alpha
                     polypeptide; sodium channel, voltage-gated, type I, alpha
                     subunit; sodium channel protein type I subunit alpha;
                     sodium channel protein, brain I subunit alpha;
                     voltage-gated sodium channel subunit alpha Nav1.1; sodium
                     channel, voltage-gated, type 1, alpha polypeptide; sodium
                     channel protein type 1 subunit alpha-like"
                     /codon_start=1
                     /product="sodium channel protein type 1 subunit alpha"
                     /protein_id="NP_110502.2"
                     /db_xref="GeneID:81574"
                     /db_xref="RGD:69364"
                     /translation="MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDD
                     DENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRF
                     SATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYT
                     FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTF
                     RVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNK
                     CVQWPPTNASLEEHSIEKNVTTDYNGTLVNETVFEFDWKSYIQDSRYHYFLEGVLDAL
                     LCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTL
                     RAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQ
                     LKKQQEAAQQAAAATASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKE
                     QSGGEEKDDDEFHKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSP
                     RRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQ
                     TSRSSRMLAGLPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNG
                     TTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYK
                     FSNIFLIWDCSPYWLKVKHIVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEHFNH
                     VLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLS
                     VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK
                     SYKDCVCKIATDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVF
                     MMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKI
                     YEFIQQSFVRKQKILDEIKPLDDLNNRKDNCTSNHTTEIGKDLDCLKDVNGTTSGIGT
                     GSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLN
                     ESSSSSEGSTVDIGAPAEEQPVMEPEETLEPEACFTEGCVQRFKCCQISVEEGRGKQW
                     WNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYI
                     FILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA
                     LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVN
                     TTTGDTFEITEVNNHSDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMD
                     IMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFG
                     GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILIC
                     LNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFV
                     VVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLP
                     ALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGW
                     DGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAV
                     ILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLP
                     QPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSK
                     VSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKLKGGANLLVKED
                     MIIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKDEKAKGK"
     exon            516..634
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            635..724
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            725..853
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            854..945
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1215
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1279
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1421
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1628
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1913
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2294
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2427
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2666
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2840
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..3197
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3680
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3681..3801
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3802..3956
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3957..4130
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4131..4253
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4254..4535
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4536..4589
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4590..4727
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4728..4832
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4833..5103
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            5104..8397
                     /gene="Scn1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tactgcagag gtctctggtg catgtgtatg tgtgtgcgtg tgtttgtgta cgtatgttct
       61 gcccctgtca ggctgcagcc cttgtgaaac acttggtcac cttttgcaag aaggaatctc
      121 tgaatcgttg caactgaagg tgcggactcg gctcgggaga tgttgttcct tactgcagat
      181 agataatttt cctttttatc aggaatctca catgaagagt aaagagtaat taaaatgtgc
      241 aggatgacaa gatggagcaa acagtgcttg taccaccagg acctgacagc ttcaacttct
      301 tcaccagaga atctcttgca gctattgaaa ggcgcattgc agaagaaaaa gctaagaatc
      361 ccaagccaga caaaaaagat gatgatgaaa atggcccaaa gccgaacagt gacttggaag
      421 ctgggaagaa ccttccattt atctatggag acattcctcc agagatggtg tcggagcctc
      481 tggaggacct ggacccctac tatatcaata agaaaacttt tatagtattg aataaaggga
      541 aggccatctt ccggttcagt gccacttctg ccctgtacat tttaactccc ttcaatcctc
      601 ttaggaaaat agctattaag attttggtac actcattatt cagcatgtta attatgtgca
      661 ctattttgac gaactgtgta tttatgacaa tgagtaaccc tcctgactgg acaaagaatg
      721 tagagtacac cttcacagga atatatacct ttgaatcact aataaaaatt attgcaaggg
      781 gcttctgttt agaagatttt actttccttc gtgacccatg gaactggctg gacttcactg
      841 tcattacatt cgcatatgtg acggagtttg tggacctggg caatgtctca gcgttgagaa
      901 cattcagagt tcttcgagca ttgaaaacaa tatcagtcat tccaggcctg aagaccatcg
      961 tgggggccct gatccagtct gtgaagaagc tctctgacgt catgatcctc accgtgttct
     1021 gtctcagtgt gtttgctcta atcgggttgc agcttttcat gggcaacctg aggaataagt
     1081 gtgtacagtg gccccccacc aacgcttccc ttgaggaaca tagcatagag aagaatgtaa
     1141 ctacggatta caacggcaca cttgtaaatg aaaccgtgtt tgaatttgac tggaaatcat
     1201 acattcaaga ctcaagatat cattatttcc tggagggtgt tttagatgca ctactgtgtg
     1261 gaaatagctc tgatgcaggc caatgtccag aaggttacat gtgtgtaaaa gctggcagaa
     1321 accctaacta tggttacaca agctttgaca ccttcagctg ggcatttctg tccctgtttc
     1381 gactgatgac tcaggacttc tgggaaaatc tttaccaact gacattgcgt gctgccggga
     1441 aaacatacat gatatttttt gtgctggtca ttttcttggg ctcattctac ctgataaact
     1501 tgatcctggc tgtggtggcc atggcctatg aggaacagaa ccaggccaca ttggaggagg
     1561 ctgaacagaa ggaggcagag tttcagcaga tgctggagca actgaagaag cagcaggaag
     1621 ccgcacagca ggcggcggca gcaacagcat cagaacattc cagggagccc agtgcagcgg
     1681 gcaggctctc agatagctct tcagaagcct ccaagttgag ttcaaagagc gctaaagaaa
     1741 ggcggaatcg gaggaaaaaa agaaaacaga aagagcagtc tggaggggaa gagaaagatg
     1801 atgatgaatt ccacaaatcc gagtccgaag atagcatcag gaggaagggc ttccgcttct
     1861 ccatagaagg gaacagactg acctatgaaa agaggtactc ttccccacat cagtctctgt
     1921 tgagcattcg cggctcactg ttttccccga gacgcaatag cagaacaagt cttttcagct
     1981 tcagagggcg agcgaaggac gtggggtctg agaatgattt tgcggacgat gagcacagca
     2041 ccttcgagga caatgagagc aggagagact ctctgtttgt tccccgaaga catggagagc
     2101 gacgcaacag taacctcagc caaaccagca gatcctcccg aatgctggcg gggcttccag
     2161 caaacgggaa gatgcacagc acagtggatt gcaatggtgt ggtttccttg gtgggcggac
     2221 cctcggttcc gacatcgcca gttggacagc ttctgccaga ggtgataata gataagccag
     2281 ctactgatga caatggaaca actactgaaa ctgagatgag aaagaggagg tcaagttctt
     2341 tccatgtttc catggacttt cttgaggatc cttcccagag gcaaagggca atgagcattg
     2401 ccagcatctt aacaaataca gtagaagaac tagaagaatc cagacagaaa tgtccaccct
     2461 gttggtataa attttccaac atatttttaa tttgggactg ttctccatat tggctaaaag
     2521 ttaaacatat tgtcaacctg gttgtgatgg acccatttgt tgacctggca attactatct
     2581 gtattgtgtt aaataccctt ttcatggcca tggagcacta ccccatgact gaacatttca
     2641 atcatgtact tacagtagga aacttggttt tcactgggat cttcacagca gaaatgttcc
     2701 tgaaaatcat tgccatggac ccttactatt atttccaaga gggctggaat atctttgatg
     2761 gtttcattgt gacactcagc ctggtagaac ttggccttgc caatgtggaa gggttatcag
     2821 ttctccgttc attccgactg ctccgagtct tcaagttggc aaagtcctgg cccacactga
     2881 acatgctcat taagatcatc ggcaactcgg tgggcgcact gggcaacctg accctggtgc
     2941 tggccatcat cgtcttcatt tttgccgtgg tcggcatgca gctgttcggc aaaagttaca
     3001 aagattgtgt ctgcaaaatt gccactgact gcaaactccc gcgctggcac atgaacgact
     3061 tcttccactc cttcctgatc gtgttccgag tgctgtgtgg ggagtggata gagaccatgt
     3121 gggactgcat ggaggtcgcg ggtcaagcca tgtgccttac tgtcttcatg atggtcatgg
     3181 tgattgggaa ccttgtggtc ctgaacctct ttctggcctt gcttctgagc tcatttagtg
     3241 cagacaacct tgcagccact gacgatgaca acgaaatgaa caaccttcaa attgctgtgg
     3301 acaggatgca caaaggagta gcttatgtaa aaagaaaaat atatgagttt attcaacagt
     3361 cctttgttag gaaacagaag atcctagatg aaattaagcc acttgatgat ctaaacaaca
     3421 gaaaagacaa ttgtacatct aaccacacga cagagattgg gaaagatctg gactgtctga
     3481 aagatgtgaa tggaaccacg agtggcatag ggaccggcag cagtgtggaa aagtacatca
     3541 ttgatgagag tgactacatg tcattcataa acaaccccag cctcaccgtg actgtgccca
     3601 ttgctgtggg agagtctgac tttgaaaact taaacacaga ggactttagc agtgaatcag
     3661 atctagaaga aagcaaagag aaactcaacg aaagcagtag ttcctcagaa ggaagcacag
     3721 tagacatcgg ggcacctgcg gaggaacagc ctgtcatgga accagaagaa acccttgagc
     3781 ccgaagcttg cttcactgaa ggctgtgtgc agagattcaa gtgctgtcaa atcagtgtgg
     3841 aagaaggaag aggaaaacag tggtggaacc ttcggagaac gtgcttccga atagttgagc
     3901 acaactggtt tgagaccttc attgtgttca tgattctcct cagtagtggt gccctggcct
     3961 ttgaggatat atacattgat cagcgaaaga cgatcaagac catgctggag tatgcagaca
     4021 aggttttcac ttacattttt atcctggaga tgctcctcaa atgggtagcc tacggctatc
     4081 aaacgtattt caccaatgcc tggtgttggc tggacttctt aattgttgat gtttcattgg
     4141 tcagtttaac agcaaatgcc ttgggttact ctgaacttgg ggccatcaag tccctaagga
     4201 cactaagagc tctgagaccc ctaagagcct tatcacgatt tgaagggatg agggtggttg
     4261 tgaatgccct gttaggagca attccatcca tcatgaatgt gcttctggtt tgccttatat
     4321 tctggctaat tttcagcatc atgggcgtaa atttgtttgc tggcaaattc taccactgtg
     4381 ttaacaccac aactggtgac acatttgaga tcaccgaagt caataatcat tctgattgcc
     4441 taaaactaat agaaagaaat gagactgccc ggtggaaaaa tgtgaaagta aactttgata
     4501 atgtaggatt tgggtatctt tctttgcttc aagttgcgac gtttaagggt tggatggata
     4561 tcatgtatgc agcagttgat tccagaaatg tggaactgca gcctaagtat gaggaaagcc
     4621 tgtacatgta cctgtacttc gtcatcttca tcatcttcgg ctcgttcttc actctaaatc
     4681 tattcatcgg tgtcatcata gacaacttca accagcagaa gaagaagttt ggaggtcaag
     4741 acatctttat gacagaagaa cagaagaaat actataatgc aatgaagaaa ttaggatcaa
     4801 aaaagccaca aaagcctatc cctcgacctg gaaacaaatt tcaaggaatg gtctttgact
     4861 ttgtaaccag acaagtgttt gacatcagca tcatgatcct catctgtctg aacatggtga
     4921 ccatgatggt ggaaacggat gaccagagcg attatgtgac aagcattttg tcacgtatca
     4981 acctggtgtt cattgtgctg ttcaccggcg agtgcgtgct gaagctcatc tccctccgcc
     5041 attattattt caccattggc tggaatattt tcgattttgt ggtggtcatc ctctccattg
     5101 taggaatgtt tcttgcggag ctgatagaga agtatttcgt gtcccctacc ctgttccgag
     5161 tcatccgcct ggccaggatt ggacgaatcc tacgcctgat caaaggcgcc aaggggatcc
     5221 gcactctgct ctttgctctg atgatgtccc ttcctgcgct gttcaacatc ggcctcctgc
     5281 ttttcctggt catgttcatc tacgccatct ttgggatgtc caactttgcc tatgttaaga
     5341 gggaagttgg aattgatgac atgttcaact ttgagacttt tggcaacagc atgatctgcc
     5401 tgttccaaat caccacctct gcgggctggg acggactgct ggcccccatc ctcaacagca
     5461 aaccccctga ctgtgaccct aataaagtta accccggaag ctcggtgaag ggggactgtg
     5521 ggaacccatc cgtggggatt ttcttttttg tcagctacat catcatatcc ttcctggtgg
     5581 tggtgaacat gtacatcgct gtcatcctgg agaacttcag cgtcgccacc gaagaaagtg
     5641 cagagcccct gagtgaggac gactttgaga tgttctacga ggtctgggag aagttcgacc
     5701 ctgacgccac tcagttcatg gaatttgaaa aattatctca gtttgcagct gctctcgaac
     5761 cccctctcaa cttaccacaa ccgaacaaac ttcagctcat tgccatggac ctgcccatgg
     5821 tgagtggaga ccgcatccac tgcctggaca tcttatttgc ttttacaaag cgggtcctgg
     5881 gcgagagtgg agagatggac gctcttcgaa tccagatgga agagcgcttc atggcttcca
     5941 acccctccaa ggtctcctat cagccaatca ctacaacgtt aaaacgaaag caagaggagg
     6001 tgtcagccgt tatcattcag cgcgcttaca ggcgccacct tttgaagcga acagtaaaac
     6061 aagcttcatt cacatacaat aagaacaaac tcaagggcgg ggctaatctt cttgtaaaag
     6121 aagacatgat cattgacagg ataaatgaaa actctattac agagaaaact gacctgacga
     6181 tgtccactgc agcttgtccg ccctcctacg accgggtgac aaagccaatc gtggagaaac
     6241 acgagcagga aggaaaagat gagaaagcca aagggaaatg aacacaaaca aacaaaaaat
     6301 aataaattgg gtgacaaatt gtttacagcc tgtgaagtca aaggactcct ttaggaagtc
     6361 aatgccaaac tgactgtttt tacacaaatt cactttaagg tcagtgcctc aataagacag
     6421 tgaccccctt gtcggcaaac tctgtgactc ttaggtaaag gggagatgac cttgacagga
     6481 ggttactgtt ctcactacca gctgacactg ctgaagacaa gagacaaatg gctatgcaga
     6541 ctgtagggac cagcgtaaag gggtgcagag ctataatttg ggggtttaac gtgaaacact
     6601 ttagtgtagt aactgtattc accgtttgca tttcaactgc cacatttgtc aggttttgta
     6661 caaactctgt tagtggattc atcttttttt taaatccata tgttgtttgt tacatgtgac
     6721 tatttttgta aacggggttt ctgttgggaa acagactaaa ggaactcttt tccctgtgtg
     6781 tcacctgggg gtattgacat ccatacagcc ctcccatctg cacaacgatg tggttttgca
     6841 tgtgagggca tgctgtacct tacgatcatg catgagaaaa aaagtcacaa ggaaagcaaa
     6901 gtcggttctt caacagttct acatcatctg tgtttctgcg gggggacggg gggaggtact
     6961 gaggtgatca tgagaccatg ggctttgccg agctggcttt gtcaactcta gcccttagtc
     7021 caaggagatt gatcgatcag acaggtcatt gagtcttagt aggtgcaaac ttcatccaaa
     7081 tgtctggagt cctgttacgt ttctgttcac tgtctcttca aagtctctaa attatgactc
     7141 tgactcccta cccccagccc tagcagagcg aattgaccaa aagaaccctt tataaattcc
     7201 cgcttaaccc tgcactttgt ttagccatct tcagctctca gcgaggttga cactgtaatg
     7261 tgttaatgaa atgctattta ttgtgtaaat agtcatttta ctctgtggtg cacgtttgag
     7321 caaacaaata atgacctaag cacagtattt attgcatcaa atacgtacca cgagaaacgt
     7381 agagtgcaag ctgtccgctg gtaatatact gtattctgta ccattataga tagtgtggat
     7441 gctgtcagtg catgtcgata ttaccatgct gcggtatcta gtttctccca ccactcagaa
     7501 tctcatactc atgagacacc ataggtcagt ggctaagtca aggaaaccgt tcagcagatt
     7561 tcatttcttt aagtcattaa gcaatagttt gcagcatttt aacaatgtct gggttgtttt
     7621 tcaattctaa gtggatgacg ttcaatgtat agccagactg tacatacatg ttcggaagac
     7681 aacactactg cttaacctgt taaaacatgt ttagagtttt ataagcaagt ataaatactg
     7741 tacaaagtca ctttcttttg tttttcagca tcatgtacat atgaagagga aattatcttc
     7801 aggttgatat cacgatcact tttcttactt tccgtccaca gcagtttttc atggaagata
     7861 tttgctaact aagaaatgaa accatgacgg ggtagtggta gatctctgct tttttaatca
     7921 cgggctttaa gtttggatta tttcataatt ttaagggaca aagtacactc acaacctcac
     7981 atccaaatta tgatttgcaa ttgggaaagg gtagaacatt tgatttatgt ttattatagt
     8041 gtctgtgcga acagatgacc ggaatgcttt ttttttctca tttttcttta ttccctaatt
     8101 tctgtttatt tttctttgct ttggaatcat gcatctctag attgttctaa atataaacgt
     8161 gagcttcgga atttcttttc ctcaaaaaca gagaggatga cacttacata gtcaattata
     8221 tcaagatatt tgtgtttctt acagaagcag accataggca cctctttttc ttaagaaaaa
     8281 aaatatttag gcaaaccgta ttcatgaact gcatgttgga aaatgctact attgcccaaa
     8341 atgatgctaa tcacaattaa aaatgtgcaa atctaataaa aattaatttt ttatttt
//
