LOCUS       NM_019265               5905 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Rattus norvegicus sodium voltage-gated channel alpha subunit 11
            (Scn11a), mRNA.
ACCESSION   NM_019265
VERSION     NM_019265.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5905)
  AUTHORS   Ri-Ge-le,A., Guo,Z.L., Wang,Q., Zhang,B.J., Kong,D.W., Yang,W.Q.,
            Yu,Y.B. and Zhang,L.
  TITLE     Tanshinone IIA Improves Painful Diabetic Neuropathy by Suppressing
            the Expression and Activity of Voltage-Gated Sodium Channel in Rat
            Dorsal Root Ganglia
  JOURNAL   Exp Clin Endocrinol Diabetes 126 (10), 632-639 (2018)
   PUBMED   29388177
  REMARK    GeneRIF: the protein expressions of voltage-gated sodium channels
            (VGSCs) alpha-subunits Nav1.3, Nav1.7 and Nav1.9 increased in
            dorsal root ganglionof diabetic rats and were normalized by TIIA
            application.
REFERENCE   2  (bases 1 to 5905)
  AUTHORS   Gawlak,M., Szulczyk,B., Berlowski,A., Grzelka,K., Stachurska,A.,
            Pelka,J., Czarzasta,K., Malecki,M., Kurowski,P., Nurowska,E. and
            Szulczyk,P.
  TITLE     Age-dependent expression of Nav1.9 channels in medial prefrontal
            cortex pyramidal neurons in rats
  JOURNAL   Dev Neurobiol 77 (12), 1371-1384 (2017)
   PUBMED   28913981
  REMARK    GeneRIF: The mRNA expression of the SCN11a gene (which encodes the
            Nav1.9 channel) in mPFC tissue was significantly higher in young
            rats than in late adolescent and adult rats.
REFERENCE   3  (bases 1 to 5905)
  AUTHORS   Lolignier,S., Bonnet,C., Gaudioso,C., Noel,J., Ruel,J., Amsalem,M.,
            Ferrier,J., Rodat-Despoix,L., Bouvier,V., Aissouni,Y., Prival,L.,
            Chapuy,E., Padilla,F., Eschalier,A., Delmas,P. and Busserolles,J.
  TITLE     The Nav1.9 channel is a key determinant of cold pain sensation and
            cold allodynia
  JOURNAL   Cell Rep 11 (7), 1067-1078 (2015)
   PUBMED   25959819
  REMARK    GeneRIF: We conclude that Nav1.9 acts as a subthreshold amplifier
            in cold-sensitive nociceptive neurons and is required for the
            perception of cold pain under normal and pathological conditions.
REFERENCE   4  (bases 1 to 5905)
  AUTHORS   Nutter,T.J. and Cooper,B.Y.
  TITLE     Persistent modification of Nav1.9 following chronic exposure to
            insecticides and pyridostigmine bromide
  JOURNAL   Toxicol Appl Pharmacol 277 (3), 298-309 (2014)
   PUBMED   24732443
  REMARK    GeneRIF: The effects of insecticides and pyridostimine bromide on
            the exprssion of Nav1.9 in muscle and vascular nociceptors is
            reported.
REFERENCE   5  (bases 1 to 5905)
  AUTHORS   Dusmez,D., Cengiz,B., Yumrutas,O., Demir,T., Oztuzcu,S.,
            Demiryurek,S., Tutar,E., Bayraktar,R., Bulut,A., Simsek,H.,
            Dagli,S.N., Kilic,T. and Bagci,C.
  TITLE     Effect of verapamil and lidocaine on TRPM and NaV1.9 gene
            expressions in renal ischemia-reperfusion
  JOURNAL   Transplant Proc 46 (1), 33-39 (2014)
   PUBMED   24507022
  REMARK    GeneRIF: verapamil and lidocaine significantly reduce the degree of
            ischemia-reperfusion injury due to effects to TRPM and Nav1.9 genes
REFERENCE   6  (bases 1 to 5905)
  AUTHORS   Decosterd,I., Ji,R.R., Abdi,S., Tate,S. and Woolf,C.J.
  TITLE     The pattern of expression of the voltage-gated sodium channels
            Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory
            neurons in experimental neuropathic pain models
  JOURNAL   Pain 96 (3), 269-277 (2002)
   PUBMED   11972999
  REMARK    GeneRIF: The pattern of expression of the voltage-gated sodium
            channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary
            sensory neurons in experimental neuropathic pain models.
REFERENCE   7  (bases 1 to 5905)
  AUTHORS   Benn,S.C., Costigan,M., Tate,S., Fitzgerald,M. and Woolf,C.J.
  TITLE     Developmental expression of the TTX-resistant voltage-gated sodium
            channels Nav1.8 (SNS) and Nav1.9 (SNS2) in primary sensory neurons
  JOURNAL   J Neurosci 21 (16), 6077-6085 (2001)
   PUBMED   11487631
REFERENCE   8  (bases 1 to 5905)
  AUTHORS   Liu,Cj., Dib-Hajj,S.D. and Waxman,S.G.
  TITLE     Fibroblast growth factor homologous factor 1B binds to the C
            terminus of the tetrodotoxin-resistant sodium channel rNav1.9a
            (NaN)
  JOURNAL   J Biol Chem 276 (22), 18925-18933 (2001)
   PUBMED   11376006
REFERENCE   9  (bases 1 to 5905)
  AUTHORS   Tate,S., Benn,S., Hick,C., Trezise,D., John,V., Mannion,R.J.,
            Costigan,M., Plumpton,C., Grose,D., Gladwell,Z., Kendall,G.,
            Dale,K., Bountra,C. and Woolf,C.J.
  TITLE     Two sodium channels contribute to the TTX-R sodium current in
            primary sensory neurons
  JOURNAL   Nat Neurosci 1 (8), 653-655 (1998)
   PUBMED   10196578
REFERENCE   10 (bases 1 to 5905)
  AUTHORS   Dib-Hajj,S.D., Tyrrell,L., Black,J.A. and Waxman,S.G.
  TITLE     NaN, a novel voltage-gated Na channel, is expressed preferentially
            in peripheral sensory neurons and down-regulated after axotomy
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8963-8968 (1998)
   PUBMED   9671787
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF059030.2.
            
            On Jul 25, 2001 this sequence version replaced NM_019265.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF059030.2 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760384 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5905
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..5905
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /note="sodium voltage-gated channel alpha subunit 11"
                     /db_xref="GeneID:29701"
                     /db_xref="RGD:3630"
     exon            1..44
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            45..318
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..5349
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /note="sodium channel, voltage-gated, type 11, alpha
                     polypeptide; sodium channel, voltage-gated, type XI, alpha
                     polypeptide; sensory neuron sodium channel 2; sodium
                     channel, voltage-gated, type XI, alpha subunit; sodium
                     channel protein type XI subunit alpha; voltage-gated
                     sodium channel subunit alpha Nav1.9; sodium channel,
                     voltage-gated, type11, alpha polypeptide; voltage-gated
                     sodium channel NAV1.9b"
                     /codon_start=1
                     /product="sodium channel protein type 11 subunit alpha"
                     /protein_id="NP_062138.1"
                     /db_xref="GeneID:29701"
                     /db_xref="RGD:3630"
                     /translation="MEERYYPVIFPDERNFRPFTSDSLAAIEKRIAIQKERKKSKDKA
                     AAEPQPRPQLDLKASRKLPKLYGDIPPELVAKPLEDLDPFYKDHKTFMVLNKKRTIYR
                     FSAKRALFILGPFNPLRSLMIRISVHSVFSMFIICTVIINCMFMANSMERSFDNDIPE
                     YVFIGIYILEAVIKILARGFIVDEFSFLRDPWNWLDFIVIGTAIATCFPGSQVNLSAL
                     RTFRVFRALKAISVISGLKVIVGALLRSVKKLVDVMVLTLFCLSIFALVGQQLFMGIL
                     NQKCIKHNCGPNPASNKDCFEKEKDSEDFIMCGTWLGSRPCPNGSTCDKTTLNPDNNY
                     TKFDNFGWSFLAMFRVMTQDSWERLYRQILRTSGIYFVFFFVVVIFLGSFYLLNLTLA
                     VVTMAYEEQNRNVAAETEAKEKMFQEAQQLLREEKEALVAMGIDRSSLNSLQASSFSP
                     KKRKFFGSKTRKSFFMRGSKTAQASASDSEDDASKNPQLLEQTKRLSQNLPVDLFDEH
                     VDPLHRQRALSAVSILTITMQEQEKFQEPCFPCGKNLASKYLVWDCSPQWLCIKKVLR
                     TIMTDPFTELAITICIIINTVFLAVEHHNMDDNLKTILKIGNWVFTGIFIAEMCLKII
                     ALDPYHYFRHGWNVFDSIVALLSLADVLYNTLSDNNRSFLASLRVLRVFKLAKSWPTL
                     NTLIKIIGHSVGALGNLTVVLTIVVFIFSVVGMRLFGTKFNKTAYATQERPRRRWHMD
                     NFYHSFLVVFRILCGEWIENMWGCMQDMDGSPLCIIVFVLIMVIGKLVVLNLFIALLL
                     NSFSNEEKDGSLEGETRKTKVQLALDRFRRAFSFMLHALQSFCCKKCRRKNSPKPKET
                     TESFAGENKDSILPDARPWKEYDTDMALYTGQAGAPLAPLAEVEDDVEYCGEGGALPT
                     SQHSAGVQAGDLPPETKQLTSPDDQGVEMEVFSEEDLHLSIQSPRKKSDAVSMLSECS
                     TIDLNDIFRNLQKTVSPKKQPDRCFPKGLSCHFLCHKTDKRKSPWVLWWNIRKTCYQI
                     VKHSWFESFIIFVILLSSGALIFEDVNLPSRPQVEKLLRCTDNIFTFIFLLEMILKWV
                     AFGFRRYFTSAWCWLDFLIVVVSVLSLMNLPSLKSFRTLRALRPLRALSQFEGMKVVV
                     YALISAIPAILNVLLVCLIFWLVFCILGVNLFSGKFGRCINGTDINMYLDFTEVPNRS
                     QCNISNYSWKVPQVNFDNVGNAYLALLQVATYKGWLEIMNAAVDSREKDEQPDFEANL
                     YAYLYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLG
                     TKKPQKPIPRPLNKCQAFVFDLVTSQVFDVIILGLIVLNMIIMMAESADQPKDVKKTF
                     DILNIAFVVIFTIECLIKVFALRQHYFTNGWNLFDCVVVVLSIISTLVSRLEDSDISF
                     PPTLFRVVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLVMFIYAIFG
                     MSWFSKVKKGSGIDDIFNFETFTGSMLCLFQITTSAGWDTLLNPMLEAKEHCNSSSQD
                     SCQQPQIAVVYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFEIFYEVW
                     EKFDPEASQFIQYSALSDFADALPEPLRVAKPNKFQFLVMDLPMVMGDRLHCMDVLFA
                     FTTRVLGDSSGLDTMKTMMEEKFMEANPFKKLYEPIVTTTKRKEEEQGAAVIQRAYRK
                     HMEKMVKLRLKDRSSSSHQVFCNGDLSSLDVAKVKVHND"
     exon            319..437
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            438..530
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            531..659
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            660..754
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            755..928
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            929..995
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1137
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1335
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1509
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1639
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1878
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2058
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2415
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2817
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..2931
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3049
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3204
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3378
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3480
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            3481..3750
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            3751..3804
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3942
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            3943..4047
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            4048..4318
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
     exon            4319..5884
                     /gene="Scn11a"
                     /gene_synonym="NaN"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctggagcca tacggtgccc tgatcctctg taccaggaag acagggtgaa gatggaggag
       61 aggtactacc cggtgatctt cccggacgag cggaatttcc gccccttcac ttccgactct
      121 ctggctgcca tagagaagcg gattgctatc caaaaggaga ggaagaagtc caaagacaag
      181 gcggcagctg agccccagcc tcggcctcag cttgacctaa aggcctccag gaagttacct
      241 aagctttatg gtgacattcc ccctgagctt gtagcgaagc ctctggaaga cctggaccca
      301 ttctacaaag accataagac attcatggtg ttgaacaaga agagaacaat ttatcgcttc
      361 agcgccaagc gggccttgtt cattctgggg ccttttaatc ccctcagaag cttaatgatt
      421 cgtatctctg tccattcagt ctttagcatg ttcatcatct gcacggtgat catcaactgt
      481 atgttcatgg cgaattctat ggagagaagt ttcgacaacg acattcccga atacgtcttc
      541 attgggattt atattttaga agctgtgatt aaaatattgg caagaggctt cattgtggat
      601 gagttttcct tcctccgaga tccgtggaac tggctggact tcattgtcat tggaacagcg
      661 atcgcaactt gttttccggg cagccaagtc aatctttcag ctcttcgtac cttccgagtg
      721 ttcagagctc tgaaggcgat ttcagttatc tcaggtctga aggtcatcgt aggtgccctg
      781 ctgcgctcgg tgaagaagct ggtagacgtg atggtcctca ctctcttctg cctcagcatc
      841 tttgccctgg tcggtcagca gctgttcatg ggaattctga accagaagtg tattaagcac
      901 aactgtggcc ccaaccctgc atccaacaag gattgctttg aaaaggaaaa agatagcgaa
      961 gacttcataa tgtgtggtac ctggctcggc agcagaccct gtcccaatgg ttctacgtgc
     1021 gataaaacca cattgaaccc agacaataat tatacaaagt ttgacaactt tggctggtcc
     1081 tttctcgcca tgttccgggt tatgactcaa gactcctggg agaggcttta ccgacagatc
     1141 ctgcggacct ctgggatcta ctttgtcttc ttcttcgtgg tggtcatctt cctgggctcc
     1201 ttctacctgc ttaacctaac cctggctgtt gtcaccatgg cttatgaaga acagaacaga
     1261 aatgtagctg ctgagacaga ggccaaggag aaaatgtttc aggaagccca gcagctgtta
     1321 agggaggaga aggaggctct ggttgccatg ggaattgaca gaagttccct taattccctt
     1381 caagcttcat ccttttcccc gaagaagagg aagtttttcg gtagtaagac aagaaagtcc
     1441 ttctttatga gagggtccaa gacggcccaa gcctcagcgt ctgattcaga ggacgatgcc
     1501 tctaaaaatc cacagctcct tgagcagacc aaacgactgt cccagaactt gccagtggat
     1561 ctctttgatg agcacgtgga ccccctccac aggcagagag cgctgagcgc tgtcagtatc
     1621 ttaaccatca ccatgcagga acaagaaaaa ttccaggagc cttgtttccc atgtgggaaa
     1681 aatttggcct ctaagtacct ggtgtgggac tgtagccctc agtggctgtg cataaagaag
     1741 gtcctgcgga ccatcatgac ggatcccttt actgagctgg ccatcaccat ctgcatcatc
     1801 atcaataccg ttttcttagc cgtggagcac cacaacatgg atgacaactt aaagaccata
     1861 ctgaaaatag gaaactgggt tttcacggga attttcatag cggaaatgtg tctcaagatc
     1921 atcgcgctcg acccttacca ctacttccgg cacggctgga atgtttttga cagcatcgtg
     1981 gccctcctga gtctcgctga tgtgctctac aacacactgt ctgataacaa taggtctttc
     2041 ttggcttccc tcagagtgct gagggtcttc aagttagcca aatcctggcc cacgttaaac
     2101 actctcatta agatcatcgg ccactccgtg ggcgcgcttg gaaacctgac tgtggtcctg
     2161 actatcgtgg tcttcatctt ttctgtggtg ggcatgcggc tcttcggcac caagtttaac
     2221 aagaccgcct acgccaccca ggagcggccc aggcggcgct ggcacatgga taatttctac
     2281 cactccttcc tggtggtgtt ccgcatcctc tgtggggaat ggatcgagaa catgtggggc
     2341 tgcatgcagg atatggacgg ctccccgttg tgcatcattg tctttgtcct gataatggtg
     2401 atcgggaagc ttgtggtgct taacctcttc attgccttgc tgctcaattc cttcagcaat
     2461 gaggagaagg atgggagcct ggaaggagag accaggaaaa ccaaagtgca gctagccctg
     2521 gatcggttcc gccgggcctt ctccttcatg ctgcacgctc ttcagagttt ttgttgcaag
     2581 aaatgcagga ggaaaaactc gccaaagcca aaagagacaa cagaaagctt tgctggtgag
     2641 aataaagact caatcctccc ggatgcgagg ccctggaagg agtatgatac agacatggct
     2701 ttgtacactg gacaggccgg ggctccgctg gccccactcg cagaggtaga ggacgatgtg
     2761 gaatattgtg gtgaaggcgg tgccctaccc acctcacaac atagtgctgg agttcaggcc
     2821 ggtgacctcc ctccagagac caagcagctc actagcccgg atgaccaagg ggttgaaatg
     2881 gaagtatttt ctgaagaaga tctgcattta agcatacaga gtcctcgaaa gaagtctgac
     2941 gcagtgagca tgctctcgga atgcagcaca attgacctga atgatatctt tagaaattta
     3001 cagaaaacag tttcccccaa aaagcagcca gatagatgct ttcccaaggg ccttagttgt
     3061 cactttctat gccacaaaac agacaagaga aagtccccct gggtcctgtg gtggaacatt
     3121 cggaaaacct gctaccaaat cgtgaagcac agctggtttg agagtttcat aatctttgtt
     3181 attctgctga gcagtggagc gctgatattt gaagatgtca atctccccag ccggccccaa
     3241 gttgagaaat tactaaggtg taccgataat attttcacat ttattttcct cctggaaatg
     3301 atcctgaagt gggtggcctt tggattccgg aggtatttca ccagtgcctg gtgctggctt
     3361 gatttcctca ttgtggtggt gtctgtgctc agtctcatga atctaccaag cttgaagtcc
     3421 ttccggactc tgcgggccct gagacctctg cgggcgctgt cccagtttga aggaatgaag
     3481 gttgtcgtct acgccctgat cagcgccata cctgccattc tcaatgtctt gctggtctgc
     3541 ctcattttct ggctcgtatt ttgtatcttg ggagtaaatt tattttctgg gaagtttgga
     3601 aggtgcatta acgggacaga cataaatatg tatttggatt ttaccgaagt tccgaaccga
     3661 agccaatgta acattagtaa ttactcgtgg aaggtcccgc aggtcaactt tgacaacgtg
     3721 gggaatgcct atctcgccct gctgcaagtg gcaacctata agggctggct ggaaatcatg
     3781 aatgctgctg tcgattccag agagaaagac gagcagccgg actttgaggc gaacctctac
     3841 gcgtatctct actttgtggt ttttatcatc ttcggctcct tctttaccct gaacctcttt
     3901 atcggtgtta ttattgacaa cttcaatcag cagcagaaaa agttaggtgg ccaagacatt
     3961 tttatgacag aagaacagaa gaaatattac aatgcaatga aaaagttagg aaccaagaaa
     4021 cctcaaaagc ccatcccaag gcccctgaac aaatgtcaag cctttgtgtt cgacctggtc
     4081 acaagccagg tctttgacgt catcattctg ggtcttattg tcttaaatat gattatcatg
     4141 atggctgaat ctgccgacca gcccaaagat gtgaagaaaa cctttgatat cctcaacata
     4201 gccttcgtgg tcatctttac catagagtgt ctcatcaaag tctttgcttt gaggcaacac
     4261 tacttcacca atggctggaa cttatttgat tgtgtggtcg tggttctttc tatcattagt
     4321 accctggttt cccgcttgga ggacagtgac atttctttcc cgcccacgct cttcagagtc
     4381 gtccgcttgg ctcggattgg tcgaatcctc aggctggtcc gggctgcccg gggaatcagg
     4441 accctcctct ttgctttgat gatgtctctc ccctctctct tcaacatcgg tctgctgctc
     4501 ttcctggtga tgttcattta cgccatcttt gggatgagct ggttttccaa agtgaagaag
     4561 ggctccggga tcgacgacat cttcaacttc gagaccttta cgggcagcat gctgtgcctc
     4621 ttccagataa ccacttcggc tggctgggat accctcctca accccatgct ggaggcaaaa
     4681 gaacactgca actcctcctc ccaagacagc tgtcagcagc cgcagatagc cgtcgtctac
     4741 ttcgtcagtt acatcatcat ctccttcctc atcgtggtca acatgtacat cgctgtgatc
     4801 ctcgagaact tcaacacagc cacggaggag agcgaggacc ctctgggaga ggacgacttt
     4861 gaaatcttct atgaggtctg ggagaagttt gaccccgagg cgtcgcagtt catccagtat
     4921 tcggccctct ctgactttgc ggacgccctg ccggagccgt tgcgtgtggc caagccgaat
     4981 aagtttcagt ttctagtgat ggacttgccc atggtgatgg gcgaccgcct ccattgcatg
     5041 gatgttctct ttgctttcac taccagggtc ctcggggact ccagcggctt ggataccatg
     5101 aaaaccatga tggaggagaa gtttatggag gccaaccctt ttaagaagct ctacgagccc
     5161 atagtcacca ccaccaagag gaaggaggag gagcaaggcg ccgccgtcat ccagagggcc
     5221 taccggaaac acatggagaa gatggtcaaa ctgaggctga aggacaggtc aagttcatcg
     5281 caccaggtgt tttgcaatgg agacttgtcc agcttggatg tggccaaggt caaggttcac
     5341 aatgactgaa ccctcatctc cacccctacc tcactgcctc acagcttagc ctccagcctc
     5401 tggcgagcag gcggcagact cactgaacac aggccgttcg atctgtgttt ttggctgaac
     5461 gaggtgacag gttggcgtcc atttttaaat gactcttgga aagatttcat gtagagagat
     5521 gttagaaggg actgcaaagg acaccgacca taacggaagg cctggaggac agtccaactt
     5581 acataaagat gagaaacaag aaggaaagat cccaggaaaa cttcagattg tgttctcagt
     5641 acattcccca atgtgtctgt tcggtgtttt gagtatgtga cctgccacat gtagctcttt
     5701 tttgcatgta cgtcaaaacc ctgcagtaag ttaatagctt gctacgggtg ttcctaccag
     5761 catcacagaa ttgggtgtat gactcaaacc taaaagcatg actctgactt gtcagtcagc
     5821 accccgactt tcagacgctc caatctctgt cccaggtgtc taacgaataa ataggtaaaa
     5881 gaaaaaaaaa aaaaaaaaaa aaaaa
//
